Regulatory T Cells (Tregs)

Regulatory T cells (Tregs) are lymphocytes that control the biological phenomenon of self-non-self-discrimination. They are the key regulators of immune response and play a critical role in immune tolerance and homeostasis. Naturally occurring CD4+CD25+ are essential in preventing autoimmune diseases. Regulator CD4+ T cells express CD25 which suppresses T cell proliferation. In addition to providing autoimmunity, it may enable tumor cells to evade the host immune response. Hence, error in the Treg-mediated robust immunosuppression often results in autoimmune diseases.

The master controller of Treg activity is the forkhead transcription factor FOXP3. Studies have proven that FOXP# is explicitly expressed in CD4+CD25+ and is needed for their development. Treg identification is usually achieved with multiple antibodies as activated T cells also upregulate CD25 T cells during the immune response associated with infection. OriGene gives you a pre-selected antibody panel for Treg marker identification.

Regulatory T Cell Marker Antibody Panel - CD3E, CD4, FOXP3, IL2RA (CD25)

Biomarker CD3E CD4 FOXP3 IL2RA
Catalog-No. UM570048

30 ul

CD3E mouse monoclonal antibody,clone UMAB54

UM870010

30 ul

CD4 mouse monoclonal antibody,clone UMAB64

UM870140

30 ul

FOXP3 mouse monoclonal antibody,clone UMAB248

TA813473S

30 ul

IL2RA mouse monoclonal antibody, clone OTI2A5

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