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Bioactive glasses-mediated ion therapy ameliorates hepatic osteodystrophy by reprogramming the liver-bone axis
Liu, Xie, Zhao et al
Bioactive Materials (2027) 68, 67-81 DOI: 10.1016/j.bioactmat.2026.08.028
Liu, Xie, Zhao et al
Bioactive Materials (2027) 68, 67-81 DOI: 10.1016/j.bioactmat.2026.08.028
AI Summary: OriGene’s DAB chromogen (catalog no. ZLI-9019) was used to visualize immunoreactivity in tissue samples, enabling the assessment of protein expression relevant to the study’s investigation of hepatic osteodystrophy and bioactive glass-mediated therapy.
Snippet: Immunoreactivity was visualized using DAB chromogen (ORIGENE, catalog no.ZLI-9019), with nuclei counterstained by Mayer's hematoxylin (30 s). Finally, slides were dehydrated, cleared, mounted, and imaged using an Olympus BX51 phase-contrast microscope
lncRNA H19 downregulation mediates oxidative stress-induced osteogenic dysfunction
Shin, Park, Yoon et al
Bone (2027) 214, 118121 DOI: 10.1016/j.bone.2026.118121
Shin, Park, Yoon et al
Bone (2027) 214, 118121 DOI: 10.1016/j.bone.2026.118121
Targeting the Lcn2/Lcn2R-Grb2 cascade ameliorates mitochondrial bioenergetic failure and neuronal death in hepatic encephalopathy
Lee, Wu, Tsai
Exp Neurol (2027) 407, 116049 DOI: 10.1016/j.expneurol.2026.116049
Lee, Wu, Tsai
Exp Neurol (2027) 407, 116049 DOI: 10.1016/j.expneurol.2026.116049
Snippet: Hepatic encephalopathy (HE) is a severe neuropsychiatric complication of liver failure characterized by a spectrum of cognitive and motor impairments. Lipocalin-2 (Lcn2)
A double-antibody sandwich ELISA based on nanobody against the viral spike protein detects porcine epidemic diarrhea virus
Wang, Yu, Zhang et al
J Virol Methods (2027) 347, 115480 DOI: 10.1016/j.jviromet.2026.115480
Wang, Yu, Zhang et al
J Virol Methods (2027) 347, 115480 DOI: 10.1016/j.jviromet.2026.115480
Snippet: The mouse anti-His tag antibody was purchased from Abmart, and the HRP-conjugated goat anti-mouse was purchased from Origene. PEDV RT–qPCR detection kits
From the Gospels to the Catacombs: Sourcing Women's Authority in the First Christian Centuries
Franchi, Barnes
Reconstructing Women's Roles in Early … (2027)
Franchi, Barnes
Reconstructing Women's Roles in Early … (2027)
Snippet: Ancient women’s influences and authority are difficult to reconstruct because men largely produced the extant sources. Consequently, this essay tries to understand and
Regulation of epithelial-mesenchymal cell-cell partners by complexes of paracrine signals and sulfated oligosaccharides
Zhang, Wauthier, Xu et al
Biomaterials (2027) 336, 124461 DOI: 10.1016/j.biomaterials.2026.124461
Zhang, Wauthier, Xu et al
Biomaterials (2027) 336, 124461 DOI: 10.1016/j.biomaterials.2026.124461
AI Summary: In this study, OriGene products, specifically the WNT3A protein (Cat# TP301183) and FGF2 protein (Cat# TP723599), were used as key paracrine signals to form complexes with synthesized sulfated oligosaccharides, enabling the investigation of their regulatory effects on epithelial-mesenchymal cell signaling and differentiation.
Snippet: Companies providing reagents and supplies: Abcam, Cambridge, MA;ACD Labs, Toronto, CA;Acris Antibodies, Inc), San Diego, CA;Advanced Bioscience Resources Inc) (ABR), Rockville, MD;Agilent Technologies, Santa Clara
Nanocarrier-mediated targeting of chemotherapy-induced DPP4 enhances T cell infiltration and improves cancer immunochemotherapy
Chen, Li, Luo et al
Bioact Mater (2027) 67, 95-113 DOI: 10.1016/j.bioactmat.2026.07.053
Chen, Li, Luo et al
Bioact Mater (2027) 67, 95-113 DOI: 10.1016/j.bioactmat.2026.07.053
Cited by 1
AI Summary: OriGene’s mouse tagged ORF clone lentiviral particle (Myc-DDK-P2A-Puro, MR222697L3V) was used in this study to manipulate DPP4 expression in cancer cells, facilitating investigation of DPP4’s role in chemokine regulation and tumor immune microenvironment.
