Cyclin D1 (CCND1) (NM_053056) Human Recombinant Protein
Recombinant protein of human cyclin D1 (CCND1)
Specifications
Product Data | |
Description | Recombinant protein of human cyclin D1 (CCND1) |
Species | Human |
Expression Host | HEK293T |
Expression cDNA Clone or AA Sequence | Recombinant protein was produced with TrueORF clone, RC204957. Click on the TrueORF clone link to view cDNA and protein sequences. |
Tag | C-Myc/DDK |
Predicted MW | 33.5 kDa |
Concentration | >50 ug/mL as determined by microplate BCA method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol |
Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Storage | Store at -80°C. |
Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Reference Data | |
RefSeq | NP_444284 |
Locus ID | 595 |
Refseq Size | 4304 |
Cytogenetics | 11q13.3 |
Refseq ORF | 885 |
Synonyms | BCL1; D11S287E; PRAD1; U21B31 |
Summary | The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of human cancers. [provided by RefSeq, Dec 2019] |
Protein Families | Druggable Genome, Stem cell - Pluripotency, Stem cell relevant signaling - DSL/Notch pathway, Stem cell relevant signaling - JAK/STAT signaling pathway, Stem cell relevant signaling - Wnt Signaling pathway |
Protein Pathways | Acute myeloid leukemia, Bladder cancer, Cell cycle, Chronic myeloid leukemia, Colorectal cancer, Endometrial cancer, Focal adhesion, Glioma, Jak-STAT signaling pathway, Melanoma, Non-small cell lung cancer, p53 signaling pathway, Pancreatic cancer, Pathways in cancer, Prostate cancer, Small cell lung cancer, Thyroid cancer, Viral myocarditis, Wnt signaling pathway |
Documents
FAQs |
SDS |
Resources
Protein Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC403284 | CCND1 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 110.00 |
|
LY403284 | Transient overexpression lysate of cyclin D1 (CCND1) |
USD 360.00 |
|
PH304957 | CCND1 MS Standard C13 and N15-labeled recombinant protein (NP_444284) |
USD 2,260.00 |
|
TP710056 | Recombinant protein of human cyclin D1(CCND1),full length,with C-terminal flag tag,expressed in sf9 cells |
USD 425.00 |
|
TP762421 | Purified recombinant protein of Human cyclin D1 (CCND1), Asn216-Leu229(8 reapeat regions linked with GGGGS), with N-terminal His tag, expressed in E.coli, 50ug |
USD 205.00 |
USD 350.00
USD 379.00