siRNA Citations

OriGene products have been used extensively by scientists worldwide to improve their research efficiency. For your reference, we have collected a representation of citations for selected OriGene products and posted them at this site.

Search citations by gene symbols or target names

Here are some of the recent papers making use of OriGene products by fellow researchers.

Target Research Paper Journal Product SKU
Optimization of Transfection Conditions for siRNA Screening Methods Mol. Biol. 2016 siRNA SR30004
MicroRNA-19b inhibits proliferation of gastric cancer cells by targeting B-cell CLL/lymphoma 3 Oncol. Rep. 2016 siRNA SR30004
Bone marrow adipocytes promote the warburg phenotype in metastatic prostate tumors via HIF-1a activation Oncotarget 2016 siRNA SR30004
Transcription factor TBX4 regulates myofibroblast accumulation and lung fibrosis J. Clin. Invest. 2016 siRNA SR30004
HERG ???? NF-?B ?????????????? ??????? 2016 siRNA SR30004
CXCL12/CXCR4 Axis Activation Mediates Prostate Myofibroblast Phenoconversion through Non-Canonical EGFR/MEK/ERK Signaling PLoS ONE 2016 siRNA SR30004
Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction cience Translational Medicine Mar 2016 siRNA SR30004
MAPK1E322K mutation increases head and neck squamous cell carcinoma sensitivity to erlotinib through enhanced secretion of amphiregulin Oncotarget Mar 2016 siRNA SR30004
DNA Methylation Profiling in Human Huntington's Disease Brain Hum. Mol. Genet. Mar 2016 siRNA SR30003
DNA Methylation Profiling in Human Huntington's Disease Brain Hum. Mol. Genet. Mar 2016 siRNA SR30004
AIM2 Inflammasome Mediates Arsenic-induced Secretion of IL-1 beta and IL-18 OncoImmunology Mar 2016 siRNA SR30004
Inhibition of adhesion, migration and of a5ß1 integrin in the HCT-116 colorectal cancer cells treated with the ruthenium drug NAMI-A J. Inorg. Biochem. Feb 2016 siRNA SR30005
HIF1a deficiency reduces inflammation in a mouse model of proximal colon cancer Dis Model Mech 2015 siRNA SR30004
L-GILZ binds p53 and MDM2 and suppresses tumor growth through p53 activation in human cancer cells Cell Death Differ. Aug 2014 siRNA SR301284
A switch from canonical to noncanonical Wnt signaling mediates early differentiation of human neural stem cells Stem Cells Aug 2014 siRNA SR301068
A switch from canonical to noncanonical Wnt signaling mediates early differentiation of human neural stem cells Stem Cells Aug 2014 siRNA SR300974
Acute Hantavirus Infection Induces Galectin-3 Binding Protein J. Gen. Virol. July 2014 siRNA SR302677
A novel function of HER2/Neu in the activation of G2/M checkpoint in response to ?-irradiation Oncogene Jun 2014 siRNA SR301445
CstF-64 supports pluripotency and regulates cell cycle progression in embryonic stem cells through histone 3' end processing Nucleic Acids Res. Jun 2014 siRNA SR301049
HIV and HCV Activate the Inflammasome in Monocytes and Macrophages via Endosomal Toll-Like Receptors without Induction of Type 1 Interferon PLoS Pathog. May 2014 siRNA SR308675
Hypoxia Inducible Regulation of Placental BOK Expression Biochem. J. May 2014 siRNA SR301415
Rescue of enzymatic function for disease-associated RPE65s containing various missense mutations in non-active sites J. Biol. Chem. May 2014 siRNA SR303852
HES1 Adropin preserves the blood-brain barrier through a Notch1/Hes1 pathway after intracerebral hemorrhage in mice J. Neurochem.2017 siRNA SR408110
JMJD6 Demethylase JMJD6 as a new regulator of interferon signaling: effects of HCV and ethanol metabolism Cellular and Molecular Gastroenterology and Hepatology 2017 siRNA SR308094
KDM5B Melanoma topology reveals a stem-like phenotype that promotes angiogenesis Sci Adv 2017 siRNA SR427794
MYC Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development Nat Commun 2017 siRNA SR321047
NOTCH1 Adropin preserves the blood-brain barrier through a Notch1/Hes1 pathway after intracerebral hemorrhage in mice J. Neurochem.2017 siRNA SR303207
RSPO1 Sirtuin-6 Preserves R-spondin-1 Expression and Increases Resistance of Intestinal Epithelium to Injury in Mice Mol Med. 2017 siRNA SR407587
SIRT6 Sirtuin-6 Preserves R-spondin-1 Expression and Increases Resistance of Intestinal Epithelium to Injury in Mice Mol Med. 2017 siRNA SR411215
STK33 STK33 promotes growth and progression of pancreatic cancer as a critical downstream mediator of HIF-1α Cancer Res. 2017 siRNA SR312240
TXNIP Protein acyltransferase DHHC3 regulates breast tumor growth, oxidative stress and senescence Cancer Res. 2017 siRNA SR307241
ABCA1 High-density lipoprotein and apolipoprotein A-I inhibit palmitate-induced translocation of toll-like receptor 4 into lipid rafts and inflammatory cytokines in 3T3-L1 adipocytes Biochem. Biophys. Res. Commun 2017 siRNA SR423449
ABCA1 Activation of Liver X Receptors inhibits of Hedgehog signaling, clonogenic growth,and self-renewal in multiple myeloma Mol. Cancer Ther. May 2014 siRNA SR300011
ABCB10 ABCB10 depletion reduces unfolded protein response in mitochondria Biochem. Biophys. Res. Commun 2017 siRNA SR308286
ABCC1 Cycloartenyl Ferulate Inhibits Paraquat-Induced Apoptosis in HK-2 Cells With the Involvement of ABCC1 J. Cell. Biochem. Sep 2015 siRNA SR302963
ABCG1 High-density lipoprotein and apolipoprotein A-I inhibit palmitate-induced translocation of toll-like receptor 4 into lipid rafts and inflammatory cytokines in 3T3-L1 adipocytes Biochem. Biophys. Res. Commun 2017 siRNA SR418897
ACLY Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination Mol. Cell 2017 siRNA SR300035
ACP1 LY6E: a conductor of malignant tumor growth through modulation of the PTEN/PI3K/Akt/HIF-1 axis Oncotarget 2016 siRNA SR30004
ACSL4 Six1 promotes colorectal cancer growth and metastasis by stimulating angiogenesis and recruiting tumor-associated macrophages Carcinogenesis 2017 siRNA SR301523
ADAM10 Chemotherapy stimulates syndecan-1 shedding: A potentially negative effect of treatment that may promote tumor relapse siRNA SR300066
ADAM17 Chemotherapy stimulates syndecan-1 shedding: A potentially negative effect of treatment that may promote tumor relapse siRNA SR304689
ADAP The adapter proteins ADAP and Nck cooperate in T cell adhesion Mol. Immunol. 72-79 60 1. April 2014 siRNA SR301681
ADH5 O-Aminobenzoyl-S-nitrosoglutathione: A fluorogenic, cell permeable, pseudo-substrate for S-nitrosoglutathione reductase Free Radic. Biol. Med. 2017 siRNA SR412637
Adipor1 Effects of obesity on severity of colitis and cytokine expression in mouse mesenteric fat. Potential role of adiponectin receptor 1 Am. J. Physiol. Gastrointest. Liver Physiol. Jan 2015 siRNA SR412651
Ago1 Novel functional small RNAs are selectively loaded onto mammalian Ago1 Nucleic Acids Res. Mar 2014 siRNA SR308857
AKT1 Follicular Stimulating Hormone Accelerates Atherogenesis by Increasing Endothelial VCAM-1 Expression Theranostics 2017 siRNA SR300143
AKT1 Modulation of EZH2 expression by MEK-ERK or PI3K-AKT signaling in lung cancer is dictated by different KRAS oncogene mutations Cancer Res. Dec 2015 siRNA SR300143
AKT1 Concurrent Targeting of KRAS and AKT by MiR-4689 Is a Novel Treatment Against Mutant KRAS Colorectal Cancer Mol Ther Nucleic Acids Mar 2015 siRNA SR300143
AKT1 PI3K/AKT pathway mediates induction of IL-1RA by TSH in fibrocytes: Modulation by PTEN J. Clin. Endocrinol. Metab. May 2014 siRNA SR300143
AKT1 Angiopoietin-2 secretion by endothelial cells exosome: regulation by the PI3K/Akt/eNOS and syndecan 4/syntenin pathways J. Biol. Chem. Nov 2013 siRNA SR300143
AKT1 Rb1 family mutation is sufficient for sarcoma initiation Nat Commun. 2013 Oct 23;4:2650 siRNA SR415524
AKT2 miR-608 regulates apoptosis in human lung adenocarcinoma via regulation of AKT2 Int. J. Oncol. 2017 siRNA SR300144
AKT2 Modulation of EZH2 expression by MEK-ERK or PI3K-AKT signaling in lung cancer is dictated by different KRAS oncogene mutations Cancer Res. Dec 2015 siRNA SR300144
AKT3 Modulation of EZH2 expression by MEK-ERK or PI3K-AKT signaling in lung cancer is dictated by different KRAS oncogene mutations Cancer Res. Dec 2015 siRNA SR306727
ALDH18A1 Global metabolic profiling identifies a pivotal role of proline and hydroxyproline metabolism in supporting hypoxic response in hepatocellular carcinoma Clin. Cancer Res.2017 siRNA SR303932
ANGPT2 Angiopoietin-2 secretion by endothelial cells exosome: regulation by the PI3K/Akt/eNOS and syndecan 4/syntenin pathways J. Biol. Chem. Nov 2013 siRNA SR300199
ANXA2 Annexin A2 Mediates Mycoplasma pneumoniae Community-Acquired Respiratory Distress Syndrome Toxin Binding to Eukaryotic Cells MBio Aug 2014 siRNA SR300208
APEX1 AT101 exerts a synergetic efficacy in gastric cancer patients with 5-FU based treatment through promoting apoptosis and autophagy Oncotarget 2016 siRNA SR300230
APLP2 Amyloid precursor-like protein 2 and sortilin do not regulate the PCSK9 convertase-mediated low density lipoprotein receptor degradation but interact with each other J. Biol. Chem. Jun 2015 siRNA SR300236
AR c-MYC drives histone demethylase PHF8 during neuroendocrine differentiation and in castration-resistant prostate cancer Oncotarget 2016 siRNA SR300264
ARF6 EGFR/ARF6 regulation of Hh signalling stimulates oncogenic Ras tumour overgrowth Nat Commun 2017 siRNA SR300275
ARG2 Human cytomegalovirus may promote tumour progression by upregulating arginase-2 Oncotarget 2016 siRNA SR300277
ARID2 Targeted next-generation sequencing for molecular diagnosis of endometriosis-associated ovarian cancer J. Mol. Med. Feb 2016 siRNA SR316272
ARNT Defining the role of oxygen tension in human neural progenitor fate Stem Cell Reports Nov 2014 siRNA SR300295
ARNT Hypoxia Inducible Regulation of Placental BOK Expression Biochem. J. May 2014 siRNA SR300295
ASAH1 Acid Ceramidase in Melanoma: Expression, Localization and Effects of Pharmacological Inhibition J. Biol. Chem. Nov 2015 siRNA SR300310
ASNS Knockdown of asparagine synthetase (ASNS) suppresses cell proliferation and inhibits tumor growth in gastric cancer cells Scand. J. Gastroenterol. Jun 2016 siRNA SR300319
ATF2 A switch from canonical to noncanonical Wnt signaling mediates early differentiation of human neural stem cells Stem Cells Aug 2014 siRNA SR300975
ATF6 Alkylating agent induced NRF2 blocks endoplasmic reticulum stress-mediated apoptosis via control of glutathione pools and protein thiol homeostasis Mol. Cancer Ther. 2016 siRNA SR307883
ATF6 Endoplasmic reticulum stress mediates house dust mite-induced airway epithelial apoptosis and fibrosis Respir. Res. Dec 2013. siRNA SR418766
ATG5 Countervailing, time-dependent effects on host autophagy promotes intracellular survival of leishmania J. Biol. Chem. 2017 siRNA SR306286
ATG5 Viability of primary cultured podocytes is associated with extracellular high glucose-dependent autophagy downregulation Mol. Cell. Biochem 2017 siRNA SR504857
ATG5 Reactive oxygen species are involved in insulin-dependent regulation of autophagy in primary rat podocytes Int. J. Biochem. Cell Biol. Mar 2016 siRNA SR504857
ATG5 The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux Autophagy Jun 2015 siRNA SR306286
ATG5 Antagonism of tumoral prolactin receptor promotes autophagy-related cell death Cell Rep 488-500 7 2. April 2014 siRNA SR306286
Atg5 Increased drug resistance associated with reduced glucose levels and an enhanced glycolysis phenotype Br. J. Pharmacol. Mar 2014 siRNA SR306286
ATG7 Liposomal honokiol induced lysosomal degradation of Hsp90 client proteins and protective autophagy in both gefitinib-sensitive and gefitinib-resistant NSCLC cells Biomaterials 2017 siRNA SR307159
Atg7 The Effect of Mechanical Ventilation on Lung Epithelial Cell Fate thesis Mar 2016 siRNA SR507240
ATG9A Countervailing, time-dependent effects on host autophagy promotes intracellular survival of leishmania J. Biol. Chem. 2017 siRNA SR312320
ATM Apoptosis-related protein-2 triggers melanoma cell death by a mechanism including both endoplasmic reticulum stress and mitochondrial dysregulation Carcinogenesis, Aug 2011; 32: 1268 - 1278. siRNA SR300330
Atox1 Roles of Atox1 and p53 in the trafficking of copper-64 to tumor cell nuclei: implications for cancer therapy J. Biol. Inorg. Chem., Jan 2014. siRNA SR300333
ATP13A3 ATP13A3 and caveolin-1 as potential biomarkers for difluoromethylornithine-based therapies in pancreatic cancers Am J Cancer Res 2016 siRNA SR312433
Atp6ap2 High Potassium Promotes Mutual Interaction between (Pro)Renin Receptor and the Local Renin-Angiotensin-Aldosterone System in Rat IMCD Cells Am. J. Physiol., Cell Physiol. 2016 siRNA SR411813
ATP6V0A2 Mammary epithelium-specific inactivation of V-ATPase reduces stiffness of extracellular matrix and enhances metastasis of breast cancer Mol Oncol 2017 siRNA SR323628
Atp6v0a2 The V-ATPase a2 isoform controls mammary gland development through Notch and TGF-ß signaling Cell Death Dis 2016 siRNA SR420750
AXL The receptor tyrosine kinase AXL mediates nuclear translocation of the epidermal growth factor receptor Sci Signal 2017 siRNA SR300386
BAG3 Withaferin A Induces Cell Death Selectively in Androgen-Independent Prostate Cancer Cells but Not in Normal Fibroblast Cells PLoS ONE Aug 2015 siRNA SR306333
BBC3 Harnessing the p53-PUMA Axis to Overcome DNA Damage Resistance in Renal Cell Carcinoma Neoplasia Dec 2014 siRNA SR308982
BCAM BCAM and LAMA5 Mediate the Recognition between Tumor Cells and the Endothelium in the Metastatic Spreading of KRAS Mutant Colorectal Cancer Clin. Cancer Res. May 2016 siRNA SR302744
BCL2 microRNA-10b Is Overexpressed and Critical for Cell Survival and Proliferation in Medulloblastoma PLoS ONE Sep 2015 siRNA SR300411
BCL2 Platelet-Derived Growth Factor Primes Cancer-Associated Fibroblasts For Apoptosis J. Biol. Chem. Jun 2014 siRNA SR300411
BCL3 MicroRNA-19b inhibits proliferation of gastric cancer cells by targeting B-cell CLL/lymphoma 3 Oncol. Rep. 2016 siRNA SR300415
BCL9L Single-walled carbon nanotubes functionalized with aptamer and piperazine-polyethylenimine derivative for targeted siRNA delivery into breast cancer cells Int J Pharm Feb 2015 siRNA SR316986
BECN1 SESN2 facilitates mitophagy by helping Parkin translocation through ULK1 mediated Beclin1 phosphorylation Sci Rep 2018 siRNA SR322490
BECN1 The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux Autophagy Jun 2015 siRNA SR305711
BECN1 GX15-070 (Obatoclax) Induces Apoptosis and Inhibits Cathepsin D- and L–Mediated Autophagosomal Lysis in Antiestrogen-Resistant Breast Cancer Cells Mol. Cancer Ther., Apr 2013; 12: 448 - 459. siRNA SR305711
BID BID-dependent release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella EMBO J. July 2014 siRNA SR300435
BIRC3 IL-1β induces up-regulation of BIRC3, a gene involved in chemoresistance to doxorubicin in breast cancer cells Cancer Lett 2017 siRNA SR319355
BIRC3 NPD1-mediated stereoselective regulation of BIRC3 expression through cREL is decisive for neural cell survival Cell Death Differ. Jan 2015 siRNA SR300232
Blvra Bliverdin reductase-A improves neurological function in a germinal matrix hemorrhage rat model Neurobiol. Dis. 2017 siRNA SR512469
Braf Identification of Bisindolylmaleimide IX as a potential agent to treat drug-resistant BCR-ABL positive leukemia Oncotarget 2016 siRNA SR420296
BRAF The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux Autophagy Jun 2015 siRNA SR300470
BRD2 H2A. Z. 1 Monoubiquitylation Antagonizes BRD2 to Maintain Poised Chromatin in ESCs Cell Reports Feb 2016 siRNA SR419051
BRD4 H2A. Z. 1 Monoubiquitylation Antagonizes BRD2 to Maintain Poised Chromatin in ESCs Cell Reports Feb 2016 siRNA SR422790
BRMS1 MicroRNA-423 enhances the invasiveness of hepatocellular carcinoma via regulation of BRMS1 Am J Transl Res 2017 siRNA SC207572
BTRC Role of integrin-linked kinase in regulating the protein stability of the MUC1-C oncoprotein in pancreatic cancer cells Oncogenesis 2017 siRNA SR305917
C3 C3a Increases VEGF and Decreases PEDF mRNA Levels in Human Retinal Pigment Epithelial Cells BioMed Research International 2016 siRNA SR300499
C3AR1 Tumor necrosis-initiated complement activation stimulates proliferation of medulloblastoma cells Inflamm. Res. Jan 2015 siRNA SR300500
C87436 NF-κB-Dependent Upregulation of (Pro)Renin Receptor Mediates High NaCl-Induced Apoptosis in Mouse Inner Medullary Collecting Duct Cells Am. J. Physiol., Cell Physiol. 2017 siRNA SR41760
Calr Aberrant Calreticulin Expression in Articular Cartilage of Dio2 Deficient Mice PLoS ONE May 2016 siRNA SR413808
Camk2a Dihydrolipoic Acid Inhibits Lysosomal Rupture and NLRP3 Through Lysosome-Associated Membrane Protein-1/Calcium/Calmodulin-Dependent Protein Kinase II/TAK1 Pathways After Subarachnoid Hemorrhage in Rat Stroke 2018 siRNA SR500835
CAPN2 Targeting Cellular Calcium Homeostasis to Prevent Cytokine-Mediated Beta Cell Death Sci Rep 2017 siRNA SR300579
CARD9 The Myeloid LSECtin Is a DAP12-Coupled Receptor That Is Crucial for Inflammatory Response Induced by Ebola Virus Glycoprotein PLoS one Mar 2016 siRNA SR311981
Casp8 Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4 Cell Rep 2017 siRNA SR415523
