Lenti Citations

OriGene products have been used extensively by scientists worldwide to improve their research efficiency. For your reference, we have collected a representation of citations for selected OriGene products and posted them at this site.

Search citations by gene symbols or target names

Here are some of the recent papers making use of OriGene products by fellow researchers.

Target Research Paper Journal Product SKU
A1CF The RNA-Binding Protein A1CF Regulates Hepatic Fructose and Glycerol Metabolism via Alternative RNA Splicing Cell Rep 2019 Lenti MR224176L1
A230097K15RIK Glycerol-3-phosphate is a FGF23 regulator derived from the injured kidney J. Clin. Invest. 2020 Lenti TL506938V
A530057A03RIK Glycerol-3-phosphate is a FGF23 regulator derived from the injured kidney J. Clin. Invest. 2020 Lenti TL517838V
ABAT Dnmt3b ablation impairs fracture repair through upregulation of Notch pathway JCI Insight 2020 Lenti TL508059V
ABCA1 ABCA1/ABCB1 Ratio Determines Chemo- and Immune-Sensitivity in Human Osteosarcoma Cells 2020 Lenti TL315036V
ABCA1 Monitoring the itinerary of lysosomal cholesterol in Niemann-Pick Type C1-deficient cells after cyclodextrin treatment J. Lipid Res. 2020 Lenti TL315036
ABCG1 Monitoring the itinerary of lysosomal cholesterol in Niemann-Pick Type C1-deficient cells after cyclodextrin treatment J. Lipid Res. 2020 Lenti TL306915
ACKR3 Modulation of CXC-motif chemokine receptor 7, but not 4, expression is related to migration of the human prostate cancer cell LNCaP: regulation by androgen and inflammatory stimuli Inflamm. Res. 2019 Lenti TL515747
ACSL1 Acyl-CoA synthetase 1 deficiency alters cardiolipin species and impairs mitochondrial function J. Lipid Res. Aug 2015 Lenti TL709438
ACTR3 Arp2/3 nucleates F-actin coating of fusing insulin granules in pancreatic β cells to control insulin secretion J. Cell. Sci. 2020 Lenti MR217895L2
ADAMTS8 Differential expression of secreted factors SOSTDC1 and ADAMTS8 cause pro-fibrotic changes in linear morphoea fibroblasts Br. J. Dermatol. 2018 Lenti RC212446L4V
ADAR Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation Nat. Med. 2016 Lenti RC207522L1
ADGRG1 GPR56/ADGRG1 is associated with response to antidepressant treatment Nat Commun 2020 Lenti MR210044L2V
AEG-1 AEG-1 promotes mesenchymal transition through the activation of Rho GTPases in human glioblastoma cells Oncol. Rep. 2016 Lenti RC207238L1
AGBL2 AGBL2 promotes cancer cell growth through IRGM-regulated autophagy and enhanced Aurora A activity in hepatocellular carcinoma Cancer Lett.2017 Lenti TL306802
AGER AGER promotes proliferation and migration in cervical cancer Biosci. Rep. 2018 Lenti RC204664L2
AGO2 AGO2 mediates MYC mRNA stability in hepatocellular carcinoma Mol. Cancer Res. 2020 Lenti TL313261
AGO2 AGO2 mediates MYC mRNA stability in hepatocellular carcinoma Mol. Cancer Res. 2020 Lenti RC218078L2
AGPAT2 Terapia génica y celular para la corrección de la Lipodistrofia Congénita Generalizada Thesis Jul 2014 Lenti TL314894
AHR Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma Nat Commun 2018 Lenti TL320259
AHR Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells Nat Commun 2017 Lenti TL320259
AIF1 AIF-regulated oxidative phosphorylation supports lung cancer development Cell Res. 2019 Lenti TL314878
AIFM1 Overexpression of apoptosis-inducing factor mitochondrion-associated 1 (AIFM1) induces apoptosis by promoting the transcription of caspase3 and DRAM in hepatoma cells Biochem. Biophys. Res. Commun. 2018 Lenti TL302572
AIRE The Role of AIRE in the Immunity Against Candida Albicans in a Model of Human Macrophages Front. Immunol. 2018 Lenti RC213497L2
AKT1 MAT1 facilitates the lung metastasis of osteosarcoma through upregulation of AKT1 expression Life Sci. 2019 Lenti TL320260
AKT3 Restoring miR122 in human stem-like hepatocarcinoma cells, prompts tumor dormancy through Smad-independent TGF-β pathway Oncotarget 2016 Lenti TL320629
ALDH18A1 Global metabolic profiling identifies a pivotal role of proline and hydroxyproline metabolism in supporting hypoxic response in hepatocellular carcinoma Clin. Cancer Res.2017 Lenti TL314847
ALDH1A1 Stemness marker ALDH1A1 promotes tumor angiogenesis via retinoic acid/HIF-1α/VEGF signalling in MCF-7 breast cancer cells J. Exp. Clin. Cancer Res. 2018 Lenti RC200723L1V
ALDH3A1 ALDH3A1 Overexpression in Melanoma and Lung Tumors Drives Cancer Stem Cell Expansion, Impairing Immune Surveillance through Enhanced PD-L1 Output Cancers (Basel) 2019 Lenti RC202440L1
ALDH3A1 Mutation of the gene encoding the circadian clock component PERIOD2 in oncogenic cells confers chemoresistance by up-regulating the Aldh3a1 gene J. Biol. Chem. 2018 Lenti TL510377
ALDH3A1 Optimized dosing schedule based on circadian dynamics of mouse breast cancer stem cells improves the anti-tumor effects of aldehyde dehydrogenase Cancer Res. 2018 Lenti TL510377
ALKBH1 The stress specific impact of ALKBH1 on tRNA cleavage and tiRNA generation bioRxiv 2020 Lenti RR214755L2V
ALOX15 PDn-3 DPA Pathway Regulates Human Monocyte Differentiation and Macrophage Function Cell Chem Biol 2018 Lenti TL314822
AMD Increased polyamines as protective disease modifiers in Congenital Muscular Dystrophy Hum. Mol. Genet. 2018 Lenti RR205647L2
AMELX Effects of full-length human amelogenin on the differentiation of dental epithelial cells and osteoblastic cells Arch. Oral Biol. 2019 Lenti RC215582L1
AMFR Aberrant corticosteroid metabolism in tumor cells enables GR takeover in enzalutamide resistant prostate cancer Elife 2017 Lenti TL316441
ANGPTL4 Interaction of tumor cells and astrocytes promotes breast cancer brain metastases through TGF-β2/ANGPTL4 axes NPJ Precis Oncol 2019 Lenti TL317168
ANO1 Suppression of CaMKIIβ Inhibits ANO1-Mediated Glioblastoma Progression Cells 2020 Lenti TL300993
ANXA2 Intracellular targeting of annexin A2 inhibits tumor cell adhesion, migration, and in vivo grafting Sci Rep 2017 Lenti TL314772
AP2S1 Murine leukemia virus glycosylated Gag reduces murine SERINC5 protein expression at steady-state levels via endosome/lysosome pathway to counteract the SERINC5 antiretroviral activity J. Virol. 2018 Lenti TL306655
AP2S1 HIV-1 Nef antagonizes SERINC5 restriction by downregulation of SERINC5 via the endosome/lysosome system J. Virol. 2018 Lenti TL306655
AQP4 Analysis of chromatin accessibility uncovers TEAD1 as a regulator of migration in human glioblastoma Nat Commun 2018 Lenti RC204693L1
ARHGEF7 ARHGEF7 promotes metastasis of colorectal adenocarcinoma by regulating the motility of cancer cells Int. J. Oncol. 2018 Lenti TL306604
ARHGEF7 ARHGEF7 promotes metastasis of colorectal adenocarcinoma by regulating the motility of cancer cells Int. J. Oncol. 2018 Lenti RC218946L1
ARID3B ARID3B Directly Regulates Ovarian Cancer Promoting Genes PLoS ONE Jun 2015 Lenti RC206328L2
ATF4 A Novel Dual Kinase Function of the RET Proto-oncogene Negatively Regulates Activating Transcription Factor 4-Mediated Apoptosis J. Biol. Chem. Mar 2015 Lenti RC222709L1
ATG5 Basal autophagy is pivotal for Hodgkin and Reed-Sternberg cells' survival and growth revealing a new strategy for Hodgkin lymphoma treatment Oncotarget 2016 Lenti TL500113
ATG7 Altered mitochondrial quality control in Atg7-deficient VSMCs promotes enhanced apoptosis and is linked to unstable atherosclerotic plaque phenotype Cell Death Dis 2019 Lenti TL504956V
ATM ATM and ATR play complementary roles in the behavior of excitatory and inhibitory vesicle populations Proc. Natl. Acad. Sci. U.S.A. 2017 Lenti TL320267
ATP1A1 ATP1A1 Integrates AKT and ERK Signaling via Potential Interaction With Src to Promote Growth and Survival in Glioma Stem Cells Front Oncol 2019 Lenti TL314602
ATP1B2 An Immunoaffinity-Based Method for Isolating Ultrapure Adult Astrocytes Based on ATP1B2 Targetting by the ACSA-2 Antibody J. Biol. Chem. 2017 Lenti TL500159
Atp7a Knockdown of copper-transporting ATPase 1 (Atp7a) impairs iron flux in fully-differentiated rat (IEC-6) and human (Caco-2) intestinal epithelial cells Metallomics 2016 Lenti TL711714
Atr ATM and ATR play complementary roles in the behavior of excitatory and inhibitory vesicle populations Proc. Natl. Acad. Sci. U.S.A. 2017 Lenti TL519184
AVPR2 Sensory primary cilium is a responsive cAMP microdomain in renal epithelia Sci Rep 2019 Lenti TL513450
AXL Modelling ponatinib resistance in tyrosine kinase inhibitor-naïve and dasatinib resistant BCR-ABL1+ cell lines Oncotarget 2018 Lenti TL320269
AXL Implication of the Receptor Tyrosine Kinase AXL in Head and Neck Cancer Progression Int J Mol Sci 2016 Lenti RC206431L2
B2M Human follicular helper T cell promoter connectomes reveal novel genes and regulatory elements at SLE GWAS loci bioRxiv 2019 Lenti TL314543
B2M Antiviral signalling in human IPSC-derived neurons recapitulates neurodevelopmental disorder phenotypes BioRxiv 2019 Lenti TL314543V
BAP1 Sensitivity of mesothelioma cells to PARP inhibitors is not dependent on BAP1 but is enhanced by temozolomide in cells with high-Schlafen 11and low-MGMT expression J Thorac Oncol 2020 Lenti RC200378L4
BCL2 Nuclear factor erythroid 2-related factor 2 enhances carcinogenesis by suppressing apoptosis and promoting autophagy in nickel-transformed cells J. Biol. Chem 2017 Lenti TL316461
BCL2 Inhibition of Bcl-2 potentiates AZD-2014-induced anti-head and neck squamous cell carcinoma cell activity Biochem. Biophys. Res. Commun. Jun 2016 Lenti TL316461
BCLN1 Autophagy Induction Results in Enhanced Anoikis-resistance in Models of Peritoneal Disease Mol. Cancer Res. 2016 Lenti TL314484
BHLHE40 BHLHE40, a third transcription factor required for insulin induction of SREBP-1c mRNA in rodent liver Elife 2018 Lenti RR206868LV
BIRC5 HAb18G/CD147 Promotes pSTAT3-Mediated Pancreatic Cancer Development via CD44s Clin Cancer Res. 2013 Nov 22 Lenti TL315477
BMI1 Lens regeneration using endogenous stem cells with gain of visual function Nature Mar 2016 Lenti TL314462
Brd4 Inhibition of BRD4 Attenuates Cardiomyocyte Apoptosis via NF-κB pathway in a Rat Model of Myocardial Infarction Cardiovasc Ther 2018 Lenti TL704216
C13ORF34 Bora downregulation results in radioresistance by promoting repair of double strand breaks PLoS ONE Mar 2015 Lenti TL307294
C1ORF115 Systematic functional identification of cancer multi-drug resistance genes Genome Biol. 2020 Lenti RC206246L2
CAB39L CAB39L elicited an anti-Warburg effect via a LKB1-AMPK-PGC1α axis to inhibit gastric tumorigenesis Oncogene 2018 Lenti TL314249
CACNA1B Reduced N-Type Ca2+Channels in Atrioventricular Ganglion Neurons Are Involved in Ventricular Arrhythmogenesis J Am Heart Assoc 2018 Lenti TL713159
CACNA1C Primary cilium regulates CaV1.2 expression through Wnt signaling J. Cell. Physiol. April 2014 Lenti TL500242
CACNA1G Tumour-specific amplitude-modulated radiofrequency electromagnetic fields induce differentiation of hepatocellular carcinoma via targeting Cav3.2 T-type voltage-gated calcium channels and Ca2+ influx EBioMedicine 2019 Lenti TL305680
CACNA1G Ca2+ and CACNA1H mediate targeted suppression of breast cancer brain metastasis by AM RF EMF EBioMedicine 2019 Lenti TL305680
CACNA1H Tumour-specific amplitude-modulated radiofrequency electromagnetic fields induce differentiation of hepatocellular carcinoma via targeting Cav3.2 T-type voltage-gated calcium channels and Ca2+ influx EBioMedicine 2019 Lenti TL314243
CACNA1H Ca2+ and CACNA1H mediate targeted suppression of breast cancer brain metastasis by AM RF EMF EBioMedicine 2019 Lenti TL314243
CACNA1I Tumour-specific amplitude-modulated radiofrequency electromagnetic fields induce differentiation of hepatocellular carcinoma via targeting Cav3.2 T-type voltage-gated calcium channels and Ca2+ influx EBioMedicine 2019 Lenti TL314242
CACNA1I Ca2+ and CACNA1H mediate targeted suppression of breast cancer brain metastasis by AM RF EMF EBioMedicine 2019 Lenti TL314242
CACNA2D1 α2δ1 may be a potential marker for cancer stem cell in laryngeal squamous cell carcinoma Cancer Biomark 2019 Lenti TL314240
CACNG4 Amplification of a calcium channel subunit CACNG4 increases breast cancer metastasis EBioMedicine 2020 Lenti RC205154L3
CACNG4 The calcium channel subunit gamma-4 is regulated by MafA and necessary for pancreatic beta-cell specification Commun Biol 2019 Lenti RC205154L2
CADM1 MicroRNA-155-3p promotes breast cancer progression through down-regulating CADM1 Onco Targets Ther 2019 Lenti TL312210
CADM1 Human T-Cell Leukemia Virus Type 1 (HTLV-1) Tax Requires CADM1/TSLC1 for Inactivation of the NF-?B Inhibitor A20 and Constitutive NF-?B Signaling PLoS Pathog. Mar 2015 Lenti TL312210
CAPN10 Clinical significance of sHER2‑ECD and calpain‑10 expression in tumor tissues of patients with breast cancer Oncol Rep 2020 Lenti TL305662
CAR3 Expression of Carbonic Anhydrase III, a Nucleus Pulposus Phenotypic Marker, is Hypoxia-responsive and Confers Protection from Oxidative Stress-induced Cell Death Sci Rep 2018 Lenti TL710299
CASP3 Overexpression of apoptosis-inducing factor mitochondrion-associated 1 (AIFM1) induces apoptosis by promoting the transcription of caspase3 and DRAM in hepatoma cells Biochem. Biophys. Res. Commun. 2018 Lenti TL305638
CASR Hypoxia-Induced Mitogenic Factor Acts as a Nonclassical Ligand of Calcium-Sensing Receptor, Therapeutically Exploitable for Intermittent Hypoxia-Induced Pulmonary Hypertension Hypertension 2017 Lenti TL709816
CASR Monocrotaline Induces Endothelial Injury and Pulmonary Hypertension by Targeting the Extracellular Calcium-Sensing Receptor J Am Heart Assoc 2017 Lenti TL709816
CBARA1 miR-181c Activates Mitochondrial Calcium Uptake by Regulating MICU1 in the Heart J Am Heart Assoc 2019 Lenti TL512307
CCDC85B CCDC85B promotes non-small cell lung cancer cell proliferation and invasion Mol. Carcinog. 2018 Lenti RC201086L1
CCL2 MCP-1 is overexpressed in triple-negative breast cancers and drives cancer invasiveness and metastasis Breast Cancer Res. Treat. 2018 Lenti TL316716
CCL2 Chemokine Signaling Facilitates Early-stage Breast Cancer Survival and Invasion through Fibroblast-dependent Mechanisms Mol. Cancer Res.2017 Lenti TL316716
CCL2 Regulatory T cells ameliorate tissue plasminogen activator-induced brain haemorrhage after stroke Brain 2017 Lenti TL501987
CCR2 Chemokine Signaling Facilitates Early-stage Breast Cancer Survival and Invasion through Fibroblast-dependent Mechanisms Mol. Cancer Res.2017 Lenti TL321181
CD180 A multi-omic analysis reveals the regulatory role of CD180 during the response of macrophages to Borrelia burgdorferi Emerg Microbes Infect 2018 Lenti TL314107
CD274 Proteolytic processing of PD-L1 by ADAM proteases in breast cancer cells Cancer Immunol. Immunother. 2019 Lenti RC213071L2V
CD274 Salmonella Typhimurium increases functional PD-L1 synergistically with IFNγ in intestinal epithelial cells viaSalmonellaPathogenicity Island-2 Infect. Immun. 2018 Lenti TL314098
Cd274 Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade-mediated tumor regression J. Clin. Invest. 2018 Lenti MR203953L2
CD274 PD-L1 up-regulation in melanoma increases disease aggressiveness and is mediated through miR-17-5p Oncotarget 2017 Lenti TL314098V
CD40 A PPARγ-dependent miR-424/503-CD40 axis regulates inflammation mediated angiogenesis Sci Rep 2017 Lenti RC201977L1
CD44 Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival Nat Commun 2018 Lenti TL314080
CD70 Breast cancer stem cells characterized by CD70 expression preferentially metastasize to the lungs Breast Cancer 2018 Lenti TL308721
