shRNA Citations

OriGene products have been used extensively by scientists worldwide to improve their research efficiency. For your reference, we have collected a representation of citations for selected OriGene products and posted them at this site.

Search citations by gene symbols or target names

Here are some of the recent papers making use of OriGene products by fellow researchers.

Target Research Paper Journal Product SKU
Suppression of Vimentin Phosphorylation by the Avian Reovirus p17 through Inhibition of CDK1 and Plk1 Impacting the G2/M Phase of the Cell Cycle PLoS ONE 2016 shRNA TR30013
Suppression of Vimentin Phosphorylation by the Avian Reovirus p17 through Inhibition of CDK1 and Plk1 Impacting the G2/M Phase of the Cell Cycle PLoS ONE 2016 shRNA TR30007
Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype Nat. Immunol. 2016 shRNA TR30012
Mutant p53 Together with TGFß Signaling Influence Organ-Specific Hematogenous Colonization Patterns of Pancreatic Cancer Clin. Cancer Res. 2016 shRNA TR30015
Displacement correlations between a single mesenchymal-like cell and its nucleus effectively link subcellular activities and motility in cell migration analysis Sci Rep 2016 shRNA TR30015
Sphingomyelin-induced inhibition of the plasma membrane calcium ATPase causes neurodegeneration in type A Niemann-Pick disease Mol. Psychiatry 2016 shRNA TR30021
Platelet integrin a6ß1 controls lung metastasis through direct binding to cancer cell-derived ADAM9 JCI Insight 2016 shRNA TR30021
Sphingosine-1-phosphate induced epithelial-mesenchymal transition of hepatocellular carcinoma via an MMP-7/ syndecan-1/TGF-ß autocrine loop Oncotarget 2016 shRNA TR30021
Loss of Trefoil Factor 2 From Pancreatic Duct Glands Promotes Formation of Intraductal Papillary Mucinous Neoplasms in Mice Gastroenterology 2016 shRNA TR30007
Identification of NEK3 Threonine 165 as a Novel Regulatory Phosphorylation Site that Modulates Focal Adhesion Remodeling Necessary for Breast Cancer Cell Migration J. Biol. Chem. 2016 shRNA TR30014
Identification of NEK3 Threonine 165 as a Novel Regulatory Phosphorylation Site that Modulates Focal Adhesion Remodeling Necessary for Breast Cancer Cell Migration J. Biol. Chem. 2016 shRNA TR30015
Loss of exogenous androgen dependence by prostate tumor cells is associated with elevated glucuronidation potential Horm Cancer Aug 2016 shRNA TR30008
IMP2 axonal localization, RNA interactome, and function in the development of axon trajectories Development 2016 shRNA TR30012
Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis Nat Commun 2016 shRNA TR30012
Nm23H1 mediates tumor invasion in esophageal squamous cell carcinoma by regulation of CLDN1 through the AKT signaling Oncogenesis 2016 shRNA TR20003
High Podocalyxin levels promote cell viability partially through up-regulation of Annexin A2 Biochem. Biophys. Res. Commun. 2016 shRNA TR30013
Epstein-Barr Virus Oncoprotein LMP1 Mediates Epigenetic Changes in Host Gene Expression through PARP1 J. Virol. 2016 shRNA TR30021
Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells Cancer Cell Jun 2016 shRNA TR30021
Folate Receptor Alpha Upregulates Oct4, Sox2 and Klf4 and Downregulates miR-138 and miR-let-7 in Cranial Neural Crest Cells Stem Cells Jun 2016 shRNA TR30013
SIRT7 promotes genome integrity and modulates non-homologous end joining DNA repair EMBO J. May 2016 shRNA TR30003
SIRT7 promotes genome integrity and modulates non-homologous end joining DNA repair EMBO J. May 2016 shRNA TR30012
Oncogenic mutations and dysregulated pathways in obesity-associated hepatocellular carcinoma Oncogene May 2016 shRNA TR30012
Characterization of SKAP/Kinastrin isoforms - The N-terminus defines tissue specificity and Pontin binding Hum. Mol. Genet. May 2016 shRNA TR30021
Involvement of the P2X7-NLRP3 axis in leukemic cell proliferation and death Sci Rep May 2016 shRNA TR30013
Upregulation of long noncoding RNA LOC100507661 promotes tumor aggressiveness in thyroid cancer Mol. Cell. Endocrinol. May 2016 shRNA Custom shRNA for ncRNA
Molecular Mechanisms of Malignant Transformation by Low Dose Cadmium in Normal Human Bronchial Epithelial Cells PLoS ONE May 2016 shRNA TR30013
HMGB1 knockdown effectively inhibits the progression of rectal cancer by suppressing HMGB1 expression and promoting apoptosis of rectal cancer cells Mol Med Rep May 2016 shRNA TR30013
OCT-4: a novel estrogen receptor-a collaborator that promotes tamoxifen resistance in breast cancer cells Oncogene Apr 2016 shRNA TR30021
FOXE3 contributes to Peters anomaly through transcriptional regulation of an autophagy-associated protein termed DNAJB1 Nature Communications Apr 2016 shRNA TR30021
Peroxiredoxin 6 (Prdx6) supports NADPH oxidase1 (Nox1)-based superoxide generation and cell migration Free Radic. Biol. Med. Apr 2016 shRNA TR20003
Peroxiredoxin 6 (Prdx6) supports NADPH oxidase1 (Nox1)-based superoxide generation and cell migration Free Radic. Biol. Med. Apr 2016 shRNA TR30003
Regulación del Uniportador de Calcio Mitocondrial por MICU1 y MICU2 thesis Apr 2016 shRNA TR30014
Inhibition of the Expression of the Small Heat Shock Protein aB-crystallin Inhibits Exosome Secretion in Human Retinal Pigment Epithelial Cells in Culture J. Biol. Chem. Apr 2016 shRNA TR30007
CD146 is a novel marker for highly tumorigenic cells and a potential therapeutic target in malignant rhabdoid tumor Oncogene Apr 2016 shRNA TR30013
Mutual inhibition of insulin signaling and PHLPP-1 determines cardioprotective efficiency of Akt in aged heart Aging (Albany NY) Mar 2016 shRNA TR30023
aCP binding to a cytosine-rich subset of polypyrimidine tracts drives a novel pathway of cassette exon splicing in the mammalian transcriptome Nucleic Acids Res. Mar 2016 shRNA TR30007
Development of a novel HAC-based gain of signal quantitative assay for measuring chromosome instability (CIN) in cancer cells Oncotarget Mar 2016 shRNA TR30007
Mic60/mitofilin overexpression alters mitochondrial dynamics and attenuates vulnerability of dopaminergic cells to dopamine and rotenone Neurobiol. Dis. Mar 2016 shRNA TR20003
NF-YA splice variants have different roles on muscle differentiation Biochim. Biophys. Acta Feb 2016 shRNA TR30021
IMP1 suppresses breast tumor growth and metastasis through the regulation of its target mRNAs Oncotarget Feb 2016 shRNA TR30007
Der Einfluss des Mismatch Reparaturfaktors hMSH2 auf distinkte Reparaturwege der DNA Doppelstrangbruch Reparatur thesis Feb 2015 shRNA TR30012
BIK Bik reduces hyperplastic cells by increasing Bak and activating DAPk1 to juxtapose ER and mitochondria Nat Commun 2017 shRNA TF500209
CD24 Comparative global immune-related gene profiling of somatic cells, human pluripotent stem cells and their derivatives: implication for human lymphocyte proliferation Exp. Mol. Med. 2017 shRNA TG321436
DAPK1 Bik reduces hyperplastic cells by increasing Bak and activating DAPk1 to juxtapose ER and mitochondria Nat Commun 2017 shRNA TF504327
LGR5 FOXO1 reduces tumorsphere formation capacity and has crosstalk with LGR5 signaling in gastric cancer cells Biochem. Biophys. Res. Commun. 2017 shRNA TF311747
LSP1 Leukocyte specific protein-1: A novel regulator of hepatocellular proliferation and migration deleted in human HCC Hepatology Sep 2014 shRNA TG702934
NDRG3 Lactate Promotes Synthetic Phenotype in Vascular Smooth Muscle Cells Circ. Res. 2017 shRNA TG303004
PARD3 Elevated expression of Par3 promotes prostate cancer metastasis by forming a Par3/aPKC/KIBRA complex and inactivating the hippo pathway J. Exp. Clin. Cancer Res. 2017 shRNA TR302678
RD3 HIV-1 viral protein R (Vpr) induces fatty liver in mice via LXRα and PPARα dysregulation: implications for HIV-specific pathogenesis of NAFLD Sci Rep 2017 shRNA TL320630
RORA Sertoli cell specific knockdown of RAR-related orphan receptor (ROR) alpha at puberty reduces sperm count in rats Gene 2017 shRNA TL705407
TNFSF10 CCN1 sensitizes esophageal cancer cells to TRAIL-mediated apoptosis Exp. Cell Res. 2017 shRNA TR308728
ABCB1 Temozolomide competes for P-glycoprotein and contributes to chemoresistance in glioblastoma cells Cancer Lett. Jul 2015 shRNA TF315032
ABCC4 Multiple drug resistance-associated protein (MRP4) exports prostaglandin E2 (PGE2) and contributes to metastasis in basal/triple negative breast cancer Oncotarget 2017 shRNA TR315025
ABCC6 Dysregulation of gene expression in ABCC6 knockdown HepG2 cells Cell. Mol. Biol. Lett. Aug 2014 shRNA TR315023
Abhd6 Serine Hydrolase Inhibitors Block Necrotic Cell Death by Preventing Calcium Overload of the Mitochondria and Permeability Transition Pore Formation J. Biol. Chem. Dec 2013. shRNA TG306904
ACKR3 CXCR7 maintains osteosarcoma invasion after CXCR4 suppression in bone marrow microenvironment Tumour Biol. 2017 shRNA TR305345
ACKR3 The chemokine receptor CXCR7 interacts with EGFR to promote breast cancer cell proliferation Mol. Cancer Aug 2014 shRNA TR305345
ACKR3 Use of shRNA for Stable Suppression of Chemokine Receptor Expression and Function in Human Cancer Cell Lines Methods Mol. Biol. Jun 2014 shRNA TG305345
ACLY ATP-Citrate Lyase Reduction Mediates Palmitate-induced Apoptosis in Pancreatic Beta Cells J. Biol. Chem., Oct 2010; 285: 32606 - 32615 shRNA TR505684
ACP5 ACP5, a direct transcriptional target of FoxM1, promotes tumor metastasis and indicates poor prognosis in hepatocellular carcinoma Oncogene doi:10.1038/onc.2013.90 shRNA TG314985
ACSL1 Acyl-CoA synthetase 1 deficiency alters cardiolipin species and impairs mitochondrial function J. Lipid Res. Aug 2015 shRNA TL709438
ACTN4 Alpha-actinin-4 is Required for Amoeboid-type Invasiveness of Melanoma Cells J. Biol. Chem. Oct 2014 shRNA TG314967
ACVRL1 The role of Alk-1 and Alk-5 in the mechanosensing of chondrocytes Cell. Mol. Biol. Lett. Dec 2014 shRNA TG710699
ADAM8 ADAM8 expression in breast cancer derived brain metastases: Functional implications on MMP-9 expression and transendothelial migration in breast cancer cells Int. J. Cancer 2017 shRNA TF314948
ADAM8 ADAM8 as a drug target in pancreatic cancer Nat Commun Jan 2015 shRNA TF314948
ADAMTS15 Genetic Inactivation of ADAMTS15 Metalloprotease in Human Colorectal Cancer Cancer Res., Jun 2009; 69: 4926 - 4934 shRNA TR306839
ADAR ADAR1 restricts LINE-1 retrotransposition Nucleic Acids Res. 2016 shRNA TG306828
ADAR1 Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma Nature Medicine 19, 209-216 doi:10.1038/nm.3043 shRNA TG306828
Adcy5 Adenylate cyclase 5 coordinates the action of ADP, P2Y1, P2Y13 and ATP-gated P2X7 receptors on axonal elongation J. Cell Sci., Jan 2012; 125: 176 - 188. shRNA TG506651
Adcyap1 Age-Related Decline of Autocrine Pituitary Adenylate Cyclase-Activating Polypeptide Impairs Angiogenic Capacity of Rat Cerebromicrovascular Endothelial Cells J. Gerontol. A Biol. Sci. Med. Sci. Aug 2014 shRNA TR709809
ADIPOR1 Underactivation of the adiponectin-adiponectin receptor 1 axis in clear cell renal cell carcinoma: implications for progression Clin Exp Metastasis. 2013 Oct 5 shRNA TG306815
ADM2 Adrenomedullin2 (ADM2)/Intermedin (IMD): A potential role in the pathophysiology of Preeclampsia J. Clin. Endocrinol. Metab. 2016 shRNA TR306813
ADORA2A Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy J. Clin. Invest. 2017 shRNA TF314920
ADRB2 Housing temperature-induced stress drives therapeutic resistance in murine tumour models through ß2-adrenergic receptor activation Nat Commun Mar 2015 shRNA TG314911
ADX Mitochondrial Targeting of Cytochrome P450 (CYP) 1B1 and its Role in Polycyclic Aromatic Hydrocarbon-Induced Mitochondrial Dysfunction J. Biol. Chem., Feb 2014. shRNA TG313008
