AAV Products and Services

Adeno-associated virus (AAV) is a small, non-enveloped virus with a single stranded DNA genome. This virus is commonly used as an efficient vehicle to mediate DNA delivery into mammalian cells, both in vitro and in vivo. The benefits of using AAV for research purposes rank from tissue sensitivity, high transduction efficiency, stable gene expression and low immunogenicity.

Solutions for entire AAV workflow

Conveniently choose which AAV accessory product supports your research efforts.

Cotransfection

Packaging Cell Line

Concentration & Purification

AAV Particles Ready for Transduction

AAV Serotype Selection Guide

One of the useful features of AAV is its serotypes, which defines the preference of the types of cells/organs they infect. The tables below provide the selection guide for in vitro and in vivo applications.

Cell Line AAV-1 AAV-2 AAV-3 AAV-4 AAV-5 AAV-6 AAV-8 AAV-9 AAV-DJ AAV-DJ/8
Huh-7 13 100 2.5 0.0 0.1 10 0.7 0.0 500 0.2
HEK293 25 100 2.5 0.1 0.1 5 0.7 0.1 500 0.3
HeLa 3 100 2.0 0.1 6.7 1 0.2 0.1 667 0.2
HepG2 3 100 16.7 0.3 1.7 5 0.3 ND 1250 0.5
Hep1A 20 100 0.2 1.0 0.1 1 0.2 0.0 400 0.1
911 17 100 11 0.2 0.1 17 0.1 ND 500 0.0
CHO 100 100 14 1.4 333 50 10 1.0 25000 5.0
COS 33 100 33 3.3 5.0 14 2.0 0.5 500 0.3
MeWo 10 100 20 0.3 6.7 10 1.0 0.2 2857 1.0
NIH3T3 10 100 2.9 2.9 0.3 10 0.3 ND 500 0.1
A549 14 100 20 ND 0.5 10 0.5 0.1 1000 0.1
HT1180 20 100 10 0.1 0.3 33 0.5 0.1 333 0.2
Monocytes 1111 100 ND ND 125 1429 ND ND 100 ND
Immature DC 2500 100 ND ND 222 2857 ND ND 200 ND
Mature DC 2222 100 ND ND 333 3333 ND ND 100 ND

Note: Infectivity rates normalized to AAV-2 = 100. ND = Not Determined.

Grimm D, Lee JS, Wang L, et al. In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses. J virol. 2008;82(12):5887-5911. doi:10.1128/JVI.00254-08

All AAV Products at a Glance 

AAV Vectors
Flexible reporter & promoter options
AAV Serotyping Kits
In-vitro & In-vivo AAV serotypes application guide
AAV Control Particles
For quantifying transduction efficiency
AAV ORF Particles
Transduction-ready AAV particles for overexpression
AAV Concentrator
Increase AAV Titer up to 100x
AAV ELISA Kits
Quantitative AAV capsid titer
AAV Antibodies
Antibodies against denatured AAV capsid and replicase for different serotypes
AAV Packaging
High-quality, ready-to-use viral particles tailored to specific experimental needs
AAV qPCR
Check recent research progress with the qPCR kit for AAV

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