Snippet: mouse tagged ORF clone lentiviral particle (Myc-DDK-P2A-Puro, MR222697L3V) was purchased from OriGene Technologies, Inc. (MD, USA). The pLentipuro3/TO/V5-GW/EGFP-Firefly Luciferase plasmid was sourced from Addgene (MA, USA). Both murine and human DPP4 siRNA (siDPP4) and control siRNA (siCT) we
Sorting nexin 10 promotes triple-negative breast cancer progression through modulating cholesterol biosynthesis via stabilizing SREBP2
Guo, Li, Zhang et al
Cancer Biol Ther (2026) 27 (1), 2749334 DOI: 10.1080/15384047.2026.2749334
Guo, Li, Zhang et al
Cancer Biol Ther (2026) 27 (1), 2749334 DOI: 10.1080/15384047.2026.2749334
Snippet: s used as an internal control. The antibodies used in this study were β-actin (1:5000, 66009-1-Ig, Proteintech), SNX10 (1:500, sc-293380, Santa Cruz, 1:1000, TA808896S, OriGene Technologies), SREBP1 (1:1000, 14088-1-AP, Proteintech), SREBP2 (1:1000, 28212-1-AP, Proteintech), HMGCR (1:1000, ET1702-41, Hanzhou Huaan Biotech), SCAP (1:500, Sc-13553, Santa Cruz), Flag-ta
Genetic variants of the transporter SLC22A4 affect the abundance and survival of Fusobacterium nucleatum in colorectal cancer
Chouaibi, Fertitta, Porreca et al
Gut Microbes (2026) 18 (1), 2681818-2681818 DOI: 10.1080/19490976.2026.2681818
Chouaibi, Fertitta, Porreca et al
Gut Microbes (2026) 18 (1), 2681818-2681818 DOI: 10.1080/19490976.2026.2681818
Cited by 1
AI Summary: OriGene contributed to this study by providing the lentiviral construct encoding mouse Slc22a4 cDNA tagged with monomeric GFP (SKU MR208779L4), which was used to engineer colorectal cancer stem cells for functional analysis of SLC22A4 variants.
Snippet: The lentiviral construct encoding the mouse Slc22a4 cDNA (NM_019687) tagged at the C terminus with monomeric (m)GFP (#SKU MR208779L4) was purchased from OriGene (Rockville, MD, US);the MISSION pLKO.1-puro empty control vector (cat. #SHC016) was obtained from Sigma/Merck
Combination therapy with a novel CD2-targeted costimulatory bispecific antibody overcomes limitations of CD3 T cell engager treatment for solid tumors
Danquah, Pichery, Eden et al
MAbs (2026) 18 (1), 2684378 DOI: 10.1080/19420862.2026.2684378
Danquah, Pichery, Eden et al
MAbs (2026) 18 (1), 2684378 DOI: 10.1080/19420862.2026.2684378
AI Summary: OriGene’s CD2-GFP cDNA expression constructs were used to transfect HEK293 cells, enabling the researchers to monitor CD2 expression and transfection efficiency in their study of novel CD2-targeted bispecific antibodies for solid tumor immunotherapy.
Snippet: cells were generated by transfection of HEK293 cells with a cDNA expression construct encoding the full-length human or mouse CD2 open reading frame with C-terminal green fluorescent protein-fusion (Origene) to monitor transfection efficiency.Human primary cell isolationHuman PBMCs were isolated from buffy coats, which were obtained
ABHD17C regulates the efficacy of lenvatinib in suppressing hepatocellular carcinoma
Wang, Wang, Ma et al
Cancer Biol Ther (2026) 27 (1), 2693350 DOI: 10.1080/15384047.2026.2693350
Wang, Wang, Ma et al
Cancer Biol Ther (2026) 27 (1), 2693350 DOI: 10.1080/15384047.2026.2693350
AI Summary: OriGene's ABHD17C antibody (catalog number TA335493) was used in this study to detect ABHD17C protein expression, enabling the authors to investigate its role in modulating lenvatinib efficacy in hepatocellular carcinoma.