AES Repression of HNF1a-mediated transcription by amino-terminal enhancer of split (AES) Biochem. Biophys. Res. Commun. Dec 2015 shRNA TR306804
AES Amino-terminal Enhancer of Split (AES) Interacts with the Oncoprotein NUP98-HOXA9 and Enhances Its Transforming Ability J. Biol. Chem., Nov 2011; 286: 38989 - 39001. shRNA TR306804
AGBL2 AGBL2 promotes cancer cell growth through IRGM-regulated autophagy and enhanced Aurora A activity in hepatocellular carcinoma Cancer Lett.2017 shRNA TL306802
AGBL3 Structural modeling and functional characterization of mammalian cytosolic carboxypeptidases 2 and 3 Thesis Sep 2014 shRNA TG318365
AGPAT2 Terapia génica y celular para la corrección de la Lipodistrofia Congénita Generalizada Thesis Jul 2014 shRNA TL314894
AGXT In Silico Modeling of Liver Metabolism in a Human Disease Reveals a Key Enzyme for Histidine and Histamine Homeostasis Cell Rep May 2016 shRNA TR314885
Ahnak Neurite outgrowth induced by NGF or L1CAM via activation of the TrkA receptor is sustained also by the exocytosis of enlargeosomes Proc. Natl. Acad. Sci. U.S.A. Nov 2014 shRNA TR514924
Ahnak2 AHNAK2 Participates in the Stress-Induced Nonclassical FGF1 Secretion Pathway J. Cell. Biochem. Jan 2015 shRNA TG512658
AHR Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells Nat Commun 2017 shRNA TL320259
AHR Interleukin-24 as a target cytokine of environmental aryl hydrocarbon receptor agonist exposure in the lung Toxicol. Appl. Pharmacol 2017 shRNA TR320259
AHR Indole-3-Carbinol Triggers Aryl Hydrocarbon Receptor-dependent Estrogen Receptor (ER){alpha} Protein Degradation in Breast Cancer Cells Disrupting an ER{alpha}-GATA3 Transcriptional Cross-Regulatory Loop Mol. Biol. Cell, Apr 2010; 21: 1166 - 1177 shRNA TR320259
AHRR Wood Smoke Enhances Cigarette Smoke-Induced Inflammation by Inducing the Aryl Hydrocarbon Receptor Repressor in Airway Epithelial Cells Am. J. Respir. Cell Mol. Biol. Aug 2014 shRNA TR306787
AIF (RFP) Notch/HES1-mediated PARP1 activation: a cell type–specific mechanism for tumor suppression Blood, Mar 2011; 117: 2891 - 2900 shRNA TR302572
AIM2 Francisella tularensis Reveals a Disparity between Human and Mouse NLRP3 Inflammasome Activation J. Biol. Chem., Nov 2011; 286: 39033 - 39042. shRNA TR314876
AKT1 Redox signalling to nuclear regulatory proteins by reactive oxygen species contributes to oestrogen-induced growth of breast cancer cells Br. J. Cancer May 2015 shRNA TR320260
AKT3 Restoring miR122 in human stem-like hepatocarcinoma cells, prompts tumor dormancy through Smad-independent TGF-β pathway Oncotarget 2016 shRNA TL320629
Alas1 Heterochromatin protein (HP)1γ is not only in the nucleus but also in the cytoplasm interacting with actin in both cell compartments Biochim. Biophys. Acta 2017 shRNA TG500071
ALDH18A1 Global metabolic profiling identifies a pivotal role of proline and hydroxyproline metabolism in supporting hypoxic response in hepatocellular carcinoma Clin. Cancer Res.2017 shRNA TL314847
ALDH1B1 Aldehyde Dehydrogenase 1B1 as a Modulator of Pancreatic Adenocarcinoma Pancreas 2016 shRNA TF314844
ALDH1B1 ALDH1B1 Is Crucial for Colon Tumorigenesis by Modulating Wnt/ß-Catenin, Notch and PI3K/Akt Signaling Pathways PLoS ONE May 2015 shRNA TF314844
ALG-2 Structural and Functional Study of Apoptosis-linked Gene-2/Heme-binding Protein 2 Interactions in HIV-1 Production J. Biol. Chem. 2016 shRNA TR310558
ALOX12 Identification of 14-series sulfido-conjugated mediators that promote resolution of infection and organ protection Proc. Natl. Acad. Sci. U.S.A. Oct 2014 shRNA TR314824
ALOX15 Mechanistic Contribution of Ubiquitous 15-Lipoxygenase-1 Expression Loss in Cancer Cells to Terminal Cell Differentiation Evasion Cancer Prevention Research, Dec 2011; 4: 1961 - 1972. shRNA TR314822
AMFR Aberrant corticosteroid metabolism in tumor cells enables GR takeover in enzalutamide resistant prostate cancer Elife 2017 shRNA TL316441
AMPKB1 Reduced expression of AMPK-ß1 during tumor progression enhances the oncogenic capacity of advanced ovarian cancer Mol. Cancer Mar 2014 shRNA TG315591
ANAX2 Annexin A2 is a C-terminal PCSK9 binding protein that regulates endogenous LDL receptor levels J. Biol. Chem., Sep 2008; 10.1074/jbc.M805971200. shRNA TR314772
ANG2 Angiopoietin-2 Regulates Cortical Neurogenesis in the Developing Telencephalon Cereb Cortex, Jul 2011; 21: 1695 - 1702. shRNA TR500092
Angpt2 Angiopoietin-2 Regulates Cortical Neurogenesis in the Developing Telencephalon Cereb Cortex, Dec 2010; 10.1093/cercor/bhq243 shRNA TR514004
ANXA1 Differential expression of ANXA1 in benign human gastrointestinal tissues and cancers BMC Cancer July 2014 shRNA TR314775
ANXA2 Intracellular targeting of annexin A2 inhibits tumor cell adhesion, migration, and in vivo grafting Sci Rep 2017 shRNA TL314772
Anxa2 Annexin A2 Enhances Complement Activation by Inhibiting Factor H J. Immunol. Feb 2016 shRNA TF500250
ANXA2R The Annexin a2 Promotes Development in Arthritis through Neovascularization by Amplification Hedgehog Pathway PLoS ONE Mar 2016 shRNA TG315286
ANXA6 Balancing functions of annexin A6 maintain equilibrium between hypertrophy and apoptosis in cardiomyocytes Cell Death Dis Sep 2015 shRNA TG314768
ANXA6 Cytosolic dynamics of annexin A6 triggers feedback regulation of hypertrophy via atrial natriuretic peptide in cardiomyocytes J. Biol. Chem., Jan 2014. shRNA TG314768
AP2A1 Constitutive Clathrin-mediated Endocytosis of CTLA-4 Persists during T Cell Activation J. Biol. Chem., Mar 2012; 287: 9429 - 9440. shRNA TR314754
APBB1 Fe65 Suppresses Breast Cancer Cell Migration and Invasion through Tip60 Mediated Cortactin Acetylation Sci Rep Jul 2015 shRNA TG306652
APCS Complex formation with Pentraxin-2 regulates Factor X plasma levels and macrophage interactions Blood 2017 shRNA TR501968
APOE3 Apolipoprotein E3 (ApoE3) but Not ApoE4 Protects against Synaptic Loss through Increased Expression of Protein Kinase C J. Biol. Chem., May 2012; 287: 15947 - 15958. shRNA TR314721
APRT Activation of AMP-Activated Protein Kinase by Adenine Alleviates TNF-Alpha-Induced Inflammation in Human Umbilical Vein Endothelial Cells PLoS ONE Nov 2015 shRNA TG320095
Aqp1 Aquaporin 1 is Important for Maintaining Secretory Granule Biogenesis in Endocrine Cells Mol. Endocrinol., Aug 2008; 22: 1924 - 1934 shRNA TR500121
AR Stromal Hyaluronan Interaction with Epithelial CD44 Variants Promotes Prostate Cancer Invasiveness by Augmenting Expression and Function of Hepatocyte Growth Factor and Androgen Receptor J. Biol. Chem., Jun 2010; 285: 19821 - 19832 shRNA TR320265
Arf6 Arf6 regulates the cycling and the readily releasable pool of synaptic vesicles at hippocampal synapse Elife Jan 2016 shRNA TF710999
Arf6 Antagonistic Functions of Dishevelleds Regulate Frizzled3 Endocytosis via Filopodia Tips in Wnt-Mediated Growth Cone Guidance J. Neurosci. Dec 2013. shRNA TG500130
ARHGAP15 Forkhead box P3 regulates ARHGAP15 expression and affects migration of glioma cells through the Rac1 signaling pathway Cancer Sci 2017 shRNA TR306620
ARHGEF17 Phosphorylation of Cdc42 Effector Protein-4 (CEP4) by Protein Kinase C Promotes Motility of Human Breast Cells J. Biol. Chem. Aug 2014 shRNA TG314673
ARHGEF9 RhoGEF9 splice isoforms influence neuronal maturation and synapse formation downstream of α2 GABAA receptors PLoS Genet.2017 shRNA TF517554
Arid1a BAF complexes facilitate decatenation of DNA by topoisomerase IIa Nature 497, 624-627 doi:10.1038/nature12146 shRNA TG306603
ARID2 Essential Role of ARID2 Protein-containing SWI/SNF Complex in Tissue-specific Gene Expression J. Biol. Chem., Feb 2012; 287: 5033 - 5041. shRNA TR306601
ARNTL Circadian Modulation of 8-Oxoguanine DNA Damage Repair Sci Rep Sep 2015 shRNA TR314656
ARRB1 Clenbuterol Induces Cell Cycle Arrest in C2C12 Myoblasts by Delaying p27 Degradation through β-arrestin 2 Signaling International Journal of Biological Science 2017 shRNA TG510701
ARRB1 Downregulation of β-arrestin 1 suppresses glioblastoma cell growth and glycolysis via inhibition of Src signaling Exp. Cell Res. 2017 shRNA TR306568
ARRB1 β-Arrestin 1 has an essential role in neurokinin-1 receptor-mediated glioblastoma cell proliferation and G2/M phase transition J. Biol. Chem 2017 shRNA TG306568
ARRB1 Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer EMBO J. May 2014 shRNA TG306568
ARRB1 ß-Arrestin/Ral Signaling Regulates Lysophosphatidic Acid–Mediated Migration and Invasion of Human Breast Tumor Cells Mol. Cancer Res., Jul 2009; 7: 1064 - 1077 shRNA TR306568
ARRB2 Clenbuterol Induces Cell Cycle Arrest in C2C12 Myoblasts by Delaying p27 Degradation through β-arrestin 2 Signaling International Journal of Biological Science 2017 shRNA TF517061
ARRB2 β-Arrestin 1 has an essential role in neurokinin-1 receptor-mediated glioblastoma cell proliferation and G2/M phase transition J. Biol. Chem 2017 shRNA TG306567
ARRB2 Beta-Arrestin-2 Counters CXCR7-mediated EGFR Transactivation and Proliferation Mol. Cancer Res. Feb 2016 shRNA TG306567
ARRB2 ß-Arrestin/Ral Signaling Regulates Lysophosphatidic Acid–Mediated Migration and Invasion of Human Breast Tumor Cells Mol. Cancer Res., Jul 2009; 7: 1064 - 1077 shRNA TR306567
ASB4 Expression of ankyrin repeat and SOCS box containing 4 (ASB4) confers migration and invasion properties of hepatocellular carcinoma cells Biosci Trends May 2014 shRNA TG306546
Asc Activation of inflammasomes in podocyte injury of mice on the high fat diet: Effects of ASC gene deletion and silencing Biochim. Biophys. Acta, Feb 2014. shRNA TR310027
ASCL1 Cenpj/CPAP regulates progenitor divisions and neuronal migration in the cerebral cortex downstream of Ascl1 Nat Commun Mar 2015 shRNA TR314633
ASF1B Transcriptional coactivator HCF-1 couples the histone chaperone Asf1b to HSV-1 DNA replication components PNAS, Feb 2010; 107: 2461 - 2466 shRNA TR317316
Asns Topological analysis of metabolic networks integrating co-segregating transcriptomes and metabolomes in type 2 diabetic rat congenic series Genome Med 2016 shRNA TG709676
ASPN The dual role of asporin in breast cancer progression Oncotarget 2016 shRNA TR306531
ASXL1 ASXL1 interacts with the cohesin complex to maintain chromatid separation and gene expression for normal hematopoiesis Sci Adv 2017 shRNA TG306527
ATAT1 Tubulin Acetyltransferase aTAT1 Destabilizes Microtubules Independently of Its Acetylation Activity Mol. Cell. Biol., Mar 2013; 33: 1114 - 1123. shRNA TR314302
ATF6 Insulin demand regulates ß cell number via the unfolded protein response J. Clin. Invest. Oct 2015 shRNA TR314613
ATG10 Human adenovirus type 5 induces cell lysis through autophagy and autophagy-triggered caspase activity J. Virol., Mar 2011; 10.1128/JVI.02032-10 shRNA TR306517
ATG5 Astrocytes promote progression of breast cancer metastases to the brain via a KISS1-mediated autophagy Autophagy 2017 shRNA TG314610
ATG5 Basal autophagy is pivotal for Hodgkin and Reed-Sternberg cells' survival and growth revealing a new strategy for Hodgkin lymphoma treatment Oncotarget 2016 shRNA TL500113
ATG5 Beclin-1-p53 interaction is crucial for cell fate determination in embryonal carcinoma cells J. Cell. Mol. Med. Sep 2014 shRNA TF314610
ATG5 Human adenovirus type 5 induces cell lysis through autophagy and autophagy-triggered caspase activity J. Virol., Mar 2011; 10.1128/JVI.02032-10 shRNA TR314610
ATG5 Short-chain fatty acids induced autophagy serves as an adaptive strategy for retarding mitochondria-mediated apoptotic cell death Cell Death and Differentiation (8 October 2010) doi:10.1038/cdd.2010.117 Original Paper shRNA TR314610