CAV1 Follicular Stimulating Hormone Accelerates Atherogenesis by Increasing Endothelial VCAM-1 Expression Theranostics 2017 siRNA SR319567
CAV1 CD47 and Nox1 Mediate Dynamic Fluid-Phase Macropinocytosis of Native LDL Antioxid. Redox Signal 2016 siRNA SR404266
CAV1 SMN affects membrane remodelling and anchoring of the protein synthesis machinery J. Cell. Sci. Jan 2016 siRNA SR300603
CBX4 CBX4-mediated SUMO modification regulates BMI1 recruitment at sites of DNA damage Nucleic Acids Res., Jul 2012; 40: 5497 - 5510. siRNA SR305603
CCNA2 CCNA2 facilitates epithelial-to-mesenchymal transition via the integrin αvβ3 signaling in NSCLC Int J Clin Exp Patho 2017 siRNA SR300626
CCND1 Mig-6 is down-regulated in HCC and inhibits the proliferation of HCC cells via the P-ERK/Cyclin D1 pathway Exp. Mol. Pathol. 2017 siRNA SR300410
CD133 Nerve growth factor regulates CD133 function to promote tumor cell migration and invasion via activating ERK1/2 signaling in pancreatic cancer Pancreatology 2016 siRNA SR305838
CD14 LPS and IL-1 differentially activate mouse and human astrocytes: Role of CD14 Glia Mar 2014 siRNA SR412356
CD163 The New Role of CD163 in the Differentiation of Bone Marrow Stromal Cells into Vascular Endothelial-Like Cells Stem Cells International Jan 2016 siRNA SR506300
CD24 CD24 expression is a marker for predicting clinical outcome and regulates the epithelial-mesenchymal transition in ovarian cancer via both the Akt and ERK pathways Oncol. Rep. 2017 siRNA SR319178
CD274 Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition. J. Clin. Invest. 2016 siRNA SC115168
CD274 MiR-570 inhibited the cell proliferation and invasion through directly targeting B7-H1 in hepatocellular carcinoma Tumour Biol. Jun 2015 siRNA SR309223
CD276 Hepatocellular carcinomas promote tumor-associated macrophage M2-polarization via increased B7-H3 expression Oncol. Rep. Jan 2015 siRNA SR312921
CD2BP2 TEG-1 CD2BP2 controls miRNA levels by regulating miRISC stability in C. elegans and human cells Nucleic Acids Res. 2016 siRNA SR307065
CD36 Oxidized LDL activated eosinophil polarize macrophage phenotype from M2 to M1 through activation of CD36 scavenger receptor Atherosclerosis 2017 siRNA SR300671
CD36 Inhibition of glutathione production induces macrophage CD36 expression and enhances cellular oxLDL uptake J. Biol. Chem. Jul 2015 siRNA SR300671
CD38 CD38 Mediates Angiotensin II-induced Intracellular Ca(2+) Release in Rat Pulmonary Arterial Smooth Muscle Cells Am. J. Respir. Cell Mol. Biol. July 2014 siRNA SR509476
CD3EAP Stem cell and neurogenic gene-expression profiles link prostate basal cells to aggressive prostate cancer Nat Commun Feb 2016 siRNA SR307394
CD46 Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses Immunity Jun 2015 siRNA SR302841
CD46 Intracellular sensing of complement C3 activates cell autonomous immunity Science Sep 2014 siRNA SR302841
CD55 Intracellular sensing of complement C3 activates cell autonomous immunity Science Sep 2014 siRNA SR301131
CDC25B Lats1 suppresses centrosome overduplication by modulating the stability of Cdc25B Sci Rep Nov 2015 siRNA SR417180
CDC42 MicroRNA-141 suppresses prostate cancer stem cells and metastasis by targeting a cohort of pro-metastasis genes Nat Commun 2017 siRNA SR300714
CDH13 Stem cell and neurogenic gene-expression profiles link prostate basal cells to aggressive prostate cancer Nat Commun Feb 2016 siRNA SR300727
CDK14 MiR-1202 suppresses hepatocellular carcinoma cells migration and invasion by targeting cyclin dependent kinase 14 Biomed. Pharmacother. 2017 siRNA SR303472
CDK5 Phosphorylation of kinase insert domain receptor by cyclin-dependent kinase 5 at serine 229 is associated with invasive behavior and poor prognosis in prolactin pituitary adenomas Oncotarget 2016 siRNA SR507441
CDKN1A T-cell intracellular antigens function as tumor suppressor genes Cell Death Dis Mar 2015 siRNA SR300740
CEBPB WNK4 is an adipogenic factor and its deletion reduces diet-induced obesity in mice EBioMedicine 2017 siRNA SR408590
CENPA Human Centromeres Produce Chromosome-Specific and Array-Specific Alpha Satellite Transcripts that Are Complexed with CENP-A and CENP-C Dev. Cell 2017 siRNA SR300765
CFL1 Nox2-mediated PI3K and Cofilin Activation Confers Alternate Redox Control of Macrophage Pinocytosis Antioxid. Redox Signal. 2016 siRNA SR300775
Cflar Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4 Cell Rep 2017 siRNA SR400039
CHADL Novel Small Leucine-Rich Protein Chondroadherin-like (CHADL) is Expressed in Cartilage and Modulates Chondrocyte Differentiation J. Biol. Chem. Dec 2014 siRNA SR419797
CHD5 miRNA-24-3p promotes cell proliferation and regulates chemosensitivity in head and neck squamous cell carcinoma by targeting CHD5 Future Oncol 2016 siRNA SR307707
Chil1 Atherosclerosis is exacerbated by chitinase-3-like-1 in amyloid precursor protein transgenic mice Theranostics 2018 siRNA SR412856
CHMP2B CALML5 is a ZNF750- and TINCR-induced protein that binds stratifin to regulate epidermal differentiation Genes Dev. Nov 2015 siRNA SR308637
CHOP Oleate attenuates palmitate-induced endoplasmic reticulum stress and apoptosis in placental trophoblasts Reproduction 2017 siRNA SR301166
CIITA Class II transactivator knockdown limits major histocompatibility complex II expression, diminishes immune rejection, and improves survival of allogeneic bone marrow stem cells in the infarcted heart FASEB J. May 2016 siRNA SR302895
CIRH1A Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA Proc. Natl. Acad. Sci. U.S.A. 2016 siRNA SR313737
CITED2 Electrochemical evaluation of sarcomeric a-actinin in embryoid bodies after gene silencing using an LSI-based amperometric sensor array Anal. Methods . April 2014 siRNA SR307027
CLASP1 Centrosome-declustering drugs mediate a two-pronged attack on interphase and mitosis in supercentrosomal cancer cells Cell Death Dis Nov 2014 siRNA SR308193
CLEC4E Macrophage inducible C-type lectin (Mincle) recognizes glycosylated surface (S)-layer of the periodontal pathogen Tannerella forsythia PLoS ONE 2017 siRNA SR308788
CLTC Nox2-mediated PI3K and Cofilin Activation Confers Alternate Redox Control of Macrophage Pinocytosis Antioxid. Redox Signal. 2016 siRNA SR300867
CLTC Role of flotillins in the endocytosis of GPCR in salivary gland epithelial cells Biochem. Biophys. Res. Commun. May 2016 siRNA SR300867
CLU Therapeutic targeting of myeloid-derived suppressor cells involves a novel mechanism mediated by clusterin Sci Rep 2016 siRNA SR300853
CNOT2 CNOT2 promotes proliferation and angiogenesis via VEGF signaling in MDA-MB-231 breast cancer cells Cancer Lett. 2017 siRNA SR303204
COL11A1 Activation of TWIST1 by COL11A1 promotes chemoresistance and inhibits apoptosis in ovarian cancer cells by modulating NF-κB-mediated IKKβ expression Int. J. Cancer 2017 siRNA SR300918
COL11A1 COL11A1 promotes tumor progression and predicts poor clinical outcome in ovarian cancer Oncogene doi:10.1038/onc.2013.307 siRNA SR300918
COMMD1 Copper metabolism domain-containing 1 represses the mediators involved in the terminal effector pathways of human labour and delivery Mol. Hum. Reprod. Jan 2016 siRNA SR315744
control siRNA Low Dose Ultraviolet B Irradiation Increases Hyaluronan Synthesis in Epidermal Keratinocytes via Sequential Induction of Hyaluronan Synthases Has1–3 Mediated by p38 and Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) Signaling J. Biol. Chem., Jun 2013; 288: 17999 - 18012. siRNA SR30004
COX2 MiR-21 Targets 15-PGDH and Promotes Cholangiocarcinoma Growth Mol. Cancer Res. April 2014 siRNA SR303873
CREB3 STIM-1 and ORAI-1 Channel Mediate Angiotensin-II-Induced Expression of Egr-1 in Vascular Smooth Muscle Cells J. Cell. Physiol 2017 siRNA SR500635
CRKL Escherichia coli virulence protein NleH1 interaction with the v-crk sarcoma virus CT10 oncogene-Like protein (CRKL) governs NleH1 inhibition of the ribosomal protein S3 (RPS3)/NF-kappaB pathway J Biol Chem. 2013 Oct 21 siRNA SR300987
CSA Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA Proc. Natl. Acad. Sci. U.S.A. 2016 siRNA SR300835
CSB Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA Proc. Natl. Acad. Sci. U.S.A. 2016 siRNA SR301453
CSF1R Osteosarcoma cell-intrinsic colony stimulating factor-1 receptor functions to promote tumor cell metastasis through JAG1 signaling Am J Cancer Res 2017 siRNA SR301013
CTCF DNA Methylation Profiling in Human Huntington's Disease Brain Hum. Mol. Genet. Mar 2016 siRNA SR307273
CTCF Identification of CTCF as a master regulator of the clustered protocadherin genes Nucleic Acids Res., Apr 2012; 40: 3378 - 3391. siRNA SR307273
CTGF Angiotensin II induces connective tissue growth factor expression in human hepatic stellate cells by a transforming growth factor β-independent mechanism Sci Rep 2017 siRNA SR301057
CTGF KCTD11 inhibits growth and metastasis of hepatocellular carcinoma through activating Hippo signaling Oncotarget 2017 siRNA SR301057
CTNNA3 Copy Number Variations in CTNNA3 and RBFOX1 Associate with Pediatric Food Allergy J. Immunol. Jul 2015 siRNA SR309217
CTNNB1 A novel microRNA regulator of prostate cancer epithelial-mesenchymal transition Cell Death Differ. 2017 siRNA SR301063
CTNNB1 Stem cell and neurogenic gene-expression profiles link prostate basal cells to aggressive prostate cancer Nat Commun Feb 2016 siRNA SR301063
CTNNB1 Altered Protease-Activated Receptor-1 Expression and Signaling in a Malignant Pleural Mesothelioma Cell Line, NCI-H28, with Homozygous Deletion of the ß-Catenin Gene PLoS ONE Nov 2014 siRNA SR301063
CTR1 Dextran-Catechin: An anticancer chemically-modified natural compound targeting copper that attenuates neuroblastoma growth Oncotarget 2016 siRNA SR300931
Cttn Inhibition of stress fiber formation preserves blood-brain barrier after intracerebral hemorrhage in mice J. Cereb. Blood Flow Metab. 2016 siRNA SR416350
CTTN PDCD10 (CCM3) regulates brain endothelial barrier integrity in cerebral cavernous malformation type 3: role of CCM3-ERK1/2-cortactin cross-talk Acta Neuropathol. Sep 2015 siRNA SR301402
CUL1 TRIM26 Negatively Regulates Interferon-ß Production and Antiviral Response through Polyubiquitination and Degradation of Nuclear IRF3 PLoS Pathog. Mar 2015 siRNA SR305540
CUL4A Recurrent Amplification at 13q34 Targets at CUL4A, IRS2, and TFDP1 As an Independent Adverse Prognosticator in Intrahepatic Cholangiocarcinoma PLoS ONE Dec 2015 siRNA SR305537
CUTC Silencing of Human CutC Gene (hCutC) Induces Apoptosis in HepG2 Cells Biol Trace Elem Res Dec 2015 siRNA SR309512
Cx43 Cannabinoids prevent the amyloid ß-induced activation of astroglial hemichannels: A neuroprotective mechanism Glia 2016 siRNA SR412884
Cy-3-labeled control siRNA cAMP-responsive Element Modulator a (CREMa) Suppresses IL-17F Protein Expression in T Lymphocytes from Patients with Systemic Lupus Erythematosus (SLE) J. Biol. Chem., Feb 2012; 287: 4715 - 4725. siRNA
Cyp1a1 LRH-1 mediates anti-inflammatory and antifungal phenotype of IL-13-activated macrophages through the PPAR? ligand synthesis Nat Commun Apr 2015 siRNA SR416691
Cyp1b1 LRH-1 mediates anti-inflammatory and antifungal phenotype of IL-13-activated macrophages through the PPAR? ligand synthesis Nat Commun Apr 2015 siRNA SR417055
CYP2J2 CYP2J2 expression in adult ventricular myocytes protects against external and drug induced ROS toxicity Drug Metab. Dispos. 2018 siRNA SR301109
CYP7A1 Simvastatin promotes NPC1-mediated free cholesterol efflux from lysosomes through CYP7A1/LXRa signalling pathway in oxLDL-loaded macrophages J. Cell. Mol. Med. 2016 siRNA SR319873
DCC Netrin-1 Preserves Blood-Brain Barrier Integrity Through Deleted in Colorectal Cancer/Focal Adhesion Kinase/RhoA Signaling Pathway Following Subarachnoid Hemorrhage in Rats J Am Heart Assoc 2017 siRNA SR502160
DDIT3 Withaferin A Induces Cell Death Selectively in Androgen-Independent Prostate Cancer Cells but Not in Normal Fibroblast Cells PLoS ONE Aug 2015 siRNA SR301166
DGFRB Platelet-Derived Growth Factor Receptor-β Regulates Vascular Smooth Muscle Cell Phenotypic Transformation and Neuroinflammation After Intracerebral Hemorrhage in Mice Crit. Care Med. 2016 siRNA SR422058
DHFR Towards Identifying Novel Modulators and Targets for Alzheimer's Disease Therapy Thesis Jul 2014 siRNA SR301197
DKK3 A novel FOXO1-mediated dedifferentiation blocking role for DKK3 in adrenocortical carcinogenesis BMC Cancer 2017 siRNA SR308986
DLG1 SAP97 blocks the RXR ER retention signal of NMDA receptor subunit GluN1-3 through its SH3 domain Biochim. Biophys. Acta Dec 2014 siRNA SR301211
DLGAP5 Hepatoma upregulated protein expression is involved in the pathogenesis of human breast carcinogenesis Oncol Lett Oct 2014 siRNA SR306548
DLK1 The adaptor SASH1 acts through NOTCH1 and its inhibitor DLK1 in a 3D model of lumenogenesis involving CEACAM1. Exp. Cell Res. 2017 siRNA SR305789
DMPK The pyrazolyl-urea GeGe3 inhibits tumor angiogenesis and reveals dystrophia myotonica protein kinase (DMPK)1 as a novel angiogenesis target Oncotarget 2017 siRNA SR301227
DNAJC10 IRE1 prevents endoplasmic reticulum membrane permeabilization and cell death under pathological conditions Sci Signal Jun 2015 siRNA SR512297
DNM1L Dynamin-related protein 1 mediates low glucose-induced endothelial dysfunction in human arterioles. Am. J. Physiol. Heart Circ. Physiol 2017 siRNA SR306774
DNMT3A Hypoxia-induced endothelial-mesenchymal transition is associated with RASAL1 promoter hypermethylation in human coronary endothelial cells FEBS Lett. Apr 2016 siRNA SR301246
DNMT3a cAMP responsive element modulator (CREM)a mediates chromatin remodeling of CD8 during the generation of CD3+CD4-CD8- T cells J. Biol. Chem. Dec 2013. siRNA SR301246
DNMT3a cAMP response element modulator a controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus PNAS, Oct 2012; 109: 16606 - 16611. siRNA SR301246
DROSHA Novel functional small RNAs are selectively loaded onto mammalian Ago1 Nucleic Acids Res. Mar 2014 siRNA SR309202
DSC3 The p53 target gene desmocollin 3 acts as a novel tumor suppressor through inhibiting EGFR/ERK pathway in human lung cancer Carcinogenesis, Dec 2012; 33: 2326 - 2333. siRNA SR421036
DSG2 Desmoglein 2 promotes vasculogenic mimicry in melanoma and is associated with poor clinical outcome Oncotarget 2016 siRNA SR301282
DSG2 A non-canonical role for desmoglein-2 in endothelial cells: implications for neoangiogenesis Angiogenesis 2016 siRNA SR301282
DSP Desmoplakin acts as a tumor suppressor by inhibition of the Wnt/ß-catenin signaling pathway in human lung cancer Carcinogenesis, Oct 2012; 33: 1863 - 1870. siRNA SR301285
DUSP16 Angiotensin II induces connective tissue growth factor expression in human hepatic stellate cells by a transforming growth factor β-independent mechanism Sci Rep 2017 siRNA SR312968
DUSP4 Modulation of p38 kinase by DUSP4 Is important in regulating cardiovascular function under oxidative stress Free Radic. Biol. Med. Jul 2015 siRNA SR508955
DUSP4 Redox Activation of DUSP4 by N-Acetyl Cysteine Protects Endothelial Cells from Cd(2+)-Induced Apoptosis Free Radic. Biol. Med. Jun 2014 siRNA SR508955
DYN Dynamin controls extracellular level of Awd/Nme1 metastasis suppressor protein Naunyn Schmiedebergs Arch. Pharmacol. 2016 siRNA SR301243
DYRK1A REST Regulates DYRK1A Transcription in a Negative Feedback Loop J. Biol. Chem., Mar 2011; 286: 10755 - 10763 siRNA SR301308
EDG3 Smad3 Deficiency Leads to Mandibular Condyle Degradation via the Sphingosine 1-Phosphate (S1P)/S1P3 Signaling Axis Am. J. Pathol. Aug 2015 siRNA SR412767
EGFR Novel tumor suppressor microRNA at frequently deleted chromosomal region 8p21 regulates epidermal growth factor receptor in prostate cancer Oncotarget 2016 siRNA SR301357
EGFR Celecoxib-erlotinib combination delays growth and inhibits angiogenesis in EGFR-mutated lung cancer Am J Cancer Res 2016 siRNA SR301357
EIF2A Distinctive subcellular inhibition of cytokine-induced SRC by salubrinal and fluid flow PLoS ONE Aug 2014 siRNA SR313291
EIF2AK2 Knockdown of HIP1 expression promotes ligand‑induced endocytosis of EGFR in HeLa cells Oncol. Rep. 2017 siRNA SR303767
EIF2AK2 AIM2 Inflammasome Mediates Arsenic-induced Secretion of IL-1 beta and IL-18 OncoImmunology Mar 2016 siRNA SR303767
Eif2ak3 Unfolded protein response signaling impacts macrophage polarity to modulate breast cancer cell clearance and melanoma immune checkpoint therapy responsiveness Oncotarget 2017 siRNA SR422112
EIF2AK3 Ectopic ATP Synthase Blockade Suppresses Lung Adenocarcinoma Growth by Activating the Unfolded Protein Response Cancer Res., Sep 2012; 72: 4696 - 4706. siRNA SR306267
EIF3B EIF3B silencing inhibits cell proliferation via regulating EGFR/ERK pathway in lung adenocarcinoma Int J Clin Exp Patho 2016 siRNA SR305696
Eif4g2 The thyroid hormone increases bulk histones expression by enhancing translational efficiency Mol. Endocrinol. Nov 2014 siRNA SR421103
EP300 Stat3 promotes IL-10 expression in lupus T cells through trans-activation and chromatin remodeling Proc. Natl. Acad. Sci. U.S.A. Sep 2014 siRNA SR301414
