In Vitro Transcribed mRNA · Gene Editing

Ultra-clean mRNA

Low double-stranded RNA content, Cap1 capping, and stabilized poly(A) architecture — from reporters to Cas9.

<0.1 ng/µgdsRNA (reporter mRNAs)
100%Capping efficiency
>10×Off-target reduction, Neat™ SpCas9

Neat eGFP

Neat Luc mRNA

Ultra-low dsRNA for cleaner, more reliable results
One platform, from reporter validation to CRISPR editing
Research use only

Spec Sheet

Compare at a glance

Pick the payload that matches your workflow — from reporter validation to functional gene editing.

PRODUCT USE CASE KEY DIFFERENTIATOR MODIFICATION SIZES
Neat™ Luciferase-mRNA
Luminescent expression assay Quantifiable readout via standard luminometer — no imaging needed 5' Cap1 · N1-Me-Pseudouridine
Neat™ eGFP-mRNA
Live-cell fluorescent imaging Real-time visualization in living cells — no substrate or fixation 5' Cap1 · N1-Me-Pseudouridine
Neat™ SpCas9 mRNA
CRISPR gene / cell therapy editing >10× fewer off-target edits than wild-type SpCas9 Cap1

Shared mRNA Architect

See the difference, assay by assay

Head-to-head against standard IVT mRNA, run under matched conditions.

Shared mRNA Architecture
m7G Coding Sequence Cap1 5' UTR ORF 3' UTR poly(A) N1-Me-pseudouridine substituted · low dsRNA
Cap structure
UTRs
Payload ORF
Poly(A) tail

Where They Fit

Built for the transfection bench

All three transcripts are delivered the same way — via your standard transfection reagent — and support the same core workflow, from optimization to functional editing.

Transfection optimization

Transfection optimization

Use Neat™ Luciferase-mRNA or Neat™ eGFP-mRNA to benchmark lipid nanoparticle, polymer, or electroporation conditions before committing a functional payload.
Expression & imaging assays

Expression & imaging assays

Track protein expression, localization, and cell viability in real time with luminescent or fluorescent reporter output.
CRISPR gene & cell therapy

CRISPR gene & cell therapy

Deliver transient, enhanced-specificity Neat™ SpCas9 mRNA expression for editing workflows where DNA-free, non-integrating nuclease delivery matters.

Ready to bring these into your workflow?

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