CDC2 Adenylyl cyclase activating polypeptide reduces phosphorylation and toxicity of the polyglutamine-expanded androgen receptor in spinobulbar muscular atrophy Sci Transl Med 2016 Lenti TL320288
CDC42 shRNA mediated inhibition of Cdc42 gene expression in Calu-6 lung cancer cells bioRxiv 2017 Lenti TL305497
CDC7 CDC7-dependent transcriptional regulation of RAD54L is essential for tumorigenicity and radio-resistance of glioblastoma Transl Oncol 2018 Lenti TL320578
CDH11 Analysis of chromatin accessibility uncovers TEAD1 as a regulator of migration in human glioblastoma Nat Commun 2018 Lenti RC203810L1
CDH11 Cadherin-11 involves in synovitis and increases the migratory and invasive capacity of fibroblast-like synoviocytes of osteoarthritis Int. Immunopharmacol. Mar 2015 Lenti RC203810L2
CDH3 DSCAM promotes self-avoidance in the developing mouse retina by masking the functions of cadherin superfamily members Proc. Natl. Acad. Sci. U.S.A. 2018 Lenti MR227582L1
CDK2 Cyclin-Dependent Kinase 2 Promotes Tumor Proliferation and Induces Radio Resistance in Glioblastoma Transl Oncol 2016 Lenti TL320291
CDKN1A Adenylyl cyclase activating polypeptide reduces phosphorylation and toxicity of the polyglutamine-expanded androgen receptor in spinobulbar muscular atrophy Sci Transl Med 2016 Lenti TL305469
CDKN1B Chronic p27Kip1 Induction by Dexamethasone Causes Senescence Phenotype and Permanent Cell Cycle Blockade in Lung Adenocarcinoma Cells Over-expressing Glucocorticoid Receptor Sci Rep 2018 Lenti RC201661L1
CDKN2A p16(INK4A) induces senescence and inhibits EMT through microRNA-141/microRNA-146b-5p-dependent repression of AUF1 Mol. Carcinog. 2016 Lenti RC220937L2
CDKN2A TALE-mediated epigenetic suppression of CDKN2A increases replication in human fibroblasts J. Clin. Invest. May 2015 Lenti RC220937L1
CDKN2A The Cytokine IL-6 Reactivates Breast Stromal Fibroblasts through Transcription Factor STAT3-dependent Up-regulation of the RNA Binding Protein AUF1 J. Biol. Chem. Sep 2014 Lenti RC220937L1
CEBPA C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer's disease Nat Commun 2018 Lenti TL316491
CEBPB C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer's disease Nat Commun 2018 Lenti TL320301
CGGBP1 CGGBP1 regulates CTCF occupancy at repeats Epigenetics Chromatin 2019 Lenti TL313955
CGGBP1 CGGBP1 regulates chromatin barrier activity and CTCF occupancy at repeats bioRxiv 2019 Lenti TL313955
CGGBP1 CGGBP1 regulates chromatin barrier activity and CTCF occupancy at repeats bioRxiv 2019 Lenti RC208653L1
CHCHD2 FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N(6)-Methyladenosine RNA Demethylase Cancer Cell 2016 Lenti TL317169
CHCHD4 Light-Driven Regeneration of Cone Visual Pigments through a Mechanism Involving RGR Opsin in Müller Glial Cells Neuron 2019 Lenti TL305417
CHD5 miRNA-24-3p promotes cell proliferation and regulates chemosensitivity in head and neck squamous cell carcinoma by targeting CHD5 Future Oncol 2016 Lenti RC221815L1
CHEK2 CHEK2 represses breast stromal fibroblasts and their paracrine tumor-promoting effects through suppressing SDF-1 and IL-6 BMC Cancer 2016 Lenti RC212127L1
CIC Inactivation of Capicua drives cancer metastasis Nat. Genet. 2016 Lenti RC215209L2
CLDN18 Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis J. Clin. Invest. 2018 Lenti RC212135L2
CLDN4 Ovarian Tumor Cell Expression of Claudin-4 Reduces Apoptotic Response to Paclitaxel Mol. Cancer Res. 2019 Lenti RC200490L2
CLTC Dynamin and endocytosis are required for the fusion of osteoclasts and myoblasts J. Cell Biol. Oct 2014 Lenti TL516542
Control Particle A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo Cancer Cell 2019 Lenti PS100092V
Control Particles Cathelicidin Suppresses Colon Cancer Metastasis via a P2RX7-Dependent Mechanism Molecular Therapy - Oncolytics 2019 Lenti PS100064V
CORO1B Coronin 1B serine 2 phosphorylation by p38a is critical for vascular endothelial growth factor-induced migration of human umbilical vein endothelial cells Cell. Signal. 2016 Lenti RC203023L2
Cpne7 Dentin sialophosphoprotein expression in enamel is regulated by Copine-7, a preameloblast-derived factor Arch. Oral Biol. 2017 Lenti TL513948
CRADD RAIDD Mediates TLR3 and IRF7 Driven Type I Interferon Production Cell. Physiol. Biochem. 2016 Lenti TL319843
Creb3l1 CREB3L1-mediated functional and structural adaptation of the secretory pathway in hormone-stimulated thyroid cells J. Cell. Sci.2017 Lenti TL700673
CREBBP Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence Mol. Cell 2019 Lenti RC219036L1
CRHR1 Frontline Science: Corticotropin-releasing factor receptor subtype 1 is a critical modulator of mast cell degranulation and stress-induced pathophysiology J. Leukoc. Biol. 2017 Lenti RC226816L2
CT45A1 Multi-level Proteomics Identifies CT45 as a Chemosensitivity Mediator and Immunotherapy Target in Ovarian Cancer Cell 2018 Lenti TL315298
CTNNB1 Activation of β-catenin signaling and its cross talk with estrogen and histone deacetylases in human uterine fibroids J. Clin. Endocrinol. Metab. 2019 Lenti TL313664V
CTNNBL1 Spliceosome-associated factor CTNNBL1 promotes proliferation and invasion in ovarian cancer Exp. Cell Res. 2017 Lenti RC224836L1
CTSB Cathepsin-B-mediated cleavage of Disabled-2 regulates TGF-ß-induced autophagy Nat. Cell Biol. 2016 Lenti TL305176
CUX2 MYCN amplification and ATRX mutations are incompatible in neuroblastoma Nat Commun 2020 Lenti RC222063L4
CXCL1 Plac1 Is a Key Regulator of the Inflammatory Response and Immune Tolerance In Mammary Tumorigenesis Sci Rep 2018 Lenti MR220966L1
CXCL8 IL-8 Activates Breast Cancer-Associated Adipocytes and Promotes Their Angiogenic and Tumorigenic Promoting Effects Mol. Cell. Biol. 2018 Lenti TL319476
CXCL8 IL-8 Activates Breast Cancer-Associated Adipocytes and Promotes Their Angiogenic and Tumorigenic Promoting Effects Mol. Cell. Biol. 2018 Lenti RC202075L1
CXCR3 Divergent roles of CXCR3 isoforms in promoting cancer stem-like cell survival and metastasis Breast Cancer Res. Treat. Dec 2014 Lenti TL316563
CXCR4 m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade Nat Commun 2019 Lenti RC214548L2
CXCR4 Randomly distributed K14+ breast tumor cells polarize to the leading edge to direct collective migration in response to chemical and mechanical environmental cues Cancer Res. 2019 Lenti TL500383
CXCR4 Epigenetic regulation of CXCL12 plays a critical role in mediating tumor progression and the immune response in osteosarcoma Cancer Res. 2018 Lenti TL500383
CXCR4 Epigenetic regulation of CXCL12 plays a critical role in mediating tumor progression and the immune response in osteosarcoma Cancer Res. 2018 Lenti TL313630
CXCR4 Proinflammatory CXCL12-CXCR4/CXCR7 signaling axis drives Myc-induced prostate cancer in obese mice Cancer Res. 2017 Lenti TL500383
CXCR7 Proinflammatory CXCL12-CXCR4/CXCR7 signaling axis drives Myc-induced prostate cancer in obese mice Cancer Res. 2017 Lenti TL515747
CXCR7 ShRNA knock-down of CXCR7 inhibits tumour invasion and metastasis in hepatocellular carcinoma after transcatheter arterial chemoembolization J. Cell. Mol. Med. 2017 Lenti TL305345
CXCR7 Platelet-derived SDF-1 primes the pulmonary capillary vascular niche to drive lung alveolar regeneration Nat. Cell Biol. Feb 2015 Lenti TL305345
CXCR7 Platelet-derived SDF-1 primes the pulmonary capillary vascular niche to drive lung alveolar regeneration Nat. Cell Biol. Feb 2015 Lenti TL515747
CYP1B1 Cytochrome P450 1B1 inhibition suppresses tumorigenicity of prostate cancer via caspase-1 activation Oncotarget 2017 Lenti TL313605
DAB2 Cathepsin-B-mediated cleavage of Disabled-2 regulates TGF-ß-induced autophagy Nat. Cell Biol. 2016 Lenti TL313573
DACH1 Suppression of DACH1 promotes migration and invasion of colorectal cancer via activating TGF-ß-mediated epithelial-mesenchymal transition Biochem. Biophys. Res. Commun. Mar 2015 Lenti TL313572
DDR2 Targeting DDR2 in head and neck squamous cell carcinoma with dasatinib Int. J. Cancer 2016 Lenti TL320440
DEPDC5 Acute knockdown of Depdc5 leads to synaptic defects in mTOR-related epileptogenesis Neurobiol. Dis. 2020 Lenti TL508165
DKK1 Wnt signaling modulator DKK1 as an immunotherapeutic target in ovarian cancer Gynecol. Oncol. 2020 Lenti MR203629L3
DKK3 DKK3 knockdown confers negative effects on the malignant potency of head and neck squamous cell carcinoma cells via the PI3K/Akt and MAPK signaling pathways Int. J. Oncol. 2018 Lenti TL313463
DLL3 Near infrared photoimmunotherapy targeting DLL3 for small cell lung cancer EBioMedicine 2020 Lenti RC200005L2V
DNAJB1 FOXE3 contributes to Peters anomaly through transcriptional regulation of an autophagy-associated protein termed DNAJB1 Nature Communications Apr 2016 Lenti TL313427
DNM2 Arp2/3 nucleates F-actin coating of fusing insulin granules in pancreatic β cells to control insulin secretion J. Cell. Sci. 2020 Lenti RC223585L2
DNMT1 Targeted phosphoproteomics of the Ras signaling network reveal regulatory mechanisms mediated by oncogenic KRAS bioRxiv 2019 Lenti RC226414L1
DNMT1 Epigenetic regulation of CXCL12 plays a critical role in mediating tumor progression and the immune response in osteosarcoma Cancer Res. 2018 Lenti TL514641
DNMT1 Epigenetic regulation of CXCL12 plays a critical role in mediating tumor progression and the immune response in osteosarcoma Cancer Res. 2018 Lenti TL313404
DNMT1 Cancer associated fibroblasts in pancreatic cancer are reprogrammed by tumor-induced alterations in genomic DNA methylation Cancer Res. 2016 Lenti TL313404
DNMT3A Epigenetic regulation of CXCL12 plays a critical role in mediating tumor progression and the immune response in osteosarcoma Cancer Res. 2018 Lenti TL500549
DNMT3A Epigenetic regulation of CXCL12 plays a critical role in mediating tumor progression and the immune response in osteosarcoma Cancer Res. 2018 Lenti TL304938
DOT1L Targeting histone methyltransferase DOT1L by a novel psammaplin A analog inhibits growth and metastasis of triple-negative breast cancer Molecular Therapy - Oncolytics 2019 Lenti RC218547L2
DRAM1 Overexpression of apoptosis-inducing factor mitochondrion-associated 1 (AIFM1) induces apoptosis by promoting the transcription of caspase3 and DRAM in hepatoma cells Biochem. Biophys. Res. Commun. 2018 Lenti TL307117
DRD2 The Dopamine D2 Receptor Contributes to the Spheroid Formation Behavior of U87 Glioblastoma Cells Pharmacology 2019 Lenti RC213065L3V
DRD2 Role of Dopamine Receptors in the Anticancer Activity of ONC201 Neoplasia 2017 Lenti TL304907
DSP Changes in mRNA/protein expression and signaling pathways in in vivo passaged mouse ovarian cancer cells PLoS ONE 2018 Lenti TL519230
DUSP23 Profiling analysis of protein tyrosine phosphatases during neuronal differentiation Neurosci. Lett. Dec 2015 Lenti TL317251
DUSP5 Dual specificity phosphatase 5 regulates perfusion recovery in experimental peripheral artery disease Vasc Med 2019 Lenti TL518256
E2F1 Non-overlapping Control of Transcriptome by Promoter- and Super-Enhancer-Associated Dependencies in Multiple Myeloma Cell Rep 2018 Lenti RC208247L2
EBF2 Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing Nature 2019 Lenti MR224591L3
EDEM2 Innate sensing of influenza A virus hemagglutinin glycoproteins by the host endoplasmic reticulum (ER) stress pathway triggers a potent antiviral response via ER-associated protein degradation J. Virol. 2017 Lenti TL304849
EFEMP1 The matrix protein Fibulin-3 promotes KISS1R induced triple negative breast cancer cell invasion Oncotarget 2018 Lenti TL313284
EGFL7 Attenuation of EGFL7 expression inhibits growth hormone-producing pituitary adenomas growth and invasion Hum. Gene Ther. 2018 Lenti TL508528
EGFL7 EGFL7 participates in regulating biological behavior of growth hormone-secreting pituitary adenomas via Notch2/DLL3 signaling pathway Tumour Biol. 2017 Lenti TL713010
EGFR EGFR signaling confers resistance to BET inhibition in hepatocellular carcinoma through stabilizing oncogenic MYC J. Exp. Clin. Cancer Res. 2019 Lenti TL320326
EGFR Activation of EGFR/p38/HIF-1a is pivotal for angiogenesis and tumorigenesis of malignantly transformed cells induced by hexavalent chromium J. Biol. Chem. May 2016 Lenti TL320326
EGR1 Early growth response 1 regulates hematopoietic support and proliferation in human primary bone marrow stromal cells Haematologica 2019 Lenti TL313277
EIF3F Nuclear control of lung cancer cells migration, invasion and bioenergetics by eukaryotic translation initiation factor 3F Oncogene 2019 Lenti RC201740L3
EIF4E Activation of Tyrosine Metabolism in CD13+ Cancer Stem Cells Drives Relapse in Hepatocellular Carcinoma Cancer Res Treat 2019 Lenti TL313244
EMSY EMSY expression affects multiple components of skin barrier with relevance to atopic dermatitis Journal of Allergy and Clinical Immunology 2019 Lenti RC216916L4
ENG Inhibition of endoglin exerts anti-tumor effects through the regulation of non-Smad TGF-β signaling in angiosarcoma J. Invest. Dermatol. 2020 Lenti RC221699L1V
EP300 Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence Mol. Cell 2019 Lenti RC223265L1
EPAS1 miR-147b-mediated TCA cycle dysfunction and pseudohypoxia initiate drug tolerance to EGFR inhibitors in lung adenocarcinoma Nat Metab 2019 Lenti TL315484
ERA Modulation effects of black-vinegar based supplement against a high-fat dietary habit: antiobesity/hypolipidemic, antioxidative, and energy-metabolism effects J. Sci. Food Agric. 2020 Lenti TL510613
ERBB2 Tuning the Antigen Density Requirement for CAR T Cell Activity Cancer Discov 2020 Lenti RC212583L1
ERBB2 The S100A4 Protein Signals through the ErbB4 Receptor to Promote Neuronal Survival Theranostics 2018 Lenti TL709823
ERBB2 Directed Evolution of Scanning Unnatural-Protease-Resistant (SUPR) Peptides for in Vivo Applications Chembiochem 2016 Lenti TL320342
ERBB2 Transmembrane Domain Targeting Peptide Antagonizing ErbB2/Neu Inhibits Breast Tumor Growth and Metastasis Cell Rep Sep 2014 Lenti TL320342
ERCC2 ERCC2 Helicase Domain Mutations Confer Nucleotide Excision Repair Deficiency and Drive Cisplatin Sensitivity in Muscle-Invasive Bladder Cancer Clin. Cancer Res. 2018 Lenti RC215058L1
ERCC2 XPD localizes in mitochondria and protects the mitochondrial genome from oxidative DNA damage Nucleic Acids Res. May 2015 Lenti TL313180
ERCC4 A Unique Subset of Epithelial Ovarian Cancers with Platinum Sensitivity and PARP Inhibitor Resistance Cancer Res. Feb 2015 Lenti RC223300L1
ERCC6 Elevated Expression of ERCC6 Confers Resistance to 5-Fluorouracil and Is Associated with Poor Patient Survival in Colorectal Cancer DNA Cell Biol. 2017 Lenti TL313176
ESR1 17β-estradiol binding to ERα promotes the progression of prolactinoma through estrogen-response element-induced CaBP-9k up-regulation Biosci. Rep. 2020 Lenti TL510613
ESR1 Estrogen receptors orchestrate cell growth and differentiation to facilitate liver regeneration Theranostics 2018 Lenti RC213277L2
ESR1 PAC down-regulates estrogen receptor alpha and suppresses epithelial-to-mesenchymal transition in breast cancer cells BMC Cancer 2016 Lenti TL320346
ESR2 Estrogen receptors orchestrate cell growth and differentiation to facilitate liver regeneration Theranostics 2018 Lenti RC218519L2
ESRRA NURR1 and ERR1 Modulate the Expression of Genes of a DRD2 Coexpression Network Enriched for Schizophrenia Risk J. Neurosci. 2020 Lenti MR225753L1
ESRRA NURR1 and ERR1 Modulate the Expression of Genes of a DRD2 Coexpression Network Enriched for Schizophrenia Risk J. Neurosci. 2020 Lenti TL502583