ATG5 Energy Restriction as an Antitumor Target of Thiazolidinediones J. Biol. Chem., Mar 2010; 285: 9780 - 9791 shRNA TR314610
Atg7 Notch1 regulated autophagy controls survival and suppressor activity of activated murine T-regulatory cells Elife Jun 2016 shRNA TG504956
Atg7 Autophagy is required and protects against apoptosis during myoblast differentiation Biochem. J. May 2014 shRNA TG504956
ATG7 Antagonism of tumoral prolactin receptor promotes autophagy-related cell death Cell Rep 488-500 7 2. April 2014 shRNA TG314609
ATG7 Epoxyeicosatrienoic acids protect cardiac cells during starvation by modulating an autophagic response shRNA TG504956
ATG7 Energy Restriction as an Antitumor Target of Thiazolidinediones J. Biol. Chem., Mar 2010; 285: 9780 - 9791 shRNA TR314609
ATG7 Eradication of Intracellular Salmonella Typhimurium with a Small-Molecule, Host Cell-Directed Agent Antimicrob. Agents Chemother., Oct 2009; 10.1128/AAC.00555-09 shRNA TR504956
ATM ATM and ATR play complementary roles in the behavior of excitatory and inhibitory vesicle populations Proc. Natl. Acad. Sci. U.S.A. 2017 shRNA TL320267
ATM ATM expression predicts Veliparib and Irinotecan sensitivity in gastric cancer by mediating P53 independent regulation of cell cycle and apoptosis Mol. Cancer Ther. 2016 shRNA TR320267
ATM ATM regulation of IL-8 links oxidative stress to cancer cell migration and invasion Elife Jun 2015 shRNA TG320267
ATP1B2 An Immunoaffinity-Based Method for Isolating Ultrapure Adult Astrocytes Based on ATP1B2 Targetting by the ACSA-2 Antibody J. Biol. Chem. 2017 shRNA TL500159
ATP5J Over-Expression of the ATP5J Gene Correlates with Cell Migration and 5-Fluorouracil Sensitivity in Colorectal Cancer PLoS One. 2013 Oct 4;8(10):e76846 shRNA TR314579
Atp7a Knockdown of copper-transporting ATPase 1 (Atp7a) impairs iron flux in fully-differentiated rat (IEC-6) and human (Caco-2) intestinal epithelial cells Metallomics 2016 shRNA TL711714
ATP7A A Role for the ATP7A Copper-transporting ATPase in Macrophage Bactericidal Activity J. Biol. Chem., Dec 2009; 284: 33949 - 33956 shRNA TR314562
ATP7A Copper transport into the secretory pathway is regulated by oxygen in macrophages J. Cell Sci., May 2009; 122: 1315 - 1321. shRNA TR314562
Atp7a Cell-specific ATP7A transport sustains copper-dependent tyrosinase activity in melanosomes Nature 454, 1142 - 1146 (23 Jul 2008), doi: 10.1038/nature07163, Letter shRNA TR314562
Atr ATM and ATR play complementary roles in the behavior of excitatory and inhibitory vesicle populations Proc. Natl. Acad. Sci. U.S.A. 2017 shRNA TL519184
AURKA Cucurbitacin-I inhibits Aurora kinase A, Aurora kinase B and survivin, induces defects in cell cycle progression and promotes ABT-737-induced cell death in a caspase-independent manner in malignant human glioma cells Cancer Biology & Therapy Nov 2014 shRNA TR320538
AURKB Cucurbitacin-I inhibits Aurora kinase A, Aurora kinase B and survivin, induces defects in cell cycle progression and promotes ABT-737-induced cell death in a caspase-independent manner in malignant human glioma cells Cancer Biology & Therapy Nov 2014 shRNA TR320607
B2M Mouse and Human CD1d-Self-Lipid Complexes Are Recognized Differently by Murine Invariant Natural Killer T Cell Receptors PLoS ONE May 2016 shRNA TR314543
B3GALNT1 Human Intestinal Tissue and Cultured Colonic Cells Contain Globotriaosylceramide Synthase mRNA and the Alternate Shiga Toxin Receptor, Globotetraosylceramide Infect. Immun., Nov 2010; 78: 4488 - 4499 shRNA TR306471
BAG3 A novel miR-371a-5p-mediated pathway, leading to BAG3 upregulation in cardiomyocytes in response to epinephrine, is lost in Takotsubo cardiomyopathy Cell Death Dis Oct 2015 shRNA TR314524
BAK1 Paraquat Induces Cell Death Through Impairing Mitochondrial Membrane Permeability Mol. Neurobiol. May 2015 shRNA TF712171
BAK1 BAX/BAK–Independent Mitoptosis during Cell Death Induced by Proteasome Inhibition Mol. Cancer Res., Aug 2009; 7: 1268 - 1284 shRNA TR314515
BAX Secreted frizzled-related protein 5 protects against oxidative stress-induced apoptosis in human aortic endothelial cells via downregulation of Bax J. Biochem. Mol. Toxicol. 2017 shRNA TR306440
BAX Paraquat Induces Cell Death Through Impairing Mitochondrial Membrane Permeability Mol. Neurobiol. May 2015 shRNA TF709871
BAZ1B DNA damage response defect in Williams-Beuren syndrome Int. J. Mol. Med. 2017 shRNA TG306439
BAZ1B PLA2G16 represents a switch between entry and clearance of Picornaviridae Nature 2017 shRNA TG306439
Bcl-2 Survivin inhibitor YM155 induces mitochondrial dysfunction, autophagy, DNA damage and apoptosis in BclxL silenced glioma cell lines Molecular carcinogenesis 2016 shRNA TR316461
Bcl-2 Survivin inhibitor YM155 induces mitochondrial dysfunction, autophagy, DNA damage and apoptosis in BclxL silenced glioma cell lines Molecular carcinogenesis 2016 shRNA TR316461
BCL2 IL-13 in LPS-Induced Inflammation Causes Bcl-2 Expression to Sustain Hyperplastic Mucous cells Sci Rep 2018 shRNA TG316461
BCL2 Blocking Bcl-2 resolves IL-13-mediated mucous cell hyperplasia in a Bik-dependent manner J. Allergy Clin. Immunol. 2017 shRNA TR316461
BCL2 Nuclear factor erythroid 2-related factor 2 enhances carcinogenesis by suppressing apoptosis and promoting autophagy in nickel-transformed cells J. Biol. Chem 2017 shRNA TL316461
BCL2 Inhibition of Bcl-2 potentiates AZD-2014-induced anti-head and neck squamous cell carcinoma cell activity Biochem. Biophys. Res. Commun. Jun 2016 shRNA TL316461
BCL2 Parecoxib Protects Mouse Cortical Neurons Against OGD/R Induced Neurotoxicity by Up-Regulating Bcl-2 Neurochem. Res. Jun 2015 shRNA TG316461
BCL2L11 RIPK1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy Autophagy May 2015 shRNA TG306422
BCLN1 Autophagy Induction Results in Enhanced Anoikis-resistance in Models of Peritoneal Disease Mol. Cancer Res. 2016 shRNA TL314484
BCLN1 Autophagy Induction Results in Enhanced Anoikis-resistance in Models of Peritoneal Disease Mol. Cancer Res. 2016 shRNA TL314484
BDNF A unique homeostatic signaling pathway links synaptic inactivity to postsynaptic mTORC1 J. Neurosci. 2018 shRNA TG306410
BECN1 RIPK1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy Autophagy May 2015 shRNA TG314484
BECN1 Beclin-1-p53 interaction is crucial for cell fate determination in embryonal carcinoma cells J. Cell. Mol. Med. Sep 2014 shRNA TF314484
BECN1 Antagonism of tumoral prolactin receptor promotes autophagy-related cell death Cell Rep 488-500 7 2. April 2014 shRNA SC117750
BECN1 From autophagy to senescence and apoptosis in Angiotensin II-treated vascular endothelial cells APMIS Mar 2014 shRNA TG314484
BECN1 Enhancement of Autophagy during Lytic Replication by the Kaposi's Sarcoma-Associated Herpesvirus Replication and Transcription Activator J. Virol., Aug 2010; 84: 7448 - 7458 shRNA TR314484
BECN1 Eradication of Intracellular Salmonella Typhimurium with a Small-Molecule, Host Cell-Directed Agent Antimicrob. Agents Chemother., Oct 2009; 10.1128/AAC.00555-09 shRNA TR314484
BID Inhibition of O-GlcNAcase sensitizes apoptosis and reverses bortezomib resistance in mantle cell lymphoma through modification of truncated Bid Mol. Cancer Ther.2017 shRNA TF314477
BIRC5 Cucurbitacin-I inhibits Aurora kinase A, Aurora kinase B and survivin, induces defects in cell cycle progression and promotes ABT-737-induced cell death in a caspase-independent manner in malignant human glioma cells Cancer Biology & Therapy Nov 2014 shRNA TR315477
BIRC5 HAb18G/CD147 Promotes pSTAT3-Mediated Pancreatic Cancer Development via CD44s Clin Cancer Res. 2013 Nov 22 shRNA TL315477
BIRC5 Molecular Chaperone gp96 Is a Novel Therapeutic Target of Multiple Myeloma Clin Cancer Res. 2013 Nov 15;19(22):6242-51 shRNA TG315477
BIRC5 IL-6 in human cytomegalovirus secretome promotes angiogenesis and survival of endothelial cells through the stimulation of survivin Blood, Jan 2011; 117: 352 - 361 shRNA TR315477
Bit1 The Anoikis Effector Bit1 Inhibits EMT through Attenuation of TLE1-Mediated Repression of E-Cadherin in Lung Cancer Cells PLoS ONE 2016 shRNA TR302190
BMI1 Polycomb protein BMI1 regulates osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells downstream of GSK3 Stem Cells Dev. Apr 2016 shRNA TG314462
BMI1 Lens regeneration using endogenous stem cells with gain of visual function Nature Mar 2016 shRNA TL314462
BMI1 BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair J. Cell Biol., Oct 2010; 191: 45 - 60 shRNA TR314462
BMP4 Growth and metastasis of lung adenocarcinoma is potentiated by BMP4-mediated immunosuppression OncoImmunology 2016 shRNA TG516759
BMP4 BMP4 depletion by miR-200 inhibits tumorigenesis and metastasis of lung adenocarcinoma cells Mol. Cancer Sep 2015 shRNA TG516759
BMX BMX negatively regulates BAK function thereby increasing apoptotic resistance to chemotherapeutic drugs Cancer Res. Feb 2015 shRNA TR320275
BMX Bone Marrow X Kinase–Mediated Signal Transduction in Irradiated Vascular Endothelium Cancer Res., Apr 2008; 68: 2861 - 2869. shRNA TR320275
BNIP3 Role of HIF-1a in regulating autophagic cell survival during cerebral ischemia reperfusion in rats Oncotarget 2017 shRNA TG316465
BNIP3 Autophagy Induction Results in Enhanced Anoikis-resistance in Models of Peritoneal Disease Mol. Cancer Res. 2016 shRNA TR316465
BNIP3 Autophagy Induction Results in Enhanced Anoikis-resistance in Models of Peritoneal Disease Mol. Cancer Res. 2016 shRNA TR316465
BNIP3 Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis J. Cell Biol., Jul 2012; 198: 103 - 114. shRNA TR316465
BNIP3L Role of HIF-1a in regulating autophagic cell survival during cerebral ischemia reperfusion in rats Oncotarget 2017 shRNA TG316466
Brd4 Inhibition of BRD4 Attenuates Cardiomyocyte Apoptosis via NF-κB pathway in a Rat Model of Myocardial Infarction Cardiovasc Ther 2018 shRNA TL704216
BRE Anti-apoptotic protein BRE/BRCC45 attenuates apoptosis through maintaining the expression of caspase inhibitor XIAP in mouse Lewis lung carcinoma D122 cells Apoptosis, Jan 2014. shRNA TG505808
BSG Secreted cyclophilin A mediates G1/S phase transition of cholangiocarcinoma cells via CD147/ERK1/2 pathway Tumour Biol. Oct 2014 shRNA TG314429
BST2 The interferon-induced protein BST-2/CD317 restricts release of virions from infected cells and is down-regulated from the cell surface by HIV-1 Vpu Cell Host Microbe. 2008 April 17; 3(4): 245-252 shRNA TR314427
BTBD14B NAC-1, a potential stem cell pluripotency factor, contributes to paclitaxel resistance in ovarian cancer through inactivating Gadd45 pathway Oncogene 28, 1941-1948 (23 March 2009) shRNA TR306354
C13orf15 Response gene to complement 32 interacts with Smad3 to promote epithelial-mesenchymal transition of human renal tubular cells Am J Physiol Cell Physiol, Jun 2011; 300: C1415 - C1421 shRNA TR315657
C13ORF34 Bora downregulation results in radioresistance by promoting repair of double strand breaks PLoS ONE Mar 2015 shRNA TL307294
C16orf5 Expression of the p53 Target CDIP Correlates with Sensitivity to TNFa-Induced Apoptosis in Cancer Cells Cancer Res., May 2012; 72: 2373 - 2382. shRNA TR315650
C1ORF106 INAVA promotes aggressiveness of papillary thyroid cancer by upregulating MMP9 expression Cell Biosci 2018 shRNA TR306059
CA9 Inhibition of carbonic anhydrase IX (CA9) sensitizes renal cell carcinoma to ionizing radiation Oncol. Rep. Oct 2015 shRNA TG314250
CA9 Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis In Vivo and Inhibition Enhances Anti-VEGF Therapy Clin. Cancer Res., Jun 2012; 18: 3100 - 3111. shRNA TR314250