Snippet: ABHD17C ORIGENE, China TA335493 1:500 Cleaved-caspase 3 Cell Signaling Technology, USA #9661 1:500 p-PI3K #4228 1:500
Discovery of novel murine PML isoforms
Anderová, Horníková, Šroller et al
Nucleus (2026) 17 (1), 2646815 DOI: 10.1080/19491034.2026.2646815
Anderová, Horníková, Šroller et al
Nucleus (2026) 17 (1), 2646815 DOI: 10.1080/19491034.2026.2646815
AI Summary: OriGene contributed plasmids for mPML-tRFP expression, which were used to study the localization and behavior of novel murine PML isoforms in this research.
Snippet: arboring a stop codon introduced at the end of the mPML coding sequence (mPML-S), yielding non-tagged mPML proteins, were used in this study. For mPML-tRFP expression, plasmids were either purchased (OriGene;Eurofins Genomics Blue Heron) or constructed based on their exon composition using entry sequences from commercial plasmids, MEF RT-PCR product sequences (pENTR Directional TOPO Cloning Kit,
ENPP3 drives ccRCC progression by cGAMP hydrolysis and STING-IFN suppression
Ma, Wu, Lin et al
Cancer Biol Ther (2026) 27 (1), 2632995 DOI: 10.1080/15384047.2026.2632995
Ma, Wu, Lin et al
Cancer Biol Ther (2026) 27 (1), 2632995 DOI: 10.1080/15384047.2026.2632995
AI Summary: OriGene's recombinant human STING (TMEM173) protein (TP308418) was administered intraperitoneally to RCC4 xenograft-bearing mice to probe STING signaling in the anti-tumor effects of ENPP3 inhibition in ccRCC. This allowed the authors to link STING pathway engagement to changes in tumor-associated macrophage populations.
Snippet: ol (shNT) RCC4 xenografts (n = 3/group) were harvested at day 18;where indicated mice received three i.p. injections of 250 µg neutralizing (WT) STING (TP308418, Origene). Tumors were minced and digested, filtered, red-cell-lysed, and stained with Zombie-NIR (1:1000, 423106, BioLegend), F4/80-PE (1:200, 123111, BioLegend), CD206-APC-Cy7 (M1 macrophages, 1:200,
In vitro generated macrophages reflect the immunosuppressive phenotype of in vivo glioblastoma-associated macrophages
Nazzaro, Mardis, Artomov et al
Oncoimmunology (2026) 15 (1), 2610562 DOI: 10.1080/2162402X.2025.2610562
Nazzaro, Mardis, Artomov et al
Oncoimmunology (2026) 15 (1), 2610562 DOI: 10.1080/2162402X.2025.2610562
AI Summary: In this study, OriGene's TNF (NM_013693) qPCR primer was used to measure TNF gene expression, contributing to the analysis of macrophage phenotypes in the in vitro glioblastoma model.
Snippet: oggle="yes">SDHA (endogenous control, IDT, Mm.PT.56a.12170577), GZMB (IDT, Mm.PT.58.42155916), IFNG (IDT, Mm.PT.58.41769240), TNF (Origene, NM_013693), and IL2 (IDT, Mm.PT.58.1
Fusobacterium nucleatum plays a pathogenic role in a murine model of irritable bowel syndrome by modulating intestinal purine metabolism and promoting mast cell activation
Hou, Ning, Liu et al
Gut Microbes (2026) 18 (1), 2620124 DOI: 10.1080/19490976.2026.2620124
Hou, Ning, Liu et al
Gut Microbes (2026) 18 (1), 2620124 DOI: 10.1080/19490976.2026.2620124
Cited by 4
AI Summary: OriGene’s siTran 2.0 transfection reagent (TT320001) was used to deliver siRNA targeting purine nucleoside phosphorylase (PNP) in intestinal epithelial cells, enabling the study of PNP’s role in Fusobacterium nucleatum-induced IBS-like symptoms in mice.
Snippet: nces targeting PNP were as follows: siPNP sense: 5′-GAUCUUUGACUACGGUGAA-3′;siPNP antisense: 5′-UUCACCGUAGUCAAAGAUC-3′. Transfection was carried out with siTran 2.0 (TT320001, Origene).Peritoneal mast cell cultures (PMCs)Peritoneal cells isolated from C57BL/6 mice aged 6–10 weeks were cultured in RPMI164
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