EZH2 A non-canonical function of Ezh2 preserves immune homeostasis EMBO Rep 2017 Lenti RC202054L1
EZH2 Long noncoding RNA H19 regulates EZH2 expression by interacting with miR-630 and promotes cell invasion in nasopharyngeal carcinoma Biochem. Biophys. Res. Commun. May 2016 Lenti TL304713
EZH2 Sunitinib dose-escalation overcomes transient resistance in clear cell renal cell carcinoma and is associated with epigenetic modifications Mol. Cancer Ther. Dec 2014 Lenti TL304713
FANCI CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI Cell Death Discov 2019 Lenti RC226384L4
FBL Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells Cancer Cell Jun 2016 Lenti TL313054
FBXW7 F-Box/WD Repeat Domain-Containing 7 Induces Chemotherapy Resistance in Colorectal Cancer Stem Cells Cancers (Basel) 2019 Lenti TL304541
FERMT2 The focal adhesion protein kindlin-2 controls mitotic spindle assembly by inhibiting histone deacetylase 6 and maintaining α-tubulin acetylation J. Biol. Chem. 2020 Lenti TL310359
Fgf15 A Genetic Screen Identifies Hypothalamic Fgf15 as a Regulator of Glucagon Secretion Cell Rep 2016 Lenti TL514099
FGFR3 Modulation of HCV reinfection after orthotopic liver transplantation by fibroblast growth factor-2 and other non-interferon mediators Gut Mar 2015 Lenti RC215533L2
FLT1 Injured Axons Instruct Schwann Cells to Build Constricting Actin Spheres to Accelerate Axonal Disintegration Cell Rep 2019 Lenti RC224406L2
FN1 Fibronectin 1 promotes migration and invasion of papillary thyroid cancer and predicts papillary thyroid cancer lymph node metastasis Onco Targets Ther 2017 Lenti TL304489
FOLR1 Anti-Folate Receptor alpha-directed Antibody Therapies Restrict the Growth of Triple Negative Breast Cancer Clin. Cancer Res. 2018 Lenti TL304479
FOLR1 Modification of cytokine-induced killer cells with folate receptor alpha (FRα)-specific chimeric antigen receptors enhances their antitumor immunity toward FRα-positive ovarian cancers Mol. Immunol. 2017 Lenti RC221050L1
FOLR2 Targeting of folate receptor-beta on acute myeloid leukemia blasts with chimeric antigen receptor expressing T cells Blood Apr 2015 Lenti RC212993L1
FOS Nkx6.1-mediated insulin secretion and ß-cell proliferation is dependent on upregulation of c-Fos FEBS Lett. May 2016 Lenti TL710577
FOSL1 The histone deacetylase inhibitor LBH589 inhibits undifferentiated pleomorphic sarcoma growth via downregulation of FOS-like antigen 1 Mol. Carcinog. 2018 Lenti RC202104L2
FOXA3 Estrogen receptors orchestrate cell growth and differentiation to facilitate liver regeneration Theranostics 2018 Lenti RC202363L2
FOXD3 Activation of Tyrosine Metabolism in CD13+ Cancer Stem Cells Drives Relapse in Hepatocellular Carcinoma Cancer Res Treat 2019 Lenti TL312939
FOXO3 Mitochondrial FOXO3a is involved in amyloid ß peptide-induced mitochondrial dysfunction J. Bioenerg. Biomembr. Jan 2016 Lenti TL704976
FSCN1 Fascin is Critical for the Maintenance of Breast Cancer Stem Cell Pool Predominantly via the Activation of the Notch Self-Renewal Pathway Stem Cells 2016 Lenti TL312916
FTO FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell bioRxiv 2020 Lenti TL308064
FTO The m6A eraser FTO facilitates proliferation and migration of human cervical cancer cells Cancer Cell Int. 2019 Lenti TL308064
FTO R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling Cell 2018 Lenti TL308064
FTO Kaposi's Sarcoma-Associated Herpesvirus Utilizes and Manipulates RNA N6-Adenosine Methylation To Promote Lytic Replication J. Virol. 2017 Lenti TL308064
FTO FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N(6)-Methyladenosine RNA Demethylase Cancer Cell 2016 Lenti TL308064
FUS Senataxin mutations elicit motor neuron degeneration phenotypes and yield TDP-43 mislocalization in ALS4 mice and human patients Acta Neuropathol. 2018 Lenti RC201808L2
FZD4 Norrin mediates tumor-promoting and -suppressive effects in glioblastoma via Notch and WNT J. Clin. Invest. 2020 Lenti RC217286L1
FZD4 Norrin mediates tumor-promoting and -suppressive effects in glioblastoma via Notch and WNT J. Clin. Invest. 2020 Lenti TL312883
FZD4 Wnt5a/FZD4 Mediates the Mechanical Stretch-Induced Osteogenic Differentiation of Bone Mesenchymal Stem Cells Cell. Physiol. Biochem. 2018 Lenti TL500740
FZD5 ARID3B Directly Regulates Ovarian Cancer Promoting Genes PLoS ONE Jun 2015 Lenti RC213960L2
GAB2 Gab2 Ablation Reverses the Stemness of HER2-Overexpressing Breast Cancer Cells Cell. Physiol. Biochem. 2018 Lenti TL312875
GABRG2 Shifting hippocampal excitation/inhibition balance modifies despair-like behavior in mice bioRxiv 2020 Lenti TL515175
GABRG2 Hippocampal GABA-inhibitory circuitry regulates despair-like behavior in mice bioRxiv 2020 Lenti TL515175
GATA1 The Il9 CNS-25 Regulatory Element Controls Mast Cell and Basophil IL-9 Production J. Immunol. 2019 Lenti TL500772
GATA4 Meox1 accelerates myocardial hypertrophic decompensation through Gata4 Cardiovasc. Res.2017 Lenti TL500773
GCC2 Evaluation of TAK-264, an Antibody-Drug Conjugate in Pancreatic Cancer Cell Lines and Patient-Derived Xenograft Models Clin Cancer Drugs 2018 Lenti TL312820
GDF15 Subregional differences in astrocytes underlie selective neurodegeneration or protection in Parkinson's disease models in culture Glia 2019 Lenti TL710232
GFAT1 Enhanced hexosamine metabolism drives metabolic and signaling networks involving hyaluronan production and O-GlcNAcylation to exacerbate breast cancer Cell Death Dis 2019 Lenti TL511601V
GFPT1 Hyperglycemia exacerbates colon cancer malignancy through hexosamine biosynthetic pathway Oncogenesis 2017 Lenti TL511601
GLUL Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma Nat. Cell Biol. Dec 2015 Lenti TL312740
GMNN Geminin deletion increases the number of fetal hematopoietic stem cells by affecting the expression of key transcription factors Development Jan 2015 Lenti TL304304
GOLPH3 Lentivirus Mediated GOLPH3 shRNA Inhibits Growth and Metastasis of Esophageal Squamous Cancer Asian Pac. J. Cancer Prev. 5391-6 Nov 2013 Lenti TL317415
GORASP2 Grasp55-/- mice display impaired fat absorption and resistance to high-fat diet-induced obesity Nat Commun 2020 Lenti RC202946L3
GORASP2 Alternative splicing switches STIM1 targeting to specialized membrane contact sites and modifies SOCE bioRxiv 2020 Lenti RC202946L3
GPAM Glycerol-3-phosphate is a FGF23 regulator derived from the injured kidney J. Clin. Invest. 2020 Lenti TL500848V
GPAT4 Glycerol-3-phosphate is a FGF23 regulator derived from the injured kidney J. Clin. Invest. 2020 Lenti TL512820V
GPR158 Gpr158 mediates osteocalcin's regulation of cognition J. Exp. Med. 2017 Lenti TL509693
GPRC5A Orphan G protein-coupled receptor GPRC5A modulates integrin ß1-mediated epithelial cell adhesion Cell Adh Migr 2016 Lenti RC200118L1
GRHL2 Porphyromonas gingivalis Impairs Oral Epithelial Barrier through Targeting GRHL2 J. Dent. Res. 2019 Lenti TL304206
GRHL2 Grainyhead-like 2 (GRHL2) knockout abolishes oral cancer development through reciprocal regulation of the MAP kinase and TGF-β signaling pathways Oncogenesis 2018 Lenti TL304206
GRIN2B Synaptic proximity enables NMDAR signalling to promote brain metastasis Nature 2019 Lenti RC223623L2
GRSF1 Loss of RNA-binding protein GRSF1 activates mTOR to elicit a proinflammatory transcriptional program Nucleic Acids Res. 2019 Lenti TL312593
GRSF1 GRSF1 suppresses cell senescence Aging (Albany NY) 2018 Lenti TL312593V
Gucy1a3 Reciprocal regulation between O-GlcNAcylation and tribbles pseudokinase 2 (TRIB2) maintains transformative phenotypes in liver cancer cells Cell. Signal. 2016 Lenti MR210068L1
GUCY2C A Novel GUCY2C-CD3 T cell Engaging Bispecific construct (PF-07062119) for the Treatment of Gastrointestinal Cancers Clin. Cancer Res. 2020 Lenti RC213901L3
GULP1 Integrated transcriptomic and epigenomic analysis of ovarian cancer reveals epigenetically silenced GULP1 Cancer Lett. 2018 Lenti TL304167
H19 Long noncoding RNA H19 regulates EZH2 expression by interacting with miR-630 and promotes cell invasion in nasopharyngeal carcinoma Biochem. Biophys. Res. Commun. May 2016 Lenti TL318197
HAT1 HAT1 Coordinates Histone Production and Acetylation via H4 Promoter Binding Molecular Cell 2019 Lenti RC209571L1
HAT1 HAT1 Coordinates Histone Production and Acetylation via H4 Promoter Binding Molecular Cell 2019 Lenti TL312517
HBP1 Transcription factor ICBP90 regulates the MIF promoter and immune susceptibility locus J. Clin. Invest. Feb 2016 Lenti TL312507
HDAC2 Ethanol exposure regulates Gabra1 expression via histone deacetylation at the promoter in cultured cortical neurons J. Pharmacol. Exp. Ther. 2017 Lenti TL711866
HDAC4 HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder Hum. Mol. Genet. 2016 Lenti TL510852
HDAC6 Rational cotargeting of HDAC6 and BET proteins yields synergistic antimyeloma activity Blood Adv 2019 Lenti RC209649L4V
HDGF A novel SNP in the 5' regulatory region of organic anion transporter 1 is associated with chronic kidney disease Sci Rep 2018 Lenti RC204148L1
HEY2 Defining human cardiac transcription factor hierarchies using integrated single-cell heterogeneity analysis Nat Commun 2018 Lenti RC202544L2
HGF New Paradigms to Assess Consequences of Long-Term, Low-Dose Curcumin Exposure in Lung Cancer Cells Molecules 2020 Lenti TL312467
HIF1A Sulforaphane Inhibits Nonmuscle Invasive Bladder Cancer Cells Proliferation through Suppression of HIF-1α-Mediated Glycolysis in Hypoxia J. Agric. Food Chem. 2019 Lenti TL320380
HIF1A miR-147b-mediated TCA cycle dysfunction and pseudohypoxia initiate drug tolerance to EGFR inhibitors in lung adenocarcinoma Nat Metab 2019 Lenti TL320380
HIF1A A facile in vitro platform to study cancer cell dormancy under hypoxic microenvironments using CoCl2 J Biol Eng 2018 Lenti TL320380
HIF1A Activation of EGFR/p38/HIF-1a is pivotal for angiogenesis and tumorigenesis of malignantly transformed cells induced by hexavalent chromium J. Biol. Chem. May 2016 Lenti TL320380
HIF1A Cell type-dependent modulation of the gene encoding heat shock protein HSPA2 by hypoxia-inducible factor HIF-1: Down-regulation in keratinocytes and up-regulation in HeLa cells Biochim. Biophys. Acta Jul 2015 Lenti TL320380
HIPK1 Human follicular helper T cell promoter connectomes reveal novel genes and regulatory elements at SLE GWAS loci bioRxiv 2019 Lenti TL320769
HMGB1 High mobility group box 1 promotes sorafenib resistance in HepG2 cells and in vivo BMC Cancer 2017 Lenti RC205918L2
HMGCR Inhibition of cholesterol biosynthesis overcomes enzalutamide resistance in castration-resistant prostate cancer (CRPC) J. Biol. Chem. 2018 Lenti TL312393
HMOX1 Synthetically Lethal Interactions of Heme Oxygenase-1 and Fumarate Hydratase Genes Biomolecules 2020 Lenti TL312388
HMOX1 Atorvastatin and Conditioned Media from Atorvastatin-Treated Human Hematopoietic Stem/Progenitor-Derived Cells Show Proangiogenic Activity In Vitro but Not In Vivo Mediators of Inflammation 2019 Lenti TL500966
Hmox1 Bacteroides fragilis Enterotoxin Upregulates Heme Oxygenase-1 in Intestinal Epithelial Cells via a Mitogen-Activated Protein Kinases- and NF-?B-Dependent Pathway, Leading to Modulation of Apoptosis Infect. Immun. Jun 2016 Lenti MR203944L1
HNF1A Estrogen receptors orchestrate cell growth and differentiation to facilitate liver regeneration Theranostics 2018 Lenti RC211201L2
HNF1A Aberrant Activation of a Gastrointestinal Transcriptional Circuit in Prostate Cancer Mediates Castration Resistance Cancer Cell 2017 Lenti RC211201L1
HNF4A Estrogen receptors orchestrate cell growth and differentiation to facilitate liver regeneration Theranostics 2018 Lenti RC217863L2
Hnf4a Hepatocyte Nuclear Factor-4 alpha in Noise-Induced Cochlear Neuropathy Dev Neurobiol Apr 2016 Lenti TL500970
HNF4G miR-34a Inhibits Proliferation and Invasion of Bladder Cancer Cells by Targeting Orphan Nuclear Receptor HNF4G Disease Markers Mar 2015 Lenti RC219703L2
HNRNPD The inflammatory/cancer-related IL-6/STAT3/NF-?B positive feedback loop includes AUF1 and maintains the active state of breast myofibroblasts Oncotarget 2016 Lenti RC201796L2
HNRNPD The Cytokine IL-6 Reactivates Breast Stromal Fibroblasts through Transcription Factor STAT3-dependent Up-regulation of the RNA Binding Protein AUF1 J. Biol. Chem. Sep 2014 Lenti RC201796L1
HOXA13 CDH17 is a downstream effector of HOXA13 in modulating the Wnt/β-catenin signaling pathway in gastric cancer Eur Rev Med Pharmacol Sci 2017 Lenti RC209698L1
HOXB9 A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer Nat Commun Apr 2016 Lenti RC213735L2
HOXC13 Transcriptional regulation of the proto-oncogene Zfp521 by SPI1 (PU.1) and HOXC13 Genesis 2016 Lenti TL304059
HOXD10 Homeobox D10, a tumor suppressor, inhibits the proliferation and migration of esophageal squamous cell carcinoma J. Cell. Biochem. 2019 Lenti RC210208L3
HPSE Sphingosine-1-phosphate induced epithelial-mesenchymal transition of hepatocellular carcinoma via an MMP-7/ syndecan-1/TGF-ß autocrine loop Oncotarget 2016 Lenti TL307138
HSF1 C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer's disease Nat Commun 2018 Lenti TL312318
HSPA5 ER stress sensor, glucose regulatory protein 78 (GRP78) regulates redox status in pancreatic cancer thereby maintaining "stemness" Cell Death Dis 2019 Lenti TL312303
HSPA5 ER translocation of the MAPK pathway drives therapy resistance in BRAF mutant melanoma Cancer Discov 2018 Lenti TL500881
HSPA5 Mahanine drives pancreatic adenocarcinoma cells into endoplasmic reticular stress-mediated apoptosis through modulating sialylation process and Ca2+-signaling Sci Rep 2018 Lenti TL312303
HSPB2 Schisandrin B ameliorates high glucose-induced vascular endothelial cells injury by regulating Noxa/Hsp27/NF-κB signaling pathway Biochem. Cell Biol. 2019 Lenti TL312300
HYAL4 A Novel Splice Variant of HYAL-4 Drives Malignant Transformation and Predicts Outcome in Bladder Cancer Patients Clin. Cancer Res. 2020 Lenti TL312276
ICAM-5 ICAM-5/Telencephalin Is a Functional Entry Receptor for Enterovirus D68 Cell Host & Microbe 2016 Lenti TL312266
ICAM1 Cell-specific targeting by Clostridium perfringens β-toxin unraveled: the role of CD31 as the toxin receptor bioRxiv 2019 Lenti RC200714L3
ICOSLG Non-immune cell-derived ICOS ligand functions as a renoprotective αvβ3 integrin-selective antagonist J. Clin. Invest. 2019 Lenti RC208975L2
ICOSLG Non-immune cell-derived ICOS ligand functions as a renoprotective αvβ3 integrin-selective antagonist J. Clin. Invest. 2019 Lenti TL303997
IDO1 Targeting the kynurenine pathway for the treatment of cisplatin resistant lung cancer Mol. Cancer Res. 2019 Lenti TL312147
IDO1 Tumor-Repopulating Cells Induce PD-1 Expression in CD8+T Cells by Transferring Kynurenine and AhR Activation Cancer Cell 2018 Lenti TL511273
IDO1 Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells Nat Commun 2017 Lenti RC206592L1
IDO1 Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells Nat Commun 2017 Lenti TL312147
IGFIR The insulin-like growth factor I receptor regulates glucose transport by astrocytes Glia 2016 Lenti TL501056
IL-37 Interleukin-37 suppresses the osteogenic responses of human aortic valve interstitial cells in vitro and alleviates valve lesions in mice Proc. Natl. Acad. Sci. U.S.A 2017 Lenti TL303957
Il27 Targeting Interleukin(IL)-30/IL-27p28 signaling in cancer stem-like cells and host environment synergistically inhibits prostate cancer growth and improves survival J Immunother Cancer 2019 Lenti TL507534
IL6 Antitumor and Anti-Invasive Effect of Apigenin on Human Breast Carcinoma through Suppression of IL-6 Expression Int J Mol Sci 2019 Lenti TL312162
