Cervical Cancer

Cervical cancer, which develops in the tissues of the cervix, can be classified into two types: squamous cell carcinoma and adenocarcinoma. Smoking and human papillomavirus (HPV) infection are the key risk factors. Several studies have led the discovery of a range of biomarkers including several polymorphisms, microRNAs, mRNA and serum biomarkers.

Potential biomarkers 1, 2, 3, 4

HPV E6-E7 ANXA2 ASF1B A1AT PYCR2 TTR ApoA-1 VDBP

Key genes mutated in cervical cancer 5

CASP8 ERBB3 HLA-A MED1 SHKBP1 TGFBR2

Other genes

PD-L1 PD-L2 KRAS ARID1A PTEN

One of the challenges in cervical cancer is to distinguish between squamous cell carcinoma (SCC) from adenocarcinoma (AEC) 6 In a recent study, Li et al. showed that a combination of cytokeratin 5/6 (CK5/6), p63, p40 and MUC5AC are useful in differentiating cervical adenocarcinoma from cervical squamous cell carcinoma using immunohistochemistry 7

CK5/6

CK5/6
Mesothelioma tissue stained for Cytokeratin 5 & 6 with mouse monoclonal antibody Cat # TA327667

p63

p63
Human Lung Carcinoma tissue stained for p63 with mouse monoclonal antibody Cat # TA802078

p40

p40-1.jpg
Human Tonsil stained for p40 with mouse monoclonal antibody Cat # TA592167

MUC5AC

MUC5AC
Human Stomach tissue stained for MUC5AC with mouse monoclonal antibody Cat # TA327703


References:

  1. Pal A, Kundu R. Human Papillomavirus E6 and E7: The Cervical Cancer Hallmarks and Targets for Therapy. Front Microbiol. 2020 Jan 21;10:3116.
  2. Wang Z, Jiang C, Pang L, Jia W, Wang C, Gao X, Zhang X, Dang H, Ren Y. ANXA2 is a potential marker for the diagnosis of human cervical cancer. Biomark Med. 2021 Jan;15(1):57-67.
  3. Liu X, Song J, Zhang Y, Wang H, Sun H, Feng X, Hou M, Chen G, Tang Q, Ji M. ASF1B promotes cervical cancer progression through stabilization of CDK9. Cell Death Dis. 2020 Aug 26;11(8):705
  4. Keeratichamroen S, Subhasitanont P, Chokchaichamnankit D, Weeraphan C, Saharat K, Sritana N, Kantathavorn N, Wiriyaukaradecha K, Sricharunrat T, Paricharttanakul NM, Auewarakul C, Svasti J, Srisomsap C. Identification of potential cervical cancer serum biomarkers in Thai patients. Oncol Lett. 2020 Jun;19(6):3815-3826.
  5. Burk R. et al. The Cancer Genome Atlas Research Network., Nature 543, 378–384 (2017).
  6. Li H, Jing X, Yu J, et al. A combination of cytokeratin 5/6, p63, p40 and MUC5AC are useful for distinguishing squamous cell carcinoma from adenocarcinoma of the cervix. Diagn Pathol. 2020;15(1):104
  7. Ma Y et al. Expression of p63 and CK5/6 in early-stage lung squamous cell carcinoma is not only an early diagnostic indicator but also correlates with a good prognosis. Thorac Cancer. 2015;6(3):288–95.