siRNA (27-mer): A Potent Mechanism for Gene Silencing
Trilencer-27 siRNA kits contain Dicer-Substrate duplexes that provide two critical improvements over the use of traditional 21mer siRNA designs. It takes advantage of the natural processing by Dicer to produce 10-fold higher potency and specificity than shorter 21-mer siRNA forms. The 27-mer duplexes also evade mammalian interferon response when expressed in mammalian cells and initiate strong and specific gene silencing. Learn more about Dicer-Substrate technology in this Nature Publication .
Key Features and Benefits
- Genome wide coverage against human, mouse and rat genes: view citations
- 27mer Dicer-substrate duplex : higher potency & minimal interferon response
Each of our siRNA products come as a kit. It contains 3 unique 27mer siRNA duplexes (2 nmol each), one negative control and one buffer. Each gene specific siRNA is labeled as the kit catalog number plus a/b/c. For example:
| Kit Catalog | Kit Component |
|---|---|
| SRXXXXXX |
|
Bulk Order Options
If you purchased our kits and already know which one works best for your gene, you can order this single siRNA in bulk by submitting a bulk request form. Each 10 nmol of single siRNA duplex is charged for $375. Delivery time is around 2 weeks.
Additional Products You May Need
Recent Citations using our siRNA Oligo Duplexes
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1 The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension Published in Communications Biology , using |
PubMed: 37620393 |
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2 Mitochondrial cytochrome P450 1B1 is involved in pregnenolone synthesis in human brain cells Published in The Journal of Biological Chemistry , using |
PubMed: 37442234 |
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3 AQP3-Dependent PI3K/Akt Modulation in Breast Cancer Cells. Published in International journal of molecular sciences , using |
PubMed: 37175840 |
| RNAi Resources |