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Immunohistochemistry (IHC) Antibodies

Antibodies for IHC, IF, Multiplex IHC, and Spatial Proteomics

Over 50,000 IHC-validated antibodies tested on human tissues help you generate reproducible, publication-ready staining in demanding pathology and research workflows, including IF, multiplex immunostaining and spatial proteomics.

Explore OriGene's three flagship antibody brands - UltraMAB, TrueMAB, and TrueRAB, each built for specificity, sensitivity, and consistent IHC performance.

  • awesomeicons/regular/check-circle 50,000+ IHC-validated antibodies for normal and disease tissues
  • awesomeicons/regular/check-circle 19,000+ OriGene-branded antibody clones with extensive validation and citations
  • awesomeicons/regular/check-circle Unconjugated, BSA & Azide-free options available
  • awesomeicons/regular/check-circle Commercial licensing opportunity available
  • awesomeicons/regular/check-circle Easy IHC reagent search with gene-based navigation and matched controls
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Why OriGene Antibodies Matter in IHC

Antibody specificity is critical in IHC, where false-positive stainig can mislead biomaker interpretation and clinical research decisions. OriGene uses multi-layered validation strategies to ensure antibodies recognize the intended target.

Multi-Platform Validation

Multi-Platform Validation

Western blot, knockout cell lysates, and 10k protein chip screening enhances confidence in target recognition
Extensive Tissue Testing

Extensive Tissue Testing

IHC validation on diverse panels of human tissues demonstrates robust straining patterns and reduces the risk of off-target binding.
Peer-Reviewed Citations

Peer-Reviewed Citations

Extensive use in IHC publications, including oncology trials and biomarker studies, underscores reliability at the bench and in translational studies.
Research Spotlight

Specialized IHC Solutions

Discover antibodies validated for your specific research area, with citations and application data to support your work.

CALPONIN1

IHC-Validated Antibodies for Immunology & Oncology Research

Immuno-oncology reseach depends on robust IHC antibodies to profile immune checkpoints, tumor-infiltrating lymphocytes, and tumor antigens in FFPE biopsies.

KEY TARGETS

  • Checkpoint molecules: CTLA-4, PD-1, PD-L1
  • Cancer-testis antigen: MAGE-A4 (clone OTI1F9)
  • Adhesion markers: CD146 (MCAM)

Featured Antibodies

IHC-Validated Antibodies for Neurology & Brain Research

IHC is central to mapping protein expression across brain regions, characterizing neuronal and glial populations, and tracking neurodegeneration.

KEY TARGETS

  • Neuronal markers and receptors
  • Ion channels and signaling proteins
  • Glial cell markers

um500005

Featured Antibodies

IHC, IF Antibodies in Citations

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CALPONIN1
  • Target: CALPONIN1
  • SKU: AM20594PU-N
  • Application: Spatial
  • Citation: https://doi.org/10.1038/s41598-025-27324-y
cd8a
cd19
cpa1
gr2-lrg
zscan18

Complete Solutions

Integrated IHC Controls & Samples

Find all the companion materials needed for successful IHC experiments: tissue samples, microarrays, and control

FFPE Tissue Sections

High-quality FFPE human tissues processed under strict standards and delivered as ready-to-use slides.

  • Optimally cut, paraffin-embedded sections on SuperFrost Plus slides
  • Guaranteed detection of listed protein targets with recommended protocols

Control Slides for IHC

Pre-validated human tissue control slides designed to confirm target antigenicity and ensure reliable IHC assay performance across experiments.

  • Guaranteed target detection using serially cut human tissues QC-validated with OriGene antibodies
  • Unbaked SuperFrost® Plus slides support lab-specific baking protocols for consistent, reproducible staining
  • Includes positive and negative controls for clinically relevant markers such as ALK, PD-1, and PD-L1

Tissue Microarrays (TMAs)

Emable high-throughput IHC profiling across many patient or tissue samples on a single slide.

  • Efficiently screen antibodu performance and biomarker prevalence
  • Convserve reagents and time across cohorts

CytoSections Controls

FFPE sections of HEK29T cells transiently transfected with CDNA expressing specific target genes.

  • Ready-to-use positive and negative controls for IHC, ICC, IF, and ISH
  • Ideal for validating new antibodies including rare mutations

awesomeicons/solid/window-maximize  Custom Development

Extend Your IHC Workflow

For emerging biomarkers or proprietary targets, OriGene's custom antibody development services provide tailor-made monoclonal antibodies optimized for IHC.

awesomeicons/regular/check-circle Antigen design and production using full-length human proteins expressed in HEK293T cells

awesomeicons/regular/check-circle Comprehensive validation packages including Western blot, IHC on tissue panels, and IF

awesomeicons/regular/check-circle Customizable screening and selection criteria based on your application requirements

awesomeicons/regular/check-circle Expert consultation throughout the development process

IHC Resources