HSD17B13
HSD17B13 (17-β-hydroxysteroid dehydrogenase type 13) is a member of the HSD17Bs superfamily and has a known biological function in hepatic lipid metabolism. It has been identified as a new liver-specific lipid droplet-associated protein involved in developing non-alcoholic fatty liver disease (NAFLD). Various treatments and drug development studies targeting different splicing variants of HSD17B13 have shown promising results, indicating HSD17B13 as a potentially therapeutic target.
OriGene offers a range of tools for analyzing HSD17B13
Featured Products:
Human Recombinant Protein |
Rabbit Monoclonal Antibody |
ELISA Kit |
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| Bioactive human HSD17B13 recombinant protein with high specific activity | Rabbit monoclonal HSD17B13 Antibody, Clone OTIR5C10 for WB, IHC applications | Quantitative detection of human HSD17B13 in serum, plasma, and cell lysates |
HSD17B13 enzymatic activity with 75μM β-estradiol as a substrate, measured by NADH production (indicated by luminescence). |
Carcinoma of Human liver tissue stained using anti-HSD17B13 rabbit monoclonal antibody. |
Human HSD17B13 ELISA kit provides sensitivity as low as 100 pg/mL |
Application in Research:
OriGene's products play a crucial role in HSD17B13-related research, as demonstrated by frequently cited in well-reputed journals. Sven T. et al. used recombinant human HSD17B13 (OriGene: ) to discover a novel HSD17B13 inhibitor using a high-throughput screening method (Figure 1)1. Quentin A. et al. used recombinant human HSD17B13 (OriGene: ) to develop a bioluminescent retinol dehydrogenase assay for HSD17B13.2
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References
- Sven et al. 2023 Feb. doi: 10.1016/j.jhep.2020.04.003
- Quentin et al. 2021 Nov. doi: 10.1021/acs.jmedchem.2c01884