CABP7 Modulation of Phosphatidylinositol 4-Phosphate levels by CaBP7 controls cytokinesis in mammalian cells Mol. Biol. Cell Feb 2015 shRNA TG305684
CACNA1C Primary cilium regulates CaV1.2 expression through Wnt signaling J. Cell. Physiol. April 2014 shRNA TL500242
CADM1 Human T-Cell Leukemia Virus Type 1 (HTLV-1) Tax Requires CADM1/TSLC1 for Inactivation of the NF-?B Inhibitor A20 and Constitutive NF-?B Signaling PLoS Pathog. Mar 2015 shRNA TL312210
CAII Carbonic anhydrase activation is associated with worsened pathological remodeling in human ischemic diabetic cardiomyopathy J Am Heart Assoc Mar 2014 shRNA TG314258
CAII Carbonic anhydrase activation is associated with worsened pathological remodeling in human ischemic diabetic cardiomyopathy J Am Heart Assoc Mar 2014 shRNA TG710298
CALCR Amylin Modulates the Mesolimbic Dopamine System toControl Energy Balance Neuropsychopharmacology Jul 2014 shRNA TG712173
CALCR Reductions of the components of the calreticulin/calnexin quality-control system by proteasome inhibitors and their relevance in a rodent model of Parkinson's disease J. Neurosci. Res. May 2014 shRNA TG314223
CALD1 Development of an Integrated Genomic Classifier for a Novel Agent in Colorectal Cancer: Approach to Individualized Therapy in Early Development Clin. Cancer Res., Jun 2010; 16: 3193 - 3204 shRNA TR305670
CALU Enhanced functional recombinant factor VII production by HEK 293 cells stably transfected with VKORC1 where the gamma-carboxylase inhibitor calumenin is stably suppressed by shRNA transfection Thrombosis Research Volume 122, Issue 3, 2008, Pages 405-410 shRNA TR314215
CAMKK2 Growth inhibition of human gastric adenocarcinoma cells in vitro by STO-609 is independent of calcium/calmodulin-dependent protein kinase kinase-beta and adenosine monophosphate-activated protein kinase Am J Transl Res May 2016 shRNA TF320643
CARD11 MiR-539 inhibits thyroid cancer cell migration and invasion by directly targeting CARMA1 Biochem. Biophys. Res. Commun. Jul 2015 shRNA TG305653
CASK CNTNAP2 stabilizes interneuron dendritic arbors through CASK Mol. Psychiatry 2018 shRNA TG516864
CASK Lateral Membrane-Specific MAGUK CASK Down-Regulates NaV1.5 Channel in Cardiac Myocytes. Circ. Res. 2016 shRNA TF320586
CASK Organisation et régulation des canaux sodiques et potassiques cardiaques par les protéines MAGUK Thesis Sep 2014 shRNA TF320586
CASP1 Plasmodium falciparum Histidine-Rich Protein II Compromises Brain Endothelial Barriers and May Promote Cerebral Malaria Pathogenesis MBio Jun 2016 shRNA TG305640
CASP12 Modulation of Plasmid DNA Vaccine Antigen Clearance by Caspase 12 RNA interference (RNAi) Potentiates Vaccination Clin. Vaccine Immunol., Feb 2011; 10.1128/CVI.00390-10 shRNA TR500273
CASP6 Several Nuclear Events during Apoptosis Depend on Caspase-3 Activation but Do Not Constitute a Common Pathway PLoS ONE 4(7): e6234. doi:10.1371/journal.pone.0006234 shRNA TR307410
CASP8 Regression of apoptosis-resistant colorectal tumors by induction of necroptosis in mice J. Exp. Med. 2017 shRNA TG305635
CASR Hypoxia-Induced Mitogenic Factor Acts as a Nonclassical Ligand of Calcium-Sensing Receptor, Therapeutically Exploitable for Intermittent Hypoxia-Induced Pulmonary Hypertension Hypertension 2017 shRNA TL709816
CASR Monocrotaline Induces Endothelial Injury and Pulmonary Hypertension by Targeting the Extracellular Calcium-Sensing Receptor J Am Heart Assoc 2017 shRNA TL709816
CASR Reciprocal regulation of two G protein-coupled receptors sensing extracellular concentrations of Ca2+ and H Proc. Natl. Acad. Sci. U.S.A. Aug 2015 shRNA TF513061
CAT Oncogenic transformation of human lung bronchial epithelial cells induced by arsenic involves ROS-dependent activation of STAT3-miR-21-PDCD4 mechanism Sci Rep 2016 shRNA TR314184
CAT Different roles of ROS and Nrf2 in Cr(VI)-induced inflammatory responses in normal and Cr(VI)-transformed cells. Toxicol. Appl. Pharmacol. 2016 shRNA TG314184
CAT Different roles of ROS and Nrf2 in Cr(VI)-induced inflammatory responses in normal and Cr(VI)-transformed cells Toxicol. Appl. Pharmacol. 2016 shRNA TR314184
CAT Anti-oncogenic and oncogenic properties of Nrf2 in arsenic-induced carcinogenesis J. Biol. Chem. Sep 2015 shRNA TG314184
CAT Role of reactive oxygen species in arsenic-induced transformation of human lung bronchial epithelial (BEAS-2B) cells Biochem. Biophys. Res. Commun. Jan 2015 shRNA TF314184
CAV1 Aberrant Promoter Methylation of Caveolin-1 Is Associated with Favorable Response to Taxane-Platinum Combination Chemotherapy in Advanced NSCLC PLoS ONE Sep 2014 shRNA TF314183
CAV1 Cell Entry of Avian Reovirus Follows a Caveolin-1-mediated and Dynamin-2-dependent Endocytic Pathway That Requires Activation of p38 Mitogen-activated Protein Kinase (MAPK) and Src Signaling Pathways as Well as Microtubules and Small GTPase Rab5 Protein J. Biol. Chem., Sep 2011; 286: 30780 - 30794. shRNA TR314183
CB1 Protective Role of Cannabinoid Receptor Type 2 in a Mouse Model of Diabetic Nephropathy Diabetes, Sep 2011; 60: 2386 - 2396. shRNA TR316500
Cbfb Functions of Smad Transcription Factors in TGF-ß1-Induced Selectin Ligand Expression on Murine CD4 Th Cells J. Immunol. 2016 shRNA TR500286
CBLN4 Cerebellin 4, a synaptic protein that enhances inhibitory activity and resistance of neurons to Amyloid beta toxicity Neurobiology of Aging Nov 2014 shRNA TG516844
CBX4 CBX4-mediated SUMO modification regulates BMI1 recruitment at sites of DNA damage Nucleic Acids Res., Mar 2012; 10.1093/nar/gks222. shRNA TR314171
CCL19 CCR7/CCL19 Controls Expression of EDG-1 in T Cells J. Biol. Chem., Apr 2012; 287: 11656 - 11664. shRNA TR319889
CCL2 Chemokine Signaling Facilitates Early-stage Breast Cancer Survival and Invasion through Fibroblast-dependent Mechanisms Mol. Cancer Res.2017 shRNA TL316716
CCL2 Regulatory T cells ameliorate tissue plasminogen activator-induced brain haemorrhage after stroke Brain 2017 shRNA TL501987
CCN1 CCN1 induces a reversible epithelial–mesenchymal transition in gastric epithelial cells Laboratory Investigation (10 May 2010) doi:10.1038/labinvest.2010.101 Research Article shRNA TR712084
CCND1 PAC exhibits potent anti-colon cancer properties through targeting cyclin D1 and suppressing epithelial-to-mesenchymal transition Mol. Carcinog. Jan 2015 shRNA TG305536
CCND3 L-Arginine availability regulates T lymphocyte cell cycle progression Blood. 2007 Feb 15;109(4):1568-73. shRNA TR320286
CCR2 Chemokine Signaling Facilitates Early-stage Breast Cancer Survival and Invasion through Fibroblast-dependent Mechanisms Mol. Cancer Res.2017 shRNA TL321181
CCR4 A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer J. Clin. Invest 2017 shRNA TR314127
CCR4 A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer J. Clin. Invest 2017 shRNA TR500386
CCR7 The role of CCL21/CCR7 chemokine axis in breast cancer-induced lymphangiogenesis Molecular Cancer Jan 2015 shRNA TF314124
CD109 CD109 plays a role in osteoclastogenesis PLoS ONE Apr2013 shRNA TG507140
CD2 Epigenetic Inactivation of the BRCA1 Interactor SRBC and Resistance to Oxaliplatin in Colorectal Cancer J. Natl. Cancer Inst. Nov 2013 shRNA TG314102
CD24 Characterisation of mesothelioma-initiating cells and their susceptibility to anti-cancer agents PLoS ONE May 2015 shRNA TR321436
CD274 PD-L1 up-regulation in melanoma increases disease aggressiveness and is mediated through miR-17-5p Oncotarget 2017 shRNA TL314098V
CD274 Bidirectional crosstalk between PD-L1 expression and epithelial to mesenchymal transition: significance in claudin-low breast cancer cells Mol. Cancer Aug 2015 shRNA TG314098
CD274 Investigating the role of PD-L1 pathway in human ovarian cancer Thesis Sep 2014 shRNA TG314098
CD38 Autophagy maturation associated with CD38-mediated regulation of lysosome function in mouse glomerular podocytes J. Cell. Mol. Med. Nov 2013 shRNA TR314088
CD44 CD44-shRNA recombinant adenovirus inhibits cell proliferation, invasion, and migration, and promotes apoptosis in HCT116 colon cancer cells Int. J. Oncol 2017 shRNA TG314080
CD44 Targeting Cancer Stem Cells in Castration-Resistant Prostate Cancer Clin. Cancer Res 2016 shRNA TG314080
CD44 Impacts of CD44 knockdown in cancer cells on tumor and host metabolic systems revealed by quantitative imaging mass spectrometry Nitric Oxide Nov 2014 shRNA TR314080
CD44 alpha3/4 Fucosyltransferase 3-Dependent Synthesis of Sialyl Lewis A on CD44 Variant Containing Exon 6 Mediates Polymorphonuclear Leukocyte Detachment from Intestinal Epithelium during Transepithelial Migration J Immunol. 2013 Nov 1;191(9):4804-17 shRNA TG314080
CD44 CD44 Proteolysis Increases CREB Phosphorylation and Sustains Proliferation of Thyroid Cancer Cells Cancer Res., Mar 2012; 72: 1449 - 1458. shRNA TR314080
CD44 Neutrophil Migration across Intestinal Epithelium: Evidence for a Role of CD44 in Regulating Detachment of Migrating Cells from the Luminal Surface J. Immunol., Dec 2010; 185: 7026 - 7036 shRNA TR314080
CD44 Stimulation of TLRs by LMW-HA induces self-defense mechanisms in vaginal epithelium Immunology and Cell Biology (23 November 2010) doi:10.1038/icb.2010.140 Original Article shRNA TR314080
CD73 Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis PNAS, Jan 2010; 107: 1547 - 1552 shRNA TR515992
CD9 Different states of integrin LFA-1 aggregation are controlled through its association with tetraspanin CD9 Biochim. Biophys. Acta May 2015 shRNA TR314060
CDC2 Adenylyl cyclase activating polypeptide reduces phosphorylation and toxicity of the polyglutamine-expanded androgen receptor in spinobulbar muscular atrophy Sci Transl Med 2016 shRNA TL320288
Cdc42 Integrating transient cellular and nuclear motions to comprehensively describe cell migration patterns Sci Rep 2018 shRNA TF510719
CDC42 shRNA mediated inhibition of Cdc42 gene expression in Calu-6 lung cancer cells bioRxiv 2017 shRNA TL305497
CDC42 IQGAP1 regulates cell proliferation through a novel CDC42-mTOR pathway J. Cell Sci., Jun 2009; 122: 2024 - 2033 shRNA TR305497
CDC73 A role for the RNA pol II–associated PAF complex in AID-induced immune diversification J. Exp. Med., Oct 2012; 209: 2099 - 2111. shRNA TG305495
CDC73 A role for the RNA pol II–associated PAF complex in AID-induced immune diversification J. Exp. Med., Sep 2012; 10.1084/jem.20112145. shRNA TR305495
CDH1 Downregulation of E-cadherin is an essential event in activating bold beta-catenin/Tcf-dependent transcription and expression of its target genes in Pdcd4 knockdown cells Oncogene advance online publication 28 September 2009; doi: 10.1038/onc.2009.302 shRNA TR314042
CDH11 Reciprocal regulation of the Cadherin-11/Stat3 axis by caveolin-1 in mouse fibroblasts and lung carcinoma cells Biochim. Biophys. Acta 2018 shRNA TF509242
CDH2 The FGFR4-388arg Variant Promotes Lung Cancer Progression by N-Cadherin Induction Sci Rep 2018 shRNA HC138304
CDH26 Cadherin-26 (CDH26) regulates airway epithelial cell cytoskeletal structure and polarity Cell Discov 2018 shRNA TF305478
CDH3 HOXA9 promotes homotypic and heterotypic cell interactions that facilitate ovarian cancer dissemination via its induction of P-cadherin Mol. Cancer July 2014 shRNA TG314033
CDK2 Cyclin-Dependent Kinase 2 Promotes Tumor Proliferation and Induces Radio Resistance in Glioblastoma Transl Oncol 2016 shRNA TL320291
CDK2 Cyclin-Dependent Kinase 2 Promotes Tumor Proliferation and Induces Radio Resistance in Glioblastoma Transl Oncol 2016 shRNA TL320291
CDK4 Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways PLoS ONE Aug 2015 shRNA TG320293
CDKN1A Adenylyl cyclase activating polypeptide reduces phosphorylation and toxicity of the polyglutamine-expanded androgen receptor in spinobulbar muscular atrophy Sci Transl Med 2016 shRNA TL305469