EPAS1 Defining the role of oxygen tension in human neural progenitor fate Stem Cell Reports Nov 2014 siRNA SR301415
EPG5 The Vici syndrome protein EPG5 regulates intracellular nucleic acid trafficking linking autophagy to innate and adaptive immunity Autophagy 2017 siRNA SR311692
EPRS EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice Nature 2017 siRNA SR422951
ERBB2 HER2 Impedes MLK3 Kinase Activity to Support Breast Cancer Cell Survival J. Biol. Chem. Jul 2015 siRNA SR301443
ERBB2 A novel function of HER2/Neu in the activation of G2/M checkpoint in response to ?-irradiation Oncogene Jun 2014 siRNA SR301443
ERBB3 A novel function of HER2/Neu in the activation of G2/M checkpoint in response to ?-irradiation Oncogene Jun 2014 siRNA SR301444
ERBB4 Receptor tyrosine kinase ERBB4 mediates acquired resistance to ERBB2 inhibitors in breast cancer cells Cell Cycle Feb 2015 siRNA SR301445
Ern1 Unfolded protein response signaling impacts macrophage polarity to modulate breast cancer cell clearance and melanoma immune checkpoint therapy responsiveness Oncotarget 2017 siRNA SR421536
ERN1 MYC regulates the unfolded protein response and glucose and glutamine uptake in endocrine resistant breast cancer Mol. Cancer Oct 2014 siRNA SR301457
ERO1A Endoplasmic Reticulum Oxidase 1α is Critical for Collagen Secretion from and Membrane Type 1-Matrix Metalloproteinase levels in Hepatic Stellate Cells J. Biol. Chem. 2017 siRNA SR309340
ESR1 Six1 promotes colorectal cancer growth and metastasis by stimulating angiogenesis and recruiting tumor-associated macrophages Carcinogenesis 2017 siRNA SR301461
ESR1 Transcription factor activity of estrogen receptor a activation upon nonylphenol or bisphenol A treatment enhances the in vitro proliferation, invasion, and migration of neuroblastoma cells Onco Targets Ther 2016 siRNA SR301461
ESR1 17ß-estradiol induces stearoyl-CoA desaturase-1 expression in estrogen receptor-positive breast cancer cells BMC Cancer May 2015 siRNA SR301461
ESR1 Estrogen regulation of anti-apoptotic bcl-2 family member mcl-1 expression in breast cancer cells PLoS ONE Jun 2014 siRNA SR301461
ESR1 Oestrogen induced downregulation of TFPI expression is mediated by ERa Thrombosis Research . April 2014 siRNA SR301461
ETS1 ANGPTL2 increases bone metastasis of breast cancer cells through enhancing CXCR4 signaling Sci Rep Mar 2015 siRNA SR301470
ETS2 Membrane-bound β-catenin degradation is enhanced by ETS2-mediated Siah1 induction in Helicobacter pylori-infected gastric cancer cells Oncogenesis 2017 siRNA SR301471
ETS2 ETS2 and Twist1 promote invasiveness of Helicobacter pylori-infected gastric cancer cells by inducing Siah2 Biochem. J. Apr 2016 siRNA SR301471
EXOSC10 Chromatin Dynamics and the RNA Exosome Function in Concert to Regulate Transcriptional Homeostasis Cell Rep Nov 2015 siRNA SR420984
EXOSC5 Chromatin Dynamics and the RNA Exosome Function in Concert to Regulate Transcriptional Homeostasis Cell Rep Nov 2015 siRNA SR406507
EZH2 MiR-101 Targets the EZH2/Wnt/ß-Catenin the Pathway to Promote the Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells Sci Rep 2016 siRNA SR301494
EZH2 Modulation of EZH2 expression by MEK-ERK or PI3K-AKT signaling in lung cancer is dictated by different KRAS oncogene mutations Cancer Res. Dec 2015 siRNA SR301494
EZH2 VEGF/VEGFR-2 upregulates EZH2 expression in lung adenocarcinoma cells and EZH2 depletion enhances the response to platinum-based and VEGFR-2-targeted therapy Clin. Cancer Res. May 2014 siRNA SR301494
FAM111A Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components Nat. Cell Biol., Feb 2014. siRNA SR311883
FAM20C Functional analysis of mutant FAM20C in Raine syndrome with FGF23-related hypophosphatemia Bone July 2014 siRNA SR511577
FBXW7 Role of integrin-linked kinase in regulating the protein stability of the MUC1-C oncoprotein in pancreatic cancer cells Oncogenesis 2017 siRNA SR310654
Fbxw7 MicroRNA-27b exerts an oncogenic function by targeting Fbxw7 in human hepatocellular carcinoma Tumour Biol. 2016 siRNA SR310654
FCGR2A CD163 and IgG Codefend against Cytotoxic Hemoglobin via Autocrine and Paracrine Mechanisms J. Immunol., May 2013; 190: 5267 - 5278. siRNA SR301549
FCGR3A CD163 and IgG Codefend against Cytotoxic Hemoglobin via Autocrine and Paracrine Mechanisms J. Immunol., May 2013; 190: 5267 - 5278. siRNA SR301551
FGF5 A Hippo and Fibroblast Growth Factor Receptor Autocrine Pathway in Cholangiocarcinoma Journal of Biological Chemistry 2017 siRNA SR301573
FGFR1 A Hippo and Fibroblast Growth Factor Receptor Autocrine Pathway in Cholangiocarcinoma Journal of Biological Chemistry 2017 siRNA SR301583
FGFR1 miR-296 inhibits proliferation and induces apoptosis by targeting FGFR1 in human hepatocellular carcinoma. FEBS Lett. 2016 siRNA SR301583
FGFR3 Stem cell and neurogenic gene-expression profiles link prostate basal cells to aggressive prostate cancer Nat Commun Feb 2016 siRNA SR301584
FGFR4 A Hippo and Fibroblast Growth Factor Receptor Autocrine Pathway in Cholangiocarcinoma Journal of Biological Chemistry 2017 siRNA SR301587
FLNA Filamin A (FLNA) modulates chemosensitivity to docetaxel in triple-negative breast cancer through the MAPK/ERK pathway Tumour Biol. Nov 2015 siRNA SR301624
FLOT1 Role of flotillins in the endocytosis of GPCR in salivary gland epithelial cells Biochem. Biophys. Res. Commun. May 2016 siRNA SR306899
FLOT2 Role of flotillins in the endocytosis of GPCR in salivary gland epithelial cells Biochem. Biophys. Res. Commun. May 2016 siRNA SR301627
FLT1 Adipose Stromal Cell Contact with Endothelial Cells Results in Loss of Complementary Vasculogenic Activity Mediated by Induction of Activin A Stem Cells Jun 2015 siRNA SR301628
FOS Withaferin A Induces Cell Death Selectively in Androgen-Independent Prostate Cancer Cells but Not in Normal Fibroblast Cells PLoS ONE Aug 2015 siRNA SR301647
FOXM1 A novel microRNA, hsa-miR-6852 differentially regulated by Interleukin-27 induces necrosis in cervical cancer cells by downregulating the FoxM1 expression Sci Rep 2018 siRNA SR301615
FOXM1 Pregnancy-associated plasma protein A regulates mitosis and is epigenetically silenced in breast cancer J. Pathol. Jun 2014 siRNA SR301615
FOXO1 A novel FOXO1-mediated dedifferentiation blocking role for DKK3 in adrenocortical carcinogenesis BMC Cancer 2017 siRNA SR301618
FOXO1 Cutting Edge: Differential Regulation of PTEN by TCR, Akt, and FoxO1 Controls CD4+ T Cell Fate Decisions J. Immunol. May 2015 siRNA SR418715
FOXO3 A novel microRNA, hsa-miR-6852 differentially regulated by Interleukin-27 induces necrosis in cervical cancer cells by downregulating the FoxM1 expression Sci Rep 2018 siRNA SR301619
FOXO3 The inhibition of activated hepatic stellate cells proliferation by arctigenin through G0/G1 phase cell cycle arrest: Persistent p27(Kip1) induction by interfering with PI3K/Akt/FOXO3a signaling pathway Eur. J. Pharmacol. Dec 2014 siRNA SR301619
FSCN1 The retinoic acid-metabolizing enzyme CYP26A1 upregulates fascin and promotes the malignant behavior of breast carcinoma cells Oncol. Rep. Jun 2015 siRNA SR304498
FSHR Follicular Stimulating Hormone Accelerates Atherogenesis by Increasing Endothelial VCAM-1 Expression Theranostics 2017 siRNA SR301661
FSTL1 Follistatin-Like 1 Attenuates Apoptosis via Disco-Interacting Protein 2 Homolog A/Akt Pathway After Middle Cerebral Artery Occlusion in Rats Stroke Aug 2014 siRNA SR307656
FTH1 cAMP signaling regulates DNA hydroxymethylation by augmenting the intracellular labile ferrous iron pool Elife 2017 siRNA SR301663
FTH1 cAMP Signaling Regulates DNA Demethylation by Augmenting the Intracellular Labile Ferrous Iron Pool bioRxiv 2017 siRNA SR301663
FTO N6-Adenosine Methylation in MiRNAs PLoS ONE Feb 2015 siRNA SR312322
FURIN PACE4 Proteolytically Processes LOXL2 with little impact on its catalytic activity J. Biol. Chem. 2017 siRNA SR303336
FURIN The effects of cytokines on spontaneous hepatitis B surface antigen seroconversion in chronic hepatitis B virus infection J. Immunol. Jan 2015 siRNA SR303336
FUT3 alpha3/4 Fucosyltransferase 3-Dependent Synthesis of Sialyl Lewis A on CD44 Variant Containing Exon 6 Mediates Polymorphonuclear Leukocyte Detachment from Intestinal Epithelium during Transepithelial Migration J Immunol. 2013 Nov 1;191(9):4804-17 siRNA SR301673
FZD1 Wnt pathway in atypical teratoid rhabdoid tumors Neuro-oncology Sep 2014 siRNA SR305440
Fzd7 Frizzled Gene Expression and Negative Regulation of Canonical WNT-ß?-catenin Signaling in Mouse F9 Teratocarcinoma Cells Biochemistry and Cell Biology 2016 siRNA SR417570
G6pdx G6pd Deficiency Does Not Affect the Cytosolic Glutathione or Thioredoxin Antioxidant Defense in Mouse Cochlea J. Neurosci. 2017 siRNA SR416484
GABPA Cytosolic sulfotransferase 1A3 is induced by dopamine and protects neuronal cells from dopamine toxicity: role of D1 receptor-NMDA receptor coupling J Biol Chem. 2013 Oct 17 siRNA SR301693
GAPDH Target-Selective Protein S-Nitrosylation by Sequence Motif Recognition Cell Oct 2014 siRNA SR301734
GAPDH Establishing 3-nitrotyrosine as a biomarker for the vasculopathy of Fabry disease Kidney Int., Jan 2014. siRNA SR301734
GATA3 TOX expression and role in CTCL. J Eur Acad Dermatol Venereol 2016 siRNA SR320264
GBA Establishing 3-nitrotyrosine as a biomarker for the vasculopathy of Fabry disease Kidney Int., Jan 2014. siRNA SR301748
GCLC Pyrrolidine dithiocarbamate reverses Bcl-xL-mediated apoptotic resistance to doxorubicin by inducing paraptosis Carcinogenesis 2018 siRNA SR301815
GCLC Inhibition of glutathione production induces macrophage CD36 expression and enhances cellular oxLDL uptake J. Biol. Chem. Jul 2015 siRNA SR301815
GDF9 Insulin-like 3 induced rat preantral follicular growth is mediated by growth differentiation factor 9 Endocrinology. 2013 Oct 29. siRNA SR505007
GDNF Decreased DNA methylation in the promoter region of the WNT5A and GDNF genes may promote the osteogenicity of mesenchymal stem cells from patients with ossified spinal ligaments J. Pharmacol. Sci. Apr 2015 siRNA SR301778
GEMIN4 Gemin4 functions as a coregulator of the mineralocorticoid receptor J. Mol. Endocrinol. Jan 2015 siRNA SR309405
GHR TITLE: Growth hormone receptor (GHR) knockdown sensitizes human melanoma cells to chemotherapy by attenuating expression of ABC drug efflux pumps researchgate.net 2017 siRNA SR301794
GHR Growth Hormone Receptor Knockdown Sensitizes Human Melanoma Cells to Chemotherapy by Attenuating Expression of ABC Drug Efflux Pumps Horm Cancer 2017 siRNA SR301794
GHR Targeting growth hormone receptor in human melanoma cells attenuates tumor progression and epithelial mesenchymal transition via suppression of multiple oncogenic pathways Oncotarget 2017 siRNA SR301794
GIPR TCF1 links GIPR signaling to the control of beta cell function and survival Nat. Med. Dec 2015 siRNA SR406328
GJA1 Prenatal exposure to inflammatory conditions increases Cx43 and Panx1 unopposed channel opening and activation of astrocytes in the offspring effect on neuronal survival Glia Jun 2015 siRNA SR412884
GJA1 Astrocytes inhibit nitric oxide-dependent Ca(2+) dynamics in activated microglia: Involvement of ATP released via pannexin 1 channels Glia. 2013 Dec;61(12):2023-37 siRNA SR512943
GJB6 HIV-tat alters Connexin43 expression and trafficking in human astrocytes: role in NeuroAIDS J Neuroinflammation Mar 2016 siRNA SR307369
GLA Establishing 3-nitrotyrosine as a biomarker for the vasculopathy of Fabry disease Kidney Int., Jan 2014. siRNA SR301812
GLI1 Gli1 inhibition suppressed cell growth and cell cycle progression and induced apoptosis as well as autophagy depending on ERK1/2 activity in human chondrosarcoma cells Cell Death Dis, Jan 2014. siRNA SR301820
GLP1R Exendin-4 attenuates neuronal death via GLP-1R/PI3K/Akt pathway in early brain injury after subarachnoid hemorrhage in rats Neuropharmacology 2017 siRNA SR415041
GLP1R TCF1 links GIPR signaling to the control of beta cell function and survival Nat. Med. Dec 2015 siRNA SR415041
GLP1R Metformin ameliorates lipotoxicity-induced mesangial cell apoptosis partly via upregulation of Glucagon like peptide-1 receptor (GLP-1R) Arch. Biochem. Biophys. Aug 2015 siRNA SR510491
GLS MYC regulates the unfolded protein response and glucose and glutamine uptake in endocrine resistant breast cancer Mol. Cancer Oct 2014 siRNA SR301829
GNA11 Allosteric Modulation of the Calcium-Sensing Receptor Rectifies Signaling Abnormalities Associated with G-protein alpha-11 Mutations causing Hypercalcemic and Hypocalcemic Disorders J. Biol. Chem. Mar 2016 siRNA SR301839
GNAT3 Activation of the sweet taste receptor, T1R3, by the artificial sweetener sucralose regulates the pulmonary endothelium Am. J. Physiol. Lung Cell Mol. Physiol. 2017 siRNA SR411970
Gpbar1 TGR5 suppresses high glucose-induced upregulation of fibronectin and transforming growth factor-ß1 in rat glomerular mesangial cells by inhibiting RhoA/ROCK signaling Endocrine 2016 siRNA SR510164
GPX1 Expression of glutathione peroxidase 1 in the spheno-occipital synchondrosis and its role in ROS-induced apoptosis Eur J Orthod Oct 2014 siRNA SR405153
GRIK2 GRIK2 has a role in the maintenance of urothelial carcinoma stem-like cells, and its expression is associated with poorer prognosis Oncotarget 2017 siRNA SR301950
GRIK2 GRIK2 has a role in the maintenance of urothelial carcinoma stem-like cells, and its expression is associated with poorer prognosis Oncotarget 2017 siRNA SR301950
GRIK2 GRIK2 has a role in the maintenance of urothelial carcinoma stem-like cells, and its expression is associated with poorer prognosis Oncotarget 2017 siRNA SR301950
GSC Bone Morphogenetic Protein-10 induces cardiomyocyte proliferation and improves cardiac function after myocardial infarction J. Cell. Biochem. Jun 2014 siRNA SR315497
GSK-3B GSK-3ß/NFAT Signaling Is Involved in Testosterone-Induced Cardiac Myocyte Hypertrophy PLoS ONE 2016 siRNA SR506287
GSR Pyrrolidine dithiocarbamate reverses Bcl-xL-mediated apoptotic resistance to doxorubicin by inducing paraptosis Carcinogenesis 2018 siRNA SR301982
GSTO1 Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor Nat Commun 2016 siRNA SR306263
H19 MiR-675-5p supports hypoxia induced epithelial to mesenchymal transition in colon cancer cells Oncotarget 2017 siRNA SR319206
H19 CD90+ liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA Mol. Cancer Aug 2015 siRNA SR319206
HADHA Association of HADHA with human RNA silencing machinery Biochem. Biophys. Res. Commun. Sep 2015 siRNA SR302056
HAVCR2 Hepatitis A virus cellular receptor 2 (HAVCR2) is decreased with viral infection and regulates pro-labour mediators OA Am. J. Reprod. Immunol. 2017 siRNA SR313697
HBP1 HBP1 promoter methylation augments the oncogenic ß-catenin to correlate with prognosis in NSCLC J. Cell. Mol. Med. Jun 2014 siRNA SR308913
HCAR2 Butyrate attenuates lipolysis in adipocytes co-cultured with macrophages through non-prostaglandin E2-mediated and prostaglandin E2-mediated pathways Lipids Health Dis 2016 siRNA SR412150
HCLS1 SDF1a-induced interaction of the adapter proteins Nck and HS1 facilitates actin polymerization and migration in T cells Eur. J. Immunol. Oct 2014 siRNA SR302078
HDAC3 Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon Clin Epigenetics Sep 2015 siRNA SR305837
HDAC6 Histone deacetylase 6 promotes insulin resistance via deacetylating phosphatase and tensin homolog (PTEN) in ovarian OVCAR-3 cells International Journal of Clinical and Experimental Pathology 2016 siRNA HP209063
HERG HERG ???? NF-?B ?????????????? ??????? 2016 siRNA SR302526
HIF1A Global metabolic profiling identifies a pivotal role of proline and hydroxyproline metabolism in supporting hypoxic response in hepatocellular carcinoma Clin. Cancer Res.2017 siRNA SR302102
HIF1A Bone marrow adipocytes promote the warburg phenotype in metastatic prostate tumors via HIF-1a activation Oncotarget 2016 siRNA SR302102
HIF1A SOX2 Promotes the Epithelial to Mesenchymal Transition of Esophageal Squamous Cells by Modulating Slug Expression through the Activation of STAT3/HIF-a Signaling Int J Mol Sci Sep 2015 siRNA SR302102
HIF1A Hypoxia Inducible Regulation of Placental BOK Expression Biochem. J. May 2014 siRNA SR302102
HIF1A VEGF/VEGFR-2 upregulates EZH2 expression in lung adenocarcinoma cells and EZH2 depletion enhances the response to platinum-based and VEGFR-2-targeted therapy Clin. Cancer Res. May 2014 siRNA SR302102
HIST1H1C Histone H1 and Chromosomal Protein HMGN2 Regulate Prolactin-Induced STAT5 Transcription Factor Recruitment and Function in Breast Cancer Cells J. Biol. Chem 2016 siRNA SR302039
HIST1H1C Histone H1 and Chromosomal Protein HMGN2 Regulate Prolactin-Induced STAT5 Transcription Factor Recruitment and Function in Breast Cancer Cells J. Biol. Chem 2016 siRNA SR302039
HMGA2 Stem cell and neurogenic gene-expression profiles link prostate basal cells to aggressive prostate cancer Nat Commun Feb 2016 siRNA SR305363
