17β-Hydroxysteroid dehydrogenase (HSD17B)
17β-Hydroxysteroid dehydrogenase (HSD17B) are multifunctional enzymes that not only catalyzes the oxidation/reduction of the 17β-hydroxyl/keto group in position C17, C18 and C19 steroids but also execute reactions in intermediary metabolism. 14 isoforms of HSD17B is known. The tissue expression characteristics varies from being tissue specific to ubiquitous. Deficiency in HSD17B4 and HSD17B10 is associated with inborn metabolism errors in humans, which underlines the significance of HSD17B’s role as a metabolic enzyme.
OriGene offers a comprehensive suite of products to analyze HSD17B function. It includes cDNA clones, recombinant proteins, antibodies and other reagents for analyzing in human, mouse and rat. For details, refer to the table.
OriGene offers 4 biologically active isoforms of HSD17B protein: HSD17B2 , HSD17B4 , HSD17B10, HSD17B13
HSD17B2 catalyzes the interconversion of testosterone and androstenedione, as well as estradiol and estrone; in addition to having 20-alpha-HSD activity. It uses NADH as its substrate unlike HSD17B3 which uses NADPH. Studies show that it might play a role in the pathology of breast cancer, prostate cancer, endometriosis and osteoporosis.
Tissue distribution: Liver, Intestine, Endometrium, Placenta, Pancreas, Prostate, Colon, Bone.
Bioactive protein: OriGene offers a bioactive HSD17B2 (Cat# TP30329) with a high specific activity as show in the graph on the left.
Other HSD17B2 reagents:
Clones
Proteins
Antibodies
Lentivirus & siRNA
HSD17B4 is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids and as a catalyst in the formation of 3-ketoacyl-CoA. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). In addition defects in this enzyme is associated with Perrault syndrome and prostate cancer.
Tissue distribution: Ubiquitous including liver, heart, kidney, pancreas and more.
Bioactive protein: OriGene offers a bioactive HSD17B4 (Cat# TP300460) with a high specific activity as show in the graph on the left.
Other HSD17B4 reagents:
Clones
Proteins
Antibodies
Lentivirus & siRNA
HSD17B10 is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids and steroids, and is a subunit of mitochondrial ribonuclease P, which is involved in tRNA maturation. The protein has been implicated in the development of Alzheimer disease, and mutations in the gene are the cause of 17beta-hydroxysteroid dehydrogenase type 10 (HSD10) deficiency.
Tissue distribution: Ubiquitous including liver, heart, intestine, kidney, sebaceous gland, ovary and more.
Bioactive protein: OriGene offers a bioactive HSD17B10 (Cat# TP301734) with a high specific activity as show in the graph on the left.
Other HSD17B10 reagents:
Clones
Proteins
Antibodies
Lentivirus & siRNA
HSD17B13 is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids and as a catalyst in the formation of 3-ketoacyl-CoA. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). In addition defects in this enzyme is associated with Perrault syndrome and prostate cancer.
Tissue distribution: liver, bone marrow, lung, ovary, testis, kidney, brain, bladder, nasal epithelia, skeletal muscle.
Bioactive protein: OriGene offers a bioactive HSD17B4 (Cat# TP300460) with a high specific activity as show in the graph on the left.
Other HSD17B13 reagents:
Clones
Proteins
Antibodies
Lentivirus & siRNA
14 Isoforms of HSD17B
Gene name | Cellular location | Tissue distribution | Pathology |
---|---|---|---|
HSD17B1 | Cytosol | Ovary, endometrium, breast, brain, prostate, placenta | Breast cancer, prostate cancer, endometriosis |
HSD17B2 | ER | Liver, intestine, endometrium, placenta, pancreas, prostate, colon, bone | Breast cancer, prostate cancer, endometriosis, osteoporosis |
HSD17B3 | ER | Testis, ovary, blood, saliva, skin, adipose tissue, brain, bone | 17β-HSD3 deficiency, prostate cancer |
HSD17B4
(DBP, MFP2) |
PXS | Liver, heart, prostate, testis, lung, skeletal muscle, kidney, pancreas, thymus, ovary, intestine, placenta, brain, spleen, colon, lymphocytes | 17β-HSD3 deficiency, prostate cancer |
HSD17B5
(AKR1C3) |
Nucleus, cytosol | Prostate, mammary gland, liver, kidney, lung, heart, small intestine, colon, uterus, testis, brain, skeletal muscle, adipose tissue | Breast cancer, prostate cancer |
HSD17B6 | Endosomes | Liver, testis, lung, spleen, brain, ovary, kidney, adrenal, prostate | Hypotrichosis2, Cortisone reductase deficiency, ovary sarcoma, ovarian endometrioid stromal sarcoma |
HSD17B7 | PM, ER | Ovary, corpus luteum, uterus, placenta, liver, breast, testis, brain, adrenal gland, small intestine, lung, thymus, prostate, adipose tissue, others | Breast cancer |
HSD17B8 | MC | Prostate, placenta, kidney, brain, cerebellum, heart, lung, small intestine, ovary, testis, adrenal, stomach | Polycystic kidney disease |
HSD17B9
(RDH5) |
ER | Retina, liver, adipose tissue, blood, others | Fundus albipunctatus |
HSD17B10 | MC | Liver, small intestine, colon, kidney, heart, brain, placenta, lung, ovary, testis, spleen, thymus, prostate, peripheral blood leukocytes | 17β-HSD10 deficiency, MRXS10, Alzheimer's disease |
HSD17B11 | ER, EP | Liver, pancreas, intestine, kidney, adrenal gland, heart, lung, testis, ovary, placenta, sebaceous gland | Lymphoma, cutaneous t-cell lymphoma |
HSD17B12 | ER | Heart, skeletal muscle, liver, kidney, adrenal gland, testis, placenta, cerebellum, pancreas, stomach, small intestine, large intestine, trachea, lung, thyroid, esophagus, prostate, aorta, urinary bladder, spleen, skin, brain, ovary, breast, uterus, vagina | Neuroblastoma, central hypoventilation syndrome, qualitative platelet defect, Ovarian cancer |
HSD17B13 | ER, EP | Liver, bone marrow, lung, ovary, testis, kidney, skeletal muscle, brain, bladder, nasal epithelia | Mucopolysaccharidosis Iii, Pseudohermaphroditism, Benign Meningioma |
HSD17B14 | Cytosol | Liver, kidney, brain, gallbladder, breast, adrenal, placenta | Breast cancer (prognostic) |