CDKN1A 15-PGDH inhibits hepatocellular carcinoma growth through 15-keto-PGE2/PPAR?-mediated activation of p21WAF1/Cip1 Oncogene doi:10.1038/onc.2013.69 shRNA TG305469
CDKN1A Vorinostat and bortezomib exert synergistic antiproliferative and proapoptotic effects in colon cancer cell models Mol. Cancer Ther., Feb 2009; 8: 342 - 349 shRNA TR305469
CDKN1A Enhanced Antitumor Therapy by Inhibition of p21waf1 in Human Malignant Mesothelioma Clin. Cancer Res., Aug 2008; 14: 5099 - 5107 shRNA TR305469
CDKN1B Kaposi's Sarcoma-Associated Herpesvirus Transactivator Rta Induces Cell Cycle Arrest in G0/G1 Phase by Stabilizing and Promoting Nuclear Localization of p27kip J. Virol. 13226-38 Nov 2013 shRNA TR314022
CDKN1B KSHV encoded Rta induces cell cycle arrest J. Virol. Dec 2013. shRNA TG314022
CDKN2B Runx1 and p21 synergistically limit the extent of hair follicle stem cell quiescence in vivo PNAS, Mar 2013; 110: 4634 - 4639. shRNA TG320299
CEBPA Regulation of the Flt3 Gene in Haematopoietic Stem and Early Progenitor Cells PLoS ONE Sep 2015 shRNA TF316491
CEL Oncogenic mutations and dysregulated pathways in obesity-associated hepatocellular carcinoma Oncogene May 2016 shRNA TR313998
CENP-B A two-step mechanism for epigenetic specification of centromere identity and function Nature Cell Biology doi:10.1038/ncb2805 shRNA TG313993
CENPJ Cenpj/CPAP regulates progenitor divisions and neuronal migration in the cerebral cortex downstream of Ascl1 Nat Commun Mar 2015 shRNA TG305452
CEP55 Suppression of CEP55 reduces cell viability and induces apoptosis in human lung cancer Oncol. Rep. 2016 shRNA TR305437
CFLAR Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates Nat. Med 2017 shRNA TG500356
CFLAR TNF Apoptosis Protection Fraction (TAPF) prevents apoptosis induced by TNF, but not by Fas or TRAIL, via NF-?B-induced increase in cFLIP Cytokine Jul 2015 shRNA TR313960
CFLAR Inhibition of NF-{kappa}B Signaling by Quinacrine Is Cytotoxic to Human Colon Carcinoma Cell Lines and Is Synergistic in Combination with Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) or Oxaliplatin J. Biol. Chem., Jun 2010; 285: 19162 - 19172 shRNA TR313960
CFTR High CFTR expression in Philadelphia chromosome-positive acute leukemia protects and maintains continuous activation of BCR-ABL and related signaling pathways in combination with PP2A Oncotarget 2017 shRNA TG313958
CFTR High level of CFTR expression is associated with tumor aggression and knockdown of CFTR suppresses proliferation of ovarian cancer in vitro and in vivo Oncol. Rep. May 2015 shRNA TG313958
CHCHD2 FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N(6)-Methyladenosine RNA Demethylase. Cancer Cell 2016 shRNA TL317169
CHCHD3 ChChd3, an Inner Mitochondrial Membrane Protein, Is Essential for Maintaining Crista Integrity and Mitochondrial Function J. Biol. Chem., Jan 2011; 286: 2918 - 2932 shRNA TR305418
CHCHD4 Human Mitochondrial MIA40 (CHCD4) is a component of Fe/S cluster export machinery Biochem. J. Aug 2015 shRNA TR305417
CHD1 The Role of CHD1 in DNA Rearrangements and Progression of Prostate Cancer Grant Jul 2013 shRNA TR313946
CHEK1 Serine/Threonine Kinase CHEK1-Dependent Transcriptional Regulation of RAD54L Promotes Proliferation and Radio Resistance in Glioblastoma Translational Oncology 2017 shRNA TR320302
CHEK1 Serine/Threonine Kinase CHEK1-Dependent Transcriptional Regulation of RAD54L Promotes Proliferation and Radio Resistance in Glioblastoma. Transl Oncol 2017 shRNA TR320302
CHI3L1 YKL-40 regulated epithelial-mesenchymal transition and migration/invasion enhancement in non-small cell lung cancer BMC Cancer Aug 2015 shRNA TR316497
CHIP A Critical Role for CHIP in the Aggresome Pathway Mol. Cell. Biol., Jan 2009; 29: 116 - 128. shRNA TR316909
CHRM3 Molecular mechanisms of synergy of corneal muscarinic and nicotinic acetylcholine receptors in upregulation of E-cadherin expression Int. Immunopharmacol. May 2015 shRNA TR313926
CHRM4 Molecular mechanisms of synergy of corneal muscarinic and nicotinic acetylcholine receptors in upregulation of E-cadherin expression Int. Immunopharmacol. May 2015 shRNA TR313925
CHRNA3 Molecular mechanisms of synergy of corneal muscarinic and nicotinic acetylcholine receptors in upregulation of E-cadherin expression Int. Immunopharmacol. May 2015 shRNA TR313921
CHRNA3 Mechanisms of tumor-promoting activities of nicotine in lung cancer: synergistic effects of cell membrane and mitochondrial nicotinic acetylcholine receptors BMC Cancer Mar 2015 shRNA TG313921
CHRNA4 Mechanisms of tumor-promoting activities of nicotine in lung cancer: synergistic effects of cell membrane and mitochondrial nicotinic acetylcholine receptors BMC Cancer Mar 2015 shRNA TG313920
CHRNA7 Molecular mechanisms of synergy of corneal muscarinic and nicotinic acetylcholine receptors in upregulation of E-cadherin expression Int. Immunopharmacol. May 2015 shRNA TR313917
CHRNA7 Mechanisms of tumor-promoting activities of nicotine in lung cancer: synergistic effects of cell membrane and mitochondrial nicotinic acetylcholine receptors BMC Cancer Mar 2015 shRNA TG313917
CHRNA9 Molecular mechanisms of synergy of corneal muscarinic and nicotinic acetylcholine receptors in upregulation of E-cadherin expression Int. Immunopharmacol. May 2015 shRNA TR305392
CHRNA9 Mechanisms of tumor-promoting activities of nicotine in lung cancer: synergistic effects of cell membrane and mitochondrial nicotinic acetylcholine receptors BMC Cancer Mar 2015 shRNA TG305392
CIITA Pollen-induced antigen presentation by mesenchymal stem cells and T cells from allergic rhinitis Clinical & Translational Immunology (2013) 2, e7 shRNA TR313899
CISH MicroRNA-98 and let-7 Confer Cholangiocyte Expression of Cytokine-Inducible Src Homology 2-Containing Protein in Response to Microbial Challenge J. Immunol., Aug 2009; 183: 1617 - 1624 shRNA TR316498
CLDN1 Claudin-1 induces epithelial–mesenchymal transition through activation of the c-Abl-ERK signaling pathway in human liver cells Oncogene doi: 10.1038/onc.2012.505 shRNA TR305370
Cldn3 Claudin-4 is required for AMPK-modulated paracellular permeability in submandibular gland cells J Mol Cell Biol Dec 2014 shRNA TG711499
Cldn4 Claudin-4 is required for AMPK-modulated paracellular permeability in submandibular gland cells J Mol Cell Biol Dec 2014 shRNA TG701533
Cltc Clathrin Assembly Defines the Onset and Geometry of Cortical Patterning Dev. Cell2017 shRNA TF710306
CLTC Dynamin and endocytosis are required for the fusion of osteoclasts and myoblasts J. Cell Biol. Oct 2014 shRNA TL516542
Cltc Dysregulation of nectin-2 in the testicular cells: An explanation of cadmium-induced male infertility Biochim. Biophys. Acta July 2014 shRNA TG516542
CNR1 The role of CB1 in intestinal permeability and inflammation The FASEB Journal 2017 shRNA TR316500
CNR1 Cannabinoid Receptors Modulate Neuronal Morphology and AnkyrinG Density at the Axon Initial Segment Front Cell Neurosci 2017 shRNA TG512614
CNTNAP2 CNTNAP2 stabilizes interneuron dendritic arbors through CASK Mol. Psychiatry 2018 shRNA TG510300
COG4 Structural basis for a human glycosylation disorder caused by mutation of the COG4 gene PNAS, Aug 2009; 106: 13329 - 13334 shRNA TR317052
COL23A1 Collagen XXIII: A Potential Biomarker for the Detection of Primary and Recurrent Non–Small Cell Lung Cancer Cancer Epidemiol. Biomarkers Prev., May 2010; 19: 1362 - 1372 shRNA TR317712
COL6A1 Mutant p53 Together with TGFß Signaling Influence Organ-Specific Hematogenous Colonization Patterns of Pancreatic Cancer Clin. Cancer Res. 2016 shRNA TF500404
COL6A1 Mutant p53 Together with TGFß Signaling Influence Organ-Specific Hematogenous Colonization Patterns of Pancreatic Cancer Clin. Cancer Res. 2016 shRNA MG223027
COMMD7 COMMD7 is correlated with a novel NF-?B positive feedback loop in hepatocellular carcinoma Oncotarget 2016 shRNA TR305276
COPRS Myc and Omomyc functionally associate with the Protein Arginine Methyltransferase 5 (PRMT5) in glioblastoma cells Sci Rep Nov 2015 shRNA TF306098
COPS5 Redox signalling to nuclear regulatory proteins by reactive oxygen species contributes to oestrogen-induced growth of breast cancer cells Br. J. Cancer May 2015 shRNA TR313776
COQ4 Haploinsufficiency of COQ4 causes coenzyme Q10 deficiency J. Med. Genet., Mar 2012; 49: 187 - 191. shRNA TR305264
COX2 Premetastatic soil and prevention of breast cancer brain metastasis Neuro Oncology, Jul 2013; 15: 891 - 903. shRNA TG310074
Cpne7 Dentin sialophosphoprotein expression in enamel is regulated by Copine-7, a preameloblast-derived factor Arch. Oral Biol. 2017 shRNA TL513948
CPT1C Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress Genes & Dev., May 2011; 25: 1041 - 1051 shRNA TR305235
CRADD RAIDD Mediates TLR3 and IRF7 Driven Type I Interferon Production Cell. Physiol. Biochem. 2016 shRNA TL319843
CRBN Lenalidomide Stabilizes the Erythropoietin Receptor by Inhibiting the E3 Ubiquitin Ligase RNF41 Cancer Research Apr 2016 shRNA TG305228
CREB1 Genetic Evidence for Critical Roles of P38a Protein in Regulating Mast Cell Differentiation and Chemotaxis through Distinct Mechanisms J. Biol. Chem., Jun 2012; 287: 20258 - 20269. shRNA TR313740
Creb3l1 CREB3L1-mediated functional and structural adaptation of the secretory pathway in hormone-stimulated thyroid cells J. Cell. Sci.2017 shRNA TL700673
CREBBP Epigenetic modifiers promote mitochondrial biogenesis and oxidative metabolism leading to enhanced differentiation of neuroprogenitor cells Cell Death Dis 2018 shRNA TF712619
CREBBP Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer Nature Genetics 44, 1104-1110 doi:10.1038/ng.2396 shRNA TR313738
Creg1 CREG promotes vasculogenesis by activation of VEGF/PI3K/Akt pathway Frontiers in Bioscience Jun 2014 shRNA TG510293
CRYAB Inhibition of the Expression of the Small Heat Shock Protein aB-crystallin Inhibits Exosome Secretion in Human Retinal Pigment Epithelial Cells in Culture J. Biol. Chem. Apr 2016 shRNA TG313715
CSF1 Colony-stimulating factor 1 potentiates lung cancer bone metastasis Lab. Invest., Jan 2014. shRNA TG305200
CSF2 Autophagy inhibition by sustained over-production of IL-6 contributes to arsenic-induced carcinogenesis Cancer Res. May 2014 shRNA TF313703
CSF2 Immune-Dependent and Independent Antitumor Activity of GM-CSF Aberrantly Expressed by Mouse and Human Colorectal Tumors Cancer Res., Jan 2013; 73: 395 - 405. shRNA MC208342
CSK SRC-family kinases are activated in non-small cell lung cancer and promote the survival of epidermal growth factor receptor-dependent cell lines. Am J Pathol. 2007 Jan;170(1):366-76. shRNA TR320311
CSMD1 Loss of CSMD1 expression is associated with high tumour grade and poor survival in invasive ductal breast carcinoma Breast Cancer Res Treat DOI 10.1007/s10549-009-0500-4 shRNA TR305196
CSNK2A1 Ikaros regulation of the BCL6/BACH2 axis and its clinical relevance in acute lymphoblastic leukemia Oncotarget 2017 shRNA TG320317
CTCF Identification of CTCF as a master regulator of the clustered protocadherin genes Nucleic Acids Res., Dec 2011; 10.1093/nar/gkr1260. shRNA TR313675
CTCFL BORIS Binding to the Promoters of Cancer Testis Antigens, MAGEA2, MAGEA3, and MAGEA4, Is Associated with Their Transcriptional Activation in Lung Cancer Clin. Cancer Res., Jul 2011; 17: 4267 - 4276. shRNA TR305184
CTCFL BAT3 and SET1A form a complex with CTCFL/BORIS to modulate H3K4 histone dimethylation and gene expression Mol. Cell. Biol. 2008; 28(21): p. 6720-6729 shRNA TR305184