HMGB1 High mobility group box-B1 (HMGB1) mediates the hypoxia-induced mesenchymal transition of osteoblast cells via activating ERK/JNK signaling Cell Biol. Int. Apr 2016 siRNA SR302140
HMGB1 Correlation of HMGB1 expression to progression and poor prognosis of adenocarcinoma and squamous cell/adenosquamous carcinoma of gallbladder Am J Transl Res Oct 2015 siRNA SR302140
HMGB3 Regulation of HMGB3 by antitumor miR-205-5p inhibits cancer cell aggressiveness and is involved in prostate cancer pathogenesis J. Hum. Genet. 2017 siRNA SR302142
HMGN2 HMGN2 Inducibly Binds a Novel Transactivation Domain in Nuclear PRLr to Coordinate Stat5a-Mediated Transcription Mol. Endocrinol., Sep 2011; 25: 1550 - 1564. siRNA SR302144
HNRNPA1 Regulation of oncogenic KRAS signaling via a novel KRAS-integrin-linked kinase-hnRNPA1 regulatory loop in human pancreatic cancer cells Oncogene Nov 2015 siRNA SR302164
HNRNPD Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development Nat Commun 2017 siRNA SR302168
HNRNPK Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43 Hum. Mol. Genet. Nov 2014 siRNA SR302173
HNRNPL Interplay between miR-574-3p and hnRNP L regulates VEGFA mRNA translation and tumorigenesis Nucleic Acids Res. 2017 siRNA SR302174
HOPX HOPX is methylated and exerts tumour suppressive function through Ras-induced senescence in human lung cancer J. Pathol. Oct 2014 siRNA SR313554
HOXD10 The roles of HOXD10 in the development and progression of head and neck squamous cell carcinoma (HNSCC) Br. J. Cancer July 2014 siRNA SR302213
HPGD ?-3 polyunsaturated fatty acids upregulate 15-PGDH expression in cholangiocarcinoma cells by inhibiting miR-26a/b expression Cancer Res. Feb 2015 siRNA SR302220
HPRT1 CYP2J2 expression in adult ventricular myocytes protects against external and drug induced ROS toxicity Drug Metab. Dispos. 2018 siRNA SR302223
HSF1 Withaferin A Induces Cell Death Selectively in Androgen-Independent Prostate Cancer Cells but Not in Normal Fibroblast Cells PLoS ONE Aug 2015 siRNA SR302246
HSP60 Lysine biotinylation and methionine oxidation in the heat shock protein HSP60 synergize in the elimination of reactive oxygen species in human cell cultures The Journal of Nutritional Biochemistry, Jan 2014. siRNA SR302265
HSPA1A Cypate-Conjugated Porous Upconversion Nanocomposites for Programmed Delivery of Heat Shock Protein 70 Small Interfering RNA for Gene Silencing and Photothermal Ablation Advanced Functional materials Mar 2016 siRNA SR302251
HSPA1B The Anti-Inflammatory Effects of the Small Molecule Pifithrin-µ on BV2 Microglia Dev. Neurosci. Feb 2015 siRNA SR418598
HSPA4 Proteomic analysis reveals heat shock protein 70 has a key role in polycythemia Vera Mol. Cancer 142 Nov 2013 siRNA SR302255
Hspa5 Unfolded protein response signaling impacts macrophage polarity to modulate breast cancer cell clearance and melanoma immune checkpoint therapy responsiveness Oncotarget 2017 siRNA SR418749
HSPA5 MYC regulates the unfolded protein response and glucose and glutamine uptake in endocrine resistant breast cancer Mol. Cancer Oct 2014 siRNA SR302256
HSPA6 Withaferin A Induces Cell Death Selectively in Androgen-Independent Prostate Cancer Cells but Not in Normal Fibroblast Cells PLoS ONE Aug 2015 siRNA SR302257
HSPA8 DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway Nat. Cell Biol 2016 siRNA SR302258
HTRA1 The genomic landscape of schwannoma Nat. Genet. 2016 siRNA SR303800
Idh1 G6pd Deficiency Does Not Affect the Cytosolic Glutathione or Thioredoxin Antioxidant Defense in Mouse Cochlea J. Neurosci. 2017 siRNA SR413740
IDH1 IDH1 regulates phospholipid metabolism in developing astrocytes Neurosci. Lett. Sep 2014 siRNA SR302305
IFITM1 Interferon-Induced Transmembrane Protein 3 Inhibits Hantaan Virus Infection, and Its Single Nucleotide Polymorphism rs12252 Influences the Severity of Hemorrhagic Fever with Renal Syndrome Front Immunol 2016 siRNA SR305589
IFITM2 Interferon-Induced Transmembrane Protein 3 Inhibits Hantaan Virus Infection, and Its Single Nucleotide Polymorphism rs12252 Influences the Severity of Hemorrhagic Fever with Renal Syndrome Front Immunol 2016 siRNA SR307202
IFITM3 Interferon-Induced Transmembrane Protein 3 Inhibits Hantaan Virus Infection, and Its Single Nucleotide Polymorphism rs12252 Influences the Severity of Hemorrhagic Fever with Renal Syndrome Front Immunol 2016 siRNA SR323108
Ifnb1 Activation of dopamine D1 receptor decreased NLRP3-mediated inflammation in intracerebral hemorrhage mice J Neuroinflammation 2018 siRNA SR510605
IGF1R Insulin promotes cell migration by regulating PSA-NCAM Exp. Cell Res 2017 siRNA SR302344
IGF1R Targeting insulin-like growth factor 1 receptor inhibits pancreatic cancer growth and metastasis PLoS ONE May 2014 siRNA SR302344
IKBKE Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1 J. Med. Chem. 2017 siRNA SR306417
IL17RA Interleukin-17 Stimulates STAT3-Mediated Endothelial Cell Activation for Neutrophil Recruitment Cell. Physiol. Biochem. Aug 2015 siRNA SR308461
IL17RC Interleukin-17 Stimulates STAT3-Mediated Endothelial Cell Activation for Neutrophil Recruitment Cell. Physiol. Biochem. Aug 2015 siRNA SR313678
IL1A Cancer cell-derived IL-1a induces CCL22 and the recruitment of regulatory T cells OncoImmunology Apr 2016 siRNA SR302364
IL1A Cancer cell-derived IL-1a induces CCL22 and the recruitment of regulatory T cells OncoImmunology Apr 2016 siRNA SR407748
Il1b Cancer cell-derived IL-1a induces CCL22 and the recruitment of regulatory T cells OncoImmunology Apr 2016 siRNA SR407717
Il1f6 Novel amphiphilic lipid augments the co-delivery of erlotinib and IL36 siRNA into the skin for psoriasis treatment J Control Release May 2016 siRNA SR403515
IL33 Interleukin-33 predicts poor prognosis and promotes ovarian cancer cell growth and metastasis through regulating ERK and JNK signaling pathways Mol Oncol 2016 siRNA SR314047
IL6ST Discovery of a Novel Orally Active Small-Molecule gp130 Inhibitor for the Treatment of Ovarian Cancer Mol. Cancer Ther., Jun 2013; 12: 937 - 949. siRNA SR302381
INHBA Hypoxia-induced activin A diminishes endothelial cell vasculogenic activity J. Cell. Mol. Med. 2017 siRNA SR302421
INSR Insulin promotes cell migration by regulating PSA-NCAM Exp. Cell Res 2017 siRNA SR302436
IRAK3 Transduction of Functionally Contrasting Signals by Two Mycobacterial PPE Proteins Downstream of TLR2 Receptors J. Immunol. 2016 siRNA SR307690
IRAK3 Glucocorticoids suppress inflammation via the upregulation of negative regulator IRAK-M Nat Commun Jan 2015 siRNA SR307690
IRF7 Comparison of tamoxifen and letrozole response in mammary preneoplasia of ER and aromatase overexpressing mice defines an immune-associated gene signature linked to tamoxifen resistance Carcinogenesis Nov 2014 siRNA SR302451
IRS2 Recurrent Amplification at 13q34 Targets at CUL4A, IRS2, and TFDP1 As an Independent Adverse Prognosticator in Intrahepatic Cholangiocarcinoma PLoS ONE Dec 2015 siRNA SR305694
ITGA5 Inhibition of adhesion, migration and of a5ß1 integrin in the HCT-116 colorectal cancer cells treated with the ruthenium drug NAMI-A J. Inorg. Biochem. Feb 2016 siRNA SR302461
ITGAV Insulin promotes cell migration by regulating PSA-NCAM Exp. Cell Res 2017 siRNA SR302468
ITGB1 Hematopoietic-to-mesenchymal transition of adipose tissue macrophages is regulated by integrin β1 and fabricated fibrin matrices Adipocyte 2017 siRNA SR420242
ITGB1 MMP-2 and MMP-9 expression induced by porphyromonas gingivalis in gingival epithelial cell was influenced by integrinß1 expression Chin J Clinicians Jun 2015 siRNA SR302470
ITPKB miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain EMBO Mol Med 2016 siRNA SR302488
JAG1 Osteosarcoma cell-intrinsic colony stimulating factor-1 receptor functions to promote tumor cell metastasis through JAG1 signaling Am J Cancer Res 2017 siRNA SR300128
JUN A switch from canonical to noncanonical Wnt signaling mediates early differentiation of human neural stem cells Stem Cells Aug 2014 siRNA SR302499
Kalrn Kalirin, a GEF for Rac1, plays an important role in FSTL-1-mediated glucose uptake in skeletal muscle cells Cellular Signalling 2016 siRNA SR505738
Kalrn Kalirin, a GEF for Rac1, plays an important role in FSTL-1-mediated glucose uptake in skeletal muscle cells Cellular Signalling 2016 siRNA SR505738
KAP1 Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy PNAS, Apr 2013; 110: 6841 - 6846. siRNA TG320633
KCNJ2 Rise and Fall of Kir2.2 Current by TLR4 Signaling in Human Monocytes: PKC-Dependent Trafficking and PI3K-Mediated PIP2 Decrease J. Immunol. Oct 2015 siRNA SR302528
KCNN4 KCa3.1 channel inhibition leads to an ICAM-1 dependent increase of cell-cell adhesion between A549 lung cancer and HMEC-1 endothelial cells Oncotarget 2017 siRNA SR302550
KCNN4 KCa3.1 as an Effective Target for Inhibition of Growth and Progression of Intrahepatic Cholangiocarcinoma J Cancer 2017 siRNA SR302550
Kcnn4 Inhibition of vascular calcification by block of intermediate conductance calcium-activated potassium channels with TRAM-34 Pharmacol. Res. May 2014 siRNA SR414096
KCTD1 KCTD11 inhibits growth and metastasis of hepatocellular carcinoma through activating Hippo signaling Oncotarget 2017 siRNA SR315580
KDR VEGF/VEGFR-2 upregulates EZH2 expression in lung adenocarcinoma cells and EZH2 depletion enhances the response to platinum-based and VEGFR-2-targeted therapy Clin. Cancer Res. May 2014 siRNA SR302557
KDR Increased VEGFR-2 Gene Copy Is Associated with Chemoresistance and Shorter Survival in Patients with Non–Small-Cell Lung Carcinoma Who Receive Adjuvant Chemotherapy Cancer Res., Aug 2011; 71: 5512 - 5521. siRNA SR302557
KIF26B Kif26b controls endothelial cell polarity through the Dishevelled/Daam1-dependent planar cell polarity signaling pathway Mol. Biol. Cell Jan 2016 siRNA SR310475
KL Role of Klotho in migration and proliferation of human dermal microvascular endothelial cells. Microvasc. Res. 2016 siRNA SR306202
KLF4 Upregulation of KLF4 by methylseleninic acid in human esophageal squamous cell carcinoma cells: Modification of histone H3 acetylation through HAT/HDAC interplay Mol. Carcinog. May 2014 siRNA SR306162
KLHL15 Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection. Nat Commun 2016 siRNA SR312886
KRAS Ral A, via activating the mitotic checkpoint, sensitizes cells lacking a functional Nf1 to apoptosis in the absence of protein kinase C Oncotarget 2016 siRNA SR320806
KRAS Modulation of EZH2 expression by MEK-ERK or PI3K-AKT signaling in lung cancer is dictated by different KRAS oncogene mutations Cancer Res. Dec 2015 siRNA SR302601
L1TD1 Embryonic stem cell-related protein L1TD1 is required for cell viability, neurosphere formation and chemoresistance in medulloblastoma Stem Cells Dev. Jul 2015 siRNA SR310168
LAMC1 Systems analysis identifies miR-29b regulation of invasiveness in melanoma Mol. Cancer 2016 siRNA SR302649
LAMC2 Aberrant expression of laminin ?2 correlates with poor prognosis and promotes invasion in extrahepatic cholangiocarcinoma J Surg Res. 2013 Oct 2. pii: S0022-4804(13)00850-0 siRNA SR302651
Lamp1 Dihydrolipoic Acid Inhibits Lysosomal Rupture and NLRP3 Through Lysosome-Associated Membrane Protein-1/Calcium/Calmodulin-Dependent Protein Kinase II/TAK1 Pathways After Subarachnoid Hemorrhage in Rat Stroke 2018 siRNA SR508640
Lamtor1 p18, a novel adaptor protein, regulates pulmonary endothelial barrier function via enhanced endocytic recycling of VE-cadherin FASEB J. Nov 2014 siRNA SR513910
LAMTOR2 LAMTOR2-Mediated Modulation of NGF/MAPK Activation Kinetics during Differentiation of PC12 Cells PLoS ONE e95863 9 4. April 2014 siRNA SR309134
LAMTOR5 Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses Immunity Jun 2015 siRNA SR307168
LASP1 Systems analysis identifies miR-29b regulation of invasiveness in melanoma Mol. Cancer 2016 siRNA SR302655
LDLR Lipopolysaccharide Is Cleared from the Circulation by Hepatocytes via the Low Density Lipoprotein Receptor PLoS ONE May 2016 siRNA SR302668
LEFTY1 Gefitinib and Luteolin Cause Growth Arrest of Human Prostate Cancer PC-3 Cells via Inhibition of Cyclin G-Associated Kinase and Induction of miR-630 PLoS ONE Jun 2014 siRNA SR307250
LGALS1 Expression of galectin-1 in carcinoma-associated fibroblasts promotes gastric cancer cell invasion through upregulation of integrin ß1 Cancer Sci. Sep 2014 siRNA SR302674
LGMN Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer/'s disease NATURE COMMUNICATIONS Nov 2015 siRNA SR303790
LGMN Local mitochondrial-endolysosomal microfusion cleaves the voltage-dependent anion channel 1 to promote survival in hypoxia Mol. Cell. Biol. Feb 2015 siRNA SR303790
LMNA Nuclear envelope structural defect underlies the main cause of aneuploidy in ovarian carcinogenesis BMC Cell Biol. 2016 siRNA SR302703
LMNA Nuclear envelope structural defect underlies the main cause of aneuploidy in ovarian carcinogenesis BMC Cell Biol. 2016 siRNA SR302703
LOXL2 Lysyl oxidase-like protein-2 regulates sprouting angiogenesis and type IV collagen assembly in the endothelial basement membrane Blood, Oct 2011; 118: 3979 - 3989. siRNA SR302716
LRP1 ApoE4 and Aß Oligomers Reduce BDNF Expression via HDAC Nuclear Translocation J. Neurosci. May 2015 siRNA SR302723
Lrp5 Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction cience Translational Medicine Mar 2016 siRNA SR423069
LRRC2 Transcriptome-wide co-expression analysis identifies LRRC2 as a novel mediator of mitochondrial and cardiac function PLoS ONE 2017 siRNA SR312419
LTBP-4 Increased expression of latent TGF-β-binding protein 4 affects the fibrotic process in scleroderma by TGF-β/SMAD signaling Lab. Invest 2017 siRNA SR305517
LY6E LY6E: a conductor of malignant tumor growth through modulation of the PTEN/PI3K/Akt/HIF-1 axis Oncotarget 2016 siRNA SR302746
LY6E LY6E: a conductor of malignant tumor growth through modulation of the PTEN/PI3K/Akt/HIF-1 axis Oncotarget 2016 siRNA SR302746
LY6E LY6E: a conductor of malignant tumor growth through modulation of the PTEN/PI3K/Akt/HIF-1 axis Oncotarget 2016 siRNA SR302746
LYST Small interfering RNA-mediated silencing of nicotinamide phosphoribosyltransferase (NAMPT) and lysosomal trafficking regulator (LYST) induce growth inhibition and apoptosis in human multiple myeloma cells: A preliminary study Bosn J Basic Med Sci 2016 siRNA SR300809
LYST Small interfering RNA-mediated silencing of nicotinamide phosphoribosyltransferase (NAMPT) and lysosomal trafficking regulator (LYST) induce growth inhibition and apoptosis in human multiple myeloma cells: A preliminary study Bosn J Basic Med Sci 2016 siRNA SR300809
MAD2L1 Taxifolin Enhances Andrographolide-Induced Mitotic Arrest and Apoptosis in Human Prostate Cancer Cells via Spindle Assembly Checkpoint Activation PLoS One. 2013;8(1):e54577 siRNA SR302764
MAP1LC3B The apoptotic effect of 1'S-1'-Acetoxychavicol Acetate (ACA) enhanced by inhibition of non-canonical autophagy in human non-small cell lung cancer cells PLoS ONE 2017 siRNA SR313079
MAP2K1 Modulation of EZH2 expression by MEK-ERK or PI3K-AKT signaling in lung cancer is dictated by different KRAS oncogene mutations Cancer Res. Dec 2015 siRNA SR303761
MAP2K1 The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux Autophagy Jun 2015 siRNA SR303761
MAP2K6 Mixed Lineage Kinase 3 Mediates the Induction of CXCL10 by a STAT1-Dependent Mechanism during Hepatocyte Lipotoxicity J. Cell. Biochem 2017 siRNA SR303765
MAP2K7 Calcium-Ask1-MKK7-JNK2-c-Src Signaling Cascade Mediates Disruption of Intestinal Epithelial Tight Junctions by Dextran Sulfate Sodium Biochem. J. Nov 2014 siRNA SR303766
MAP3K11 Mixed Lineage Kinase 3 Mediates the Induction of CXCL10 by a STAT1-Dependent Mechanism during Hepatocyte Lipotoxicity J. Cell. Biochem 2017 siRNA SR302913
MAP3K13 Survival of Head and Neck Cancer Cells Relies upon LZK Kinase-Mediated Stabilization of Mutant p53 Cancer Res. 2017 siRNA SR306071
MAP3K5 Calcium-Ask1-MKK7-JNK2-c-Src Signaling Cascade Mediates Disruption of Intestinal Epithelial Tight Junctions by Dextran Sulfate Sodium Biochem. J. Nov 2014 siRNA SR302865
MAPK1 Mixed Lineage Kinase 3 Mediates the Induction of CXCL10 by a STAT1-Dependent Mechanism during Hepatocyte Lipotoxicity J. Cell. Biochem 2017 siRNA SR303751
MAPK1 MAPK1E322K mutation increases head and neck squamous cell carcinoma sensitivity to erlotinib through enhanced secretion of amphiregulin Oncotarget Mar 2016 siRNA SR303751
MCL1 Autophagy inhibition by sustained over-production of IL-6 contributes to arsenic-induced carcinogenesis Cancer Res. May 2014 siRNA SR302834
MCM2 MCM2-regulated functional networks in lung cancer by multi-dimensional proteomic approach Sci Rep 2017 siRNA SR302835
MCPIP1 MCPIP1 restricts HIV infection and is rapidly degraded in activated CD4+ T cells Proc. Natl. Acad. Sci. U.S.A. 19083-8 Nov 2013 siRNA SR312813
Mcu Sequential forward and reverse transport of the Na+ Ca2+ exchanger generates Ca2+ oscillations within mitochondria Nat Commun 2018 siRNA SR508660
Mcu Mitochondrial Calcium Uniporter MCU Supports Cytoplasmic Ca2+ Oscillations, Store-Operated Ca2+ Entry and Ca2+-Dependent Gene Expression in Response to Receptor Stimulation PLoS ONE July 2014 siRNA SR508660