IL6 Targeting Interleukin-6 (IL-6) Sensitizes Anti-PD-L1 Treatment in a Colorectal Cancer Preclinical Model Med. Sci. Monit. 2018 Lenti MR227281L2
IL6R Metformin inhibits IL-6 signaling by decreasing IL-6R expression on multiple myeloma cells Leukemia 2019 Lenti TL312161
INA a-Internexin and Peripherin: Expression, Assembly, Functions, and Roles in Disease Methods in Enzymology Nov 2015 Lenti RC202877L2
INA a-Internexin and Peripherin: Expression, Assembly, Functions, and Roles in Disease Methods in Enzymology Nov 2015 Lenti MR208054L2
INA a-Internexin and Peripherin: Expression, Assembly, Functions, and Roles in Disease Methods in Enzymology Nov 2015 Lenti RR215311L2
INPP4B INPP4B exerts a dual function in the stemness of colorectal cancer stem-like cells through regulating Sox2 and Nanog expression Carcinogenesis 2019 Lenti TL312138
IRS4 Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking Nat. Genet. 2016 Lenti RC218385L1
ITGA2 CD49b inhibits osteogenic differentiation and plays an important role in osteosarcoma progression Oncotarget 2017 Lenti RC212617L1
ITGA5 O-GlcNAcylation of ITGA5 facilitates the occurrence and development of colorectal cancer Exp. Cell Res. 2019 Lenti TL312094
ITGAM Microglial complement receptor 3 regulates brain Aß levels through secreted proteolytic activity J. Exp. Med 2017 Lenti TL501116
ITGB5 αvβ5 integrin mediates the effect of vitronectin on the initial stage of differentiation in mouse cerebellar granule cell precursors Brain Res. 2018 Lenti TL516440
ITGB5 αvβ5 integrin mediates the effect of vitronectin on the initial stage of differentiation in mouse cerebellar granule cell precursors Brain Res. 2018 Lenti MR222893L1
JARID2 Jarid2 enhances the progression of bladder cancer through regulating PTEN/AKT signaling Life Sci. 2019 Lenti TL312055
JMJD6 Elevated expression of JMJD6 is associated with oral carcinogenesis and maintains cancer stemness properties Carcinogenesis Dec 2015 Lenti TL310083
JPH3 Junctophilin Proteins Tether a Cav1-RyR2-KCa3.1 Tripartite Complex to Regulate Neuronal Excitability Cell Rep 2019 Lenti TL705996
JPH4 Junctophilin Proteins Tether a Cav1-RyR2-KCa3.1 Tripartite Complex to Regulate Neuronal Excitability Cell Rep 2019 Lenti TL700489
KAT8 Chromatin regulation by Histone H4 acetylation at Lysine 16 during cell death and differentiation in the myeloid compartment Nucleic Acids Res. 2019 Lenti TL303060
KCNK2 Trabecular Meshwork TREK-1 Channels Function as Polymodal Integrators of Pressure and pH Invest. Ophthalmol. Vis. Sci. 2019 Lenti TL312003
KDM3A Hypoxia-inducible KDM3A addiction in multiple myeloma Blood Adv 2018 Lenti TL303857
KDM4B Ascorbate and Iron Are Required for the Specification and Long-Term Self-Renewal of Human Skeletal Mesenchymal Stromal Cells Stem Cell Reports 2020 Lenti RC223401L3
KDM4B Ascorbate and Iron Are Required for the Specification and Long-Term Self-Renewal of Human Skeletal Mesenchymal Stromal Cells Stem Cell Reports 2020 Lenti TL312052
KDM5A Vitamin C promotes pluripotency of human induced pluripotent stem cells via the histone demethylase JARID1A Biol. Chem. 2016 Lenti TL312057
KDM6A Contingencies of UTX/KDM6A Action in Urothelial Carcinoma Cancers (Basel) 2019 Lenti RC210861L2
KDM6A MBD3/NuRD loss participates with KDM6A program to promote DOCK5/8 expression and Rac GTPase activation in human acute myeloid leukemia FASEB J. 2019 Lenti RC210861L4
KDM6A THE ROLE OF KDM6A/UTX IN BLADDER CANCER: FROM MUTATIONS TO THERAPEUTIC INTERVENTION thesis Oct 2015 Lenti RC210861L2
KDM6B Notch-effector CSL promotes squamous cell carcinoma by repressing histone demethylase KDM6B J. Clin. Invest. 2018 Lenti HC141378
KDSR Sphingolipid dysregulation due to lack of functional KDSR impairs proplatelet formation causing thrombocytopenia Haematologica 2018 Lenti RC201153L3
KEAP1 Nrf2 and HIF1α converge to arsenic-induced metabolic reprogramming and the formation of the cancer stem-like cells Theranostics 2020 Lenti RC202189L4
KHSRP KSRP specifies monocytic and granulocytic differentiation through regulating miR-129 biogenesis and RUNX1 expression Nat Commun 2017 Lenti TL311984
KIAA0101 PCNA-associated factor P15PAF , targeted by FOXM1, predicts poor prognosis in high-grade serous ovarian cancer patients Int. J. Cancer 2018 Lenti RC216104L3
KIF13A KIF13A mediates the activity-dependent transport of ESCRT-0 proteins in axons bioRxiv 2020 Lenti TL706020
KIF18A Expression of KIF18A Is Associated with Increased Tumor Stage and Cell Proliferation in Prostate Cancer Med. Sci. Monit. 2019 Lenti TL303697
KIF26B Upregulation of KIF26B, Cell Migration and Proliferation of Human Ovarian Cancer Cell Lines In Vitro, and Patient Outcomes from Human Bioinformatic Analysis Med. Sci. Monit. 2018 Lenti TL508079
KIF3B Identification of kinesin family member 3B (KIF3B) as a molecular target for gastric cancer Kaohsiung J. Med. Sci. 2020 Lenti TL311910
KIR2DL5A KIR2DL5 mutation and loss underlies sporadic dermal neurofibroma pathogenesis and growth Oncotarget 2017 Lenti RC213765L2
KITLG A juxtacrine/paracrine loop between C-Kit and stem cell factor promotes cancer stem cell survival in epithelial ovarian cancer Cell Death Dis 2019 Lenti RC213540L4
KL Lentiviral vector–mediated overexpression of Klotho in the brain improves Alzheimer's disease–like pathology and cognitive deficits in mice Neurobiology of Aging 2019 Lenti MR227101L2
KL Ginsenoside-Rg1 Protects against Renal Fibrosis by Regulating the Klotho/TGF-β1/Smad Signaling Pathway in Rats with Obstructive Nephropathy Biol. Pharm. Bull. 2018 Lenti TL711301
KL Lentiviral-mediated klotho up-regulation improves aging-related memory deficits and oxidative stress in senescence-accelerated mouse prone-8 mice Life Sci. 2018 Lenti MR227101L2
Kl Protective Effect of Klotho against Ischemic Brain Injury Is Associated with Inhibition of RIG-I/NF-κB Signaling Front Pharmacol 2017 Lenti MR227101L2
Kl Protective Effect of Klotho against Ischemic Brain Injury Is Associated with Inhibition of RIG-I/NF-κB Signaling Front Pharmacol 2017 Lenti TL711301
KLF2 Flow-dependent expression of ectonucleotide tri(di)phosphohydrolase-1 and suppression of atherosclerosis J. Clin. Invest. Jun 2015 Lenti RC210042L1
KLF3 Epigenetic silencing of Kruppel like factor-3 increases expression of pro-metastatic miR-182 Cancer Lett. Aug 2015 Lenti TL303669
KLF4 JAK2 inhibition in JAK2V617F-bearing leukemia cells enriches CD34+ leukemic stem cells that are abolished by the telomerase inhibitor GRN163L Biochem. Biophys. Res. Commun. 2020 Lenti TL316853
KLF4 TFAP2C- and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment Cell Stem Cell 2019 Lenti TL316853
KLF4 Kruppel-like factor4 regulates PRDM1 expression through binding to an autoimmune risk allele JCI Insight 2017 Lenti TL316853
KMT2A Targeting the MLL complex in castration-resistant prostate cancer Nat. Med. Apr 2015 Lenti TL311462
KMT2B Targeting the MLL complex in castration-resistant prostate cancer Nat. Med. Apr 2015 Lenti TL315696
KNSTRN Characterization of SKAP/Kinastrin isoforms - The N-terminus defines tissue specificity and Pontin binding Hum. Mol. Genet. May 2016 Lenti TL306156
LAMC2 LAMC2 regulated by microRNA-125a-5p accelerates the progression of ovarian cancer via activating p38 MAPK signalling Life Sci. 2019 Lenti RC222076L4
LAMP1 Hydroxypropyl-beta and -gamma cyclodextrins rescue cholesterol accumulation in Niemann-Pick C1 mutant cell via lysosome-associated membrane protein 1 Cell Death Dis 2018 Lenti TL311795
LARS PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase Nat Commun 2020 Lenti RC221682L3
LDHA Sirtuin 6 suppresses hypoxia-induced inflammatory response in human osteoblasts via inhibition of reactive oxygen species production and glycolysis-A therapeutic implication in inflammatory bone resorption Biofactors 2016 Lenti TL311769
LDLR Low-Density Lipoprotein Receptor-Mediated Lipidome-Transcriptome Reprogramming Impulses to Cisplatin Insensitivity bioRxiv 2018 Lenti RC200006L2
LEF1 Single-cell Analysis Reveals a Preexisting Drug-Resistant Subpopulation in the Luminal Breast Cancer Subtype Cancer Res. 2019 Lenti RC208663L1
LEF1 BMP and WNT signalling cooperate through LEF1 in the neuronal specification of adult hippocampal neural stem and progenitor cells Sci Rep 2018 Lenti RC225565L2
Lenti Concentrator Establishment of an induced pluripotent cell line from Taiwan black silkie chick embryonic fibroblasts for replication-incompetent virus production Sci Rep 2019 Lenti TR30025
Lenti Concentrator Insulin Induces Microtubule Stabilization and Regulates the Microtubule Plus-End Tracking Protein Network in Adipocytes Mol. Cell Proteomics 2019 Lenti TR30025
Lenti Concentrator The mitochondrial metabolic function of DJ-1 is modulated by 14-3-3β FASEB J. 2019 Lenti TR30025
Lenti Titer Kit RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43 Neuron 2019 Lenti TR30038
Lenti-vpak packaging Genome-wide RNAi Screen identifies PMPCB as a therapeutic vulnerability in EpCAM+ hepatocellular carcinoma Cancer Res. 2019 Lenti TR30037
Lenti-vpak packaging Oncogenic and osteolytic functions of histone demethylase NO66 in castration-resistant prostate cancer Oncogene 2019 Lenti TR30037
Lenti-vpak packaging The impact of hepatic HSP72 on insulin signaling Am. J. Physiol. Endocrinol. Metab. 2018 Lenti TR30037
Lenti-vpak packaging Drug-induced aneuploidy and polyploidy is a mechanism of disease relapse in MYC/BCL2-addicted diffuse large B-cell lymphoma Oncotarget 2018 Lenti TR30037P5
Lenti-vpak packaging Infants Uniquely Express High Levels of RBM3 and Other Cold-Adaptive Neuroprotectant Proteins in the Human Brain Dev. Neurosci. 2018 Lenti TR30037
Lenti-vpak packaging Targeting LRH‑1 in hepatoblastoma cell lines causes decreased proliferation Oncol. Rep. 2018 Lenti TR30037
Lenti-vpak packaging Targeting Interleukin-6 (IL-6) Sensitizes Anti-PD-L1 Treatment in a Colorectal Cancer Preclinical Model Med. Sci. Monit. 2018 Lenti TR30037
Lenti-vpak packaging Wnt5a/FZD4 Mediates the Mechanical Stretch-Induced Osteogenic Differentiation of Bone Mesenchymal Stem Cells Cell. Physiol. Biochem. 2018 Lenti TR30037
Lenti-vpak packaging Engineering PD-1-Presenting Platelets for Cancer Immunotherapy Nano Lett. 2018 Lenti TR300037
Lenti-vpak packaging CADM1 is essential for KSHV-encoded vGPCR-and vFLIP-mediated chronic NF-κB activation PLoS Pathog. 2018 Lenti TR30037
Lenti-vpak packaging Interleukin-23 promotes the migration and invasion of gastric cancer cells by inducing epithelial-to-mesenchymal transition via the STAT3 pathway Biochem. Biophys. Res. Commun. 2018 Lenti TR30037
Lenti-vpak packaging The role ofcalgranulin Bgene on the biological behavior of squamous cervical cancer in vitro and in vivo Cancer Manag Res 2018 Lenti TR30037
Lenti-vpak packaging AGBL2 promotes cancer cell growth through IRGM-regulated autophagy and enhanced Aurora A activity in hepatocellular carcinoma Cancer Lett.2017 Lenti TR30037
Lenti-vpak packaging Interferon-γ is a master checkpoint regulator of cytokine-induced differentiation Proc. Natl. Acad. Sci. U.S.A. 2017 Lenti TR30037
Lenti-vpak packaging Whole-transcriptome microarray analysis reveals regulation of Rab4 by RBM5 in neurons Neuroscience 2017 Lenti TR30037P5
Lenti-vpak packaging MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism Nat Commun 2017 Lenti TR30037
Lenti-vpak packaging Curcumin inhibits prostate cancer by targeting PGK1 in the FOXD3/miR-143 axis Cancer Chemother. Pharmacol. 2017 Lenti TR30037
Lenti-vpak packaging A stemness-related ZEB1-MSRB3 axis governs cellular pliancy and breast cancer genome stability Nat. Med. 2017 Lenti TR30037
Lenti-vpak packaging β-Carotene suppresses osteoclastogenesis and bone resorption by suppressing NF-κB signaling pathway Life Sci 2017 Lenti TR30037
Lenti-vpak packaging Metabolic Adaptation to Nutritional Stress in Human Colorectal Cancer Sci Rep 2016 Lenti TR30037
Lenti-vpak packaging Targeting tissue inhibitor of metalloproteinase 1/2 using a shRNA lentiviral system offers a novel treatment strategy against hepatic fibrosis Int J Clin Exp Med 2016 Lenti TR30037
Lenti-vpak packaging TFAP2C-mediated upregulation of TGFBR1 promotes lung tumorigenesis and epithelial-mesenchymal transition Exp. Mol. Med. 2016 Lenti TR30037
Lenti-vpak packaging Sphingomyelin-induced inhibition of the plasma membrane calcium ATPase causes neurodegeneration in type A Niemann-Pick disease Mol. Psychiatry 2016 Lenti TR30037
Lenti-vpak packaging TFAP2C promotes lung tumorigenesis and aggressiveness through miR-183- and miR-33a-mediated cell cycle regulation Oncogene 2016 Lenti TR30037
Lenti-vpak packaging MiR-122 targets VEGFC in bladder cancer to inhibit tumor growth and angiogenesis Am J Transl Res 2016 Lenti TR30037
Lenti-vpak packaging Coronin 1B serine 2 phosphorylation by p38a is critical for vascular endothelial growth factor-induced migration of human umbilical vein endothelial cells Cell. Signal. 2016 Lenti TR30037
Lenti-vpak packaging Expression of RXFP1 is Decreased in Idiopathic Pulmonary Fibrosis: Implications for Relaxin-Based Therapies Am. J. Respir. Crit. Care Med. Jun 2016 Lenti TR30037
Lenti-vpak packaging Bacteroides fragilis Enterotoxin Upregulates Heme Oxygenase-1 in Intestinal Epithelial Cells via a Mitogen-Activated Protein Kinases- and NF-?B-Dependent Pathway, Leading to Modulation of Apoptosis Infect. Immun. Jun 2016 Lenti TR30037
Lenti-vpak packaging Targeting carbonic anhydrase IX improves the anti-cancer efficacy of mTOR inhibitors Oncotarget 2016 Lenti TR30037
Lenti-vpak packaging ß-cell deletion of Nr4a1 and Nr4a3 nuclear receptors impedes mitochondrial respiration and insulin secretion Am. J. Physiol. Endocrinol. Metab. May 2016 Lenti TR30037
Lenti-vpak packaging Lens regeneration using endogenous stem cells with gain of visual function Nature Mar 2016 Lenti TR30037
Lenti-vpak packaging Serum Amyloid A3 Secreted by Preosteoclasts Inhibits Parathyroid Hormone-Stimulated cAMP Signaling in Murine Osteoblasts J. Biol. Chem. Dec 2015 Lenti TR30037
Lenti-vpak packaging Improvement of mTORC1-driven overproduction of apoB-containing triacylglyceride-rich lipoproteins by short-chain fatty acids, 4-phenylbutyric acid and (R)-a-lipoic acid, in human hepatocellular carcinoma cells Biochim. Biophys. Acta Dec2015 Lenti TR30037
Lenti-vpak packaging Disease-Causing SDHAF1 Mutations Impair Transfer of Fe-S Clusters to SDHB Cell Metab. Dec 2015 Lenti TR30037
Lenti-vpak packaging THE ROLE OF KDM6A/UTX IN BLADDER CANCER: FROM MUTATIONS TO THERAPEUTIC INTERVENTION thesis Oct 2015 Lenti TR30037
Lenti-vpak packaging Insulin enhances RANKL-induced osteoclastogenesis via ERK1/2 activation and induction of NFATc1 and Atp6v0d2 Cell. Signal. Sep 2015 Lenti TR30037
Lenti-vpak packaging SLC9A3R1 stimulates autophagy via BECN1 stabilization in breast cancer cells Autophagy Jul 2015 Lenti TR30037
Lenti-vpak packaging Tumour-suppressive function of SIRT4 in human colorectal cancer Br. J. Cancer Jun 2015 Lenti TR30037
Lenti-vpak packaging Flow-dependent expression of ectonucleotide tri(di)phosphohydrolase-1 and suppression of atherosclerosis J. Clin. Invest. Jun 2015 Lenti TR30037
Lenti-vpak packaging ATTENUATION OF mTORC1-DRIVEN SECRETION OF LIPOPROTEINS ANDTRIACYLGLYCERIDES BY SHORT CHAIN FATTY ACIDS: MECHANISTICINSIGHT INTO THE PATHOGENESIS OF HYPERTRIGLYCERIDEMIA Thesis Apr 2015 Lenti TR30037
Lenti-vpak packaging Phosphorylation and Inactivation of GSK3ß by Dual-Specificity Tyrosine(Y)-Phosphorylation-Regulated Kinase 1A (Dyrk1A) J. Biol. Chem. Dec 2014 Lenti TR30037