CTCFL DNA Methyltransferase 1 and 3B Activate BAG-1 Expression via Recruitment of CTCFL/BORIS and Modulation of Promoter Histone Methylation Cancer Res., Apr 2008; 68: 2726 - 2735 shRNA TR305184
CTNNB1 Rhinovirus 3C protease suppresses apoptosis and triggers caspase-independent cell death Cell Death Dis 2018 shRNA TG313664
CTNNB1 ß-Catenin Activates the HOXA10 and CDX4 Genes in Myeloid Progenitor Cells J. Biol. Chem., Nov 2012; 287: 39589 - 39601. shRNA TG313664
CTNND1 P120ctn may participate in epithelial-mesenchymal transition in OSCC Indian J Cancer May 2016 shRNA TF313663
CTNND2 d-Catenin promotes prostate cancer cell growth and progression by altering cell cycle and survival gene profiles Molecular Cancer 2009, 8:19 shRNA TR313662
CTR9 A role for the RNA pol II–associated PAF complex in AID-induced immune diversification J. Exp. Med., Oct 2012; 209: 2099 - 2111. shRNA TG313659
CTR9 A role for the RNA pol II–associated PAF complex in AID-induced immune diversification J. Exp. Med., Sep 2012; 10.1084/jem.20112145. shRNA TR313659
CTSA Serine carboxypeptidase SCPEP1 and Cathepsin A play complementary roles in regulation of vasoconstriction via inactivation of endothelin-1 PLoS Genet. Feb 2014 shRNA TF501716
CTSB Cathepsin-B-mediated cleavage of Disabled-2 regulates TGF-ß-induced autophagy Nat. Cell Biol. 2016 shRNA TL305176
CTSL1 Cathepsin L inactivation leads to multimodal inhibition of prostate cancer cell dissemination in a preclinical bone metastasis model Int. J. Cancer Jan 2016 shRNA TG305172
CUGBP1 Regulation of cyclin-dependent kinase 4 translation through CUG-binding protein 1 and microRNA-222 by polyamines Mol. Biol. Cell, Sep 2011; 22: 3055 - 3069. shRNA TR514753
custom BCL2 Nicotine increases the resistance of lung cancer cells to cisplatin through enhancing Bcl-2 stability Br. J. Cancer, Feb 2014. shRNA
custom OMA1 Stress-triggered Activation of the Metalloprotease Oma1 Involves its C-terminal Region and is Important for Mitochondrial Stress Protection in Yeast J. Biol. Chem. Mar 2014 shRNA
custom OMA1 Stress-triggered Activation of the Metalloprotease Oma1 Involves its C-terminal Region and is Important for Mitochondrial Stress Protection in Yeast J. Biol. Chem. Mar 2014 shRNA
custom OMA1 Stress-triggered Activation of the Metalloprotease Oma1 Involves its C-terminal Region and is Important for Mitochondrial Stress Protection in Yeast J. Biol. Chem. Mar 2014 shRNA
custom OMA1 Stress-triggered Activation of the Metalloprotease Oma1 Involves its C-terminal Region and is Important for Mitochondrial Stress Protection in Yeast J. Biol. Chem. Mar 2014 shRNA
custom OMA1 Stress-triggered Activation of the Metalloprotease Oma1 Involves its C-terminal Region and is Important for Mitochondrial Stress Protection in Yeast J. Biol. Chem. Mar 2014 shRNA
custom VPU The Expression of HIV-1 Vpu in Monocytes Causes Increased Secretion of TGF-β that Activates Profibrogenic Genes in Hepatic Stellate Cells PLoS ONE, Feb 2014. shRNA
Cx3cr1 Emergent role of the fractalkine axis in dissemination of peritoneal metastasis from epithelial ovarian carcinoma Oncogene 2016 shRNA TR509718
CXCL10 Tumor-Suppressive Effects of Natural-type Interferon-ß through CXCL10 in Melanoma Biochem. Biophys. Res. Commun. Jun 2015 shRNA TG313633
CXCL12 CXCL12 secreted from glioma stem cells regulates their proliferation J. Neurooncol., Jan 2014. shRNA TR501994
CXCL8 A Novel TNF-mediated Mechanism of Direct Epithelial Sodium Channel Activation Am. J. Respir. Crit. Care Med. July 2014 shRNA TG319476
CXCL8 Tumor-derived CXCL8 signaling augments stroma-derived CCL2-promoted proliferation and CXCL12-mediated invasion of PTEN-deficient prostate cancer cells Oncotarget July 2014 shRNA TG319476
CXCR1 IL-8, GRO and MCP-1 produced by hepatocellular carcinoma microenvironment determine the migratory capacity of human bone marrow-derived mesenchymal stromal cells without affecting tumor aggressiveness Oncotarget 2017 shRNA TG312158
CXCR2 IL-8, GRO and MCP-1 produced by hepatocellular carcinoma microenvironment determine the migratory capacity of human bone marrow-derived mesenchymal stromal cells without affecting tumor aggressiveness Oncotarget 2017 shRNA TG312157
CXCR2 CXCR2 Expression in Tumor Cells Is a Poor Prognostic Factor and Promotes Invasion and Metastasis in Lung Adenocarcinoma Cancer Res., Jan 2013; 73: 571 - 582. shRNA TG312157
CXCR3 Divergent roles of CXCR3 isoforms in promoting cancer stem-like cell survival and metastasis Breast Cancer Res. Treat. Dec 2014 shRNA TL316563
CXCR4 Proinflammatory CXCL12-CXCR4/CXCR7 signaling axis drives Myc-induced prostate cancer in obese mice Cancer Res. 2017 shRNA TL500383
CXCR4 EZH2-mediated loss of miR-622 determines CXCR4 activation in hepatocellular carcinoma Nat Commun Sep 2015 shRNA TR313630
CXCR7 Proinflammatory CXCL12-CXCR4/CXCR7 signaling axis drives Myc-induced prostate cancer in obese mice Cancer Res. 2017 shRNA TL515747
CXCR7 ShRNA knock-down of CXCR7 inhibits tumour invasion and metastasis in hepatocellular carcinoma after transcatheter arterial chemoembolization J. Cell. Mol. Med. 2017 shRNA TL305345
CXCR7 Platelet-derived SDF-1 primes the pulmonary capillary vascular niche to drive lung alveolar regeneration Nat. Cell Biol. Feb 2015 shRNA TL305345
CXCR7 Platelet-derived SDF-1 primes the pulmonary capillary vascular niche to drive lung alveolar regeneration Nat. Cell Biol. Feb 2015 shRNA TL515747
CYBB Early and Late Events Induced by PolyQ-expanded Proteins: IDENTIFICATION OF A COMMON PATHOGENIC PROPERTY OF POLYQ-EXPANDED PROTEINS J. Biol. Chem., Feb 2011; 286: 4727 - 4741 shRNA TR313616
CYGB Cytoglobin, the Newest Member of the Globin Family, Functions as a Tumor Suppressor Gene Cancer Res., Sep 2008; 68: 7448 - 7456 shRNA TR305139
CYGB Cytoglobin, the Newest Member of the Globin Family, Functions as a Tumor Suppressor Gene Cancer Research 68, 7448, September 15, 2008 shRNA TR305139
Cyp11a1 Steroidogenic enzyme Cyp11a1 regulates Type 2 CD8+ T cell skewing in allergic lung disease PNAS, May 2013; 110: 8152 - 8157. shRNA TG500467
CYP1B1 Cytochrome P450 1B1 inhibition suppresses tumorigenicity of prostate cancer via caspase-1 activation Oncotarget 2017 shRNA TL313605
DAB2 Cathepsin-B-mediated cleavage of Disabled-2 regulates TGF-ß-induced autophagy Nat. Cell Biol. 2016 shRNA TL313573
DACH1 Suppression of DACH1 promotes migration and invasion of colorectal cancer via activating TGF-ß-mediated epithelial-mesenchymal transition Biochem. Biophys. Res. Commun. Mar 2015 shRNA TL313572
DDR2 Targeting DDR2 in head and neck squamous cell carcinoma with dasatinib Int. J. Cancer 2016 shRNA TL320440
DDR2 DDR2 facilitates hepatocellular carcinoma invasion and metastasis via activating ERK signaling and stabilizing SNAIL1 J. Exp. Clin. Cancer Res. Sep 2015 shRNA TR320440
DDX6 The RNA helicase DDX6 regulates cell-fate specification in neural stem cells via miRNAs Nucleic Acids Res. Mar 2015 shRNA TG313512
DEPDC5 DEPDC5 and NPRL3 modulate cell size, filopodial outgrowth, and localization of mTOR in neural progenitor cells and neurons Neurobiol. Dis. 2018 shRNA TG508165
DICER Dicer-Mediated Upregulation of BCRP Confers Tamoxifen Resistance in Human Breast Cancer Cells Clin. Cancer Res., Oct 2011; 17: 6510 - 6521. shRNA TR304991
DICER1 Impaired DICER1 function promotes stemness and metastasis in colon cancer Oncogene. 2013 Oct 7. shRNA TR304991
Dicer1 Aging-Induced Dysregulation of Dicer1-Dependent MicroRNA Expression Impairs Angiogenic Capacity of Rat Cerebromicrovascular Endothelial Cells J Gerontol A Biol Sci Med Sci, Aug 2013; 68: 877 - 891. shRNA TR304991
DICER1 Aging-Induced Dysregulation of Dicer1-Dependent MicroRNA Expression Impairs Angiogenic Capacity of Rat Cerebromicrovascular Endothelial Cells J Gerontol A Biol Sci Med Sci, Dec 2012; 10.1093/gerona/gls242. shRNA TG304991
DKK1 A Positive Feedback Loop Regulates the Expression of Polycomb Group Protein BMI1 via WNT Signaling Pathway J. Biol. Chem., Feb 2013; 288: 3406 - 3418. shRNA TG313465
DKK1 Tobacco Smoke Induces Polycomb-Mediated Repression of Dickkopf-1 in Lung Cancer Cells Cancer Res., Apr 2009; 69: 3570 - 3578 shRNA TR313465
DLC1 Aberrant DNA methylation of alternative promoter of DLC1 isoform 1 in meningiomas J. Neurooncol 2016 shRNA TG304982
DLG1 Differential Regulation of Two Isoforms of the Glial Glutamate Transporter EAAT2 by DLG1 and CaMKII J. Neurosci. Apr 2015 shRNA TF313458
Dll1 Notch1 regulated autophagy controls survival and suppressor activity of activated murine T-regulatory cells Elife Jun 2016 shRNA TG500534
DLX4 The Homeoprotein DLX4 Stimulates NF-?B Activation and CD44-Mediated Tumor-Mesothelial Cell Interactions in Ovarian Cancer Am. J. Pathol. Jun 2015 shRNA TG313449
DLX4 Homeodomain protein DLX4 counteracts key transcriptional control mechanisms of the TGF-ß cytostatic program and blocks the antiproliferative effect of TGF-ß Oncogene (7 February 2011) doi:10.1038/onc.2011.4 Original Article shRNA TR313449
DNAJB1 FOXE3 contributes to Peters anomaly through transcriptional regulation of an autophagy-associated protein termed DNAJB1 Nature Communications Apr 2016 shRNA TL313427
DNM2 Bovine Ephemeral Fever Virus Uses a Clathrin-Mediated and Dynamin 2-Dependent Endocytosis Pathway That Requires Rab5 and Rab7 as Well as Microtubules J. Virol., Dec 2012; 86: 13653 - 13661. shRNA TG313406
DNM2 Cell Entry of Avian Reovirus Follows a Caveolin-1-mediated and Dynamin-2-dependent Endocytic Pathway That Requires Activation of p38 Mitogen-activated Protein Kinase (MAPK) and Src Signaling Pathways as Well as Microtubules and Small GTPase Rab5 Protein J. Biol. Chem., Sep 2011; 286: 30780 - 30794. shRNA TG313406
DNMT1 Cancer associated fibroblasts in pancreatic cancer are reprogrammed by tumor-induced alterations in genomic DNA methylation Cancer Res. 2016 shRNA TL313404
DNMT1 CD66+ cells in cervical pre-cancers are partially differentiated progenitors with neoplastic traits Cancer Res. Sep 2014 shRNA TR313404
DPYSL2 A Collapsin Response Mediator Protein 2 Isoform Controls Myosin II-Mediated Cell Migration and Matrix Assembly by Trapping ROCK II Mol. Cell. Biol., May 2012; 32: 1788 - 1804. shRNA TR313374
DRD2 Role of Dopamine Receptors in the Anticancer Activity of ONC201 Neoplasia 2017 shRNA TL304907
DSCR1 Pyrrolidine dithiocarbamate (PDTC) inhibits inflammatory signaling via expression of regulator of calcineurin activity 1 (RCAN1): Anti-inflammatory mechanism of PDTC through RCAN1 induction Biochem. Pharmacol. 2017 shRNA TR511392
DSP Desmoplakin acts as a tumor suppressor by inhibition of the Wnt/ß-catenin signaling pathway in human lung cancer Carcinogenesis, Aug 2012; 10.1093/carcin/bgs226. shRNA TR313354
DUB3 The Deubiquitinating Enzyme USP17 Is Highly Expressed in Tumor Biopsies, Is Cell Cycle Regulated, and Is Required for G1-S Progression Cancer Res., Apr 2010; 70: 3329 - 3339 shRNA TR307933
DUOX2 Contribution of Dual Oxidase 2 (DUOX2) to Hyper-Radiosensitivity in Human Gastric Cancer Cells Radiat. Res. Aug 2015 shRNA TR313350
DUOXA1 Dual Oxidase Maturation factor 1 (DUOXA1) overexpression increases reactive oxygen species production and inhibits murine muscle satellite cell differentiation Cell Commun. Signal, Jan 2014. shRNA TR304888
DUSP10 mTORC2 modulates feedback regulation of p38 MAPK activity via DUSP10/MKP5 to confer differential responses to PP242 in glioblastoma Genes Cancer Nov 2014 shRNA TG304883
Dusp10 Co-inhibition of NF-?B and JNK is synergistic in TNF-expressing human AML J. Exp. Med. May 2014 shRNA TG513100
DUSP19 USP17 regulates Ras activation and cell proliferation by blocking RCE 1 activity J. Biol. Chem., Feb 2009; 10.1074/jbc.M807216200. shRNA TR304880