MDM2 Loss of LZAP inactivates p53 and regulates sensitivity of cells to DNA damage in a p53-dependent manner Oncogenesis 2017 siRNA SR302849
MECOM The PU.1-Modulated MicroRNA-22 Is a Regulator of Monocyte/Macrophage Differentiation and Acute Myeloid Leukemia PLoS Genet. 2016 siRNA SR301479
MEF2A p38MAPK Signaling Enhances Glycolysis Through the Up-Regulation of the Glucose Transporter GLUT-4 in Gastric Cancer Cells Cell. Physiol. Biochem. Apr 2015 siRNA SR302855
MEMO1 HRG/HER2/HER3 signaling promotes AhR-mediated Memo-1 expression and migration in colorectal cancer Oncogene 2016 siRNA SR309508
Meox2 Regulation of mesenchymal signaling in palatal mucosa differentiation Histochem. Cell Biol. 2017 siRNA SR408862
Met p66ShcA Promotes Breast Cancer Plasticity by Inducing an Epithelial to Mesenchymal Transition Mol. Cell. Biol. July 2014 siRNA SR422761
MFN1 Mitofusin 1 and optic atrophy 1 shift metabolism to mitochondrial respiration during aging Aging Cell 2017 siRNA SR310844
MGAT5 Epithelial-to-Mesenchymal Transition of RPE Cells In Vitro Confers Increased ß1,6-N-Glycosylation and Increased Susceptibility to Galectin-3 Binding PLoS ONE Jan 2016 siRNA SR302886
MGEA5 Linking Cancer Metabolism to DNA Repair and Accelerated Senescence Mol. Cancer Res 2016 siRNA SR307308
MIOX Beneficial Effects of Myo-Inositol Oxygenase Deficiency in Cisplatin-Induced AKI J. Am. Soc. Nephrol. 2016 siRNA SR310776
MKP-1 Transduction of Functionally Contrasting Signals by Two Mycobacterial PPE Proteins Downstream of TLR2 Receptors J. Immunol. 2016 siRNA SR301295
MMP2 A Key Role of microRNA-29b for the Suppression of Colon Cancer Cell Migration by American Ginseng PLoS One. 2013 Oct 9;8(10):e75034 siRNA SR302925
Mmp9 2-Methoxyestradiol Causes MMP 9 Mediated Transactivation of EGFR and Angiotensin Type 1 Receptor Downregulation in Rat Aortic Smooth Muscle Cells Am. J. Physiol., Cell Physiol. 2018 siRNA SR513162
MPO Effect of myeloperoxidase inhibition on gene expression profiles in HL-60 cells exposed to 1, 2, 4,-benzenetriol Toxicology, Feb 2014. siRNA SR302954
MPV17L2 MPV17L2 is required for ribosome assembly in mitochondria Nucleic Acids Res. Jun 2014 siRNA SR313662
MRI-1 Role for human arylamine N-acetyltransferase 1 in the methionine salvage pathway Biochem. Pharmacol. 2016 siRNA SR313419
MRI-1 Role for human arylamine N-acetyltransferase 1 in the methionine salvage pathway Biochem. Pharmacol. 2016 siRNA SR313419
MSRA Targeting tyrosine kinase inhibitor resistant non-small-cell lung cancer by inducing EGFR degradation via methionine 790 oxidation Antioxid. Redox Signal. Nov 2015 siRNA SR302974
MSX1 Oncogenic deregulation of NKL homeobox gene MSX1 in mantle cell lymphoma Leuk. Lymphoma Nov 2013 siRNA SR302977
MSX2 Oncogenic deregulation of NKL homeobox gene MSX1 in mantle cell lymphoma Leuk. Lymphoma Nov 2013 siRNA SR302978
MTOR Activation of MTOR in pulmonary epithelium promotes LPS-induced acute lung injury Autophagy 2016 siRNA SR301656
MVK DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway Nat. Cell Biol 2016 siRNA SR303014
MVK Knockdown of MVK does not lead to changes in NALP3 expression or activation J Inflamm (Lond) Feb 2015 siRNA SR413228
MX1 MicroRNA-211 promotes non-small-cell lung cancer proliferation and invasion by targeting MxA Onco Targets Ther 2017 siRNA SR303015
Myb AML suppresses hematopoiesis by releasing exosomes that contain microRNAs targeting c-MYB Sci Signal 2016 siRNA SR418501
MYBL2 A novel microRNA, hsa-miR-6852 differentially regulated by Interleukin-27 induces necrosis in cervical cancer cells by downregulating the FoxM1 expression Sci Rep 2018 siRNA SR303021
MYC Human prostate luminal cell differentiation requires NOTCH3 induction by p38-MAPK and MYC J. Cell. Sci. 2017 siRNA SR303025
MYC Human RNA polymerase II associated factor 1 complex promotes tumorigenesis by activating c-MYC transcription in non-small cell lung cancer Biochem. Biophys. Res. Commun. Aug 2015 siRNA SR303025
MYC Defining the role of oxygen tension in human neural progenitor fate Stem Cell Reports Nov 2014 siRNA SR303025
MYC Transient Induction of ING4 by MYC Drives Prostate Epithelial Cell Differentiation and its Disruption Drives Prostate Tumorigenesis Cancer Res. April 2014 siRNA SR303025
MYCN JQ1 synergizes with the Bcl-2 inhibitor ABT-263 against MYCN-amplified small cell lung cancer Oncotarget 2017 siRNA SR303027
MYCN The Role of Histone Demethylase KDM4B in Myc Signaling in Neuroblastoma J. Natl. Cancer Inst. Jun 2015 siRNA SR303027
MYCN Defining the role of oxygen tension in human neural progenitor fate Stem Cell Reports Nov 2014 siRNA SR303027
MYH9 PKC412 normalizes mutation-related keratin filament disruption and hepatic injury in mice by promoting keratin-myosin binding Hepatology Jun 2015 siRNA SR303039
MYOD1 Epicatechin elicits MyoD-dependent myoblast differentiation and myogenic conversion of fibroblasts PLoS ONE 2017 siRNA SR410431
NAMPT Small interfering RNA-mediated silencing of nicotinamide phosphoribosyltransferase (NAMPT) and lysosomal trafficking regulator (LYST) induce growth inhibition and apoptosis in human multiple myeloma cells: A preliminary study Bosn J Basic Med Sci 2016 siRNA SR306835
NAMPT Small interfering RNA-mediated silencing of nicotinamide phosphoribosyltransferase (NAMPT) and lysosomal trafficking regulator (LYST) induce growth inhibition and apoptosis in human multiple myeloma cells: A preliminary study Bosn J Basic Med Sci 2016 siRNA SR306835
NAMPT Endogenous NAMPT dampens chemokine expression and apoptotic responses in stressed tubular cells Biochim. Biophys. Acta Nov 2013 siRNA SR306835
NAT1 Role for human arylamine N-acetyltransferase 1 in the methionine salvage pathway Biochem. Pharmacol. 2016 siRNA SR300003
NAT1 Role for human arylamine N-acetyltransferase 1 in the methionine salvage pathway Biochem. Pharmacol. 2016 siRNA SR300003
Nat1 Nat1 Deficiency Is Associated with Mitochondrial Dysfunction and Exercise Intolerance in Mice Cell Rep 2016 siRNA SR408355
NAT8L Cancer-specific production of N-acetylaspartate via NAT8L overexpression in non-small cell lung cancer and its potential as a circulating biomarker Cancer Prev Res (Phila) Oct 2015 siRNA SR317479
NCAN Antihypoxic effect of miR-24 in SH-SY5Y cells under hypoxia via downregulating expression of neurocan Biochem. Biophys. Res. Commun. Jun 2016 siRNA SR301035
NCK1 SDF1a-induced interaction of the adapter proteins Nck and HS1 facilitates actin polymerization and migration in T cells Eur. J. Immunol. Oct 2014 siRNA SR303089
NCK1 The adapter proteins ADAP and Nck cooperate in T cell adhesion Mol. Immunol. 72-79 60 1. April 2014 siRNA SR303089
Nck2 Nck2 deficiency in mice results in increased adiposity associated with adipocyte hypertrophy and enhanced adipogenesis Diabetes Jun 2016 siRNA SR412820
NCL Nucleolin stabilizes G-quadruplex structures folded by the LTR promoter and silences HIV-1 viral transcription Nucleic Acids Res. Sep 2015 siRNA SR303090
NCL Epithelial-mesenchymal transition in human gastric cancer cell lines induced by TNF-a-inducing protein of Helicobacter pylori Int. J. Cancer Nov 2013 siRNA SR303090
NDUFV1 Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells Elife 2017 siRNA SR415063
NEDD9 Computational Reconstruction of NF?B Pathway Interaction Mechanisms during Prostate Cancer PLoS Comput. Biol. Apr 2016 siRNA SR303132
negative control cAMP signaling regulates DNA hydroxymethylation by augmenting the intracellular labile ferrous iron pool Elife 2017 siRNA SR30004
negative control Regulation of mesenchymal signaling in palatal mucosa differentiation Histochem. Cell Biol. 2017 siRNA SR30004
Negative Control Down-regulation of Stearoyl-CoA Desaturase-1 Increases Susceptibility to Palmitic Acid-Induced Lipotoxicity in Human Trophoblast Cells The Journal of Nutritional Biochemistry 2017 siRNA SR30004
Negative Control Phagocytosis of environmental or metabolic crystalline particles induces cytotoxicity by triggering necroptosis across a broad range of particle size and shape Sci Rep 2017 siRNA SR30004
Negative Control Down-regulation of stearoyl-CoA desaturase-1 increases susceptibility to palmitic-acid-induced lipotoxicity in human trophoblast cells The Journal of nutritional biochemistry 2017 siRNA SR30004
Negative Control Knockdown of HIP1 expression promotes ligand‑induced endocytosis of EGFR in HeLa cells Oncol. Rep. 2017 siRNA SR30004
Negative Control Follicular Stimulating Hormone Accelerates Atherogenesis by Increasing Endothelial VCAM-1 Expression Theranostics 2017 siRNA SR30004
negative control Receptor Interacting Protein-2 acts as negative regulator for nontypeable Haemophilus influenzae-induced mucin MUC5AC expression ntegrative Molecular Medicine 2017 siRNA SR30004
Negative Control De novo triiodothyronine formation from thyrocytes activated by Thyroid Stimulating Hormone J. Biol. Chem. 2017 siRNA SR30004
Negative Control Tissue factor pathway inhibitor attenuates ER stress-induced inflammation in human M2-polarized macrophages Biochem. Biophys. Res. Commun. 2017 siRNA SR300004
Negative Control cAMP Signaling Regulates DNA Demethylation by Augmenting the Intracellular Labile Ferrous Iron Pool bioRxiv 2017 siRNA SR30004
Negative Control The deubiquitinating enzymes USP4 and USP17 target hyaluronan synthase 2 and differentially affect its function Oncogenesis 2017 siRNA SR30004
Negative Control TITLE: Growth hormone receptor (GHR) knockdown sensitizes human melanoma cells to chemotherapy by attenuating expression of ABC drug efflux pumps researchgate.net 2017 siRNA SR30004
Negative Control Panobinostat Enhances Growth Suppressive Effects of Progestin on Endometrial Carcinoma by Increasing Progesterone Receptor and Mitogen-Inducible Gene-6 Horm Cancer 2017 siRNA SR30004
Negative Control Oleate attenuates palmitate-induced endoplasmic reticulum stress and apoptosis in placental trophoblasts Reproduction 2017 siRNA SR30004
Negative Control 17β-estradiol-induced ACSL4 protein expression promotes an invasive phenotype in estrogen receptor positive mammary carcinoma cells. Carcinogenesis 2017 siRNA SR30004
Negative Control CRIPTO and its signaling partner GRP78 drive the metastatic phenotype in human osteotropic prostate cancer Oncogene 2017 siRNA SR30004
Negative Control MiR-675-5p supports hypoxia induced epithelial to mesenchymal transition in colon cancer cells Oncotarget 2017 siRNA SR30004
Negative Control EGFR/ARF6 regulation of Hh signalling stimulates oncogenic Ras tumour overgrowth Nat Commun 2017 siRNA SR30004
Negative Control PUMILIO/FOXP1 signaling drives expansion of hematopoietic stem/progenitor and leukemia cells Blood 2017 siRNA SR30004
Negative Control Interleukin-27 Enhances the Potential of Reactive Oxygen Species Generation from Monocyte-derived Macrophages and Dendritic cells by Induction of p47(phox) Sci Rep 2017 siRNA SR30004
Negative Control Multiple UBXN family members inhibit retrovirus and lentivirus production and canonical NFκΒ signaling by stabilizing IκBα PLoS Pathog 2017 siRNA SR30004
Negative Control Histone H1 and Chromosomal Protein HMGN2 Regulate Prolactin-Induced STAT5 Transcription Factor Recruitment and Function in Breast Cancer Cells J. Biol. Chem 2016 siRNA SR30004
Negative Control Novel tumor suppressor microRNA at frequently deleted chromosomal region 8p21 regulates epidermal growth factor receptor in prostate cancer Oncotarget 2016 siRNA SR30004
Negative Control ERK5 kinase activity is dispensable for cellular immune response and proliferation Proc. Natl. Acad. Sci. U.S.A. 2016 siRNA SR30004
Negative Control Crizotinib inhibits NF2-associated schwannoma through inhibition of focal adhesion kinase 1 Oncotarget 2016 siRNA SR30004
negative control siRNA Systems analysis identifies miR-29b regulation of invasiveness in melanoma Mol. Cancer 2016 siRNA SR30004
NF1 Ral A, via activating the mitotic checkpoint, sensitizes cells lacking a functional Nf1 to apoptosis in the absence of protein kinase C Oncotarget 2016 siRNA SR303147
NFATC1 MiR-125a targets TNF receptor-associated factor 6 to inhibit osteoclastogenesis Exp. Cell Res. Dec 2013. siRNA SR303149
Nfe2l2 Hispidulin prevents sevoflurane- Induced memory dysfunction in aged rats Biomed. Pharmacother.2017 siRNA SR417984
NFE2L2 7-Methoxy-(9H-ß-Carbolin-1-Il)-(E)-2-Propenoic Acid, a ß-Carboline Alkaloid from Eurycoma Longifolia, Exhibits Anti-Inflammatory Effects by Activating the Nrf2/Heme Oxygenase-1 Pathway J. Cell. Biochem. Aug 2015 siRNA SR417984
Nfe2l2 Sappanone A exhibits anti-inflammatory effects via modulation of Nrf2 and NF-?B Int. Immunopharmacol. Jun 2015 siRNA SR417984
NFE2L2 Reduction of DNA damage induced by titanium dioxide nanoparticles through Nrf2 in vitro and in vivo Journal of Hazardous Materials May 2015 siRNA SR303156
NFE2L2 Caffeoylglycolic acid methyl ester, a major constituent of sorghum, exhibits anti-inflammatory activity via the Nrf2/heme oxygenase-1 pathway RSC Advances Feb 2015 siRNA SR417984
Nfe2l2 Anti-inflammatory and heme oxygenase-1 inducing activities of lanostane triterpenes isolated from mushroom Ganoderma lucidum in RAW264.7 cells Toxicol. Appl. Pharmacol. Sep 2014 siRNA SR417984
NFKB2 Biliary tract instillation of a SMAC mimetic induces TRAIL-dependent acute sclerosing cholangitis-like injury in mice Cell Death Dis 2017 siRNA SR303162
NFKBIB Let-7e modulates the inflammatory response in vascular endothelial cells through ceRNA crosstalk Sci Rep 2017 siRNA SR303164
NGFR Neurotrophin Receptors TrkA, p75(NTR), and Sortilin are Increased and Targetable in Thyroid Cancer Am. J. Pathol. 2017 siRNA SR303174
NIACR1 Anti-inflammatory effects of BHBA in both in vivo and in vitro Parkinson¿s disease models are mediated by GPR109A-dependent mechanisms J Neuroinflammation Jan 2015 siRNA SR509630
NKX2 Myofibroblasts are distinguished from activated skin fibroblasts by the expression of AOC3 and other associated markers Proc. Natl. Acad. Sci. U.S.A. Mar 2016 siRNA SR315976
NKX3 OCT-4: a novel estrogen receptor-a collaborator that promotes tamoxifen resistance in breast cancer cells Oncogene Apr 2016 siRNA SR303186
NLRP3 HIV and HCV Activate the Inflammasome in Monocytes and Macrophages via Endosomal Toll-Like Receptors without Induction of Type 1 Interferon PLoS Pathog. May 2014 siRNA SR314415
NME4 NDPK-D (NM23-H4)-mediated externalization of cardiolipin enables elimination of depolarized mitochondria by mitophagy Cell Death Differ. Jan 2016 siRNA SR404588
Nos2 The level of nitric oxide regulates lipocalin-2 expression under inflammatory condition in RINm5F beta-cells Biochem. Biophys. Res. Commun. May 2016 siRNA SR500964
NOS2A Target-Selective Protein S-Nitrosylation by Sequence Motif Recognition Cell Oct 2014 siRNA SR303202
NOS3 Role for reactive oxygen species in flow stimulated inner medullary collecting duct endothelin-1 production Am. J. Physiol. Renal Physiol. 2017 siRNA SR422386
NOS3 Histone deacetylase inhibitors promote eNOS expression in vascular smooth muscle cells and suppress hypoxia-induced cell growth J. Cell. Mol. Med 2017 siRNA SR515427
NOS3 MALAT1 and HOTAIR Long Non-Coding RNAs Play Opposite Role in Estrogen-Mediated Transcriptional Regulation in Prostate Cancer Cells Sci Rep 2016 siRNA SR303203
NOTCH1 Zinc finger RNA-binding protein promotes non-small-cell carcinoma growth and tumor metastasis by targeting the Notch signaling pathway Am J Cancer Res 2017 siRNA SR303207
NOTCH1 The microvascular niche instructs T cells in large vessel vasculitis via the VEGF-Jagged1-Notch pathway Sci Transl Med 2017 siRNA SR303207
NOTCH1 Rhamnetin induces sensitization of hepatocellular carcinoma cells to a small molecular kinase inhibitor or chemotherapeutic agents Biochim. Biophys. Acta Apr 2016 siRNA SR303207
NOTCH1 Stem cell and neurogenic gene-expression profiles link prostate basal cells to aggressive prostate cancer Nat Commun Feb 2016 siRNA SR303207
Notch1 Macrophage-Derived Delta-like 1 Enhances Interleukin-6 and Matrix Metalloproteinase-3 Production by Fibroblast-Like Synoviocytes in Arthritic Mice Arthritis & rheumatology Jun 2014 siRNA SR423522
NOTCH1 cAMP-responsive Element Modulator a (CREMa) Contributes to Decreased Notch-1 Expression in T Cells from Patients with Active Systemic Lupus Erythematosus (SLE) J. Biol. Chem., Dec 2012; 287: 42525 - 42532. siRNA SR303207
NOTCH2 NOTCH2 signaling confers immature morphology and aggressiveness in human hepatocellular carcinoma cells Oncol. Rep. Oct 2015 siRNA SR303209
Notch2 Macrophage-Derived Delta-like 1 Enhances Interleukin-6 and Matrix Metalloproteinase-3 Production by Fibroblast-Like Synoviocytes in Arthritic Mice Arthritis & rheumatology Jun 2014 siRNA SR423507
NOTCH3 Mouse model of CADASIL reveals novel insights into Notch3 function in adult hippocampal neurogenesis Neurobiol. Dis. Dec 2014 siRNA SR423462
Nox2 Nox2-mediated PI3K and Cofilin Activation Confers Alternate Redox Control of Macrophage Pinocytosis Antioxid. Redox Signal. 2016 siRNA SR301088
