Amyotrophic Lateral Sclerosis (ALS) is described as a neurodegenerative disease and characterized by degeneration of upper and lower motor neurons. ALS is specified by mid-to-late-life onset, selective neuronal death and the formation of protein deposits in affected neuronal tissues similar to other neurodegenerative diseases, like Alzheimer's disease, Parkinson's disease and Huntington's disease. Sporadic cases of ALS occur with no family history of ALS. Familial ALS is due to inherited mutations spread throughout the SOD1 polypeptide.
Superoxide dismutase (SOD) is an antioxidant enzyme and as such part of the defense system against reactive oxygen species. SOD catalyses the dismutation reaction of the superoxide radical anion (O2-) to hydrogen peroxide (H2O2) through glutathione reductase and catalase. Several classes of SODs have been identified, which include the intracellular copper/zinc SOD (Cu/Zn-SOD, SOD1), the mitochondrial manganese SOD (Mn-SOD, SOD2) and the extracellular copper/zinc SOD (ECSOD, SOD3).
SOD1 antibody, cat# TA500495. Western blot with of extracts (35ug) from 6 different cell lines.
Recombinant TDP43 protein purified from HEK293 cells, cat# TP310639.
TA309896 staining of TDP43 (red) in formalin fixed adult rat hippocampus. Hippocampal neuron nuclei are stained strongly. GFAP (green) shows the processes of astrocytic glial cells. Nuclei of all cells are revealed with DAPI (blue).
SOD1 is found in all eukaryotic species as a homodimeric 32 kDa enzyme, which contains one Cu- and one Zn-ion each. SOD1 neutralizes supercharged oxygen molecules (superoxide radicals), which can damage cells if their levels are not controlled. The mechanism through which mutant SOD1 causes ALS is not known, but instability, misfolding and aggregation of mutant SOD1 is hypothesized. Biochemical markers of SOD1 misfolding have been noticed as early indicators of ALS. One such marker is the appearance of detergent insoluble precipitates of SOD1 which correlate well with disease onset and progression.
Expression validated SOD2 ORF clone, cat# RC202330, Western validation with an anti-DDK antibody (SKU TA50011-100). L: Control HEK293 lysate R: Over-expression lysate.
The cellular protein TAR DNA-binding protein 43 (TARDBP, TDP43) functions as a DNA-binding protein and specifically binds to the TAR DNA sequence motifs of HIV. TARDBP protein has been identified as a major pathological protein of sporadic and familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions with or without motor neuron disease. Therefore, TARDBP defines a novel class of neurodegenerative diseases called TARDBP proteinopathies.
|SOD1||anti hu SOD1 mouse monocl. antibody; for WB, IHC, FC||TA500495|
|SOD1||anti hu, ms, rt SOD1 rabbit polycl. antibody; for WB, IHC||TA326813|
|SOD1||hu SOD1 ORF clone, Myc-DDK tagged||RC200725|
|SOD1||hu SOD1 lentiviral ORF clone, Myc-DDK tagged||RC200725L2|
|SOD1||Hu SOD1 lentiviral ORF clone, Myc-DDK tagged, mam. resistance||RC200725L4|
|SOD1||hu SOD1 lentiviral particles||RC200725L2V|
|SOD1||hu SOD1 lentiviral particles||RC200725L4V|
|SOD1||hu SOD1 recomb. protein, mammalian expressed||TP300725|
|SOD1||hu SOD1 siRNA||SR304518|
|SOD1||hu SOD1 shRNA in lentiviral vector||TL309191|
|SOD1||hu SOD1 shRNA as lentiviral particles||TL309191V|
|SOD1||hu SOD1 CRISPR kit||KN400725|
|SOD1||hu SOD1 ELISA kit||EA100096|
|SOD2||anti hu, dg SOD2 mouse monocl. antibody; for WB||TA501887|
|SOD2||anti hu, ms, rt SOD2 rabbit polycl. antibody; for WB, IHC||TA327034|
|SOD2||hu SOD2 ORF clone, Myc-DDK tagged||RC202330|
|SOD2||hu SOD2 lentiviral ORF clone, Myc-DDK tagged||RC202330L2|
|SOD2||Hu SOD2 lentiviral ORF clone, Myc-DDK tagged, mam. resistance||RC202330L4|
|SOD2||hu SOD2 lentiviral particles||RC202330L2V|
|SOD2||hu SOD2 lentiviral particles||RC202330L4V|
|SOD2||hu SOD2 recomb. protein, mammalian expressed||TP302330|
|SOD2||hu SOD2 siRNA||SR304519|
|SOD2||hu SOD2 shRNA in lentiviral vector||TL309190|
|SOD2||hu SOD2 shRNA as lentiviral particles||TL309190V|
|SOD2||hu SOD2 CRISPR kit||KN402330|
|SOD3||anti hu, ms, rt SOD3 mouse monocl. antibody; for IF||TA326420|
|SOD3||anti hu, ms,rt SOD3 rabbit polycl. antibody; for WB||TA326421|
|SOD3||hu SOD3 ORF clone, Myc-DDK tagged||RC204156|
|SOD3||hu SOD3 lentiviral ORF clone, Myc-DDK tagged||RC204156L2|
|SOD3||Hu SOD3 lentiviral ORF clone, Myc-DDK tagged, mam. resistance||RC204156L4|
|SOD3||hu SOD3 lentiviral particles||RC204156L2V|
|SOD3||hu SOD3 lentiviral particles, incl. mam. resistance||RC204156L4V|
|SOD3||hu SOD3 recomb. protein, mammalian expressed||TP304156|
|SOD3||hu SOD3 siRNA||SR304520|
|SOD3||hu SOD3 shRNA in lentiviral vector||TL316735|
|SOD3||hu SOD3 shRNA as lentiviral particles||TL316735V|
|SOD3||hu SOD3 CRISPR kit||KN404156|
|TDP43||anti hu, ms, rt TDP43 mouse monocl. antibody; for IF||TA309896|
|TDP43||anti hu, ms TDP43 rabbit polycl. antibody; for WB, IHC, IF||TA324524|
|TDP43||hu SOD3 ORF clone, Myc-DDK tagged||RC210639|
|TDP43||hu SOD3 lentiviral ORF clone, Myc-DDK tagged||RC210639L2|
|TDP43||Hu SOD3 lentiviral ORF clone, Myc-DDK tagged, mam. resistance||RC210639L4|
|TDP43||hu SOD3 lentiviral particles||RC210639L2V|
|TDP43||hu SOD3 lentiviral particles, incl. mam. resistance||RC210639L4V|
|TDP43||hu TDP43 recomb. protein, mammalian expressed||TP310639|
|TDP43||hu TDP43 siRNA||SR308276|
|TDP43||hu SOD3 shRNA in lentiviral vector||TL308946|
|TDP43||hu SOD3 shRNA as lentiviral particles||TL308946V|
|TDP43||hu TDP43 CRISPR kit||KN410639|