Lenti-vpak packaging kit Formononetin inhibits tumor growth by suppression of EGFR-Akt-Mcl-1 axis in non-small cell lung cancer J. Exp. Clin. Cancer Res. 2020 Lenti TR30037
Lenti-vpak packaging kit Development of a laboratory scalable process for enhancing lentivirus production by transient transfection of HEK293 adherent cultures Gene Ther. 2020 Lenti TR30037
Lenti-vpak packaging kit Alpha-Catulin, a New Player in a Rho Dependent Apical Constriction That Contributes to the Mouse Neural Tube Closure Front. Cell Dev. Biol. 2020 Lenti TR30037
Lenti-vpak packaging kit Deguelin suppresses non-small cell lung cancer by inhibiting EGFR signaling and promoting GSK3β/FBW7-mediated Mcl-1 destabilization Cell Death Dis 2020 Lenti TR30037
Lenti-vpak packaging kit A rare codon-based translational program of cell proliferation Genome Biol. 2020 Lenti TR30037
Lenti-vpak packaging kit The deubiquitinase OTUB1 augments NF-κB-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13 Cell. Mol. Immunol. 2020 Lenti TR30037
Lenti-vpak packaging kit Knockdown of P3H4 inhibits proliferation and invasion of bladder cancer Aging (Albany NY) 2020 Lenti TR30037
Lenti-vpak packaging kit Endocytosis of very low-density lipoproteins: an unexpected mechanism for lipid acquisition by breast cancer cells J. Lipid Res. 2019 Lenti TR30037
Lenti-vpak packaging kit Enhanced hexosamine metabolism drives metabolic and signaling networks involving hyaluronan production and O-GlcNAcylation to exacerbate breast cancer Cell Death Dis 2019 Lenti TR30037
Lenti-vpak packaging kit DCLK1 INTEGRATES INDUCTION OF TRIB3, EMT, DRUG RESISTANCE, and POOR PROGNOSIS IN COLORECTAL CANCER Carcinogenesis 2019 Lenti TR30037
Lenti-vpak packaging kit Fenretinide via NOXA induction, enhanced activity of the BCL-2 inhibitor venetoclax in high BCL-2-expressing neuroblastoma preclinical models Mol. Cancer Ther. 2019 Lenti TR30037
Lenti-vpak packaging kit The chromatin remodeler SMARCD3 regulates cell cycle progression and its expression predicts survival outcome in ER+ breast cancer bioRxiv 2019 Lenti TR30037
Lenti-vpak packaging kit Endocytosis of very low-density lipoprotein particles: an unexpected mechanism for lipid acquisition by breast cancer cells bioRxiv 2019 Lenti TR30037
Lenti-vpak packaging kit TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis Nat Commun 2019 Lenti TR30037
Lenti-vpak packaging kit Subregional differences in astrocytes underlie selective neurodegeneration or protection in Parkinson's disease models in culture Glia 2019 Lenti TR30037
Lenti-vpak packaging kit Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis Mol Neurodegener 2019 Lenti TR30037
Lenti-vpak packaging kit Thioredoxin system as a gatekeeper in caspase-6 activation and nuclear lamina integrity: Implications for Alzheimer's disease Free Radic. Biol. Med. 2019 Lenti TR30037
Lenti-vpak packaging kit EGFR signaling confers resistance to BET inhibition in hepatocellular carcinoma through stabilizing oncogenic MYC J. Exp. Clin. Cancer Res. 2019 Lenti TR30037
Lenti-vpak packaging kit Overexpression of CD59 inhibits apoptosis of T-acute lymphoblastic leukemia via AKT/Notch1 signaling pathway Cancer Cell Int. 2019 Lenti TR30037
Lenti-vpak packaging kit Activating transcription factor 3 enhances chemosensitivity of dichloroacetic acid via p53 pathway in cervical squamous epithelial cancer cells Tropical Journal of Pharmaceutical Research 2018 Lenti TR30037
LGALS1 Galectin-1 suppression delineates a new strategy to inhibit myeloma-induced angiogenesis and tumoral growth in vivo Leukemia 2016 Lenti TL311756
LPA Effects of LPA1 and LPA6 on the regulation of colony formation activity in colon cancer cells treated with anticancer drugs J. Recept. Signal Transduct. Res. 2018 Lenti TL311698
LPA Involvement of LPA receptor-5 in the enhancement of cell motile activity by phorbol ester and anticancer drug treatments in melanoma A375 cells Biochem. Biophys. Res. Commun. 2018 Lenti TL311698
LPCAT3 Caspase-independent hepatocyte death: A result of the decrease of lysophosphatidylcholine acyltransferase 3 in non-alcoholic steatohepatitis J. Gastroenterol. Hepatol. 2018 Lenti RC209485L2
LPL Endocytosis of very low-density lipoprotein particles: an unexpected mechanism for lipid acquisition by breast cancer cells bioRxiv 2019 Lenti TL311692
Lrp6 Oncogenic KRAS signalling promotes the Wnt/ß-catenin pathway through LRP6 in colorectal cancer Oncogene Dec 2014 Lenti TL706439
LY6C Ly6C+ Inflammatory Monocyte Differentiation Partially Mediates Hyperhomocysteinemia-Induced Vascular Dysfunction in Type 2 Diabetic db/db Mice Arterioscler. Thromb. Vasc. Biol. 2019 Lenti TL513893
MAF Unraveling the transcriptional determinants of Liver Sinusoidal Endothelial Cell specialization Am. J. Physiol. Gastrointest. Liver Physiol. 2020 Lenti RC209247L2
MAGEA12 Overexpression and Implications of Melanoma-associated Antigen A12 in Pathogenesis of Human Cutaneous Squamous Cell Carcinoma Anticancer Res. 2019 Lenti TL311615V
MAGI2 Disruption of MAGI2-RapGEF2-Rap1 signaling contributes to podocyte dysfunction in congenital nephrotic syndrome caused by mutations in MAGI2 Kidney International 2019 Lenti TL311600
MAMLD1 Attenuation of MAMLD1 Expression Suppresses the Growth and Migratory Properties of Gonadotroph Pituitary Adenomas Pathol. Oncol. Res. 2019 Lenti TL313623
MAN1A1 Reduced mannosidase MAN1A1 expression leads to aberrant N-glycosylation and impaired survival in breast cancer Br. J. Cancer 2018 Lenti TL311595
MAP1LC3B Curcumin induces apoptotic cell death and protective autophagy by inhibiting AKT/mTOR/p70S6K pathway in human ovarian cancer cells Arch. Gynecol. Obstet. 2019 Lenti RC207356L3
MAP2K1 MiR-16 regulates the pro-tumorigenic potential of lung fibroblasts through the inhibition of HGF production in an FGFR-1- and MEK1-dependent manner J Hematol Oncol 2018 Lenti RC218460L1
MAP3K12 Intrathecal Injection of Dual Zipper Kinase shRNA Alleviating the Neuropathic Pain in a Chronic Constrictive Nerve Injury Model Int J Mol Sci 2018 Lenti TL709656
MAPRE1 EB1- and EB2-dependent anterograde trafficking of TRPM4 regulates focal adhesion turnover and cell invasion FASEB J. 2019 Lenti TL316980
MAPT Increased Tau Expression Correlates With IDH Mutation in Infiltrating Gliomas and Impairs Cell Migration J. Neuropathol. Exp. Neurol. 2020 Lenti RC217773L2V
MAPT miR-186 regulates chemo-sensitivity to paclitaxel via targeting MAPT in non-small cell lung cancer (NSCLC) Molecular BioSystems 2016 Lenti RC216166L1
MARK4 MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism Nat Commun 2017 Lenti TL303343
MAVS Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas Cancer Cell 2019 Lenti TL307181
MBNL1 Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization Nat Commun 2019 Lenti TL303325
MCAM CD146 interacts with galectin-3 to mediate endothelial cell migration FEBS Lett. 2018 Lenti TL311550
MCL1 MicroRNA-451 sensitizes lung cancer cells to cisplatin through regulation of Mcl-1 Mol. Cell. Biochem. 2016 Lenti RC231044L2
Mcm4 Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells Nature July 2014 Lenti TL514127
Mcm6 Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells Nature July 2014 Lenti TL510769
MDC1 BRCT-domain protein BRIT1 influences class switch recombination Proc. Natl. Acad. Sci. U.S.A. 2017 Lenti TL517490
MDM2 MDM2 derived from dedifferentiated liposarcoma extracellular vesicles induces MMP2 production from preadipocytes Cancer Res. 2019 Lenti TL311529
MDM2 p16 Controls p53 Protein Expression through miR-dependent Destabilization of MDM2 Mol. Cancer Res. 2018 Lenti TL311529
MDM2 p53 participates in the protective effects of ischemic post-conditioning against OGD-reperfusion injury in primary cultured spinal cord neurons Neurosci. Lett 2016 Lenti TL311529
MED19 MED19 alters AR occupancy and gene expression in prostate cancer cells, driving MAOA expression and growth under low androgen bioRxiv 2019 Lenti RC206806L1
MEG3 Long Noncoding RNA (lncRNA) Maternally Expressed Gene 3 (MEG3) Participates in Chronic Obstructive Pulmonary Disease through Regulating Human Pulmonary Microvascular Endothelial Cell Apoptosis Med Sci Monit 2020 Lenti TL320132
MEG3 Mechanism associated with aberrant lncRNA MEG3 expression in gestational diabetes mellitus Exp Ther Med 2019 Lenti TL320132
MEG3 Skp2 regulates non-small cell lung cancer cell growth by Meg3 and miR-3163 Tumour Biol. Oct 2015 Lenti TL320132
MEIS2 Unraveling the transcriptional determinants of Liver Sinusoidal Endothelial Cell specialization Am. J. Physiol. Gastrointest. Liver Physiol. 2020 Lenti RC222807L2
MET Role of HGF/c-Met in the treatment of colorectal cancer with liver metastasis J. Biochem. Mol. Toxicol. 2019 Lenti TL320418
METTL3 Kaposi's Sarcoma-Associated Herpesvirus Utilizes and Manipulates RNA N6-Adenosine Methylation To Promote Lytic Replication J. Virol. 2017 Lenti TL303281
MEX3A The RNA-Binding Ubiquitin Ligase MEX3A Affects Glioblastoma Tumorigenesis by Inducing Ubiquitylation and Degradation of RIG-I Cancers (Basel) 2020 Lenti TL308061
MFN2 Mul1 restrains Parkin-mediated mitophagy in mature neurons by maintaining ER-mitochondrial contacts Nat Commun 2019 Lenti TL506067
MGA Genomic and Transcriptomic Characterization of Natural Killer T Cell Lymphoma Cancer Cell 2020 Lenti TL317004
MGEA5 O-GlcNAcase targets pyruvate kinase M2 to regulate tumor growth Oncogene 2019 Lenti TL315637
MGRN1 E3 ligase mahogunin (MGRN1) influences amyloid precursor protein maturation and secretion Oncotarget 2017 Lenti TL303267
MGRN1 Aging Triggers Cytoplasmic Depletion and Nuclear Translocation of the E3 Ligase Mahogunin: A Function for Ubiquitin in Neuronal Survival Mol. Cell 2017 Lenti TL702100
MLH1 MicroRNA-148b regulates radioresistance in non-small lung cancer cells via regulation of MutL homolog 1 Biosci. Rep. Jan 2016 Lenti TL320419
MLH1 MicroRNA-148b regulates radioresistance in non-small lung cancer cells via regulation of MutL homolog 1 Biosci. Rep. Jan 2016 Lenti RC201607L1
MLLT4 Concomitant binding of Afadin to LGN and F-actin directs planar spindle orientation Nat. Struct. Mol. Biol. Feb 2016 Lenti TL311457
MLX The glucose-sensing transcription factor MLX promotes myogenesis via myokine signaling Genes Dev. Dec 2015 Lenti TL513600
MMP-7 Sphingosine-1-phosphate induced epithelial-mesenchymal transition of hepatocellular carcinoma via an MMP-7/ syndecan-1/TGF-ß autocrine loop Oncotarget 2016 Lenti TL311438
MMP9 MicroRNA-3713 regulates bladder cell invasion via MMP9 Sci Rep 2016 Lenti TL311436
MNAT1 MAT1 facilitates the lung metastasis of osteosarcoma through upregulation of AKT1 expression Life Sci. 2019 Lenti TL311433
MNX1 MNX1 is oncogenically upregulated in African-American prostate cancer Cancer Res. 2016 Lenti TL319509
MPV17 The mitochondrial inner membrane protein MPV17 prevents uracil accumulation in mitochondrial DNA J. Biol. Chem. 2018 Lenti TL316619
MSLN Mesothelin promotes epithelial-to-mesenchymal transition and tumorigenicity of human lung cancer and mesothelioma cells Mol. Cancer 2017 Lenti TL311377
MSLN Role of mesothelin in carbon nanotube-induced carcinogenic transformation of human bronchial epithelial cells Am. J. Physiol. Lung Cell Mol. Physiol. 2016 Lenti TL311377
MSRB3 A stemness-related ZEB1-MSRB3 axis governs cellular pliancy and breast cancer genome stability Nat. Med. 2017 Lenti TL315359
MTFP1 Mitochondrial protein 18 is a positive apoptotic regulator in cardiomyocytes under oxidative stress Clin. Sci. 2019 Lenti TL307024
MUCL1 HER2 drives Mucin-like 1 to control proliferation in breast cancer cells Oncogene Jan 2016 Lenti RC213754L1
MX2 MX2 is an interferon-induced inhibitor of HIV-1 infection Nature. 2013 Oct 24;502(7472):563-6. Lenti TL311334
MYB Regulation of the Flt3 Gene in Haematopoietic Stem and Early Progenitor Cells PLoS ONE Sep 2015 Lenti TL311329
MYC PD-L1 is overexpressed on breast cancer stem cells through notch3/mTOR axis OncoImmunology 2020 Lenti TL311323V
MYC A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo Cancer Cell 2019 Lenti RC201611L1V
MYC A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo Cancer Cell 2019 Lenti RC201611L3V
MYC MYC Amplification as a Potential Mechanism of Primary Resistance to Crizotinib in ALK-Rearranged Non-Small Cell Lung Cancer: A Brief Report Transl Oncol 2018 Lenti RC201611L4
MYCN A conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human Nat Commun 2018 Lenti MR207382L2
MYH10 Cytoplasmic mislocalization of RNA splicing factors and aberrant neuronal gene splicing in TDP-43 transgenic pig brain Mol Neurodegener Sep 2015 Lenti TL711338
MYO5A Actin and Myosin-dependent localization of mRNA to dendrites PLoS ONE Mar 2014 Lenti TL311295
NAV3 MiR-21 promoted proliferation and migration in hepatocellular carcinoma through negative regulation of Navigator-3 Biochem. Biophys. Res. Commun. Jul 2015 Lenti TL311261
NDP Norrin mediates tumor-promoting and -suppressive effects in glioblastoma via Notch and WNT J. Clin. Invest. 2020 Lenti RC206555L2
NDP Norrin mediates tumor-promoting and -suppressive effects in glioblastoma via Notch and WNT J. Clin. Invest. 2020 Lenti TL316631
Negative Control Breast cancer-associated skeletal muscle mitochondrial dysfunction and lipid accumulation is reversed by PPARG BioRxiv 2020 Lenti PS100093V
Negative Control TRIM37 is highly expressed during mitosis in CHON-002 chondrocytes cell line and is regulated by miR-223 Bone 2020 Lenti TR30021V
Negative Control ABCA1/ABCB1 Ratio Determines Chemo- and Immune-Sensitivity in Human Osteosarcoma Cells 2020 Lenti TR30021V
Negative Control Alpha-Catulin, a New Player in a Rho Dependent Apical Constriction That Contributes to the Mouse Neural Tube Closure Front. Cell Dev. Biol. 2020 Lenti TR30021
Negative Control Rational cotargeting of HDAC6 and BET proteins yields synergistic antimyeloma activity Blood Adv 2019 Lenti PS100093V
Negative Control Mouse genome-wide association studies and systems genetics uncover the genetic architecture associated with hepatic pharmacokinetic and pharmacodynamic properties of a constrained ethyl antisense oligonucleotide targeting Malat1 PLoS Genet. 2018 Lenti TR30021V
Negative Control Differential expression of secreted factors SOSTDC1 and ADAMTS8 cause pro-fibrotic changes in linear morphoea fibroblasts Br. J. Dermatol. 2018 Lenti PS100093V
Negative Control Multi-level Proteomics Identifies CT45 as a Chemosensitivity Mediator and Immunotherapy Target in Ovarian Cancer Cell 2018 Lenti TR30021
Negative Control Down-regulation of 14-3-3 zeta sensitizes human glioblastoma cells to apoptosis induction Apoptosis 2018 Lenti TR30021V
NEK7 EK7 Regulates NLRP3 Inflammasome Activation and Neuroinflammation Post-traumatic Brain Injury Front Mol Neurosci 2019 Lenti TL515241
NELF RNAP II processivity is a limiting step for HIV-1 transcription independent of orientation to and activity of endogenous neighboring promoters Virology Sep 2015 Lenti TL317072
NELFE Oncogenic Activation of the RNA Binding Protein NELFE and MYC Signaling in Hepatocellular Carcinoma Cancer Cell 2017 Lenti RC208658L2
NEUROD1 Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice Nat. Neurosci 2017 Lenti TL311201
NEUROD1 Rapid neurogenesis through transcriptional activation in human stem cells Mol. Syst. Biol. Nov 2014 Lenti TL311201
NF1 Pathogenic mutations in neurofibromin identifies a leucine-rich domain regulating glioma cell invasiveness Oncogene 2019 Lenti TL509076