NOX4 Role for reactive oxygen species in flow stimulated inner medullary collecting duct endothelin-1 production Am. J. Physiol. Renal Physiol. 2017 siRNA SR417683
NOX4 Nrf2 mediates redox adaptation in NOX4-overexpressed non-small cell lung cancer cells Exp. Cell Res 2017 siRNA SR309388
NOX4 NOX4 supports glycolysis and promotes glutamine metabolism in non-small cell lung cancer cells Free Radical Biology and Medicine 2016 siRNA SR309388
Nox4 Nox4 contributes to the hypoxia-mediated regulation of actin cytoskeleton in cerebrovascular smooth muscle Life Sci. 2016 siRNA SR309388
NPM1 iTRAQ-based Quantitative Proteomic Analysis of Nasopharyngeal Carcinoma J. Cell. Biochem. Feb 2015 siRNA SR303222
NR1I2 Antidiuretic Action of Collecting Duct (Pro)Renin Receptor Downstream of Vasopressin and PGE2 Receptor EP4 J. Am. Soc. Nephrol. 2016 siRNA SR513127
NR1I3 Resveratrol Increases Hepatic SHBG Expression through Human Constitutive Androstane Receptor: a new Contribution to the French Paradox Sci Rep 2017 siRNA SR306706
NR4A2 The pharmacological stimulation of Nurr1 improves cognitive functions via enhancement of adult hippocampal neurogenesis Stem Cell Res 2016 siRNA SR513154
Nrf1 Icariin Induces Synoviolin Expression through NFE2L1 to Protect Neurons from ER Stress-Induced Apoptosis PLoS ONE Mar 2015 siRNA SR504532
NSUN7 ZNF750 Expression Is a Potential Prognostic Biomarker in Esophageal Squamous Cell Carcinoma Oncology 2017 siRNA SR312557
NTRK1 Neurotrophin Receptors TrkA, p75(NTR), and Sortilin are Increased and Targetable in Thyroid Cancer Am. J. Pathol. 2017 siRNA SR303249
NUAK2 The AMPK-related kinase SNARK regulates muscle mass and myocyte survival J. Clin. Invest. Dec 2015 siRNA SR418439
OBSCN Loss of giant obscurins from breast epithelium promotes epithelial-to-mesenchymal transition, tumorigenicity and metastasis Oncogene Nov 2014 siRNA SR313312
OCLN HIV alters gap junction-mediated intercellular communication in human brain pericytes Frontiers in Molecular Neuroscience 2017 siRNA SR303274
OCLN Occludin regulates glucose uptake and ATP production in pericytes by influencing AMP-activated protein kinase activity J. Cereb. Blood Flow Metab. 2017 siRNA SR303274
OGT Linking Cancer Metabolism to DNA Repair and Accelerated Senescence Mol. Cancer Res 2016 siRNA SR305553
OMA1 The Role and Regulation of Mitochondrial Dynamics in Cisplatin Resistance in Human Gynecologic Cancer Cells Thesis Jun 2015 siRNA SR314494
OMA1 p53 is required for cisplatin-induced processing of the mitochondrial fusion protein L-Opa1 that is mediated by the mitochondrial metallopeptidase Oma1 in Gynecologic Cancers J. Biol. Chem. Aug 2014 siRNA SR314494
Opa1 Sequential forward and reverse transport of the Na+ Ca2+ exchanger generates Ca2+ oscillations within mitochondria Nat Commun 2018 siRNA SR505373
OPA1 Mitofusin 1 and optic atrophy 1 shift metabolism to mitochondrial respiration during aging Aging Cell 2017 siRNA SR303287
ORAI1 Ca(2+) Channel Re-localization to Plasma-Membrane Microdomains Strengthens Activation of Ca(2+)-Dependent Nuclear Gene Expression Cell Rep Jul 2015 siRNA SR313705
ORMDL3 Cutting Edge: Targeting Epithelial ORMDL3 Increases, Rather than Reduces, Airway Responsiveness and Is Associated with Increased Sphingosine-1-Phosphate J. Immunol 2017 siRNA SR403232
OSR1 WNK4 is an adipogenic factor and its deletion reduces diet-induced obesity in mice EBioMedicine 2017 siRNA SR407609
OST4 OST4 is a subunit of the mammalian oligosaccharyltransferase required for efficient N-glycosylation J. Cell Sci., Jun 2013; 126: 2595 - 2606. siRNA SR319126
P2RX4 Relative Role of Akt, ERK and CREB in Alcohol-Induced Microglia P2X4R Receptor Expression Alcohol Alcohol. Mar 2016 siRNA SR412195
P2RY6 Human Keratinocytes Respond to Extracellular UTP by Induction of Hyaluronan Synthase 2 Expression and Increased Hyaluronan Synthesis J. Biol. Chem 2017 siRNA SR303329
p53 SCO2 Induces p53-Mediated Apoptosis by Thr845 Phosphorylation of ASK-1 and Dissociation of the ASK-1–Trx Complex Mol. Cell. Biol., Apr 2013; 33: 1285 - 1302. siRNA SR304901
PAF1 Human RNA polymerase II associated factor 1 complex promotes tumorigenesis by activating c-MYC transcription in non-small cell lung cancer Biochem. Biophys. Res. Commun. Aug 2015 siRNA SR310177
Panx1 Cannabinoids prevent the amyloid ß-induced activation of astroglial hemichannels: A neuroprotective mechanism Glia 2016 siRNA SR414119
PANX1 Prenatal exposure to inflammatory conditions increases Cx43 and Panx1 unopposed channel opening and activation of astrocytes in the offspring effect on neuronal survival Glia Jun 2015 siRNA SR414119
PANX1 Pannexin 1 Channels Mediate the Release of ATP into the Lumen of the Rat Urinary Bladder J. Physiol. (Lond.) Jan 2015 siRNA SR513786
PANX1 Astrocytes inhibit nitric oxide-dependent Ca(2+) dynamics in activated microglia: Involvement of ATP released via pannexin 1 channels Glia. 2013 Dec;61(12):2023-37 siRNA SR513786
PAPPA MiR-490-3p modulates the proliferation of vascular smooth muscle cells induced by ox-LDL through targeting PAPP-A Cardiovasc Res, Jul 2013; 10.1093/cvr/cvt172. siRNA SR303354
PAPPA MiR-490-3p modulates proliferation of vascular smooth muscle cells induced by ox-LDL through targeting PAPP-A Cardiovascular Research Advance Access Jul 2013 siRNA SR303354
PARK2 Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD(+)/SIRT1 Reduction Cell May 2014 siRNA SR303355
PARK2 Mitochondria directly donate their membrane to form autophagosomes during a novel mechanism of parkin-associated mitophagy Cell Biosci 16 4 1. April 2014 siRNA SR303355
PARK7 The Parkinsonism-associated protein DJ-1/Park7 prevents glycation damage in human keratinocyte Biochem. Biophys. Res. Commun. Mar 2016 siRNA SR307752
PAX4 PAR2 regulates regeneration, transdifferentiation, and death Cell Death Dis 2016 siRNA SR303361
PCSK6 PACE4 Proteolytically Processes LOXL2 with little impact on its catalytic activity J. Biol. Chem. 2017 siRNA SR303337
PCYT1A MYC is a positive regulator of choline metabolism and impedes mitophagy-dependent necroptosis in diffuse large B-cell lymphoma Blood Cancer J 2017 siRNA SR303397
PCYT1A Hepatitis C virus induced changes in cellular lipids-identifying novel host antiviral drug target Thesis Aug 2014 siRNA SR303397
PDCD10 MicroRNA-425-5p regulates chemoresistance in colorectal cancer cells via regulation of Programmed Cell Death 10 J. Cell. Mol. Med. Dec 2015 siRNA SR307707
PDE1B Confinement Sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways Cell Rep May 2016 siRNA SR303418
Pdgfd Role of PDGF-D and PDGFR-ß in neuroinflammation in experimental ICH mice model Exp. Neurol. Jun 2016 siRNA SR407408
PDGFR Inhibition of stress fiber formation preserves blood-brain barrier after intracerebral hemorrhage in mice J. Cereb. Blood Flow Metab. 2016 siRNA SR422058
PDLIM2 Klotho ameliorates cyclosporine A-induced nephropathy via PDLIM2/NF-kB p65 signaling pathway Biochem. Biophys. Res. Commun 2017 siRNA SR411767
PDZRN3 PDZRN3 destabilizes endothelial cell-cell junctions through a PKCζ-containing polarity complex to increase vascular permeability Sci. Signal 2017 siRNA SR307944
PDZRN3 Kif26b controls endothelial cell polarity through the Dishevelled/Daam1-dependent planar cell polarity signaling pathway Mol. Biol. Cell Jan 2016 siRNA SR307944
PDZRN3 The ubiquitin ligase PDZRN3 is required for vascular morphogenesis through Wnt/planar cell polarity signalling Nat Commun Sep 2014 siRNA SR307944
PECAM-1 Syndecan-4 controls lymphatic vasculature remodeling during embryonic development Development 2016 siRNA SR303439
PEMT Hepatitis C virus induced changes in cellular lipids-identifying novel host antiviral drug target Thesis Aug 2014 siRNA SR307049
PFKFB3 GM-CSF Enhances Macrophage Glycolytic Activity In Vitro and Improves Detection of Inflammation In Vivo J. Nucl. Med. 2016 siRNA SR416726
PFKFB3 Bioenergetic mechanisms in astrocytes may contribute to amyloid plaque deposition and toxicity J. Biol. Chem. Mar 2015 siRNA SR303464
PFKFB3 Bioenergetic mechanisms in astrocytes may contribute to amyloid plaque deposition and toxicity JBC Papers in Press Mar 2015 siRNA SR303464
PGC1a Rosiglitazone promotes neurite outgrowth and mitochondrial function in N2A cells via PPARgamma pathway Mitochondrion Dec 2013. siRNA SR420231
PHB The Role and Regulation of Mitochondrial Dynamics in Cisplatin Resistance in Human Gynecologic Cancer Cells Thesis Jun 2015 siRNA SR303488
PHF8 c-MYC drives histone demethylase PHF8 during neuroendocrine differentiation and in castration-resistant prostate cancer Oncotarget 2016 siRNA SR308029
PHLPP1 Role of PHLPP1 in inflammation response: Its loss contributes to gliomas development and progression Int. Immunopharmacol. Mar 2016 siRNA SR308119
PI31 Molecular and Cellular Roles of PI31 (PSMF1) in Regulation of Proteasome Function J. Biol. Chem. April 2014 siRNA SR306299
PIK3C2A PI3K/AKT pathway mediates induction of IL-1RA by TSH in fibrocytes: Modulation by PTEN J. Clin. Endocrinol. Metab. May 2014 siRNA SR303516
Pik3c2b PI3 kinases p110a and PI3K-C2ß negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets Molecular Metabolism May 2016 siRNA SR423087
PIM1 Pim1 kinase is upregulated in glioblastoma multiforme and mediates tumor cell survival Neuro-oncology Aug 2014 siRNA SR303522
PINK1 Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD(+)/SIRT1 Reduction Cell May 2014 siRNA SR312201
PIP Role of dendritic cell maturation factors produced by human invariant NKT cells in immune tolerance J. Leukoc. Biol. 2016 siRNA SR303531
PIP Role of dendritic cell maturation factors produced by human invariant NKT cells in immune tolerance J. Leukoc. Biol. 2016 siRNA SR303531
PKD1 The tumor promoter-activated protein kinase Cs are a system for regulating filopodia Cytoskeleton (Hoboken) 2017 siRNA SR421194
PKD2 The tumor promoter-activated protein kinase Cs are a system for regulating filopodia Cytoskeleton (Hoboken) 2017 siRNA SR421480
PKD2L1 TRP channels in brown and white adipogenesis from human progenitors: new therapeutic targets and the caveats associated with the common antibiotic, streptomycin FASEB J. 2017 siRNA SR305958
PLEKHG3 PLEKHG3 enhances polarized cell migration by activating actin filaments at the cell front Proc. Natl. Acad. Sci. U.S.A. 2016 siRNA SR308671
PLIN2 Hepatitis B virus X induces inflammation and cancer in mice liver through dysregulation of cytoskeletal remodeling and lipid metabolism Oncotarget 2016 siRNA SR300083
PLK1 PLK1 promotes epithelial-mesenchymal transition and metastasis of gastric carcinoma cells Am J Transl Res 2016 siRNA SR310998
PLK1 PLK1 promotes epithelial-mesenchymal transition and metastasis of gastric carcinoma cells Am J Transl Res 2016 siRNA SR310998
PLOD3 Recruitment of Matrix Metalloproteinase-9 (MMP-9) to the fibroblast cell surface by Lysyl Hydroxylase-3 (LH3) triggers TGF-ß activation and fibroblast differentiation J. Biol. Chem. Mar 2015 siRNA SR305927
PNPLA8 SREBP-2/PNPLA8 axis improves non-alcoholic fatty liver disease through activation of autophagy Sci Rep 2016 siRNA SR309408
POLR3A Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA Proc. Natl. Acad. Sci. U.S.A. 2016 siRNA SR307620
PPARG Alpha-Tocopherol prevents esophageal squamous cell carcinoma by modulating PPARγ-Akt signaling pathway at the early stage of carcinogenesis Oncotarget 2017 siRNA SR303655
PPARGC1A Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes Cell 2017 siRNA SR420231
PPARGC1A The neuroprotective role of metformin in advanced glycation end product treated human neural stem cells is AMPK-dependent Biochim. Biophys. Acta Jan 2015 siRNA SR420231
PPIC Systems analysis identifies miR-29b regulation of invasiveness in melanoma Mol. Cancer 2016 siRNA SR303664
PPP2CA PP2AC Level Determines Differential Programing of p38-TSC-mTOR Signaling and Therapeutic Response to p38-Targeted Therapy in Colorectal Cancer EBioMedicine Nov 2015 siRNA SR303682
PPP5C Structural and functional basis of protein phosphatase 5 substrate specificity Proc. Natl. Acad. Sci. U.S.A. 2016 siRNA SR303702
Prdm1 Increased cathepsin S in Prdm1-/- dendritic cells alters the TFH cell repertoire and contributes to lupus Nat. Immunol. 2017 siRNA SR420429
PRDM1 Cellular differentiation regulator BLIMP1 induces Epstein-Barr virus lytic reactivation in epithelial and B cells by activating transcription from both the R and Z promoters J. Viro Nov 2014 siRNA SR300437
PRKAA1 Re-sensitization of radiation resistant colorectal cancer cells to radiation through inhibition of AMPK pathway Oncol Lett May 2016 siRNA SR303721
PRKAA1 LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress Nat. Cell Biol. Apr 2016 siRNA SR303721
PRKAA2 LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress Nat. Cell Biol. Apr 2016 siRNA SR303722
PRKACA Regulation of Mitochondrial poly (ADP-ribose) Polymerase Activation by the ß-adrenoceptor/cAMP/Protein Kinase A Axis During Oxidative Stress Molecular PHARMACOLOGY July 2014 siRNA SR303725
PRKCA The Syndecan-4/Protein Kinase Ca Pathway Mediates Prostaglandin E2-induced Extracellular Regulated Kinase (ERK) Activation in Endothelial Cells and Angiogenesis in Vivo J. Biol. Chem., May 2013; 288: 12712 - 12721. siRNA SR303735
PRKCA Protein Kinases D2 and D3 Are Novel Growth Regulators in HCC1806 Triple-negative Breast Cancer Cells Anticancer Res, Feb 2013; 33: 393 - 399. siRNA SR303735
PRKCE Rise and Fall of Kir2.2 Current by TLR4 Signaling in Human Monocytes: PKC-Dependent Trafficking and PI3K-Mediated PIP2 Decrease J. Immunol. Oct 2015 siRNA SR303738
PRKDC Identification of PRKDC (protein kinase, DNA-activated, catalytic polypeptide) as an essential gene for colorectal cancer (CRCs) cells Gene Mar 2016 siRNA SR303748
PRNP The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through Dipeptidyl Aminopeptidase-like protein 6 J. Biol. Chem. Nov 2013 siRNA SR303776
PS100001 Macrophage-Derived Delta-like 1 Enhances Interleukin-6 and Matrix Metalloproteinase-3 Production by Fibroblast-Like Synoviocytes in Arthritic Mice Arthritis & rheumatology Jun 2014 siRNA SR30004
PS100020 SDF1a-induced interaction of the adapter proteins Nck and HS1 facilitates actin polymerization and migration in T cells Eur. J. Immunol. Oct 2014 siRNA SR30004
Psmd13 Pharmacological Amelioration of Cone Survival and Vision in a Mouse Model for Leber Congenital Amaurosis J. Neurosci. May 2016 siRNA SR412711
PSMD13 Temperature-sensitive retinoid isomerase activity of RPE65 mutants associated with Leber Congenital Amaurosis J. Biochem. Mar 2015 siRNA SR303852
PSMD2 Angiopoietin-2 secretion by endothelial cells exosome: regulation by the PI3K/Akt/eNOS and syndecan 4/syntenin pathways J. Biol. Chem. Nov 2013 siRNA SR303842
PSMD3 The transition zone protein Rpgrip1l regulates proteasomal activity at the primary cilium J. Cell Biol. Jul 2015 siRNA SR416821
PTEN Neuronal RARß Signaling Modulates PTEN Activity Directly in Neurons and via Exosome Transfer in Astrocytes to Prevent Glial Scar Formation and Induce Spinal Cord Regeneration J. Neurosci. Nov 2015 siRNA SR413443
PTEN PI3K/AKT pathway mediates induction of IL-1RA by TSH in fibrocytes: Modulation by PTEN J. Clin. Endocrinol. Metab. May 2014 siRNA SR303860
PTEN NVP-BEZ235, a dual PI3K/mTOR inhibitor, induces cell death through alternate routes in prostate cancer cells depending on the PTEN genotype Apoptosis Mar 2014 siRNA SR303860
PTGES miR-21 modulates prostaglandin signaling and promotes gastric tumorigenesis by targeting 15-PGDH Biochem. Biophys. Res. Commun.2017 siRNA SR306338
PTGS2 Differential expression of cyclooxygenase-2 in metastatic melanoma affects progression free survival Oncotarget 2016 siRNA SR303873
PTGS2 Phenolcarboxylic acids from medicinal herbs exert anticancer effects through disruption of COX-2 activity Phytomedicine Jun 2014 siRNA SR303873
PTGS2 Ubiquitin-Proteasomal Degradation of COX-2 in TGF-ß Stimulated Human Endometrial Cells Is Mediated Through Endoplasmic Reticulum Mannosidase I Endocrinology, Jan 2012; 153: 426 - 437. siRNA SR303873
PTK2 Phosphoinositide 3-kinase p85beta regulates invadopodium formation Biol Open Sep 2014 siRNA SR421142
PTX3 Constitutive Expression of PTX3 by Human Amniotic Membrane Cells Leads to Formation of the HC-HA/PTX3 Complex J. Biol. Chem. Mar 2014 siRNA SR303915
PTX3 PTX3 Controls Activation of Matrix Metalloproteinase 1 and Apoptosis in Conjunctivochalasis Fibroblasts Invest. Ophthalmol. Vis. Sci., Jun 2012; 53: 3414 - 3423. siRNA SR303915
PUM1 PUMILIO/FOXP1 signaling drives expansion of hematopoietic stem/progenitor and leukemia cells Blood 2017 siRNA SR306467
PUM2 PUMILIO/FOXP1 signaling drives expansion of hematopoietic stem/progenitor and leukemia cells Blood 2017 siRNA SR308223
PXN Paxillin is positively correlated with the clinicopathological factors of colorectal cancer, and knockdown of Paxillin improves sensitivity to cetuximab in colorectal cancer cells ONCOLOGY REPORTS Jan 2016 siRNA SR303929
RAB27B Hypomethylated Rab27b is a progression-associated prognostic biomarker of glioma regulating MMP-9 to promote invasion Oncol. Rep. Jul 2015 siRNA SR303953
