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Lentiviral Products & Services

Pre-titered, ready-to-use lentiviral particles for stable gene expression and silencing. Trusted by leading research institutions worldwide.

With validated high affinity antibodies coupled to magnetic beads (>90% high iron oxide beads), OriGene offers reliable and high specific capture of EV subpopulations from various biofluids, cell culture media.

>107
TU/ml Guaranteed
35K+
Lenti-ORF Clones
>1yr
Infectivity Stability
3rdGen
Biosaety System

Products & Solutions

Lenti-ORF Particles

Lenti-ORF Particles

Tagged lentiviral ORF particles for stable over-expression of your gene of interest. Available in DDK, GFP, RFP, and untagged formats across 35,000+ human and mouse ORFs.
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Lenti-shRNA Particles

Lenti-shRNA Particles

Pre-packaged shRNA lentiviral particles for durable gene knockdown. Validated 4- construct sets against each target gene ensure reliable silencing in any cell type.
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Inducible Expression

Inducible Expression

Tet-On inducible lentiviral particles and stable cell lines for tightly controlled, doseresponsive gene expression. Ideal for toxic gene studies.
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Lentiviral CRISPR Vectors

Lentiviral CRISPR Vectors

All-in-one lentiviral vectors expressing Cas9 and gRNA for efficient gene knockout, activation (CRISPRa), or repression (CRISPRi) via stable delivery.
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Lenti Accessories

Lenti Accessories

Everything you need in-house: VPak packaging kits, LentiTran™ transfection reagent, Lenti Stabilizer™, and concentration columns
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Custom Lentivirus Production

Custom Lentivirus Production

Lenti-ORF and Lenti-shRNA, providing high-titer (up to 10<sup>10</sup> TU/mL), 3rd-generation viral particles designed for efficient gene delivery in difficult-to-transduce cells and in vivo animal studies.
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Lenti-ORF Particles

Tagged lentiviral ORF particles for stable over-expression of your gene of interest. Available in DDK, GFP, RFP, and untagged formats across 35,000+ human and mouse ORFs.

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Lenti-shRNA Particles

Pre-packaged shRNA lentiviral particles for durable gene knockdown. Validated 4- construct sets against each target gene ensure reliable silencing in any cell type.

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Inducible Expression

Tet-On inducible lentiviral particles and stable cell lines for tightly controlled, doseresponsive gene expression. Ideal for toxic gene studies.

Inducible Systems chevron-circle-right

Lentiviral CRISPR Vectors

All-in-one lentiviral vectors expressing Cas9 and gRNA for efficient gene knockout, activation (CRISPRa), or repression (CRISPRi) via stable delivery.

CRISPR Vectors chevron-circle-right

Lenti Accessories

Everything you need in-house: VPak packaging kits, LentiTran™ transfection reagent, Lenti Stabilizer™, and concentration columns

Browse Accessories chevron-circle-right

Custom Lentivirus Production

Lenti-ORF and Lenti-shRNA, providing high-titer (up to 1010 TU/mL), 3rd-generation viral particles designed for efficient gene delivery in difficult-to-transduce cells and in vivo animal studies.

Custom Service chevron-circle-right
awesomeicons/solid/dna

Lenti-ORF Particles

Tagged lentiviral ORF particles for stable over-expression of your gene of interest. Available in DDK, GFP, RFP, and untagged formats across 35,000+ human and mouse ORFs.

awesomeicons/solid/volume-mute

Lenti-shRNA Particles

Pre-packaged shRNA lentiviral particles for durable gene knockdown. Validated 4+ construct sets against each target gene ensure reliable silencing in any cell type.

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Inducible Expression

Tet-On inducible lentiviral particles and stable cell lines for tightly controlled, doseresponsive gene expression. Ideal for toxic gene studies.

awesomeicons/solid/hand-scissors

Lentiviral CRISPR Vectors

All-in-one lentiviral vectors expressing Cas9 and gRNA for efficient gene knockout, activation (CRISPRa), or repression (CRISPRi) via stable delivery.

awesomeicons/solid/glasses

Lenti Accessories

Everything you need in-house: VPak packaging kits, LentiTran™ transfection reagent, Lenti Stabilizer™, and concentration columns

awesomeicons/solid/cogs

Custom Lentivirus Production

Lenti-ORF and Lenti-shRNA, providing high-titer (up to 1010 TU/mL), 3rd-generation viral particles designed for efficient gene delivery in difficult-to-transduce cells and in vivo animal studies.

End-to-End Lentiviral Services

Don't have the bandwidth or infrastructure? Let OriGene’s expert team handle production from gene to validated particle — at any scale.

