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siRNA Related Product

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SKU
SR30005
RNAse free siRNA duplex re-suspension buffer (2ml)
  $130.00
In Stock*

Frequently Bought Together (1)

TT300007S A non-viral, non-electroporation, non-liposomal transfection kit using engineered mammalian proteins, tailored for high-efficiency delivery into a wide range of primary cells and difficult to transfect cell lines such as immune cells, stem cells, and neuronal cells.
20 ul
$265.00
Specifications
Specifications
Product Data
Quality Control This buffer was validated for use of re-suspension.
Storage Store at -20°C.
Components
1 vial of RNAse free siRNA duplex re-suspension buffer (2 ml)
Stability The buffer is stable for one year from date of shipping when stored at -20°C.
Shipping Ambient
Note Single siRNA duplex (10nmol) can be ordered.
Reference Data
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Documents
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NF-κB-Dependent Transcriptional Regulation of Piezo1 Mediates Bacterial Clearance on Infected Lung Stiffness
Orsini, Boulton, Abraham et al
Am J Respir Cell Mol Biol (2026)
AI Summary: OriGene products contributed to this study by providing Piezo1-targeted siRNA (Cat. No. SR423525) and control siRNA (Cat. No. SR30005), which were used to manipulate Piezo1 expression in macrophages to assess its role in bacterial clearance during pneumonia.
Snippet: …Piezo1-targeted (Cat. … SR423525) and control siRNA (Cat. … SR30005) were purchased from Origene
Spinal P2X3 receptors blockade reverses paclitaxel-induced allodynia in rats
Segura-Chama, Ramos-Chávez, Yañez-Recendis et al
Purinergic Signal (2026) 22 (1), 10 DOI: 10.1007/s11302-025-10120-8
Cited by 1
AI Summary: In this study, OriGene products—including P2X3 siRNA (cat. SR505971), Duplex Resuspension Buffer (cat. SR30005), and siTran 2.0 siRNA transfection reagent (cat. TT320001)—were used to transiently knock down P2X3 receptor expression in rats, enabling the researchers to assess the role of these receptors in paclitaxel-induced allodynia.
Snippet: d from OriGene Technologies Inc., Rockville, MD, USA (cat. SR505971), siRNA was diluted in Duplex Resuspension Buffer (cat. SR30005) and prepare for transfection with the siTran 2.0 siRNA transfection reagent (TT320001) following the manufacturer instructions;siR
NF-κB-Dependent Transcriptional Regulation of Piezo1 Mediates Bacterial Clearance on Stiffened Lung Matrix
Orsini, Boulton, Abraham et al
bioRxiv (2025)
AI Summary: OriGene’s Piezo1-targeted siRNA (Cat. No. SR423525) and control siRNA (Cat. No. SR30005) were used in this study to selectively knock down Piezo1 expression in macrophages, enabling the authors to investigate Piezo1’s role in NF-κB-dependent transcriptional regulation and bacterial clearance during pneumonia.
Snippet: Technologies (Bream, CA). The FLIPR5 Ca2+ assay kit (Cat. No. R8185) was purchased from Molecular Devices. Piezo1-targeted (Cat. No. SR423525) and control siRNA (Cat. No. SR30005) were purchased from Origene. Cell Culture, Nucleofection, and Immunoblot Analysis All animal protocols were performed as approved by the Cleveland Clinic Institutional Animal Care and Use Committee (IACUC). Bone marrow-d
FigureFigureFigure
Galectin-3 disrupts tight junctions of airway epithelial cell monolayers by inducing expression and release of matrix metalloproteinases upon influenza a infection
Iqbal, Feng, Zong et al
Glycobiology (2024)
Cited by 6
AI Summary: OriGene products, including siRNA duplexes targeting CD147 (SR319504C), integrin-β1 (SR320709C), a negative control siRNA (SR30005), and the siTran2.0 transfection reagent, were used to silence specific genes in A549 cells to investigate the role of these receptors in Galectin-3-mediated disruption of airway epithelial tight junctions during influenza A infection.
Snippet: Silencing of CD147 and integrin-β1 expression in A549 cells was achieved using siRNA duplexes (OriGene, Rockville, MD) with sequence 5ʹGCUUGCAAGAUUCCAAGUUCUCACC-3ʹ (SR319504C) targeting CD147 and 5ʹGACUGUUCUUUGGAUACUACUAGUACTT-3ʹ (SR320709C) targeting integrin-β1 and a negative control (scramble) siRNA (ID: SR30005) that did not target any human DNA sequence. …
Resolvin D4 mitigates lipopolysaccharide-induced lung injury in mice
Inomata, Tsubouchi, Takao et al
Prostaglandins, Leukotrienes and Essential Fatty Acids (2024)
Cited by 6
AI Summary: OriGene products, including 27-mer siRNAs, siTran 2.0 Transfection Reagent, and Trilencer-27 Universal Scrambled Negative Control siRNA Duplex, were used for gene knockdown experiments in BEAS-2B cells to investigate the effects of Resolvin D4 on lipopolysaccharide-induced lung injury in mice.
Snippet: …Then, siRNA Oligo duplexes as described below were combined with siTran 2.0 Transfection Reagent in transfection buffer (OriGene Technologies #TT320001) for 20 min at room temperature (final concentration 10 nM). These complexes were added directly into the culture growth medium, and incubation was performed for 72 h. Negative control cells were transfected with 10 nM of Trilencer-27 Universal Scrambled Negative Control siRNA Duplex (#SR30005). …
A defective mechanosensing pathway affects fibroblast-to-myofibroblast transition in the old male mouse heart
Angelini, Trial, Saltzman et al
iScience (2023) 26 (8), 107283 DOI: 10.1016/j.isci.2023.107283
Cited by 12
AI Summary: OriGene products, including Fermt2 Mouse siRNA Oligo duplexes (SR419055), Trilencer-27 Universal Scrambled Negative Control siRNA Duplex (SR30005), and Fermt2 Mouse Untagged clone plasmid (MC202155), were used to manipulate Kindlin-2 expression in cardiac fibroblasts, enabling the study of its role in mechanosensing and fibroblast-to-myofibroblast transition in aging male mouse hearts.
Snippet: C57bl6/J mice old male and old female (24–30 months old) National Institute of Aging ------------------------- Oligonucleotides ------------------------- Fermt2 Mouse siRNA Oligo duplexes Origene SR419055 Trilencer-27 Universal Scrambled Negative Control siRNA Duplex Origene SR30005 Fermt2 Mouse Untagged clone plasmid Origene MC202155 PCMV6-Kan/Neo Untagged Cloning Vec
FigureFigureFigure
Showing 1-6 of 23 papers.
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