RAB3A Mutant Huntingtin Impairs BDNF Release from Astrocytes by Disrupting Conversion of Rab3a-GTP into Rab3a-GDP J. Neurosci. 2016 siRNA SR402766
RAC1 MicroRNA-141 suppresses prostate cancer stem cells and metastasis by targeting a cohort of pro-metastasis genes Nat Commun 2017 siRNA SR303958
RAC1 MicroRNA-141 suppresses prostate cancer stem cells and metastasis by targeting a cohort of pro-metastasis genes Nat Commun 2017 siRNA SR303958
RAF1 The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux Autophagy Jun 2015 siRNA SR303972
RALA Ral A, via activating the mitotic checkpoint, sensitizes cells lacking a functional Nf1 to apoptosis in the absence of protein kinase C Oncotarget 2016 siRNA SR303975
Rbpj A genetic cell context-dependent role for ZEB1 in lung cancer Nat Commun 2016 siRNA SR415718
RC227466 Upregulation of KLF4 by methylseleninic acid in human esophageal squamous cell carcinoma cells: Modification of histone H3 acetylation through HAT/HDAC interplay Mol. Carcinog. Jan 2014 siRNA SR301765
Re-suspension Buffer Resveratrol Increases Hepatic SHBG Expression through Human Constitutive Androstane Receptor: a new Contribution to the French Paradox Sci Rep 2017 siRNA SR30005
REL NPD1-mediated stereoselective regulation of BIRC3 expression through cREL is decisive for neural cell survival Cell Death Differ. Jan 2015 siRNA SR304027
RELA Follicular Stimulating Hormone Accelerates Atherogenesis by Increasing Endothelial VCAM-1 Expression Theranostics 2017 siRNA SR304030
RELA ELF4 is critical for induction of type I interferon and the host antiviral response Nat. Immunol. 1237-46 Nov 2013 siRNA SR304030
REST Modulation of nuclear REST by alternative splicing: a potential therapeutic target for Huntington's disease J. Cell. Mol. Med. 2017 siRNA SR427708
REST Epigenetic gene regulation by TET3 and 5-hydroxymethylcytosine during retinal maturation Thesis Jun 2015 siRNA SR304036
REST TET3 Is Recruited by REST for Context-Specific Hydroxymethylation and Induction of Gene Expression Cell Rep Apr 2015 siRNA SR304036
Rgcc Regulator of Cell Cycle (RGCC) Expression During the Progression of Alzheimer's Disease Cell Transplant 2017 siRNA SR402545
RHEB Role of RHEB in Regulating Differentiation Fate of Mesenchymal Stem Cells for Cartilage and Bone Regeneration Int J Mol Sci 2017 siRNA SR304066
RHEB RHEB: a potential regulator of chondrocyte phenotype for cartilage tissue regeneration J Tissue Eng Regen Med Apr 2016 siRNA SR304066
RICTOR Follicular Stimulating Hormone Accelerates Atherogenesis by Increasing Endothelial VCAM-1 Expression Theranostics 2017 siRNA SR316744
RIPK2 Receptor Interacting Protein-2 acts as negative regulator for nontypeable Haemophilus influenzae-induced mucin MUC5AC expression ntegrative Molecular Medicine 2017 siRNA SR305775
RIPK3 Phagocytosis of environmental or metabolic crystalline particles induces cytotoxicity by triggering necroptosis across a broad range of particle size and shape Sci Rep 2017 siRNA SR307548
RMDN3 Altered Protein Interactions of the Endogenous Interactome of PTPIP51 towards MAPK Signaling Biomolecules 2017 siRNA SR310551
ROCK1 Targeting the Metastasis Suppressor, NDRG1, Using Novel Iron Chelators: Regulation of Stress Fiber-Mediated Tumor Cell Migration via Modulation of the ROCK1/pMLC2 Signaling Pathway Mol. Pharmacol., Feb 2013; 83: 454 - 469. siRNA SR422726
ROCK2 Rho-associated kinase is a therapeutic target in neuroblastoma Proc. Natl. Acad. Sci. U.S.A. 2017 siRNA SR306287
RPS19 Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA Proc. Natl. Acad. Sci. U.S.A. 2016 siRNA SR304179
RPTOR Follicular Stimulating Hormone Accelerates Atherogenesis by Increasing Endothelial VCAM-1 Expression Theranostics 2017 siRNA SR311531
RUNX2  Synergistic effect of JQ1 and rapamycin for treatment of human osteosarcoma Int. J. Cancer Oct 2014 siRNA SR300606
S100A4 miR-187-3p inhibits the metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by targeting S100A4 Cancer Lett. 2016 siRNA SR304214
S100A8 Role of dendritic cell maturation factors produced by human invariant NKT cells in immune tolerance J. Leukoc. Biol. 2016 siRNA SR304218
S100A8 Role of dendritic cell maturation factors produced by human invariant NKT cells in immune tolerance J. Leukoc. Biol. 2016 siRNA SR304218
S100A8 Target-Selective Protein S-Nitrosylation by Sequence Motif Recognition Cell Oct 2014 siRNA SR304218
S100A9 Target-Selective Protein S-Nitrosylation by Sequence Motif Recognition Cell Oct 2014 siRNA SR304219
S1PR2 Sphingosine-1-phosphate induces pro-remodelling response in airway smooth muscle cells Allergy July 2014 siRNA SR306152
Sac2/Innp5F Multiphasic dynamics of phosphatidylinositol 4-phosphate during phagocytosis Molecular Biology of the Cell 2016 siRNA SR422169
Sac2/Innp5F Multiphasic dynamics of phosphatidylinositol 4-phosphate during phagocytosis Molecular Biology of the Cell 2016 siRNA SR422169
SC319768 TLR2 signaling directs NO-dependent MMP-9 induction in mouse microglia Neurosci. Lett. April 2014 siRNA SR304856
SC320329 Persistent N-cadherin Expression Induced by Extended Epidermal Growth Factor Exposure Regulates Multicellular Aggregate Compaction and Sensitivity to Cisplatin Med chem S Jan 2014 siRNA SR300716
SCARB1 High-density lipoprotein and apolipoprotein A-I inhibit palmitate-induced translocation of toll-like receptor 4 into lipid rafts and inflammatory cytokines in 3T3-L1 adipocytes Biochem. Biophys. Res. Commun 2017 siRNA SR416342
SCD Down-regulation of stearoyl-CoA desaturase-1 increases susceptibility to palmitic-acid-induced lipotoxicity in human trophoblast cells The Journal of nutritional biochemistry 2017 siRNA SR304248
SCD 17ß-estradiol induces stearoyl-CoA desaturase-1 expression in estrogen receptor-positive breast cancer cells BMC Cancer May 2015 siRNA SR304248
SCD1 Stearoyl CoA desaturase is required to produce active, lipid-modified Wnt proteins Cell Rep. 2013 Sep 26;4(6):1072-81 siRNA SR411990
SCLY Diet-induced obesity in the selenocysteine lyase knockout mouse Antioxid. Redox Signal. Jul 2015 siRNA SR414271
SCO2 SCO2 Induces p53-Mediated Apoptosis by Thr845 Phosphorylation of ASK-1 and Dissociation of the ASK-1–Trx Complex Mol. Cell. Biol., Apr 2013; 33: 1285 - 1302. siRNA SR306726
SDC4 Syndecan-4 controls lymphatic vasculature remodeling during embryonic development Development 2016 siRNA SR304301
SDCBP Syntenin promotes VEGF-induced VEGFR2 endocytosis and angiogenesis by increasing ephrin-B2 function in endothelial cells Oncotarget 2017 siRNA SR321723
SDHC Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells Elife 2017 siRNA SR403916
SERPINE2 Regulation of tumor growth by circulating full-length chromogranin A Oncotarget 2016 siRNA SR303504
SESN1 SESN2 facilitates mitophagy by helping Parkin translocation through ULK1 mediated Beclin1 phosphorylation Sci Rep 2018 siRNA SR309047
SESN2 SESN2 facilitates mitophagy by helping Parkin translocation through ULK1 mediated Beclin1 phosphorylation Sci Rep 2018 siRNA SR313205
SFN CALML5 is a ZNF750- and TINCR-induced protein that binds stratifin to regulate epidermal differentiation Genes Dev. Nov 2015 siRNA SR301875
Sfrs10 Transformer 2 beta homolog (Drosophila) (TRA2B) regulates Protein Kinase C deltaI (PKCdI) splice variant expression during 3T3L1 pre-adipocyte cell cycle J. Biol. Chem. Sep 2014 siRNA SR408282
SH3PXD2A The genomic landscape of schwannoma Nat. Genet. 2016 siRNA SR306419
SHANK3 SHANK3 Deficiency Impairs Heat Hyperalgesia and TRPV1 Signaling in Primary Sensory Neurons Neuron 2016 siRNA SR313832
Siah1 Disruption of the nuclear p53-GAPDH complex protects against ischemia-induced neuronal damage Mol Brain Mar 2014 siRNA SR304369
SIK1 SIK inhibition in human myeloid cells modulates TLR and IL-1R signaling and induces an anti-inflammatory phenotype J. Leukoc. Biol. Nov 2015 siRNA SR315713
SIK2 SIK inhibition in human myeloid cells modulates TLR and IL-1R signaling and induces an anti-inflammatory phenotype J. Leukoc. Biol. Nov 2015 siRNA SR308116
SIK3 SIK inhibition in human myeloid cells modulates TLR and IL-1R signaling and induces an anti-inflammatory phenotype J. Leukoc. Biol. Nov 2015 siRNA SR308237
siRNA MicroRNA-708 Induces Apoptosis and Suppresses Tumorigenicity in Renal Cancer Cells Cancer Res., Oct 2011; 71: 6208 - 6219. siRNA
siRNA Curcumin Modulates MicroRNA-203–Mediated Regulation of the Src-Akt Axis in Bladder Cancer Cancer Prevention Research, Oct 2011; 4: 1698 - 1709. siRNA SR300144
siRNA Long-chain acyl-CoA synthetase 4 modulates prostaglandin E2 release from human arterial smooth muscle cells J. Lipid Res., Apr 2011; 52: 782 - 793 siRNA
siRNA Scrambled Control Cytosolic sulfotransferase 1A3 is induced by dopamine and protects neuronal cells from dopamine toxicity: role of D1 receptor-NMDA receptor coupling J Biol Chem. 2013 Oct 17 siRNA SR30004
SIRT1 Hyperbaric Oxygen Reduces Infarction Volume and Hemorrhagic Transformation Through ATP/NAD(+)/Sirt1 Pathway in Hyperglycemic Middle Cerebral Artery Occlusion Rats Stroke 2017 siRNA SR419269
SIRT1 TRPV1 activation counters diet-induced obesity through sirtuin-1 activation and PRDM-16 deacetylation in brown adipose tissue Int J Obes (Lond) 2017 siRNA SR308256
Sirt1 Sirt1 deficiency protects cochlear cells and delays the early onset of age-related hearing loss in C57BL/6 mice Neurobiology of Aging Mar 2016 siRNA SR419269
SIRT1 Sirtuin 1 promotes the growth and cisplatin resistance of endometrial carcinoma cells: a novel therapeutic target Lab. Invest. Sep 2015 siRNA SR308256
SIRT1 Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD(+)/SIRT1 Reduction Cell May 2014 siRNA SR308256
SIRT4 MicroRNA-15b regulates mitochondrial ROS production and the senescence-associated secretory phenotype through sirtuin 4/SIRT4 Aging (Albany NY) Feb 2016 siRNA SR308254
SIRT6 The RUNX2 Transcription Factor Negatively Regulates SIRT6 Expression to Alter Glucose Metabolism in Breast Cancer Cells J. Cell. Biochem. Mar 2015 siRNA SR309840
SLC31A1 Dextran-Catechin inhibits angiogenesis by disrupting copper homeostasis in endothelial cells Sci Rep 2017 siRNA SR300931
SLC7A2 Degradation of AMPK-α1 sensitizes BRAF inhibitor-resistant melanoma cells to arginine deprivation Mol Oncol 2017 siRNA SR304426
SLC8B1 Sequential forward and reverse transport of the Na+ Ca2+ exchanger generates Ca2+ oscillations within mitochondria Nat Commun 2018 siRNA SR312772
SLCO2B1 Association of SLCO2B1 Genotypes With Time to Progression and Overall Survival in Patients Receiving Androgen-Deprivation Therapy for Prostate Cancer J. Clin. Oncol. Dec 2015 siRNA SR307748
SMAD3 Engagement of SLAMF3 enhances CD4+ T-cell sensitivity to IL-2 and favors regulatory T-cell polarization in systemic lupus erythematosus Proc. Natl. Acad. Sci. U.S.A 2016 siRNA SR320898
Smarca1 Snf2h-mediated chromatin organization and histone H1 dynamics govern cerebellar morphogenesis and neural maturation Nat Commun Jun 2014 siRNA SR421862
SMARCF1 Downregulation of ARID1A, a component of the SWI/SNF chromatin remodeling complex, in breast cancer Journal of Cancer 2017 siRNA SR305421
SMN1 SMN affects membrane remodelling and anchoring of the protein synthesis machinery J. Cell. Sci. Jan 2016 siRNA SR304480
SMURF2 The E3 Ubiquitin Ligase SMAD Ubiquitination Regulatory Factor 2 Negatively Regulates Krüppel-like Factor 5 Protein J. Biol. Chem., Nov 2011; 286: 40354 - 40364. siRNA SR312096
SMURF2 TRB3 interacts with SMAD3 promoting tumor cell migration and invasion J. Cell Sci., Oct 2011; 124: 3235 - 3246. siRNA SR312096
SNAI2 A novel microRNA regulator of prostate cancer epithelial-mesenchymal transition Cell Death Differ. 2017 siRNA SR304468
SNW1 RNA binding protein RALY promotes Protein Arginine Methyltransferase 1 alternatively spliced isoform v2 relative expression and metastatic potential in breast cancer cells Int. J. Biochem. Cell Biol. 2017 siRNA SR307894
SOCS3 Suppressor of Cytokine Signaling 1 Is a Positive Regulator of TGF-ß-Induced Prostaglandin Production in Human Follicular Dendritic Cell-like Cells J. Immunol. May 2015 siRNA SR305948
SOCS5 Japanese Encephalitis Virus exploits the microRNA-432 to regulate the expression of Suppressor of Cytokine Signaling (SOCS) 5 Sci Rep Jun 2016 siRNA SR306430
SOX18 Sry-type HMG box 18 contributes to the differentiation of bone marrow-derived mesenchymal stem cells to endothelial cells Differentiation Apr 2015 siRNA SR310056
SOX2 Oncogenic Sox2 regulates and cooperates with VRK1 in cell cycle progression and differentiation Sci Rep Jun 2016 siRNA SR304528
SOX2 CEACAM1 Promotes Melanoma Cell Growth through Sox-2 Neoplasia Jun 2014 siRNA SR304528
SOX9 SOX9 indirectly regulates CEACAM1 expression and immune resistance in melanoma cells Oncotarget 2016 siRNA SR304532
SOX9 Sry-type HMG box 18 contributes to the differentiation of bone marrow-derived mesenchymal stem cells to endothelial cells Differentiation Apr 2015 siRNA SR304532
SOX9 In vitro osteogenic potential of human bone marrow derived MSCs is predicted by Runx2/Sox9 Ratio Tissue Eng Part A July 2014 siRNA SR304532
SP1 MicroRNA-29b Regulates Ethanol-induced Neuronal Apoptosis in the Developing Cerebellum through Sp1/Rax/PKR J. Biol. Chem., Feb 2014. siRNA SR420087
SP1 A possible gene silencing mechanism: Hypermethylation of the Keap1 promoter abrogates binding of the transcription factor Sp1 in lung cancer cells Biochem Biophys Res Commun. 2012 Nov 9;428(1):80-5 siRNA SR304537
Spns2 Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs J. Clin. Invest. Oct 2014 siRNA SR417168
Sprouty1 Atypical role of sprouty in p21 dependent inhibition of cell proliferation in colorectal cancer Mol. Carcinog. 2016 siRNA SR405932
Sprouty1 Atypical role of sprouty in p21 dependent inhibition of cell proliferation in colorectal cancer Mol. Carcinog. 2016 siRNA SR405932
SPRY1 Atypical role of sprouty in p21 dependent inhibition of cell proliferation in colorectal cancer Mol. Carcinog. Aug 2015 siRNA SR306938
SPSB1 SPSB1, a Novel Negative Regulator of the TGF-ß Signaling Pathway Targeting the Type II Receptor J. Biol. Chem. Jun 2015 siRNA SR312825
SPTBN1 IL-27 inhibits HIV-1 infection in human macrophages by down-regulating host factor SPTBN1 during monocyte to macrophage differentiation J. Exp. Med., Mar 2013; 210: 517 - 534. siRNA SR304571
SQSTM1 IL-1ß induces p62/SQSTM1 and represses androgen receptor expression in prostate cancer cells J. Cell. Biochem. Aug 2014 siRNA SR305865
SQSTM1 p62/SQSTM1 is required for cell survival of apoptosis-resistant bone metastatic prostate cancer cell lines Prostate. 2013 Sep 30. doi: 10.1002/pros.22737 siRNA SR305865
SR30004 Nuclear TRAF3 is a negative regulator of CREB in B cells Proc. Natl. Acad. Sci. U.S.A. Jan 2016 siRNA SR30004
SR30004 SMN affects membrane remodelling and anchoring of the protein synthesis machinery J. Cell. Sci. Jan 2016 siRNA SR30004
SR30004 SIK inhibition in human myeloid cells modulates TLR and IL-1R signaling and induces an anti-inflammatory phenotype J. Leukoc. Biol. Nov 2015 siRNA SR30004
SR30004 HIF1a deficiency reduces colon inflammation in a mouse model of proximal colon cancer Dis Model Mech Jul 2015 siRNA SR30004
SR30004 SPSB1, a Novel Negative Regulator of the TGF-ß Signaling Pathway Targeting the Type II Receptor J. Biol. Chem. Jun 2015 siRNA SR30004
SR30004 Phosphatidic acid (PA) increases EGF receptor (EGFR) expression by stabilizing mRNA, inhibiting RNAse-A, and by inhibiting lysosomal and proteasomal degradation of the internalized EGFR Mol. Cell. Biol. Jun 2015 siRNA SR30004
SR30004 Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap PLoS Genet. May 2015 siRNA SR30004
SR30004 Decreased DNA methylation in the promoter region of the WNT5A and GDNF genes may promote the osteogenicity of mesenchymal stem cells from patients with ossified spinal ligaments J. Pharmacol. Sci. Apr 2015 siRNA SR30004
SR30004 Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene J. Clin. Invest. Apr 2015 siRNA SR30004
SR30004 S100B is required for high glucose-induced pro-fibrotic gene expression and hypertrophy in mesangial cells Int. J. Mol. Med. Feb 2015 siRNA SR30004
SR30004 Effects of obesity on severity of colitis and cytokine expression in mouse mesenteric fat. Potential role of adiponectin receptor 1 Am. J. Physiol. Gastrointest. Liver Physiol. Jan 2015 siRNA SR30004
SR30004 BDNF repairs podocyte damage by microRNA-mediated increase of actin polymerization J. Pathol. Nov 2014 siRNA SR30004
SR30005 Post-transcriptional regulation of Rbm5 expression in undifferentiated H9c2 myoblasts In Vitro Cell. Dev. Biol. Anim. Dec 2015 siRNA SR30005
SR312201 SESN2 facilitates mitophagy by helping Parkin translocation through ULK1 mediated Beclin1 phosphorylation Sci Rep 2018 siRNA SR312201
SRC Calcium-Ask1-MKK7-JNK2-c-Src Signaling Cascade Mediates Disruption of Intestinal Epithelial Tight Junctions by Dextran Sulfate Sodium Biochem. J. Nov 2014 siRNA SR304574