Lentiviral CRISPR Vectors

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Full-service production from your plasmid or sequence. Small-scale (research) through large-scale (pre-clinical) batches with complete QC documentation.
  • Research-scale: 1.5 mL at >107 TU/mL
  • Large-scale: 50–100 mL concentrated lots
  • Full sterility and mycoplasma testing
  • Certificate of Analysis included

Custom Stable Cell Line Generation

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Submit your gene or shRNA sequence and receive validated stable over-expression or knockdown cell lines within weeks using our optimized lentiviral protocol.
  • Selection antibiotic screening & single-clone expansion
  • Expression validated by WB and qPCR
  • Cell banking and cryopreservation included

 

Custom shRNA Design & Packaging

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Our bioinformatics team designs optimized shRNA sequences against your target, then packages them into validated lentiviral particles with knockdown confirmation.
  • 4 proprietary shRNA sequences per gene
  • Knockdown efficiency >70% guaranteed
  • Delivered as plasmid and/or lentiviral particles

 

Inducible Expression Systems

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Deliver Tet-On inducible constructs into your model system. Ideal for studying essential genes, dose–response relationships, and temporal gene activation.
  • Doxycycline–inducible Tet-On 3G system
  • Tight off-state, strong on-state expression
  • Available as particles or stable cell lines

 

What is Lentivirus?

Lentivirus is a genus of retroviruses that express reverse transcriptase and integrase. These enzymes integrate viral DNA into host DNA, allowing the exploitation of host machinery for efficient and stable gene expression.

Retroviral Integration

Retroviral Integration

Lentiviral vectors integrate their genetic cargo directly into the host cell genome, enabling stable, long-term expression.
Dividing & Non-Dividing Cells

Dividing & Non-Dividing Cells

Unlike other retroviruses, lentivirus can transduce both dividing and non-dividing cells, expanding experimental possibilities.
Derived from HIV-1

Derived from HIV-1

Modified from HIV-1 with viral genes removed. Contains only LTRs and packaging signal (Ψ) for maximum safety.
Replication Deficient

Replication Deficient

Packaging genes on separate plasmids ensure pseudo-lentiviral particles cannot replicate in target cells.

Lentiviral Gene Delivery Process

1

Plasmid Transfection

Transfer genes into packaging cells

2

Virus Production

Cells produce lentiviral particles

3

Harvest & Titer

Collect and quantify virus

4

Target Cell Transduction

Infect cells of interest

5

Genomic Integration

Stable gene expression

awesomeicons/solid/award What Makes Our Particles Special

Every lot is pre-titered and shipped ready to use. Our proprietary Lenti Stabilizer™ formulation maintains full infectivity for over 12 months — so you're not racing against a degradation clock.

>107

Functional titer guaranteed per lot before shipment

+12 months

Infectivity maintained in Lenti Stabilizer™

3rd Gen

Split-genome biosafety design — no helper virus

From The Labs That Use Us

  • “
    I have used lenti-ORF plasmids for the generation of overexpression stable cells. They work well. The cell selection marker in the vector made it easier to generate stable cells.
    Reviewed By A.J.
    Medical University of South Carolina
  • “
    The ready-to-use lentivirus particles worked well in our hard-to-transduce cell lines.
    Reviewed By K.W.
    University Hospital of Tuebingen, Children's Hospital
  • “
    I purchased a lenti-ORF from OriGene. I have good transfection and transduction efficiency with OriGene's lenti products. Overall, I am extremely satisfied.
    Reviewed By S.R.
    Sidney Kimmel Cancer Center
  • “
    I used both the lentivirus and the lenti plasmids. Both of them worked very well. And the customer service is good too.
    Reviewed By B.S.
    St. Jude Children's Research Hospital
  • “
    We Purchased multiple lenti vectors from OriGene and they all worked great.
    Reviewed By S.D.
    MD Anderson Cancer Center
  • “
    Aml12 cells are very difficult to transfect using siRNAs. Hence, using OriGene's lenti-shRNA product helped tackle this issue.
    Reviewed By Y.L.
    University of Queensland
  • “
    Research labs always look for an efficient and reliable lentiviral products and OriGene has really done a great job for past several years for us. We are extremely satisfied with the product's efficacy of knockdown, literature provided and technical support when needed
    Reviewed By A.G.
    Moffitt Cancer Center
  • “
    Our lab tried to package our lentivirus using 293T cells but it was not that easy. OriGene's lentivirus provided us consistent results which made us have clear idea about the further research goals. The purchases from OriGene have been worth the price.
    Reviewed By H.T.
    University of Arkansas for Medical Sciences
  • “
    I have tried lentivirus expressing shRNA and it was working to my expectation. I am very happy with the product.
    Reviewed By G.P.
    Centre for Stem Cell Research
  • “
    We used lentiviruses to silence Pmch gene and it worked beautifully.
    Reviewed By M.F.
    USP
  • “
    Great quality, good knock-down. Super satisfied.
    Reviewed By C.H.
    Cambridge University
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