BCL2 Human siRNA Oligo Duplex (Locus ID 596)
BCL2 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each
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Specifications
Product Data | |
Purity | HPLC purified |
Quality Control | Tested by ESI-MS |
Sequences | Available with shipment |
Stability | One year from date of shipment when stored at -20°C. |
Number of Transfections | Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM). |
Note | Single siRNA duplex (10nmol) can be ordered. |
Reference Data | |
RefSeq | NM_000633, NM_000657, NM_000657.3, NM_000633.3 |
Synonyms | Bcl-2; PPP1R50 |
Components | BCL2 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 596)Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmolIncluded - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml |
Summary | This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] |
Performance Guranteed | OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency. For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required). |
Citations (3)
The use of this RNAi has been cited in the following citations: |
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LIN28B promotes the progression of colon cancer by increasing B-cell lymphoma 2 expression
,Yuan, L;Tian, J;,
Biomed. Pharmacother. 2018
,PubMed ID 29669301
[BCL2]
|
microRNA-10b Is Overexpressed and Critical for Cell Survival and Proliferation in Medulloblastoma
,Pal, R;Greene, S;,
PLoS ONE Sep 2015
,PubMed ID 26394044
[BCL2]
|
Platelet-Derived Growth Factor Primes Cancer-Associated Fibroblasts For Apoptosis
,Rizvi, S;Mertens, JC;Bronk, SF;Hirsova, P;Dai, H;Roberts, LR;Kaufmann, SH;Gores, GJ;,
J. Biol. Chem. Jun 2014
,PubMed ID 24973208
[BCL2]
|
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