NFE2L2 NRF2 regulates core and stabilizing circadian clock loops, coupling redox and timekeeping inMus musculus Elife 2018 Lenti MR226717L1
NFE2L2 Nrf2 deficiency exacerbates ochratoxin A-induced toxicity in vitro and in vivo Toxicology 2017 Lenti TL311194
NGFR Effects of p75 neurotrophin receptor on regulating hypoxia-induced angiogenic factors in retinal pigment epithelial cells Mol. Cell. Biochem. Sep 2014 Lenti TL311178
NLGN2 Synaptic deficits in iPSC-derived cortical interneurons in schizophrenia are mediated by NLGN2 and rescued by N-acetylcysteine Transl Psychiatry 2019 Lenti TL302944V
NMU The YAP1-NMU Axis Is Associated with Pancreatic Cancer Progression and Poor Outcome: Identification of a Novel Diagnostic Biomarker and Therapeutic Target Cancers (Basel) 2019 Lenti TL311154
NNAT Neuronatin is a modifier of estrogen receptor-positive breast cancer incidence and outcome Breast Cancer Res. Treat. 2019 Lenti RC200328L3
NOG Noggin rescues age-related stem cell loss in the brain of senescent mice with neurodegenerative pathology Proc. Natl. Acad. Sci. U.S.A. 2018 Lenti MR225276L2V
NOP2 A novel AHI-1-BCR-ABL-DNM2 complex regulates leukemic properties of primitive CML cells through enhanced cellular endocytosis and ROS-mediated autophagy Leukemia 2017 Lenti TL311150
NOS2 TNF-α/IL-1β-licensed mesenchymal stromal cells promote corneal allograft survival via myeloid cell-mediated induction of Foxp3+ regulatory T cells in the lung FASEB J. 2019 Lenti TL709254
NOS2 Linking of mPGES-1 and iNOS activates stem-like phenotype in EGFR-driven epithelial tumor cells Nitric Oxide 2017 Lenti RC211819L1
NPC1 NPC1 enables cholesterol mobilization during long-term potentiation that can be restored in Niemann-Pick disease type C by CYP46A1 activation EMBO Rep. 2019 Lenti TL311127
NR2F2 Defining human cardiac transcription factor hierarchies using integrated single-cell heterogeneity analysis Nat Commun 2018 Lenti RC206753L2
nr3c1 Glucocorticoid receptor beta increases migration of human bladder cancer cells Oncotarget 2016 Lenti TL320374
NR4A1 RARβ acts as both an upstream regulator and downstream effector of miR-22, which epigenetically regulates NUR77 to induce apoptosis of colon cancer cells FASEB J. 2018 Lenti TL320381
Nr4a1 ß-cell deletion of Nr4a1 and Nr4a3 nuclear receptors impedes mitochondrial respiration and insulin secretion Am. J. Physiol. Endocrinol. Metab. May 2016 Lenti TL711049
NR4A2 NURR1 and ERR1 Modulate the Expression of Genes of a DRD2 Coexpression Network Enriched for Schizophrenia Risk J. Neurosci. 2020 Lenti MR226280L1
NR4A2 NURR1 and ERR1 Modulate the Expression of Genes of a DRD2 Coexpression Network Enriched for Schizophrenia Risk J. Neurosci. 2020 Lenti TL501521
Nrf2 Role of KEAP1/NRF2 and TP53 Mutations in Lung Squamous Cell Carcinoma Development and Radiation Resistance Cancer Discov 2016 Lenti TL515053
NUMA1 Concomitant binding of Afadin to LGN and F-actin directs planar spindle orientation Nat. Struct. Mol. Biol. Feb 2016 Lenti TL311065
Nur77 Bile Acids Regulate Nuclear Receptor (Nur77) Expression and Intracellular Location to Control Proliferation and Apoptosis Mol. Cancer Res. Sep 2014 Lenti TL711049
OCIAD2 OCIAD2 suppressed tumor growth and invasion via AKT pathway in Hepatocelluar carcinoma Carcinogenesis 2017 Lenti TL311040
OCLN Occludin deficiency promotes ethanol-induced disruption of colonic epithelial junctions, gut barrier dysfunction and liver damage in mice Biochim. Biophys. Acta Dec 2015 Lenti TL311039
OGT The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis Nat Commun 2017 Lenti RC224481L1
Ogt Reciprocal regulation between O-GlcNAcylation and tribbles pseudokinase 2 (TRIB2) maintains transformative phenotypes in liver cancer cells Cell. Signal. 2016 Lenti MR211521L1
ONECUT2 ONECUT2 is a driver of neuroendocrine prostate cancer Nat Commun 2019 Lenti RC211951L3
ONECUT2 ONECUT2 Is a Targetable Master Regulator of Lethal Prostate Cancer That Suppresses the Androgen Axis SSRN 2018 Lenti RC211951L1
P2RY2 P2Y2 Nucleotide Receptor Prompts Human Cardiac Progenitor Cell Activation by Modulating Hippo Signaling Circ. Res. 2017 Lenti RC223931L2
P2RY2 P2Y2 Nucleotide Receptor Prompts Human Cardiac Progenitor Cell Activation by Modulating Hippo Signaling Circ. Res. 2017 Lenti TL302717
PA2G4 ErbB3-binding protein 1 (EBP1) represses HNF4α-mediated transcription and insulin secretion in pancreatic β-cells Journal of Biological Chemistry 2019 Lenti TL310638
PADI4 Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix Nat Commun 2018 Lenti TL310630
PARP1 Epstein-Barr Virus Oncoprotein LMP1 Mediates Epigenetic Changes in Host Gene Expression through PARP1 J. Virol. 2016 Lenti TL709663
PBK PDZ-Binding Kinase-Dependent Transcriptional Regulation of CCNB2 Promotes Tumorigenesis and Radio-Resistance in Glioblastoma Transl Oncol 2019 Lenti RC203295L2V
PBRM1 Pbrm1 Steers Mesenchymal Stromal Cell Osteolineage Differentiation by Integrating PBAF-Dependent Chromatin Remodeling and BMP/TGF-β Signaling Cell Rep 2020 Lenti TL517996
PCDH17 Loss of protocadherin-17 (PCDH-17) promotes metastasis and invasion through hyperactivation of EGFR/MEK/ERK signaling pathway in hepatocellular carcinoma Tumour Biol. Sep 2015 Lenti TL310584V
PCDH17 Loss of protocadherin-17 (PCDH-17) promotes metastasis and invasion through hyperactivation of EGFR/MEK/ERK signaling pathway in hepatocellular carcinoma Tumour Biol. Sep 2015 Lenti RC206968L1
PDCD1 m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade Nat Commun 2019 Lenti RC210364L2
PDCD1 Engineering PD-1-Presenting Platelets for Cancer Immunotherapy Nano Lett. 2018 Lenti MR227347L4
Pdcd1 Blockade of Tumor-Expressed PD-1 Promotes Lung Cancer Growth OncoImmunology 2017 Lenti MR227347L2V
PDCD10 Endothelial cell clonal expansion in the development of cerebral cavernous malformations Nat Commun 2019 Lenti RC205095L2
PDCD10 Loss of programmed cell death 10 activates tumor cells and leads to temozolomide-resistance in glioblastoma J. Neurooncol. 2018 Lenti TL302576
PDCD10 MicroRNA-425-5p regulates chemoresistance in colorectal cancer cells via regulation of Programmed Cell Death 10 J. Cell. Mol. Med. Dec 2015 Lenti RC221815L1
PDE4B Smurf2, an E3 ubiquitin ligase, interacts with PDE4B and attenuates liver fibrosis through miR-132 mediated CTGF inhibition Biochim. Biophys. Acta 2017 Lenti RC218324L3
PDE5A Expression and Function of Phosphodiesterase Type 5 in Human Breast Cancer Cell Lines and Tissues: Implications for Targeted Therapy Clin. Cancer Res. Dec 2015 Lenti TL316826
PDGFB Stromal platelet-derived growth factor receptor-β signaling promotes breast cancer metastasis in the brain Cancer Research 2020 Lenti TL501604
PDX1 Development of new preclinical models to advance adrenocortical carcinoma research Endocr. Relat. Cancer 2018 Lenti RC222354L2
PECAM1 Cell-specific targeting by Clostridium perfringens β-toxin unraveled: the role of CD31 as the toxin receptor bioRxiv 2019 Lenti RC208654L3
PEG10 PEG10 counteracts signaling pathways of TGF-β and BMP to regulate growth, motility and invasion of SW1353 chondrosarcoma cells J. Bone Miner. Metab. 2018 Lenti RC229935L1
PGR A mouse model engineered to conditionally express the progesterone receptor-B isoform Genesis 2018 Lenti MR227418L1
PHGDH Serine Biosynthesis Pathway Supports MYC-miR-494-EZH2 Feed-Forward Circuit Necessary to Maintain Metabolic and Epigenetic Reprogramming of Burkitt Lymphoma Cells Cancers (Basel) 2020 Lenti TL507159
PI4KA A Forward Genetic Screen Targeting the Endothelium Reveals a Regulatory Role for the Lipid Kinase Pi4ka in Myelo- and Erythropoiesis Cell Rep 2018 Lenti TL510615
PIK3CA Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in Colorectal Cancer Clin. Cancer Res. 2019 Lenti RC213112L1
PIM2 PIM-2 protein kinase negatively regulates T cell responses in transplantation and tumor immunity J. Clin. Invest. 2018 Lenti MR222342L2
PLCB4 Functional screening implicates miR-371-3p and peroxiredoxin 6 in reversible tolerance to cancer drugs Nat Commun 2016 Lenti TL310374
PLCG2 The Alzheimer′ s disease-associated protective Plcγ2-P522R variant promotes beneficial microglial functions bioRxiv 2020 Lenti RC200442L1
pLenti-C-mGFP Increased Tau Expression Correlates With IDH Mutation in Infiltrating Gliomas and Impairs Cell Migration J. Neuropathol. Exp. Neurol. 2020 Lenti PS100071V
pLenti-C-Myc-DDK Inhibition of endoglin exerts anti-tumor effects through the regulation of non-Smad TGF-β signaling in angiosarcoma J. Invest. Dermatol. 2020 Lenti PS100064V
PLK4 Polo‑like kinase 4 promotes tumorigenesis and induces resistance to radiotherapy in glioblastoma Oncol. Rep. 2019 Lenti TL320644V
PMCA2 Sphingomyelin-induced inhibition of the plasma membrane calcium ATPase causes neurodegeneration in type A Niemann-Pick disease Mol. Psychiatry 2016 Lenti TL509635
PNPLA2 Grasp55-/- mice display impaired fat absorption and resistance to high-fat diet-induced obesity Nat Commun 2020 Lenti RC205708L3
PNPLA2 Alternative splicing switches STIM1 targeting to specialized membrane contact sites and modifies SOCE bioRxiv 2020 Lenti RC205708L3
Positive Control Defining human cardiac transcription factor hierarchies using integrated single-cell heterogeneity analysis Nat Commun 2018 Lenti PS100071V5
POU3F1 Delaying histone deacetylase response to injury accelerates conversion into repair Schwann cells and nerve regeneration Nat Commun 2017 Lenti TL712899
POU5F1 OCT4 accelerates tumorigenesis through activating JAK/STAT signaling in ovarian cancer side population cells Cancer Manag Res 2019 Lenti RC211998L1
POU5F1 OCT-4: a novel estrogen receptor-a collaborator that promotes tamoxifen resistance in breast cancer cells Oncogene Apr 2016 Lenti TL310267
PPARD Pleotropic effects of PPARD accelerate colorectal tumor progression and invasion bioRxiv 2018 Lenti RC214735L3
PPARD Pleotropic effects of PPARD accelerate colorectal tumor progression and invasion bioRxiv 2018 Lenti MR207001L3
PPARG2 Breast cancer-associated skeletal muscle mitochondrial dysfunction and lipid accumulation is reversed by PPARG BioRxiv 2020 Lenti MR208132L4V
PPARGC1A AMPK Maintains Cellular Metabolic Homeostasis through Regulation of Mitochondrial Reactive Oxygen Species Cell Rep 2017 Lenti MR210710L2
PPARGC1A Skeletal muscle increases FGF21 expression in mitochondrial disorders to compensate for energy metabolic insufficiency by activating the mTOR-YY1-PGC1a pathway Free Radic. Biol. Med. Apr 2015 Lenti TL509292
PPM1G Phosphatidylinositol-3 kinase-dependent translational regulation of Id1 involves the PPM1G phosphatase Oncogene 2016 Lenti RC213685L1
PPP2CA PP2A inhibition sensitizes cancer stem cells to ABL tyrosine kinase inhibitors in BCR-ABL+human leukemia Sci Transl Med 2018 Lenti TL310229
PRDM1 Blimp-1 prolongs allograft survival without regimen via influencing T cell development in favor of regulatory T cells while suppressing Th1 Mol. Immunol. 2018 Lenti TL510199
PRDX4 A reference map of the human proinsulin biosynthetic interaction network bioRxiv 2019 Lenti TL510004
PRDX5 Peroxiredoxin 5 Silencing Sensitizes Dopaminergic Neuronal Cells to Rotenone via DNA Damage-Triggered ATM/p53/PUMA Signaling-Mediated Apoptosis Cells 2019 Lenti RC210709L3
PRKAB1 AMP kinase promotes glioblastoma bioenergetics and tumour growth Nat. Cell Biol. 2018 Lenti TL501734
PRKDC PRKDC regulates chemosensitivity and is a potential prognostic and predictive marker of response to adjuvant chemotherapy in breast cancer patients Oncol. Rep. 2017 Lenti TL320478
PRLR Prolactin promotes fibrosis and pancreatic cancer progression Cancer Res. 2019 Lenti TL310169
PRMT7 PRMT7 methylates eukaryotic translation initiation factor 2α and regulates its role in stress granule formation Mol. Biol. Cell 2019 Lenti RC201672L2
PRMT7 PRMT7 methylates eukaryotic translation initiation factor 2α and regulates its role in stress granule formation Mol. Biol. Cell 2019 Lenti RC201672L1
PRNP Melatonin and 5-fluorouracil co-suppress colon cancer stem cells by regulating cellular prion protein-Oct4 axis J. Pineal Res. 2018 Lenti TL302273
PRNP Hypoxia-induced expression of cellular prion protein improves the therapeutic potential of mesenchymal stem cells Cell Death Dis 2016 Lenti TL302273
PROM1 CD133 Promotes Adhesion to the Ovarian Cancer Metastatic Niche Cancer Growth Metastasis 2018 Lenti TL501745
PRSS21 Proteolytic activation of the protease-activated receptor (PAR)-2 by the GPI-anchored serine protease testisin J. Biol. Chem. Dec 2014 Lenti TL310139
PSMB5 A conserved SUMO-Ubiquitin pathway directed by RNF4/SLX5-SLX8 and PIAS4/SIZ1 drives proteasomal degradation of topoisomerase DNA-protein crosslinks bioRxiv 2019 Lenti RC209326L3
PSMB5 Inhibition of store-operated calcium entry by sub-lethal levels of proteasome inhibition is associated with STIM1/STIM2 degradation Cell Calcium Mar 2016 Lenti TL310110
PTEN PPARgamma agonists sensitize PTEN-deficient resistant lung cancer cells to EGFR tyrosine kinase inhibitors by inducing autophagy Eur. J. Pharmacol. 2018 Lenti TL320498
PTGES Linking of mPGES-1 and iNOS activates stem-like phenotype in EGFR-driven epithelial tumor cells Nitric Oxide 2017 Lenti RC202405L1
PTGES mPGES-1 in prostate cancer controls stemness and amplifies EGFR-driven oncogenicity Endocr. Relat. Cancer Jun 2015 Lenti RC202405L1
PTGS2 Construction of COX-2 short hairpin RNA expression vector and its inhibitory effect on hepatic fibrosis Biotechnology & Biotechnological Equipment 2018 Lenti TL710033
PTP4A3 Targeting ovarian cancer and endothelium with an allosteric PTP4A3 phosphatase inhibitor Oncotarget 2018 Lenti TL320652
PTPN1 Targeting pancreatic islet PTP1B improves islet graft revascularization and transplant outcomes Sci Transl Med 2019 Lenti TL310067V
PUF60 PUF60 accelerates the progression of breast cancer through downregulation of PTEN expression Cancer Manag Res 2019 Lenti TL307443
PURA Pur-alpha regulates cytoplasmic stress granule dynamics and ameliorates FUS toxicity Acta Neuropathol. Jan 2016 Lenti TL310036V
RAB11A Murine leukemia virus glycosylated Gag reduces murine SERINC5 protein expression at steady-state levels via endosome/lysosome pathway to counteract the SERINC5 antiretroviral activity J. Virol. 2018 Lenti TL310015
RAB11A HIV-1 Nef antagonizes SERINC5 restriction by downregulation of SERINC5 via the endosome/lysosome system J. Virol. 2018 Lenti TL310015
RAB5A Murine leukemia virus glycosylated Gag reduces murine SERINC5 protein expression at steady-state levels via endosome/lysosome pathway to counteract the SERINC5 antiretroviral activity J. Virol. 2018 Lenti TL309987
RAB5A HIV-1 Nef antagonizes SERINC5 restriction by downregulation of SERINC5 via the endosome/lysosome system J. Virol. 2018 Lenti TL309987
RAB7A Murine leukemia virus glycosylated Gag reduces murine SERINC5 protein expression at steady-state levels via endosome/lysosome pathway to counteract the SERINC5 antiretroviral activity J. Virol. 2018 Lenti TL309983
RAB7A HIV-1 Nef antagonizes SERINC5 restriction by downregulation of SERINC5 via the endosome/lysosome system J. Virol. 2018 Lenti TL309983
RAB7A Mevastatin blockade of autolysosome maturation stimulates LBH589-induced cell death in triple-negative breast cancer cells Oncotarget 2017 Lenti RC201776L1
RAC1 CXCL12-induced rescue of cortical dendritic spines and cognitive flexibility Elife 2020 Lenti TL320503
RAD18 AKT inhibition impairs PCNA ubiquitylation and triggers synthetic lethality in homologous recombination-deficient cells submitted to replication stress Oncogene 2019 Lenti TL302132