SRC The ShcA PTB Domain Functions as a Biological Sensor of Phosphotyrosine Signaling during Breast Cancer Progression Cancer Res., Jul 2013; 73: 4521 - 4532. siRNA SR416929
SRC miR-23b Represses Proto-oncogene Src Kinase and Functions as Methylation-Silenced Tumor Suppressor with Diagnostic and Prognostic Significance in Prostate Cancer Cancer Res., Dec 2012; 72: 6435 - 6446. siRNA SR304574
Src MicroRNA-205 Inhibits Src-Mediated Oncogenic Pathways in Renal Cancer Cancer Res., Apr 2011; 71: 2611 - 2621 siRNA SR304574
SREBF1 17ß-estradiol induces stearoyl-CoA desaturase-1 expression in estrogen receptor-positive breast cancer cells BMC Cancer May 2015 siRNA SR304579
ST8SIA2 Insulin promotes cell migration by regulating PSA-NCAM Exp. Cell Res 2017 siRNA SR305373
ST8SIA4 Insulin promotes cell migration by regulating PSA-NCAM Exp. Cell Res 2017 siRNA SR305305
STAT3 B-cell CLL/lymphoma 3 promotes glioma cell proliferation and inhibits apoptosis through the oncogenic STAT3 pathway Int. J. Oncol. 2016 siRNA SR419981
STAT3 p-21 activated kinase 4 (PAK4) maintains stem cell-like phenotypes in pancreatic cancer cells through activation of STAT3 signaling Cancer letters Jan 2016 siRNA SR304622
STAT3 Modulation of STAT3 and STAT5 activity rectifies the imbalance of Th17 and Treg cells in patients with acute coronary syndrome Clin. Immunol. Jan 2015 siRNA SR304622
STAT3 Concerted Suppression of STAT3 and GSK3ß Is Involved in Growth Inhibition of Non-Small Cell Lung Cancer by Xanthatin PLOS ONE e81945 Nov 2013 siRNA SR304622
STIM1 Ca(2+) Channel Re-localization to Plasma-Membrane Microdomains Strengthens Activation of Ca(2+)-Dependent Nuclear Gene Expression Cell Rep Jul 2015 siRNA SR304633
STK3 Phosphorylation of CHO1 by Lats1/2 regulates the centrosomal activation of LIMK1 during cytokinesis Cell Cycle Mar 2015 siRNA SR304635
STRN 17ß-Estradiol inhibits vascular smooth muscle cell migration via up-regulation of striatin protein Gynecol. Endocrinol. Aug 2015 siRNA SR304644
SULF2 Evaluating Tumor-Associated Activity of Extracellular Sulfatase by Analyzing Naturally-Occurring Substrate in Tumor Microenvironment of Hepatocellular Carcinoma Analytical Chemistry 2016 siRNA SR311046
SULT1A3 Cytosolic sulfotransferase 1A3 is induced by dopamine and protects neuronal cells from dopamine toxicity: role of D1 receptor-NMDA receptor coupling J Biol Chem. 2013 Oct 17 siRNA SR304654
SUMO1 Natural and Induced Mitochondrial Phosphate Carrier Loss: DIFFERENTIAL DEPENDENCE OF MITOCHONDRIAL METABOLISM AND DYNAMICS AND CELL SURVIVAL ON THE EXTENT OF DEPLETION J. Biol. Chem 2016 siRNA SR322139
TAS2R38 Berberine induces GLP-1 secretion through activation of bitter taste receptor pathways Biochem. Pharmacol. Jul 2015 siRNA SR303858
TAZ Poly(rC)-binding Protein 2 regulates Hippo signaling to control growth in breast epithelial cells Mol. Cell. Biol. May 2016 siRNA SR304719
TBP Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA Proc. Natl. Acad. Sci. U.S.A. 2016 siRNA SR304726
TBX2 A Pathway for the Control of Anoikis Sensitivity by E-Cadherin and Epithelial-to-Mesenchymal Transition Mol. Cell. Biol., Oct 2011; 31: 4036 - 4051. siRNA SR304727
TBXAS1 Glycyrrhizin suppresses lung adenocarcinoma cell growth through inhibition of thromboxane synthase Cell. Physiol. Biochem., Feb 2014. siRNA SR304732
TCF21 TCF21 and the environmental sensor aryl-hydrocarbon receptor cooperate to activate a pro-inflammatory gene expression program in coronary artery smooth muscle cells PLoS Genet. 2017 siRNA SR304753
TCF21 Coronary Artery Disease AssociatedTranscription Factor TCF21 Regulates SmoothMuscle Precursor Cells That Contribute to theFibrous Cap Genomics Data May 2015 siRNA SR304753
TCF21 Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap PLoS Genet. May 2015 siRNA SR304753
TCF7 TCF1 links GIPR signaling to the control of beta cell function and survival Nat. Med. Dec 2015 siRNA SR304744
TCF7 TCF1 links GIPR signaling to the control of beta cell function and survival Nat. Med. Dec 2015 siRNA SR408887
Tcf7l2 Macrophage TCF-4 Coactivates p65 to Potentiate Chronic Inflammation and Insulin Resistance in Mice Clin. Sci. Apr 2016 siRNA SR414923
TCOF1 Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA Proc. Natl. Acad. Sci. U.S.A. 2016 siRNA SR304758
TCOL shRNA Functional analysis of mutant FAM20C in Raine syndrome with FGF23-related hypophosphatemia Bone July 2014 siRNA SR30004
TDG TDG Regulates Cell Cycle Progression In Human Neural Progenitors bioRxiv 2017 siRNA SR304768
TDGF1 CRIPTO and its signaling partner GRP78 drive the metastatic phenotype in human osteotropic prostate cancer Oncogene 2017 siRNA SR304769
TDGF1 CRIPTO and its signaling partner GRP78 drive the metastatic phenotype in human osteotropic prostate cancer Oncogene 2017 siRNA SR304769
TDGF1 CRIPTO and its signaling partner GRP78 drive the metastatic phenotype in human osteotropic prostate cancer Oncogene 2017 siRNA SR304769
Tead2 The Transcription Factor Protein Sox11 Enhances Early Osteoblast Differentiation by Facilitating Proliferation and the Survival of Mesenchymal and Osteoblast Progenitors J. Biol. Chem., Aug 2013; 288: 25400 - 25413. siRNA SR305547
TERT Telomerase reverse transcriptase mutations are independent predictor of disease-free survival in Middle Eastern papillary thyroid cancer Int. J. Cancer 2017 siRNA SR417770
Tet1 Cytosine modifications modulate the chromatin architecture of transcriptional enhancers Genome Res.2017 siRNA SR423353
Tet2 Cytosine modifications modulate the chromatin architecture of transcriptional enhancers Genome Res.2017 siRNA SR423294
Tet3 Cytosine modifications modulate the chromatin architecture of transcriptional enhancers Genome Res.2017 siRNA SR423108
Tfam Redox regulation by pitx2 and pitx3 is critical for fetal myogenesis Dev. Cell May 2014 siRNA SR406788
TFDP1 Recurrent Amplification at 13q34 Targets at CUL4A, IRS2, and TFDP1 As an Independent Adverse Prognosticator in Intrahepatic Cholangiocarcinoma PLoS ONE Dec 2015 siRNA SR304794
TFDP3 TFDP3 confers chemoresistance in minimal residual disease within childhood T-cell acute lymphoblastic leukemia Oncotarget 2017 siRNA SR309663
Tissue Lysate Endothelial Nitric-oxide Synthase (eNOS) Is Activated through G-protein-coupled Receptor Kinase-interacting Protein 1 (GIT1) Tyrosine Phosphorylation and Src Protein J. Biol. Chem. Jun 2014 siRNA SR30004
TLR4 Pinocembrin protects hemorrhagic brain primarily by inhibiting toll-like receptor 4 and reducing M1 phenotype microglia Brain Behav. Immun. 2017 siRNA SR420542
TLR4 Palmitate-Induced MMP-9 Expression in the Human Monocytic Cells is Mediated through the TLR4-MyD88 Dependent Mechanism Cell. Physiol. Biochem. 2016 siRNA SR304858
TLR9 HIV and HCV Activate the Inflammasome in Monocytes and Macrophages via Endosomal Toll-Like Receptors without Induction of Type 1 Interferon PLoS Pathog. May 2014 siRNA SR310036
TNF Transmembrane TNF-a Facilitates HIV-1 Infection of Podocytes Cultured from Children with HIV-Associated Nephropathy J. Am. Soc. Nephrol 2016 siRNA SR304877
TNF Transmembrane TNF-a Facilitates HIV-1 Infection of Podocytes Cultured from Children with HIV-Associated Nephropathy J. Am. Soc. Nephrol. 2016 siRNA SR304877
TNFR1 A novel role for the apoptosis inhibitor ARC in suppressing TNFα-induced regulated necrosis Cell Death Differ., Jan 2014. siRNA SR304883
TNFRSF11B Androgen deprivation therapy sensitizes triple negative breast cancer cells to immune-mediated lysis through androgen receptor independent modulation of osteoprotegerin Oncotarget 2016 siRNA SR303289
Top2a Identification of Bisindolylmaleimide IX as a potential agent to treat drug-resistant BCR-ABL positive leukemia Oncotarget 2016 siRNA SR422969
TOX TOX expression and role in CTCL. J Eur Acad Dermatol Venereol 2016 siRNA SR306524
TP53 RASSF10 is Epigenetically Inactivated and Suppresses Cell Proliferation and Induces Cell Apoptosis by Activating the p53 Signalling Pathway in Papillary Thyroid Carcinoma Cancer Cell. Physiol. Biochem 2017 siRNA SR322075
TP53 Multisite aggregation of p53 and implications for drug rescue Proc. Natl. Acad. Sci. U.S.A 2017 siRNA SR413083
TP53 Very Low Doses of Ionizing Radiation and Redox Associated Modifiers Affect Survivin-Associated Changes in Radiation Sensitivity Free Radic. Biol. Med. 2016 siRNA SR413083
TP63 Multisite aggregation of p53 and implications for drug rescue Proc. Natl. Acad. Sci. U.S.A 2017 siRNA SR305666
TP73 Modulation of p73 isoforms expression induces anti-proliferative and pro-apoptotic activity in mantle cell lymphoma independent of p53 status Leuk. Lymphoma Apr 2016 siRNA SR304904
TRAF3 The adaptor protein TRAF3 inhibits interleukin-6 receptor signaling in B cells to limit plasma cell development Sci Signal Sep 2015 siRNA SR304928
TRAF3 The adaptor TRAF3 restrains the lineage determination of thymic regulatory T cells by modulating signaling via the receptor for IL-2 Nat. Immunol. July 2014 siRNA SR304928
TRAIP The TRAF-interacting protein (TRAIP) is a regulator of the spindle assembly checkpoint J. Cell. Sci. Oct 2014 siRNA SR306973
TRIM21 Regulatory role of TRIM21 in the type-I interferon pathway in Japanese encephalitis virus-infected human microglial cells J Neuroinflammation, Feb 2014. siRNA SR304594
TRIM22 TRIM5α and TRIM22 are differentially regulated according to HIV-1 infection phase and compartment J. Virol., Jan 2014. siRNA SR307012
TRIM29 TRIM29 as a Novel Biomarker in Pancreatic Adenocarcinoma Disease Markers 2014 . April 2014 siRNA SR308430
TRIM3 Potential role of TRIM3 as a novel tumour suppressor in colorectal cancer (CRC) development Scand. J. Gastroenterol. Dec 2015 siRNA SR307227
TRKA Nerve Growth Factor Receptor TrkA, a New Receptor in Insulin Signaling Pathway in PC12 Cells J. Biol. Chem., Aug 2013; 288: 23807 - 23813. siRNA SR303249
TRPC6 Insulin increases filtration barrier permeability via TRPC6-dependent activation of PKGIα signaling pathways Biochim. Biophys. Acta 2017 siRNA MR225311
TRPV4 TRPV4 Mechanosensitive Ion Channel Regulates Lipopolysaccharide-Stimulated Macrophage Phagocytosis J. Immunol. Nov 2015 siRNA SR420901
TRPV4 TRPV4 mediates myofibroblast differentiation and pulmonary fibrosis in mice J. Clin. Invest. Dec 2014 siRNA SR311803
TRPV6 The low PLC-d1 expression in cystic fibrosis bronchial epithelial cells induces upregulation of TRPV6 channel activity Cell Calcium Nov 2014 siRNA SR310734
TSC1 PP2AC Level Determines Differential Programing of p38-TSC-mTOR Signaling and Therapeutic Response to p38-Targeted Therapy in Colorectal Cancer EBioMedicine Nov 2015 siRNA SR304945
TSC2 PP2AC Level Determines Differential Programing of p38-TSC-mTOR Signaling and Therapeutic Response to p38-Targeted Therapy in Colorectal Cancer EBioMedicine Nov 2015 siRNA SR304946
TSTA3 Oncogenic potential of TSTA3 in breast cancer and its regulation by the tumor suppressors miR-125a-5p and miR-125b Tumour Biol. Nov 2015 siRNA SR304956
TT300001 IL-1ß induces p62/SQSTM1 and represses androgen receptor expression in prostate cancer cells J. Cell. Biochem. Aug 2014 siRNA SR30004
TWIST1 ETS2 and Twist1 promote invasiveness of Helicobacter pylori-infected gastric cancer cells by inducing Siah2 Biochem. J. Apr 2016 siRNA SR304977
UBE2M CALML5 is a ZNF750- and TINCR-induced protein that binds stratifin to regulate epidermal differentiation Genes Dev. Nov 2015 siRNA SR305963
UCK1 Expression of nucleoside-metabolizing enzymes in myelodysplastic syndromes and modulation of response to azacitidine Leukemia Dec 2013. siRNA SR313172
UCK2 Resistance to Azacitidine Is Determined at Cellular Level By Lower Expression of Nucleoside Metabolizing Enzymes Blood 2016 siRNA SR322152
UCP2 The mitochondrial uncoupling protein-2 is a master regulator of both M1 and M2 microglial responses J. Neurochem. Jul 2015 siRNA SR504079
UCP2 Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD(+)/SIRT1 Reduction Cell May 2014 siRNA SR305019
URI URI prevents potassium dichromate-induced oxidative stress and cell death in gastric cancer cells Am J Transl Res 2016 siRNA SR305745
URI1 URI expression in cervical cancer cells is associated with higher invasion capacity and resistance to cisplatin Am J Cancer Res Jun 2015 siRNA SR305745
USP18 Acetaldehyde Disrupts Interferon Alpha Signaling in Hepatitis C Virus-Infected Liver Cells by Up-Regulating USP18 Alcohol. Clin. Exp. Res. 2016 siRNA SR307736
USP18 Acetaldehyde Disrupts Interferon Alpha Signaling in Hepatitis C Virus-Infected Liver Cells by Up-Regulating USP18 Alcoholism: Clinical & Experimental Research 2016 siRNA SR307736
USP34 Inhibition of ubiquitin-specific protease 34 (USP34) induces epithelial-mesenchymal transition and promotes stemness in mammary epithelial cells Cell. Signal. 2017 siRNA SR400002
USP4 The deubiquitinating enzymes USP4 and USP17 target hyaluronan synthase 2 and differentially affect its function Oncogenesis 2017 siRNA SR305038
USP8 Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer Nat Commun Jun 2016 siRNA SR306014
VANGL2 Syndecan-4 controls lymphatic vasculature remodeling during embryonic development Development 2016 siRNA SR311428
VDR Vitamin D attenuates cerebral artery remodeling through VDR/AMPK/eNOS dimer phosphorylation pathway after subarachnoid hemorrhage in rats J. Cereb. Blood Flow Metab. 2017 siRNA SR508804
VDR Intranasal administration of vitamin D attenuates blood-brain barrier disruption through endogenous upregulation of osteopontin and activation of CD44/P-gp glycosylation signaling after subarachnoid hemorrhage in rats J. Cereb. Blood Flow Metab. 2016 siRNA SR508804
VIM Loss of SOX2 expression induces cell motility via vimentin up-regulation and is an unfavorable risk factor for survival of head and neck squamous cell carcinoma Molecular Oncology May 2015 siRNA SR305078
VPS34 Insulin activation of vacuolar protein sorting 34 mediates localized phosphatidylinositol 3-phosphate production at lamellipodia and activation of mTOR/S6K1 Cell. Signal. Feb 2014 siRNA SR303519
VRK1 VRK1 and AURKB form a complex that cross inhibit their kinase activity and the phosphorylation of histone H3 in the progression of mitosis Cell. Mol. Life Sci. 2018 siRNA SR322192
VTCN1 B7-H4 overexpression is essential for early hepatocellular carcinoma progression and recurrence Oncotarget 2017 siRNA SR312516
VTCN1 B7-H4 expression by nonhematopoetic cells in the tumor microenvironment promotes anti-tumor immunity Cancer Immunol Res Dec 2014 siRNA SR312516
WIBG CALML5 is a ZNF750- and TINCR-induced protein that binds stratifin to regulate epidermal differentiation Genes Dev. Nov 2015 siRNA SR313474
WISP1 Macrophage-derived IL-10 mediates mucosal repair by epithelial WISP-1 signaling J. Clin. Invest. 2017 siRNA SR305836
WNT3A A switch from canonical to noncanonical Wnt signaling mediates early differentiation of human neural stem cells Stem Cells Aug 2014 siRNA SR313904
WNT5A Decreased DNA methylation in the promoter region of the WNT5A and GDNF genes may promote the osteogenicity of mesenchymal stem cells from patients with ossified spinal ligaments J. Pharmacol. Sci. Apr 2015 siRNA SR305106
WWP1 MiR-21 suppresses endothelial progenitor cell proliferation by activating the TGFß signaling pathway via downregulation of WWP1 Int J Clin Exp Pathol Jan 2015 siRNA SR307565
XBP1 MYC regulates the unfolded protein response and glucose and glutamine uptake in endocrine resistant breast cancer Mol. Cancer Oct 2014 siRNA SR305120
YAP1 Poly(rC)-binding Protein 2 regulates Hippo signaling to control growth in breast epithelial cells Mol. Cell. Biol. May 2016 siRNA SR307060
ZBP1 Mitochondrial DNA damage and subsequent activation of Z-DNA binding protein 1 links oxidative stress to inflammation in epithelial cells Sci Rep 2018 siRNA SR312989
ZC3H12A An effective and efficient method of transfecting primary human chondrocytes in suspension Anal. Biochem 2017 siRNA SR312813
ZC3H12A MicroRNA-9 promotes IL-6 expression by inhibiting MCPIP1 expression in IL-1ß-stimulated human chondrocytes Arthritis & rheumatology Apr 2015 siRNA SR312813
ZEB1 Elucidating the molecular basis of PPCD: Effects of decreased ZEB1 expression on corneal endothelial cell function Mol. Vis. 2017 siRNA SR304746
ZEB1 A novel microRNA regulator of prostate cancer epithelial-mesenchymal transition Cell Death Differ. 2017 siRNA SR304746
Zeb1 A genetic cell context-dependent role for ZEB1 in lung cancer Nat Commun 2016 siRNA SR422122
ZEB1 Hypoxia enhances migration and invasion in glioblastoma by promoting a mesenchymal shift mediated by the HIF1a-ZEB1 axis Cancer Lett. Jan 2015 siRNA SR304746
Zeb1 Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression Nat Commun Oct 2014 siRNA SR422122
ZEB1 TGF-ß is an inducer of ZEB1-dependent mesenchymal transdifferentiation in glioblastoma that is associated with tumor invasion Cell Death Dis Oct 2014 siRNA SR304746
Zfp451 The SUMO2/3 specific E3 ligase ZNF451-1 regulates PML stability Int. J. Biochem. Cell Biol. Jun 2016 siRNA SR417359
Zfp521 Zfp521 promotes B-cell viability and cyclin D1 gene expression in a B cell culture system Leuk. Res. Apr 2016 siRNA SR422637