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3’ UTR Clones

Assay-ready Luc-UTR constructs for more than 20,000 human genes

The 3' UTR plasmids provide a convenient solution for quantitative assessment of the inhibitory effect between miRNAs and their potential gene targets. OriGene’s 3' UTR clones were designed by cloning the 3' UTR sequence of a gene of interest, downstream of the firefly luciferase gene. The chimeric transcript level is then regulated by its interaction with miRNA(s), which results in varied luciferase activity quantifiable by a colorimetric assay.

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microrna 3' UTR Clone

Interaction between miRNA and UTR

Reduced luciferase expression

No interaction between miRNA and UTR

No effect on luciferase expression

Features

  • Genome wide coverage (>20,000 human gene)
  • Firefly luciferase as the easy-to-assay reporter
  • RFP as reporter for transfection monitoring
  • High sensitivity from IRES-driven translation of the expression cassette

We are a loyal local customer of OriGene and we always get reliable results from using their expression plasmids.
Reviewed By J.S.
CiPA Lab
Origene had the exact clone we needed.
Reviewed By M.B.
University of Pennsylvania
Origene products are easy to use and customer service is super helpful! I've always got helped when I encountered a problem. Thank you.
Reviewed By T.T.
University of Michigan
What I like about the Origene wesbsite was that the chat line usually directs me to the right person to ask questions -- who not only answers my questions, but will provide the quote, and good to follow up on the progress, etc.
Reviewed By R.A.
Case Western Reserve University
Good quality, fast turnaround time, reasonable pricing with a vast selection
Reviewed By J.Z.
BC Cancer Research Centre
I really trust OriGene's cloning service!
Reviewed By A.C.
Icahn School of Medicine in Mount Sinai
Our lab is a frequent customer.
Reviewed By P.B.
George Washington University, School of Medicine
The technical support was great with good response time.
Reviewed By L.M.
Center for Disease Control
All products have been great or quickly exchanged.
Reviewed By K.P.
University of Toledo-HSC
Good variety of clones with good choice of labels
Reviewed By M.B.
Kirksville College of Osteopathic Medicine
We have been using OriGene for the last five years. The plasmids are amazing
Reviewed By S.K.
UT Southwestern Medical Center
Excellent quality and affordable price
Reviewed By K.P.
St. Johns University

Recent Citations using our 3' UTR Clones

1 MiR‐503 pleiotropically regulates epithelial‐mesenchymal transition and targets PTK7 to control lung cancer metastasis

Published in Cancer Medicine , using SC210336

PubMed: 37212485

2 SAYSD1 senses UFMylated ribosome to safeguard co-translational protein translocation at the endoplasmic reticulum

Published in Cell reports , using SC214181

PubMed: 36848233

3 Oncosuppressive miRNAs loaded in lipid nanoparticles potentiate targeted therapies in BRAF-mutant melanoma by inhibiting core escape pathways of resistance

Published in Oncogene , using SC209527

PubMed: 36418472
See All Citations
cDNA Clone Resources