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Custom Protein Services

From Gene Cloning to Protein Purification

2,000+
Successful
Projects

500+
Satisfied
Customers

25+
Years
Experience

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Tailored Protein Solutions for Your Research Needs

With over 25 years of experience, OriGene offers comprehensive custom protein services designed to accelerate your research. Whether you’re targeting a novel protein or need a customized solution from our collection of over 19,000 recombinant proteins, OriGene is your trusted partner for end-to-end protein development.

Our capabilities span the full workflow—from gene cloning to protein expression and high-quality protein purification. We specialize in expressing challenging targets and provide flexible expression systems tailored to your specific project needs, whether you're advancing basic research or therapeutic discovery.

 

Multiple Expression Systems

 

Scalable

 

Tag Customization

 

Site-Specific Biotinylation

 

Customization

 

Made in the USA

Case Studies

protein from 4 different expression systems

Site-specific Biotinylation

SDS-PAGE and Western verified site-specific biotinylated PKP2 human recombinant protein

Mono-biotinylated via Avi-tag

Biotin to protein ratio of 1:1 as determined by streptavidin pull down assay

KRAS Mutant Myc-DDK Image

KRAS mutant (G12D) Myc-DDK tagged human recombinant protein

Tagged and Tag free GALT human recombinant protein Image

Tagged and Tag free GALT human recombinant protein

Service Highlights

  • Transparent pricing: Invoiced only for the successful completion of milestones
  • PhD-level project manager to guide your project from start to finish
  • Same high-quality testing as our catalog products and more, as per customer needs
  • Experience in developing >12,000 cataloged recombinant protein targets
  • 2,000+ successful projects and 500+ satisfied customers
Understand Your Projects
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Define Project Milestones
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Project Communications
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Project Deliverables

Customer Testimonials

"OriGene has been an important partner for Alamar Biosciences, consistently providing top-tier catalog and custom recombinant antibodies and proteins. Their dependability and scientific knowledge have enabled us to offer tools to assist proteomics researchers at every step, from initial discovery to cutting-edge research."
-A scientist from Alamar Biosciences
"We are very happy with the HSD17B13 protein from OriGene and found great quality for our internal quality control. We've been very happy with your customer service as well, and appreciated when there was a labeling mishap on one of the proteins OriGene promptly provided a new corrected protein sample."
-A scientist from a pharmaceutical company

Expression System Comparison
  Bacterial Insect Mammalian
Advantages
  • Simple vector construction
  • Straightforward culture methods
  • High yields
  • Amenable to scaling
  • Post-translational modifications profile is like that of mammalian cells
  • Effective protein folding
  • More scalable than mammalian cells
  • Most authentic human protein products
  • Best preservation of native structure, function, and post-translational modifications
  • Create stable production cell lines for scalable solutions
Challenges
  • No post-translational modifications
  • Increased potential for improper folding
  • Potential endotoxin contamination
  • Virus production can be time-consuming
  • Tricky to culture
  • Infection can induce premature lysis
  • Complex culture conditions
  • Costly set-up and maintenance
  • Lower yields
  • Lower ceiling for batch scaling (however we still have large scale capabilities)
Common Applications
  • Structural analysis
  • Antibody production
  • Protein interactions
  • Enzyme production
  • Vaccine development
  • Functional and structural analysis
  • Expression of protein complexes
  • Expression of intracellular proteins
  • Functional and structural analysis
  • Antibody production
  • Protein interactions
  • Production of enzyme on large scale
  • Functional analysis of post-translationally modified protein

Custom Protein Expression Service Request Form

 
Recombinant Protein Resources