Huntingtin (HTT) - Untangling Neurodegeneration

Huntingtin is a gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. However, the mechanisms by which mutant huntingtin leads to neurodegeneration in Huntington's disease (HD) are still not fully understood. Studying the normal functions of huntingtin is crucial, as loss-of-function phenotypes resulting from the polyglutamine expansion may contribute to the underlying pathophysiology. Further research in this area is essential to understand the roles of this crucial protein and identify potential therapeutic targets.

Other disease associations: Breast Cancer

OriGene's products are crucial in HTT-related research, as demonstrated by their frequent citations in well-reputed journals. Marta T. et al. used the mouse HTT gene knockout kit (KN308042) to differentiate mice cardiomyocytes from HTT null mouse embryonic stem cells (ESC) and WT ESC (Figure 1)¹. Glaser T. et al. used the mouse HTT gene knockout kit (KN308042) to transfect the E14Tg2A cell (Figure 2)².

Top 5 STRING interactants based on experimental score: CREBBP, F8A1, F8A2, F8A3, and HAP1,

1. Marta T. et al. Nucleosides Nucleotides Nucleic Acids (2022). doi: 10.1080/15257770.2020.1815769
2. Glaser T. et al. Mol Psychiatry (2021). doi: 10.1038/s41380-020-0717-5