RAD18 High expression of RAD18 in glioma induces radiotherapy resistance via down-regulating P53 expression Biomed. Pharmacother. 2019 Lenti TL302132
RAD18 High expression of RAD18 in glioma induces radiotherapy resistance via down-regulating P53 expression Biomed. Pharmacother. 2019 Lenti RC201700L1
RAD21 ASXL1 interacts with the cohesin complex to maintain chromatid separation and gene expression for normal hematopoiesis Sci Adv 2017 Lenti TL501846
RANBP2 Ankyrin-G induces nucleoporin RanBP2/Nup358 to associate with the axon initial segment of neurons J. Cell. Sci. 2019 Lenti TL501860
RANGAP1 The C9orf72 repeat expansion disrupts nucleocytoplasmic transport Nature Sep 2015 Lenti RC204223L2
RAPGEF2 Disruption of MAGI2-RapGEF2-Rap1 signaling contributes to podocyte dysfunction in congenital nephrotic syndrome caused by mutations in MAGI2 Kidney International 2019 Lenti TL316875
RAPGEF4 Regulation of Glucose-Dependent Golgi-Derived Microtubules by cAMP/EPAC2 Promotes Secretory Vesicle Biogenesis in Pancreatic β Cells Curr. Biol. 2019 Lenti TL509420
RARA Retinoid receptor turnover mediated by sumoylation, ubiquitination and the valosin-containing protein is disrupted in glioblastoma Sci Rep 2019 Lenti RC200430L1
RARRES3 RARRES3 suppressed metastasis through suppression of MTDH to regulate epithelial-mesenchymal transition in colorectal cancer Am J Cancer Res Aug 2015 Lenti TL320510
RASA2 Hyperactivation of TORC1 Drives Resistance to the Pan-HER Tyrosine Kinase Inhibitor Neratinib in HER2-Mutant Cancers Cancer Cell 2020 Lenti RC224076L3
RASIP1 Rasip1 controls lymphatic vessel lumen maintenance by regulating endothelial cell junctions Development 2018 Lenti TL302100
RBM3 Infants Uniquely Express High Levels of RBM3 and Other Cold-Adaptive Neuroprotectant Proteins in the Human Brain Dev. Neurosci. 2018 Lenti TL309915
RBM38 RBM38 induces SIRT1 expression during hypoxia in non-small cell lung cancer cells by suppressing MIR34A expression Biotechnol. Lett. 2019 Lenti TL317301V
RBM5 Whole-transcriptome microarray analysis reveals regulation of Rab4 by RBM5 in neurons Neuroscience 2017 Lenti TL704115
RBPJ Dnmt3b ablation impairs fracture repair through upregulation of Notch pathway JCI Insight 2020 Lenti TL512813V
RBPJ Direct reprogramming of fibroblasts into neural stem cells by single non-neural progenitor transcription factor Ptf1a Nat Commun 2018 Lenti TL512813
RD3 HIV-1 viral protein R (Vpr) induces fatty liver in mice via LXRα and PPARα dysregulation: implications for HIV-specific pathogenesis of NAFLD Sci Rep 2017 Lenti TL320630
RETNLA Hypoxia-Induced Mitogenic Factor Acts as a Nonclassical Ligand of Calcium-Sensing Receptor, Therapeutically Exploitable for Intermittent Hypoxia-Induced Pulmonary Hypertension Hypertension 2017 Lenti TL711770
RFX7 The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity Nat. Immunol. 2018 Lenti RC211086L1
RIOK1 Targeting posttranslational modifications of RioK1 inhibits the progression of colorectal and gastric cancers bioRxiv 2017 Lenti TL320739
RNF144A RNF144A functions as a tumor suppressor in breast cancer through ubiquitin ligase activity-dependent regulation of stability and oncogenic functions of HSPA2 Cell Death Differ. 2019 Lenti TL309788
RNF144A RBR-type E3 ubiquitin ligase RNF144A targets PARP1 for ubiquitin-dependent degradation and regulates PARP inhibitor sensitivity in breast cancer cells Oncotarget 2017 Lenti TL309788
RORA Sertoli cell specific knockdown of RAR-related orphan receptor (ROR) alpha at puberty reduces sperm count in rats Gene 2017 Lenti TL705407
RPA3 Elevated Expression of RPA3 Is Involved in Gastric Cancer Tumorigenesis and Associated with Poor Patient Survival Dig. Dis. Sci. 2017 Lenti TL316699
RPS27A RPS27a enhances EBV-encoded LMP1-mediated proliferation and invasion by stabilizing of LMP1 Biochem. Biophys. Res. Commun. 2017 Lenti TL309716
RSF1 RSF1 regulates the proliferation and paclitaxel resistance via modulating NF-κB signaling pathway in nasopharyngeal carcinoma J Cancer 2017 Lenti RC218432L2
RUNX1 rs11671784 G/A variation in miR-27a decreases chemo-sensitivity of bladder cancer by decreasing miR-27a and increasing the target RUNX-1 expression Biochem. Biophys. Res. Commun. Mar 2015 Lenti RC223809L1
RXFP1 Serelaxin alleviates cardiac fibrosis through inhibiting endothelial-to-mesenchymal transition via RXFP1 Theranostics 2020 Lenti TL301865
RXFP1 Expression of RXFP1 is Decreased in Idiopathic Pulmonary Fibrosis: Implications for Relaxin-Based Therapies Am. J. Respir. Crit. Care Med. Jun 2016 Lenti RC211338L1
RXRB Prominent role of RAB39A-RXRB axis in cancer development and stemness Oncotarget 2018 Lenti RC200516L3
S100A14 Increased S100A15 expression and decreased DNA methylation of its gene promoter are involved in high metastasis potential and poor outcome of lung adenocarcinoma Oncotarget 2017 Lenti TL318900
S100A9 S100A9 regulates cisplatin chemosensitivity of squamous cervical cancer cells and related mechanism Cancer Manag Res 2018 Lenti TL316713
S100A9 The role ofcalgranulin Bgene on the biological behavior of squamous cervical cancer in vitro and in vivo Cancer Manag Res 2018 Lenti TL316713
S100G 17β-estradiol binding to ERα promotes the progression of prolactinoma through estrogen-response element-induced CaBP-9k up-regulation Biosci. Rep. 2020 Lenti TL709169
S100G Modulation effects of black-vinegar based supplement against a high-fat dietary habit: antiobesity/hypolipidemic, antioxidative, and energy-metabolism effects J. Sci. Food Agric. 2020 Lenti TL709169
SAA3 Serum Amyloid A3 Secreted by Preosteoclasts Inhibits Parathyroid Hormone-Stimulated cAMP Signaling in Murine Osteoblasts J. Biol. Chem. Dec 2015 Lenti TL501964
SALL1 SALL1 expression in acute myeloid leukemia Oncotarget 2018 Lenti TL309658
SALL4 Inflammatory Micro-environment Contributes to Stemness Properties and Metastatic Potential of HCC via the NF-κB/miR-497/SALL4 Axis Mol Ther Oncolytics 2019 Lenti TL301854
SALL4 Inflammatory microenvironment contributes to stemness properties and metastatic potential of hepatocellular carcinoma via NF-κB/miR-497/SALL4 axis Molecular Therapy - Oncolytics 2019 Lenti TL301854
SCG3 Carboxypeptidase E and Secretogranin III Coordinately Facilitate Efficient Sorting of Proopiomelanocortin to the Regulated Secretory Pathway in AtT20 Cells Mol. Endocrinol 2016 Lenti TL516044
Scrambled Control Norrin mediates tumor-promoting and -suppressive effects in glioblastoma via Notch and WNT J. Clin. Invest. 2020 Lenti TR30021
Scrambled Control Heat Shock Protein 47 Maintains Cancer Cell Growth by Inhibiting the Unfolded Protein Response Transducer IRE1α Mol. Cancer Res. 2020 Lenti TR30021
Scrambled Control GRSF1 suppresses cell senescence Aging (Albany NY) 2018 Lenti TR30021V
SDC1 Sphingosine 1-phosphate regulates proliferation, cell cycle and apoptosis of hepatocellular carcinoma cells via syndecan-1 Prog. Biophys. Mol. Biol.2017 Lenti TL309598
SDC1 Sphingosine-1-phosphate induced epithelial-mesenchymal transition of hepatocellular carcinoma via an MMP-7/ syndecan-1/TGF-ß autocrine loop Oncotarget 2016 Lenti TL309598
SDCBP Lung Adenocarcinoma Syndecan-2 Potentiates Cell Invasiveness Am. J. Respir. Cell Mol. Biol. 2018 Lenti RC215390L1
SDCBP Syntenin promotes VEGF-induced VEGFR2 endocytosis and angiogenesis by increasing ephrin-B2 function in endothelial cells Oncotarget 2017 Lenti TL309594
SDCBP Syntenin regulates TGF-ß1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-ß type I receptor internalization Oncogene Apr 2015 Lenti TL309594
SDCBP2 Lung Adenocarcinoma Syndecan-2 Potentiates Cell Invasiveness Am. J. Respir. Cell Mol. Biol. 2018 Lenti RC218898L2
SEMA3C Regulation of Sema3c and the Interaction between Cardiac Neural Crest and Second Heart Field during Outflow Tract Development Sci Rep 2017 Lenti RC205269L1
SEMA6A Nrf2 in ischemic neurons promotes retinal vascular regeneration through regulation of semaphorin 6A Proc. Natl. Acad. Sci. U.S.A. Dec 2015 Lenti TL510568
SENP2 SUMOylation determines the voltage required to activate cardiac IKs channels Proc. Natl. Acad. Sci. U.S.A. 2017 Lenti TL517117
SENP2 Accumulation of histone variant H3. 3 with age is associated with profound changes in the histone methylation landscape Nucleic Acids Research 2017 Lenti TL517117
SH2D3C Up-regulation of NSP3 by Oligomeric Aβ Accelerates Neuronal Death Through Cas-independent Rap1A Activation Neuroscience 2018 Lenti TL502696
SH3BP2 Myo1f, an Unconventional Long-Tailed Myosin, Is a New Partner for the Adaptor 3BP2 Involved in Mast Cell Migration Front Immunol 2019 Lenti RC205759L2
SIRT6 Deacetylation of Ku70 by SIRT6 attenuates Bax-mediated apoptosis in hepatocellular carcinoma Biochem. Biophys. Res. Commun 2017 Lenti RC202833L1
SKA2 Upregulation of microRNA‑520a‑3p inhibits the proliferation, migration and invasion via spindle and kinetochore associated 2 in gastric cancer Oncology Letters 2019 Lenti RC222296L3
SKP2 OCT-4: a novel estrogen receptor-a collaborator that promotes tamoxifen resistance in breast cancer cells Oncogene Apr 2016 Lenti TL301684
SLC10A1 Apical Sodium-Dependent Bile Acid Cotransporter, A Novel Transporter of Indocyanine Green, and Its Application in Drug Screening Int J Mol Sci 2020 Lenti RC210241L2
SLC10A1 Role of Sodium Taurocholate Cotransporting Polypeptide as a New Reporter and Drug-Screening Platform: Implications for Preventing Hepatitis B Virus Infections Mol Imaging Biol 2019 Lenti RC210241L2
SLC10A1 N-linked glycosylation is not essential for sodium taurocholate cotransporting polypeptide to mediate hepatitis B virus infection in vitro J. Virol. 2018 Lenti TL309420
SLC10A2 Apical Sodium-Dependent Bile Acid Cotransporter, A Novel Transporter of Indocyanine Green, and Its Application in Drug Screening Int J Mol Sci 2020 Lenti RC221202L2
SLC15A2 Dipeptide species regulate p38MAPK-Smad3 signalling to maintain chronic myelogenous leukaemia stem cells Nat Commun Aug 2015 Lenti TL503323
SLC16A1 Metabolic heterogeneity confers differences in melanoma metastatic potential Nature 2020 Lenti TL309405
SLC17A5 Nitrate uptake and metabolism in human skeletal muscle cell cultures Nitric Oxide 2019 Lenti TL309394
SLC1A5 Tumor-Repopulating Cells Induce PD-1 Expression in CD8+T Cells by Transferring Kynurenine and AhR Activation Cancer Cell 2018 Lenti TL516694
Slc2a1 The insulin-like growth factor I receptor regulates glucose transport by astrocytes Glia 2016 Lenti TL511086
Slc2a1 The insulin-like growth factor I receptor regulates glucose transport by astrocytes Glia 2016 Lenti TL501102
SLC2A1 A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect Nat Commun 3608 5 . April 2014 Lenti TL309344
SLC7A11 System χc- overexpression prevents 2-deoxy-d-ribose-induced β-cell damage Free Radic. Biol. Med. 2020 Lenti RR208495L4
SLIT1 Suppression of Slit3 induces tumor proliferation and chemoresistance in hepatocellular carcinoma through activation of GSK3β/β-catenin pathway BMC Cancer 2018 Lenti TL502069
SLITRK2 Opposite Control of Excitatory and Inhibitory Synapse Formation by Slitrk2 and Slitrk5 on Dopamine Neurons Modulates Hyperactivity Behavior Cell Rep 2020 Lenti TL514163
SLITRK5 Opposite Control of Excitatory and Inhibitory Synapse Formation by Slitrk2 and Slitrk5 on Dopamine Neurons Modulates Hyperactivity Behavior Cell Rep 2020 Lenti TL505056
SMAD2 Adult cardiac stem cells are multipotent and robustly myogenic: c-kit expression is necessary but not sufficient for their identification Cell Death Differ. 2017 Lenti RR212493L2
SMC1A ASXL1 interacts with the cohesin complex to maintain chromatid separation and gene expression for normal hematopoiesis Sci Adv 2017 Lenti TL513033
SMO Interference with SMO increases chemotherapy drug sensitivity of A2780/DDP cells by inhibiting the Hh/Gli signaling pathway J. Cell. Biochem. 2020 Lenti TL309234
SMO Targeting Smoothened Sensitizes Gastric Cancer to Chemotherapy in Experimental Models Med. Sci. Monit 2017 Lenti MR210692L2
SMO Targeting Smoothened Sensitizes Gastric Cancer to Chemotherapy in Experimental Models Med. Sci. Monit 2017 Lenti TL510788
SMOX Increased polyamines as protective disease modifiers in Congenital Muscular Dystrophy Hum. Mol. Genet. 2018 Lenti RC214652L2
SMPD3 The cationic small molecule GW4869 is cytotoxic to high phosphatidylserine-expressing myeloma cells Br. J. Haematol 2017 Lenti TL301492
SNAI1 FBXO22 possesses both pro-tumorigenic and anti-metastatic roles in breast cancer progression Cancer Res. 2018 Lenti TL309226
SNAI1 Lysyl Oxidase-like Protein LOXL2 Promotes Lung Metastasis of Breast Cancer Cancer Res. 2017 Lenti MR203505L2V
SNAI1 Endothelial Snail Regulates Capillary Branching Morphogenesis via Vascular Endothelial Growth Factor Receptor 3 Expression PLoS Genet. Jul 2015 Lenti TL502087
SNAI2 SLUG Directs the Precursor State of Human Brain Tumor Stem Cells Cancers (Basel) 2019 Lenti RC202365L1
SNCA a-Synuclein, a chemoattractant, directs microglial migration via H2O2-dependent Lyn phosphorylation Proc. Natl. Acad. Sci. U.S.A. Apr 2015 Lenti TL710189
SORL1 SORLA regulates endosomal trafficking and oncogenic fitness of HER2 Nat Commun 2019 Lenti TL309181
SORL1 SORLA-driven endosomal trafficking regulates the oncogenic fitness of HER2 bioRxiv 2018 Lenti TL309181
SOX10 m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade Nat Commun 2019 Lenti RC203545L2
SOX2 Arsenic promotes the COX2/PGE2-SOX2 axis to increase the malignant stemness properties of urothelial cells Int. J. Cancer 2018 Lenti TL309173
Sox2 YAP1 and COX2 coordinately regulate urothelial cancer stem-like cells Cancer Res.2017 Lenti TL515613
SOX7 Sox7 is involved in antibody-dependent endothelial cell activation and renal allograft injury via the Jagged1-Notch1 pathway Exp. Cell Res. 2019 Lenti TL301454
SOX9 Sox9 regulates the luminal stem/progenitor cell properties of salivary glands Experimental Cell Research 2019 Lenti TL511411
SOX9 Incomplete radiofrequency ablation promotes the development of CD133+ cancer stem cells in hepatocellular carcinoma cell line HepG2 via inducing SOX9 expression HBPD INT 2018 Lenti TL309170
SOX9 SOX9 Transcriptionally Regulates mTOR-Induced Proliferation of Basal Cell Carcinomas J. Invest. Dermatol. 2018 Lenti TL309170
SP1 Resveratrol Represses Pokemon Expression in Human Glioma Cells Molecular Neurobiology Jan 2015 Lenti TL301453
SP7 Synergistic Effects of Controlled-Released BMP-2 and VEGF from nHAC/PLGAs Scaffold on Osteogenesis BioMed Research International 2018 Lenti TL514041
SPAST Spastin Contributes to Neural Development through the Regulation of Microtubule Dynamics in the Primary Cilia of Neural Stem Cells Neuroscience 2019 Lenti TL511715
SPI1 Transcriptional regulation of the proto-oncogene Zfp521 by SPI1 (PU.1) and HOXC13 Genesis 2016 Lenti TL316738
Spry4 Novel Function of Sprouty4 as a Regulator of Stemness and Differentiation of Embryonic Stem Cells Development & Reproduciton 2016 Lenti TL509780
SQLE Squalene epoxidase drives NAFLD-induced hepatocellular carcinoma and is a pharmaceutical target Sci Transl Med 2018 Lenti TL309122
SQSTM1 Contribution of p62/SQSTM1 to PDGF-BB-induced myofibroblast-like phenotypic transition in vascular smooth muscle cells lacking Smpd1 gene Cell Death Dis 2018 Lenti TL515047
SREBF2 miR-33a Mediates the Anti-Tumor Effect of Lovastatin in Osteosarcoma by Targeting CYR61 Cell. Physiol. Biochem. 2018 Lenti TL309116
SRF Pseudotemporal Ordering of Single Cells Reveals Metabolic Control of Postnatal β Cell Proliferation Cell Metab. 2017 Lenti MR208120L2
