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Regulatory T Cells (Tregs)
Regulatory T cells (Tregs) are lymphocytes that control the biological phenomenon of self-non-self-discrimination. They are the key regulators of immune response and play a critical role in immune tolerance and homeostasis. Naturally occurring CD4+CD25+ are essential in preventing autoimmune diseases. Regulator CD4+ T cells express CD25 which suppresses T cell proliferation. In addition to providing autoimmunity, it may enable tumor cells to evade the host immune response. Hence, error in the Treg-mediated robust immunosuppression often results in autoimmune diseases.
The master controller of Treg activity is the forkhead transcription factor FOXP3. Studies have proven that FOXP is explicitly expressed in CD4+CD25+ and is needed for their development. Treg identification is usually achieved with multiple antibodies as activated T cells also upregulate CD25 T cells during the immune response associated with infection. OriGene gives you a pre-selected antibody panel for Treg marker identification.
CD3E
Immunohistochemical staining of paraffin-embedded Human colon tissue using anti-CD3E clone UMAB54 mouse monoclonal antibody. (UM500048; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
CD4
Immunohistochemical staining of paraffin-embedded Human lymph node tissue using anti-CD4 mouse monoclonal antibody. (UM800010; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min)
FOXP3
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-FOXP3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3min, UM800140) (1:200)