Dusp2 Co-inhibition of NF-?B and JNK is synergistic in TNF-expressing human AML J. Exp. Med. May 2014 shRNA TG514083
DUSP23 Profiling analysis of protein tyrosine phosphatases during neuronal differentiation Neurosci. Lett. Dec 2015 shRNA TL317251
DUSP4 Statins affect ETS1-overexpressing triple-negative breast cancer cells by restoring DUSP4 deficiency Sci Rep 2016 shRNA TG304875
Dusp6 Co-inhibition of NF-?B and JNK is synergistic in TNF-expressing human AML J. Exp. Med. May 2014 shRNA TG514782
E2F1 An E2F1/MiR-17-92 Negative Feedback Loop mediates proliferation of Mouse Palatal Mesenchymal Cells Sci Rep 2017 shRNA TG509487
E2F1 Cooperative Activation of Tissue-Specific Genes by pRB and E2F1 Cancer Res., Apr 2013; 73: 2150 - 2158. shRNA TG320325
E2F1 Transcriptional Regulation of the Human Tumor Suppressor DOK1 by E2F1 Mol. Cell. Biol., Dec 2012; 32: 4877 - 4890. shRNA TG320325
E2F6 A comprehensive ChIP-chip analysis of E2F1, E2F4, and E2F6 in normal and tumor cells reveals interchangeable roles of E2F family members. Genome Res. 2007 Nov;17(11):1550-61. shRNA TR316522
EDD Regulation of the Human Papillomavirus Type 18 E6/E6AP Ubiquitin Ligase Complex by the HECT Domain-Containing Protein EDD J. Virol., Apr 2011; 85: 3120 - 3127 shRNA
EDD Regulation of the HPV-18 E6/E6AP Ubiquitin Ligase Complex by the HECT domain-containing protein EDD J. Virol., Jan 2011; 10.1128/JVI.02004-10 shRNA TR313510
EDEM2 Innate sensing of influenza A virus hemagglutinin glycoproteins by the host endoplasmic reticulum (ER) stress pathway triggers a potent antiviral response via ER-associated protein degradation J. Virol. 2017 shRNA TL304849
EDG1(S1PR1) Sphingosine-1-phosphate promotes lymphangiogenesis by stimulating S1P1/Gi/PLC/Ca2+ signaling pathways Blood, Aug 2008; 112: 1129 - 1138. shRNA TR313301
EDG3(S1PR3) Sphingosine-1-phosphate promotes lymphangiogenesis by stimulating S1P1/Gi/PLC/Ca2+ signaling pathways Blood, Jun 2008; 10.1182/blood-2007-11-125203. shRNA TR313299
EGFL7 EGFL7 participates in regulating biological behavior of growth hormone-secreting pituitary adenomas via Notch2/DLL3 signaling pathway Tumour Biol. 2017 shRNA TL713010
EGFP The prolyl isomerase FKBP25 regulates microtubule polymerization impacting cell cycle progression and genomic stability Nucleic Acids Res. 2018 shRNA TR30001
EGFR Activation of EGFR/p38/HIF-1a is pivotal for angiogenesis and tumorigenesis of malignantly transformed cells induced by hexavalent chromium J. Biol. Chem. May 2016 shRNA TL320326
EGFR Modification of cytokine-induced killer cells with chimeric antigen receptors (CARs) enhances antitumor immunity to epidermal growth factor receptor (EGFR)-positive malignancies Cancer Immunol. Immunother. Sep 2015 shRNA TG320326
EGFR EGFR signaling defines Mcl(-)1 survival dependency in neuroblastoma Cancer Biol. Ther. Feb 2015 shRNA TG320326
EGFR Constitutive activation of epidermal growth factor receptor promotes tumorigenesis of Cr(VI)-transformed cells through decreased reactive oxygen species and apoptosis resistance development J. Biol. Chem. Dec 2014 shRNA TG320326
EGFR Optical methodology for detecting histologically unapparent nanoscale consequences of genetic alterations in biological cells PNAS. published 10 December 2008, 10.1073/pnas.0804723105 shRNA TR320326
EGFR Polyethylene glycol-mediated colorectal cancer chemoprevention: roles of epidermal growth factor receptor and Snail Mol. Cancer Ther., Sep 2008; 7: 3103 - 3111 shRNA TR320326
EGR3 Opposing role for egr3 in nucleus accumbens cell subtypes in cocaine action J. Neurosci. May 2015 shRNA TG500585
Ehmt2 Inhibition of G9a Histone Methyltransferase Converts Bone Marrow Mesenchymal Stem Cells to Cardiac Competent Progenitors Stem Cells International May 2015 shRNA TG505922
Eif2ak4 Genetic or Pharmacological Reduction of PERK Enhances Cortical-Dependent Taste Learning J. Neurosci. Oct 2014 shRNA TG511649
EIF4A1 miR-133a acts as a tumor suppressor in colorectal cancer by targeting eIF4A1 Tumour Biol. 2017 shRNA TG313247
ELAVL1 Post-Transcriptional Suppression of Proto-Oncogene c-fms Expression by Vigilin in Breast Cancer Mol. Cell. Biol., Oct 2010; 10.1128/MCB.01031-10 shRNA TR313235
ELAVL1(HuR) Regulation of non-AU-rich element containing c-fms proto-oncogene expression by HuR in breast cancer Oncogene (19 Jan 2009), doi: 10.1038/onc.2008.469 shRNA TR313235
ELAVL4 Prenatal Deletion of the RNA-Binding Protein HuD Disrupts Postnatal Cortical Circuit Maturation and Behavior J. Neurosci. Mar 2014 shRNA TG501025
ELAVL4 The role of HuD, a post-transcriptional regulator, in the development and function of the murine neocortex Thesis. January 2014 shRNA TG501025
ELF3 A transcriptional repressive role for epithelial-specific ETS factor ELF3 on estrogen receptor-alpha in breast cancer cells BIOCHEMICAL JOURNAL Feb 2016 shRNA TG313232
ELK1 GADD45a-Targeted Suicide Gene Therapy for the Prevention or Treatment of Non-Small Cell Lung Carcinoma Thesis Jun 2015 shRNA TR320328
EMILIN1 EMILIN1–a4/a9 integrin interaction inhibits dermal fibroblast and keratinocyte proliferation J. Cell Biol., Sep 2011; 10.1083/jcb.201008013. shRNA TR510314
EMX2 EMX2 Is a Predictive Marker for Adjuvant Chemotherapy in Lung Squamous Cell Carcinomas PLoS ONE Jul 2015 shRNA TF313216
EMX2(RFP Vector) EMX2 is epigenetically silenced and suppresses growth in human lung cancer Oncogene (9 August 2010) doi:10.1038/onc.2010.330 Short Communication shRNA TR313216
Entpd1 cAMP/CREB-mediated Transcriptional Regulation of Ectonucleoside Triphosphate Diphosphohydrolase 1 (CD39) Expression J. Biol. Chem., May 2010; 285: 14791 - 14805 shRNA TR500312
EPAS1 Modulation of the mevalonate pathway by Akt regulates macrophage survival and development of pulmonary fibrosis J. Biol. Chem. Nov 2014 shRNA TG315484
EPHA2 EphA2 receptor is a key player in the metastatic onset of Ewing sarcoma Int. J. Cancer 2018 shRNA TR320327
EPHA2 A Modified Adenovirus Vector-Mediated Antibody Screening Method Identifies EphA2 as a Cancer Target Transl Oncol 2017 shRNA TR320327
EPHA2 A Genome-Wide Screen Reveals Functional Gene Clusters in the Cancer Genome and Identifies EphA2 as a Mitogen in Glioblastoma Cancer Res., Nov 2006; 66: 10815-10823. shRNA TR320327
EPHB4 Erythropoietin Promotes Bone Formation through EphrinB2/EphB4 Signaling J. Dent. Res. Jan 2015 shRNA TG500619
EPHB4 Effects of Toxicologically Relevant Xenobiotics and the Lipid-Derived Electrophile 4-Hydroxynonenal on Macrophage Cholesterol Efflux: Silencing Carboxylesterase 1 Has Paradoxical Effects on Cholesterol Uptake and Efflux Chem. Res. Toxicol. Sep 2014 shRNA TG320337
EPHX2 Pro-Resolving Maresins in Inflammation: New Pathway and Mechanisms With Oral Pathogens Thesis Aug 2015 shRNA TR313191
EPHX2 Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages PLoS ONE July 2014 shRNA TR313191
ERAP1 ERAP1 reduces accumulation of aberrant and disulfide-linked forms of HLA-B27 on the cell surface Mol. Immunol. Apr 2016 shRNA TG307017
ERBB2 Directed Evolution of Scanning Unnatural-Protease-Resistant (SUPR) Peptides for in Vivo Applications Chembiochem 2016 shRNA TL320342
ERBB2 Transmembrane Domain Targeting Peptide Antagonizing ErbB2/Neu Inhibits Breast Tumor Growth and Metastasis Cell Rep Sep 2014 shRNA TL320342
ERBB3 A phosphoproteomic screen demonstrates differential dependence on HER3 for MAP kinase pathway activation by distinct PIK3CA mutations Proteomics Nov 2014 shRNA TR320343
ERBB3 microRNA-205 Regulates HER3 in Human Breast Cancer Cancer Res., Mar 2009; 69: 2195 - 2200 shRNA TR320343
ERCC2 XPD localizes in mitochondria and protects the mitochondrial genome from oxidative DNA damage Nucleic Acids Res. May 2015 shRNA TL313180
ERCC6 Elevated Expression of ERCC6 Confers Resistance to 5-Fluorouracil and Is Associated with Poor Patient Survival in Colorectal Cancer DNA Cell Biol. 2017 shRNA TL313176
ERCC6 Cockayne syndrome group B protein promotes mitochondrial DNA stability by supporting the DNA repair association with the mitochondrial membrane FASEB J, Feb 2010; 10.1096/fj.09-147991 shRNA TR313176
ERCC6 Cockayne syndrome group B protein stimulates repair of formamidopyrimidines by NEIL1 DNA glycosylase J. Biol. Chem., Jan 2009; 10.1074/jbc.M807006200. shRNA TR313176
ERN1 Insulin demand regulates ß cell number via the unfolded protein response J. Clin. Invest. Oct 2015 shRNA TG320345
ERO1A Cancer-associated oxidoreductase ERO1-α promotes immune escape through up-regulation of PD-L1 in human breast cancer Oncotarget 2017 shRNA TR313168
ERO1a Hypoxia augments MHC class I antigen presentation via facilitation of ERO1-a-mediated oxidative folding in murine tumor cells Eur. J. Immunol. 2016 shRNA TR502816
ERO1L Cancer-associated oxidoreductase ERO1-a drives the production of VEGF via oxidative protein folding and regulating the mRNA level Br. J. Cancer Apr 2016 shRNA TR313168
ERO1L Cancer-Associated Oxidase ERO1-a Regulates the Expression of MHC Class I Molecule via Oxidative Folding J. Immunol. May 2015 shRNA TR313168
ERO1L Real-time monitoring of redox changes in the mammalian endoplasmic reticulum J. Cell Sci., Jul 2011; 124: 2349 - 2356. shRNA TR313168
ERp46 Endoplasmic Reticulum Protein ERp46 in Renal Cell Carcinoma PLoS ONE Mar 2014 shRNA TG505718
ERR gamma Transcriptional mechanism for the paired miR-433 and miR-127 genes by nuclear receptors SHP and ERR{gamma} Nucleic Acids Res., Oct 2008; 36: 5727 - 5735. shRNA TR502584
ERRFI1 The induction of MIG6 under hypoxic conditions is critical for dormancy in primary cultured lung cancer cells with activating EGFR mutations Oncogene 2016 shRNA TR304737
ERRG Orphan nuclear receptor estrogen-related receptor-? suppresses in vitro and in vivo growth of prostate cancer cells via p21WAF1/CIP1 induction and as a potential therapeutic target in prostate cancer Oncogene 27, 3313 - 3328 (10 Dec 2007) shRNA TR502584
ESR1 RIZ1 is regulated by estrogen and suppresses tumor progression in endometrial cancer Biochem. Biophys. Res. Commun. 2017 shRNA TR320346
ESR1 PAC down-regulates estrogen receptor alpha and suppresses epithelial-to-mesenchymal transition in breast cancer cells BMC Cancer 2016 shRNA TL320346
ESR1 Knockdown of estrogen receptor-a induces autophagy and inhibits antiestrogen-mediated unfolded protein response activation, promoting ROS-induced breast cancer cell death FASEB J. May 2014 shRNA TR320346
ESR1 Nuclear Localization of the Transcriptional Regulator MIER1a Requires Interaction with HDAC1/2 in Breast Cancer Cells PLoS ONE Dec 2013. shRNA TG320346
ESR2 Expression of Estrogen Receptor Beta Predicts Oncologic Outcome of pT3 Upper Urinary Tract Urothelial Carcinoma Better Than Aggressive Pathological Features Sci Rep Apr 2016 shRNA TG320347
ESR2 Biologic Roles of Estrogen Receptor-ß and Insulin-Like Growth Factor-2 in Triple-Negative Breast Cancer BioMed Research International Jan 2015 shRNA TG320347
ESRRA Identification of ERR alpha as a specific partner of PGC-1 alpha for the activation of PDK4 gene expression in muscle FEBS J., Apr 2006; 273: 1669-1680. shRNA TR320451
Esrrg Transcriptional mechanism for the paired miR-433 and miR-127 genes by nuclear receptors SHP and ERR Nucleic Acids Res., Sep 2008; 10.1093/nar/gkn567. shRNA TR502584
ETS1 ETS1 transcriptional activity is increased in advanced prostate cancer and promotes the castrate-resistant phenotype Carcinogenesis, Mar 2012; 33: 572 - 580. shRNA TR313153
ETS1 ETS1 transcriptional activity is increased in advanced prostate cancer and promotes the castrate-resistant phenotype Carcinogenesis, Jan 2012; 10.1093/carcin/bgs007. shRNA TR313153