ST8SIA3 Glycolipids Recognized by A2B5 Antibody Promote Proliferation, Migration, and Clonogenicity in Glioblastoma Cells Cancers (Basel) 2019 Lenti TL301359
STAT1 Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells Nat Commun 2017 Lenti TL301349
STAT3 PD-L1 is overexpressed on breast cancer stem cells through notch3/mTOR axis OncoImmunology 2020 Lenti TL301348V
STAT3 Interleukin-23 promotes the migration and invasion of gastric cancer cells by inducing epithelial-to-mesenchymal transition via the STAT3 pathway Biochem. Biophys. Res. Commun. 2018 Lenti TL301348
STAT3 Microenvironmental interleukin-6 suppresses toll-like receptor signaling in human leukemia cells through miR-17/19A Blood Jun 2015 Lenti TL301348
STIM1 STIM Protein-NMDA2 Receptor Interaction Decreases NMDA-Dependent Calcium Levels in Cortical Neurons Cells 2020 Lenti TL309049
STIM2 STIM Protein-NMDA2 Receptor Interaction Decreases NMDA-Dependent Calcium Levels in Cortical Neurons Cells 2020 Lenti TL301342
STIP1 Stress-induced phosphoprotein 1 promotes pancreatic cancer progression through activation of the FAK/AKT/MMP signaling axis Pathology - Research and Practice 2019 Lenti TL309048
STK19 Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-Driven Melanomagenesis Cell 2019 Lenti RC219373L3
STX12 Functional screening implicates miR-371-3p and peroxiredoxin 6 in reversible tolerance to cancer drugs Nat Commun 2016 Lenti TL301328
SYK Distinct Signaling Pathways Regulate TREM2 Phagocytic and NFκB Antagonistic Activities Front Cell Neurosci 2019 Lenti TL320543
SYK SYK-targeted dendritic cell-mediated cytotoxic T lymphocytes enhance the effect of immunotherapy on retinoblastoma J. Cancer Res. Clin. Oncol. 2018 Lenti RC200413L3
Syvn1 The ubiquitin-proteasome system functionally links neuronal Tomosyn-1 to dendritic morphology J. Biol. Chem. 2017 Lenti TL704173
TARDBP Senataxin mutations elicit motor neuron degeneration phenotypes and yield TDP-43 mislocalization in ALS4 mice and human patients Acta Neuropathol. 2018 Lenti RC210639L2
TBX20 Tbx20 controls the expression of the KCNH2 gene and of hERG channels Proc. Natl. Acad. Sci. U.S.A 2017 Lenti RC212412L2
TBX20 Tbx20 controls the expression of the KCNH2 gene and of hERG channels Proc. Natl. Acad. Sci. U.S.A 2017 Lenti TL503288
TBX21 Transcription Factor T-bet in B Cells Modulates Germinal Center Polarization and Antibody Affinity Maturation in Response to Malaria Cell Rep 2019 Lenti RC207902L4V
TBX5 Defining human cardiac transcription factor hierarchies using integrated single-cell heterogeneity analysis Nat Commun 2018 Lenti RC216520L2
Tcf7l2 Macrophage TCF-4 Coactivates p65 to Potentiate Chronic Inflammation and Insulin Resistance in Mice Clin. Sci. Apr 2016 Lenti MR207325L1
TCOF1 Stable Acinar Progenitor Cell Model Identifies Treacle-Dependent Radioresistance Radiat. Res. 2019 Lenti TL704731V
TDP2 TOP2β-Dependent Nuclear DNA Damage Shapes Extracellular Growth Factor Responses via Dynamic AKT Phosphorylation to Control Virus Latency Mol. Cell 2019 Lenti RC202015L1
TDP2 Topoisomerase 2 [beta]-dependent nuclear DNA damage shapes extracellular growth factor responses through AKT phosphorylation dynamics to control virus latency bioRxiv 2019 Lenti RC202015L1
TEAD1 YAP1 plays a key role of the conversion of normal fibroblasts into cancer-associated fibroblasts that contribute to prostate cancer progression J. Exp. Clin. Cancer Res. 2020 Lenti TL513813
TEAD1 Analysis of chromatin accessibility uncovers TEAD1 as a regulator of migration in human glioblastoma Nat Commun 2018 Lenti RC215492L1
TET1 Vitamin C Promotes Astrocyte Differentiation Through DNA Hydroxymethylation Stem Cells 2018 Lenti TL706196
TET2 Reprogramming of DNA methylation at NEUROD2-bound sequences during cortical neuron differentiation Sci Adv 2019 Lenti TL513547
TET2 Tet methylcytosine dioxygenase 2 inhibits atherosclerosis via upregulation of autophagy in ApoE-/- mice Oncotarget 2016 Lenti RC215770L1
TET2 Tet methylcytosine dioxygenase 2 inhibits atherosclerosis via upregulation of autophagy in ApoE-/- mice Oncotarget 2016 Lenti TL303734
TFAM HO-1/CO system and embryonic stem cell differentiation and maturation into cardiomyocytes Antioxid. Redox Signal. Jan 2016 Lenti MR203015L2
TGFBR1 miR-140-5p alleviates the aggressive progression of Wilms' tumor through directly targeting TGFBR1 gene Cancer Manag Res 2019 Lenti TL320549
TIMD4 Autophagy-related protein Vps34 controls the homeostasis and function of antigen cross-presenting CD8α(+) dendritic cells Proc. Natl. Acad. Sci. U.S.A. 2017 Lenti MR222206L1
TIMP-1 Targeting tissue inhibitor of metalloproteinase 1/2 using a shRNA lentiviral system offers a novel treatment strategy against hepatic fibrosis Int J Clin Exp Med 2016 Lenti TL712176
TIMP-2 Targeting tissue inhibitor of metalloproteinase 1/2 using a shRNA lentiviral system offers a novel treatment strategy against hepatic fibrosis Int J Clin Exp Med 2016 Lenti TL710553
TLR2 Inflammasome Priming Mediated via Toll-Like Receptors 2 and 4, Induces Th1-Like Regulatory T Cells in De Novo Autoimmune Hepatitis Front Immunol 2018 Lenti TL320553
TLR2 Selective disruption of TLR2/MyD88 interaction inhibits inflammation and attenuates Alzheimer's pathology J. Clin. Invest. 2018 Lenti RC207597L1
TLR4 Inflammasome Priming Mediated via Toll-Like Receptors 2 and 4, Induces Th1-Like Regulatory T Cells in De Novo Autoimmune Hepatitis Front Immunol 2018 Lenti TL320555
TLR9 Inflammasome Priming Mediated via Toll-Like Receptors 2 and 4, Induces Th1-Like Regulatory T Cells in De Novo Autoimmune Hepatitis Front Immunol 2018 Lenti TL301076
TMEM163 Transmembrane 163 (TMEM163) protein effluxes zinc bioRxiv 2019 Lenti TL307341
TNF Local TNF causes NFATc1-dependent cholesterol-mediated podocyte injury J. Clin. Invest. 2016 Lenti RC206983L1
TNFRSF1A Quantitative analysis of competitive cytokine signaling predicts tissue thresholds for the propagation of macrophage activation Sci Signal 2018 Lenti TL308734
TNFRSF1A TNF-α receptor 1 knockdown in subfornical organ ameliorates sympathetic excitation and cardiac hemodynamics in heart failure rats Am. J. Physiol. Heart Circ. Physiol. 2017 Lenti TL709687
Tnfrsf21 Induction of microRNA-17-5p by p53 protects against renal ischemia-reperfusion injury by targeting death receptor 6 Kidney Int. 2017 Lenti TL706747
Tomo1 Dynamic Partitioning of Synaptic Vesicle Pools by the SNARE-Binding Protein Tomosyn J. Neurosci. 2016 Lenti TL518079
TOP2A Spatial Chromosome Folding and Active Transcription Drive DNA Fragility and Formation of Oncogenic MLL Translocations Mol. Cell 2019 Lenti TL308699
TOP2B Spatial Chromosome Folding and Active Transcription Drive DNA Fragility and Formation of Oncogenic MLL Translocations Mol. Cell 2019 Lenti TL308698
TOX TOX is a critical regulator of tumour-specific T cell differentiation Nature 2019 Lenti MR208435L2
TP53 High expression of RAD18 in glioma induces radiotherapy resistance via down-regulating P53 expression Biomed. Pharmacother. 2019 Lenti RC225604L1
TP53 ATR suppresses the pro-tumorigenic functions of breast stromal fibroblasts Oncotarget 2018 Lenti RC225604L1
TP53 Endothelial p53 Deletion Improves Angiogenesis and Prevents Cardiac Fibrosis and Heart Failure Induced by Pressure Overload in Mice J Am Heart Assoc Feb 2015 Lenti TL320558
TPP1 A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport Cell Rep 2019 Lenti TL711322
TREX1 Accumulation of cytoplasmic DNA due to ATM deficiency activates the microglial viral response system with neurotoxic consequences J. Neurosci. 2019 Lenti TL511298
TRIM3 Potential role of TRIM3 as a novel tumour suppressor in colorectal cancer (CRC) development Scand. J. Gastroenterol. Dec 2015 Lenti RC211739L1
TRIM32 Trim32 suppresses cerebellar development and tumorigenesis by degrading Gli1/sonic hedgehog signaling Cell Death Differ. 2019 Lenti RC201289L2
TRIM32 Trim32 suppresses cerebellar development and tumorigenesis by degrading Gli1/sonic hedgehog signaling Cell Death Differ. 2019 Lenti TL308646
TRIM33 Hepatic stellate cell-specific knockout of transcriptional intermediary factor 1γ aggravates liver fibrosis J. Exp. Med. 2020 Lenti TL300849
TRIM8 TRIM8 regulates stemness in glioblastoma through PIAS3-STAT3 Mol Oncol 2017 Lenti RC205812L2
TRIML2 Eutherian-specific gene TRIML2 attenuates inflammation in the evolution of placentation Mol. Biol. Evol. 2019 Lenti RC211281L1
TRIP10 Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery Elife 2017 Lenti RC201200L1
TRPM2 Transient receptor potential ion channel TRPM2 promotes AML proliferation and survival through modulation of mitochondrial function, ROS, and autophagy Cell Death Dis 2020 Lenti TL308624
TRPM7 TGFβ-induced epithelial-to-mesenchymal transition in prostate cancer cells is mediated via TRPM7 expression Mol. Carcinog. 2018 Lenti TL320704
Trps1 Transcription Factor Trps1 Promotes Tubular Cell Proliferation after Ischemia-Reperfusion Injury through cAMP-Specific 3',5'-Cyclic Phosphodiesterase 4D and AKT J. Am. Soc. Nephrol 2017 Lenti TL708847
TRPV1 Capsaicin-induced Ca2+ Signaling is Enhanced via Upregulated TRPV1 Channels in Pulmonary Artery Smooth Muscle Cells from Patients with Idiopathic PAH Am. J. Physiol. Lung Cell Mol. Physiol 2016 Lenti TL300807
TRPV5 Transient receptor potential vanilloid 5 (TRPV5), a highly Ca(2+) -selective TRP channel in the rat brain: relevance to neuroendocrine regulation J. Neuroendocrinol 2017 Lenti RR208885L4
TRPV6 Transient receptor potential vanilloid 5 (TRPV5), a highly Ca(2+) -selective TRP channel in the rat brain: relevance to neuroendocrine regulation J. Neuroendocrinol 2017 Lenti MR210315L4
TUBB3 Cathelicidin Suppresses Colon Cancer Metastasis via a P2RX7-Dependent Mechanism Molecular Therapy - Oncolytics 2019 Lenti RC200755L1V
Twist1 Vaccine-Mediated Immunotherapy Directed Against a Transcription Factor Driving the Metastatic Process Cancer Res., Feb 2014. Lenti TL308556
TXNIP Loss of TXNIP enhances peritoneal metastasis and can be abrogated by dual TORC1/2 inhibition Oncotarget 2018 Lenti TL308550
TXNRD1 Thioredoxin system as a gatekeeper in caspase-6 activation and nuclear lamina integrity: Implications for Alzheimer's disease Free Radic. Biol. Med. 2019 Lenti TL300712
TYRO3 Oncogenic role of TYRO3 receptor tyrosine kinase in the progression of pancreatic cancer Cancer Lett. 2019 Lenti TL316973
UAP1 Reciprocal Regulation Between O-GlcNAcylation and β-Catenin Facilitates Cell Viability and Inhibits Apoptosis in Liver Cancer DNA Cell Biol. 2019 Lenti TL308538
UBA2 Allosteric Inhibition of Ubiquitin-like Modifications by a Class of Inhibitor of SUMO-Activating Enzyme Cell Chem Biol 2019 Lenti RC201288L4
UBE2N The deubiquitinase OTUB1 augments NF-κB-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13 Cell. Mol. Immunol. 2020 Lenti MR201092L1
Ubqln1 Enhanced Proteostasis in Post-ischemic Stroke Mouse Brains by Ubiquilin-1 Promotes Functional Recovery Cell. Mol. Neurobiol 2016 Lenti TL515928
UHRF1 UHRF1 promotes human osteosarcoma cell invasion by downregulating the expression of E-cadherin in an Rb1-dependent manner Mol Med Rep Nov 2015 Lenti RC214251L1
VAMP3 Mouse genome-wide association studies and systems genetics uncover the genetic architecture associated with hepatic pharmacokinetic and pharmacodynamic properties of a constrained ethyl antisense oligonucleotide targeting Malat1 PLoS Genet. 2018 Lenti TL515358V
VD Hypovitaminosis D exacerbates the DNA damage load in human uterine fibroids, which is ameliorated by vitamin D3 treatment Acta Pharmacol Sin 2018 Lenti TL320568
VGLL3 Intracellular Role for the Matrix-Modifying Enzyme Lox in Regulating Transcription Factor Subcellular Localization and Activity in Muscle Regeneration Dev. Cell 2020 Lenti MR217588L1
VIM The Group B Streptococcal surface antigen I/II protein, BspC, interacts with host vimentin to promote adherence to brain endothelium and inflammation during the pathogenesis of meningitis PLoS Pathog. 2019 Lenti RC201546L1
VPS35 Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer’s Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein Stem Cell Repor ts 2018 Lenti TL300553
VRK2 Deletion of the Vaccinia B1 Kinase Reveals Essential Functions of this Enzyme Complemented Partly by the Homologous Cellular Kinase VRK2 J. Virol. 2017 Lenti RC206522L1
WIF1 Wnt Signaling Drives Prostate Cancer Bone Metastatic Tropism and Invasion Transl Oncol 2020 Lenti RC205256L1
WNT10A Optimized dosing schedule based on circadian dynamics of mouse breast cancer stem cells improves the anti-tumor effects of aldehyde dehydrogenase Cancer Res. 2018 Lenti TL502422
WNT5A Host Wnt5a Potentiates Microenvironmental Regulation of Ovarian Cancer Metastasis Cancer Res. 2020 Lenti TL320572V
XRCC5 Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination Nat Commun 2017 Lenti TL502435
XRN2 XRN2 promotes EMT and metastasis through regulating maturation of miR-10a Oncogene 2017 Lenti TL308334
YAP Corosolic acid inhibits cancer progress through inactivating YAP in hepatocellular carcinoma Oncol. Res. 2020 Lenti RC225864L3
YAP1 YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing β cells Nat Commun 2019 Lenti TL308332
Yap1 YAP1 and COX2 coordinately regulate urothelial cancer stem-like cells Cancer Res.2017 Lenti TL502437
YWHAZ Down-regulation of 14-3-3 zeta sensitizes human glioblastoma cells to apoptosis induction Apoptosis 2018 Lenti TL308321V
ZBP1 Mitochondrial DNA damage and subsequent activation of Z-DNA binding protein 1 links oxidative stress to inflammation in epithelial cells Sci Rep 2018 Lenti TL300389
ZBTB17 Miz1, a Novel Target of ING4, Can Drive Prostate Luminal Epithelial Cell Differentiation Prostate 2016 Lenti RC216143L1
ZBTB7A The miR-372-ZBTB7A Oncogenic Axis Suppresses TRAIL-R2 Associated Drug Sensitivity in Oral Carcinoma Front Oncol 2020 Lenti RC222759L2
ZDHHC18 DHHC protein family targets different subsets of glioma stem cells in specific niches J. Exp. Clin. Cancer Res. 2019 Lenti RC209313L3
ZDHHC23 DHHC protein family targets different subsets of glioma stem cells in specific niches J. Exp. Clin. Cancer Res. 2019 Lenti RC207272L3
ZDHHC23 DHHC protein family targets different subsets of glioma stem cells in specific niches J. Exp. Clin. Cancer Res. 2019 Lenti TL300344
ZEB1 Zeb1-Hdac2-eNOS circuitry identifies early cardiovascular precursors in naive mouse embryonic stem cells Nat Commun 2018 Lenti MR223095L2V
ZEB1 Knockdown of ZEB1 suppressed the formation of vasculogenic mimicry and epithelial-mesenchymal transition in the human breast cancer cell line MDA-MB-231 Mol Med Rep 2018 Lenti TL301174
ZEB1 MicroRNA-141 and MicroRNA-146b-5p Inhibit the pro-Metastatic Mesenchymal Characteristics through the RNA Binding Protein AUF1 Targeting the Transcription Factor ZEB1 and the Protein Kinase AKT J. Biol. Chem. Sep 2014 Lenti TL301174
ZEB2 A pre-existing population of ZEB2+ quiescent cells with stemness and mesenchymal features dictate chemoresistance in colorectal cancer J. Exp. Clin. Cancer Res. 2020 Lenti RC215227L2
Zfp143 The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain Nat. Genet. 2017 Lenti TL502149
ZG16B PAUF/ZG16B promotes colorectal cancer progression through alterations of the mitotic functions and the Wnt/β-catenin pathway Carcinogenesis 2019 Lenti TL307561
ZIC2 ZIC2 is Essential for Maintenance of Latency and is a Target of an Immediate-Early Protein during KSHV Lytic Reactivation J. Virol. 2017 Lenti RC220798L1