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3’ UTR Clones

Assay-ready Luc-UTR constructs for more than 20,000 human genes

The 3' UTR plasmids provide a convenient solution for quantitative assessment of the inhibitory effect between miRNAs and their potential gene targets. OriGene’s 3' UTR clones were designed by cloning the 3' UTR sequence of a gene of interest, downstream of the firefly luciferase gene. The chimeric transcript level is then regulated by its interaction with miRNA(s), which results in varied luciferase activity quantifiable by a colorimetric assay.

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microrna 3' UTR Clone

Interaction between miRNA and UTR

Reduced luciferase expression

No interaction between miRNA and UTR

No effect on luciferase expression

Features

  • Genome wide coverage (>20,000 human gene)
  • Firefly luciferase as the easy-to-assay reporter
  • RFP as reporter for transfection monitoring
  • High sensitivity from IRES-driven translation of the expression cassette

  • “
    We are a loyal local customer of OriGene and we always get reliable results from using their expression plasmids.
    Reviewed By J.S.
    CiPA Lab
  • “
    Origene had the exact clone we needed.
    Reviewed By M.B.
    University of Pennsylvania
  • “
    Origene products are easy to use and customer service is super helpful! I've always got helped when I encountered a problem. Thank you.
    Reviewed By T.T.
    University of Michigan
  • “
    What I like about the Origene wesbsite was that the chat line usually directs me to the right person to ask questions -- who not only answers my questions, but will provide the quote, and good to follow up on the progress, etc.
    Reviewed By R.A.
    Case Western Reserve University
  • “
    Good quality, fast turnaround time, reasonable pricing with a vast selection
    Reviewed By J.Z.
    BC Cancer Research Centre
  • “
    I really trust OriGene's cloning service!
    Reviewed By A.C.
    Icahn School of Medicine in Mount Sinai
  • “
    Our lab is a frequent customer.
    Reviewed By P.B.
    George Washington University, School of Medicine
  • “
    The technical support was great with good response time.
    Reviewed By L.M.
    Center for Disease Control
  • “
    All products have been great or quickly exchanged.
    Reviewed By K.P.
    University of Toledo-HSC
  • “
    Good variety of clones with good choice of labels
    Reviewed By M.B.
    Kirksville College of Osteopathic Medicine
  • “
    We have been using OriGene for the last five years. The plasmids are amazing
    Reviewed By S.K.
    UT Southwestern Medical Center
  • “
    Excellent quality and affordable price
    Reviewed By K.P.
    St. Johns University

Recent Citations using our 3' UTR Clones

1 MiR‐503 pleiotropically regulates epithelial‐mesenchymal transition and targets PTK7 to control lung cancer metastasis

Published in Cancer Medicine , using SC210336

PubMed: 37212485

2 SAYSD1 senses UFMylated ribosome to safeguard co-translational protein translocation at the endoplasmic reticulum

Published in Cell reports , using SC214181

PubMed: 36848233

3 Oncosuppressive miRNAs loaded in lipid nanoparticles potentiate targeted therapies in BRAF-mutant melanoma by inhibiting core escape pathways of resistance

Published in Oncogene , using SC209527

PubMed: 36418472
See All Citations
cDNA Clone Resources