ETS2 Inactivation of Rb in stromal fibroblasts promotes epithelial cell invasion The EMBO Journal doi:10.1038/emboj.2012.153 shRNA TR320351
Etv4 Pea3 Expression Promotes the Invasive and Metastatic Potential of Colorectal Carcinoma World Journal of Gastroenterology July 2014 shRNA TG509137
EWSR1 Ewing sarcoma breakpoint region 1 prevents transcription-associated genome instability bioRxiv Dec2015 shRNA TG313142
EXTL3 Regenerating Islet-derived 1a (Reg-1a) Protein Is New Neuronal Secreted Factor That Stimulates Neurite Outgrowth via Exostosin Tumor-like 3 (EXTL3) Receptor J. Biol. Chem., Feb 2012; 287: 4726 - 4739. shRNA TG313126
EYA1 EYA1's conformation-specificity in dephosphorylating phosphothreonine in Myc and its activity on Myc stabilization in breast cancer Mol. Cell. Biol. 2016 shRNA TR304716
EYA1 Regulation of the innate immune response by threonine-phosphatase of Eyes absent Nature. 2009 Jul 23;460(7254):520-4. shRNA TR304716
EYA2 Regulation of the innate immune response by threonine-phosphatase of Eyes absent Nature. 2009 Jul 23;460(7254):520-4. shRNA TR304715
EYA3 Regulation of the innate immune response by threonine-phosphatase of Eyes absent Nature. 2009 Jul 23;460(7254):520-4. shRNA TR316534
EYA4 Regulation of the innate immune response by threonine-phosphatase of Eyes absent Nature. 2009 Jul 23;460(7254):520-4. shRNA TR304714
EZH2 Long noncoding RNA H19 regulates EZH2 expression by interacting with miR-630 and promotes cell invasion in nasopharyngeal carcinoma Biochem. Biophys. Res. Commun. May 2016 shRNA TL304713
EZH2 EZH2-mediated loss of miR-622 determines CXCR4 activation in hepatocellular carcinoma Nat Commun Sep 2015 shRNA TR304713
EZH2 C-type lectin-like domain and fibronectin-like type II domain of phospholipase A2 receptor 1 modulate binding and migratory responses to collagen FEBS Lett. Feb 2015 shRNA TG304713
EZH2 Sunitinib dose-escalation overcomes transient resistance in clear cell renal cell carcinoma and is associated with epigenetic modifications Mol. Cancer Ther. Dec 2014 shRNA TL304713
Ezh2 NFIB-Mediated Repression of the Epigenetic Factor Ezh2 Regulates Cortical Development J. Neurosci., Feb 2014. shRNA TF304713
EZH2 EZH2/miR-30d/KPNB1 pathway regulates malignant peripheral nerve sheath tumor cell survival and tumorigenesis J Pathol. 2013 Oct 16 shRNA TG304713
EZH2 GATA-1 Utilizes Ikaros and Polycomb Repressive Complex 2 To Suppress Hes1 and To Promote Erythropoiesis Mol. Cell. Biol., Sep 2012; 32: 3624 - 3638. shRNA TR304713
FABP5 Role of Fatty Acid Binding Protein 5 (FABP5) in Breast Cancer Progression and Metastasis Thesis Apr 2013 shRNA TG316535
FAF2 Derlin-1 and UBXD8 are engaged in dislocation and degradation of lipidated ApoB-100 at lipid droplets Mol. Biol. Cell, Mar 2012; 23: 800 - 810. shRNA TR308511
FAIM2 Lifeguard inhibition of Fas-mediated apoptosis: A possible mechanism for explaining the cisplatin resistance of triple-negative breast cancer cells Biomed. Pharmacother. Feb 2016 shRNA TG313099
FANCA Upregulated ATM Gene Expression and Activated DNA Crosslink–Induced Damage Response Checkpoint in Fanconi Anemia: Implications for Carcinogenesis Mol Med 14 (3-4) 167-174 shRNA TR313071
FANCA Ataxia Telangiectasia Mutated (ATM) Gene Expression Is Reversibly Up-Regulated in FANCA-Mutant Patient Fibroblasts by an Indirect Mechanism Blood (ASH Annual Meeting Abstracts), Nov 2007; 110: 1679. shRNA TR313071
FANCD2 HPV-16 E7 Reveals a Link between DNA Replication Stress, Fanconi Anemia D2 Protein, and Alternative Lengthening of Telomere–Associated Promyelocytic Leukemia Bodies Cancer Res., Dec 2008; 68: 9954 - 9963. shRNA TR313068
FASN Up-Regulated FASN Expression Promotes Transcoelomic Metastasis of Ovarian Cancer Cell through Epithelial-Mesenchymal Transition Int J Mol Sci July 2014 shRNA TR313058
FATS FATS is an E2-independent ubiquitin ligase that stabilizes p53 and promotes its activation in response to DNA damage Oncogene Nov 2013 shRNA TG315108
FBL Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells Cancer Cell Jun 2016 shRNA TL313054
FBXO28 LPS impairs oxygen utilization in epithelia by triggering degradation of the mitochondrial enzyme Alcat1 J. Cell. Sci. Nov 2015 shRNA TG313036
FCN1 Secreted M-Ficolin Anchors onto Monocyte Transmembrane G Protein-Coupled Receptor 43 and Cross Talks with Plasma C-Reactive Protein to Mediate Immune Signaling and Regulate Host Defense J. Immunol., Dec 2010; 185: 6899 - 6910 shRNA TR313015
FFAR1 Diverse effects of G-protein-coupled free fatty acid receptors on the regulation of cellular functions in lung cancer cells Exp. Cell Res. Mar 2016 shRNA TR313001
FFAR1 Negative effects of G-protein-coupled free fatty acid receptor GPR40 on cell migration and invasion in fibrosarcoma HT1080 cells Mol. Carcinog. Sep 2015 shRNA TR313001
FFAR1 Different roles of GPR120 and GPR40 in the acquisition of malignant properties in pancreatic cancer cells Biochem. Biophys. Res. Commun. Aug 2015 shRNA TR313001
FFAR4 Different effects of G-protein-coupled receptor 120 (GPR120) and GPR40 on cell motile activity of highly migratory osteosarcoma cells Biochem. Biophys. Res. Commun 2017 shRNA TR307824
FFAR4 Different effects of GPR120 and GPR40 on cellular functions stimulated by 12-O-tetradecanoylphorbol-13-acetate in melanoma cells Biochem. Biophys. Res. Commun. Jun 2016 shRNA TF307824
Fgf15 A Genetic Screen Identifies Hypothalamic Fgf15 as a Regulator of Glucagon Secretion Cell Rep 2016 shRNA TL514099
FGF7 Regulation of Epithelial Differentiation and Proliferation by the Stroma: A Role for the Retinoblastoma Protein Journal of Investigative Dermatology doi:10.1038/jid.2012.201 shRNA TR312988
FIGHL1 FIGNL1 is overexpressed in small cell lung cancer patients and enhances NCI-H446 cell resistance to cisplatin and etoposide Oncol. Rep. 2017 shRNA TR304505
FKBP2 The Function of FK506-Binding Protein 13 in Protein Quality Control Protects Plasma Cells from Endoplasmic Reticulum Stress-Associated Apoptosis Front Immunol 2017 shRNA TG500710
FKBP3 The prolyl isomerase FKBP25 regulates microtubule polymerization impacting cell cycle progression and genomic stability Nucleic Acids Res. 2018 shRNA TR319727
FLT1 Autocrine VEGF signaling promotes cell proliferation and modulates the sorafenib treatment efficacy in hepatocellular carcinoma Hepatology May 2014 shRNA TG320360
Flt1 miR-200 Inhibits Lung Adenocarcinoma Cell Invasion and Metastasis by Targeting Flt1/VEGFR1 Mol. Cancer Res., Jan 2011; 9: 25 - 35 shRNA TG514364
FLT4 Neuropilin-2 mediates lymphangiogenesis of colorectal carcinoma via a VEGFC/VEGFR3 independent signaling Cancer Lett. Dec 2014 shRNA TG320362
FN1 Fibronectin 1 promotes migration and invasion of papillary thyroid cancer and predicts papillary thyroid cancer lymph node metastasis Onco Targets Ther 2017 shRNA TL304489
FN1 Cellular fibronectin 1 promotes VEGF-C expression, lymphangiogenesis and lymph node metastasis associated with human oral squamous cell carcinoma Clin. Exp. Metastasis Oct 2015 shRNA TR304489
Fnbp1 Clathrin Assembly Defines the Onset and Geometry of Cortical Patterning Dev. Cell2017 shRNA TF712968
FNBP1 Collective membrane dynamics emerging from curvature-dependent spatial coupling bioRxiv 2017 shRNA TG712968
FOG2 ZEB1 sensitizes lung adenocarcinoma to metastasis suppression by PI3K antagonism J. Clin. Invest. April 2014 shRNA TG512097
FOLR1 Modification of cytokine-induced killer cells with folate receptor alpha (FRα)-specific chimeric antigen receptors enhances their antitumor immunity toward FRα-positive ovarian cancers Mol. Immunol. 2017 shRNA TR304479
FOLR1 Folate Receptor Alpha Upregulates Oct4, Sox2 and Klf4 and Downregulates miR-138 and miR-let-7 in Cranial Neural Crest Cells Stem Cells Jun 2016 shRNA TG304479
FOS GLP2 Promotes Directed Differentiation from Osteosarcoma Cells to Osteoblasts and Inhibits Growth of Osteosarcoma Cells Mol Ther Nucleic Acids 2018 shRNA TG312946
FOS Glucagon-like peptide 2 promotes directed-differentiation from osteosarcoma cells to osteoblast and inhibits growth of osteosarcoma cells Molecular Therapy-Nucleic Acids 2017 shRNA TG312946
FOS Nkx6.1-mediated insulin secretion and ß-cell proliferation is dependent on upregulation of c-Fos FEBS Lett. May 2016 shRNA TL710577
FOSB Activation of the Transcription Factor FosB/Activating Protein-1 (AP-1) Is a Prominent Downstream Signal of the Extracellular Nucleotide Receptor P2RX7 in Monocytic and Osteoblastic Cells J. Biol. Chem., Oct 2010; 285: 34288 - 34298 shRNA TR312945
Fox-3 Identification of Neuronal Nuclei (Neun) As Fox-3, a new member of the Fox-1 gene family of splicing factors JBC Papers doi: 10.1074/jbc.M109.052969 shRNA
FOXA1 Forkhead box protein A1 is a prognostic predictor and promotes tumor growth of gastric cancer Onco Targets Ther Nov 2015 shRNA TR312942
FOXD3 FOXD3 is a tumor suppressor of colon cancer by inhibiting EGFR-Ras-Raf-MEK-ERK signal pathway Oncotarget 2017 shRNA TR312939
FOXD3 Epigenetic changes during disease progression in a murine model of human chronic lymphocytic leukemia PNAS, Aug 2009; 106: 13433 - 13438 shRNA TR312939
FOXO3 Mitochondrial FOXO3a is involved in amyloid ß peptide-induced mitochondrial dysfunction J. Bioenerg. Biomembr. Jan 2016 shRNA TL704976
FOXO3 Regulation of the Tumor Suppressor FOXO3 by the Thromboxane-A2 Receptors in Urothelial Cancer PLoS ONE Sep 2014 shRNA TF320359
FOXO3 Reprogramming ovarian and breast cancer cells into non-cancerous cells by low-dose metformin or SN-38 through FOXO3 activation Sci Rep July 2014 shRNA TR320359
FOXO3 AMPK Reverses the Mesenchymal Phenotype of Cancer Cells by Targeting the Akt-MDM2-Foxo3a Signaling Axis Cancer Res. July 2014 shRNA TR320359
FOXO3a Role of TRPM2 in cell proliferation and susceptibility to oxidative stress Am J Physiol Cell Physiol, Mar 2013; 304: C548 - C560. shRNA TG320359
FOXP1 FOXP1 is a key regulator of quiescence in healthy human CD3(+) CD4(+) T Cells and is constitutively repressed in CD3(-) CD4(+) T cells from patients with lymphoproliferative disorders Eur. J. Immunol. 2016 shRNA TR304471
FOXP1 FOXP1 is a key regulator of quiescence in healthy human CD3(+) CD4(+) T Cells and is constitutively repressed in CD3(-) CD4(+) T cells from patients with lymphoproliferative disorders Eur. J. Immunol. 2016 shRNA TR304471
FOXP3 Forkhead box P3 regulates ARHGAP15 expression and affects migration of glioma cells through the Rac1 signaling pathway Cancer Sci 2017 shRNA TF317157
FOXP3 Endogenous FOXP3 inhibits cell proliferation, migration and invasion in glioma cells Int J Clin Exp Med May 2015 shRNA TF317157
FRK Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways PLoS ONE Aug 2015 shRNA TG517143
FRMPD2 PDZ-domain-directed basolateral targeting of the peripheral membrane protein FRMPD2 in epithelial cells J. Cell Sci., Aug 2009; 10.1242/jcs.046854 shRNA TR312922
FSCN1 Fascin is Critical for the Maintenance of Breast Cancer Stem Cell Pool Predominantly via the Activation of the Notch Self-Renewal Pathway Stem Cells 2016 shRNA TL312916
fscn2 Fascin2 regulates cisplatin-induced apoptosis in NRK-52E cells Toxicol. Lett 2016 shRNA TG705644
FTO Kaposi's Sarcoma-Associated Herpesvirus Utilizes and Manipulates RNA N6-Adenosine Methylation To Promote Lytic Replication J. Virol. 2017 shRNA TL308064
FTO FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N(6)-Methyladenosine RNA Demethylase. Cancer Cell 2016 shRNA TL308064
Furin Furin Is the Major Proprotein Convertase Required for KISS1-to-Kisspeptin Processing PLoS ONE, Jan 2014. shRNA TF312903
FZD2 Suppression of hepatocellular carcinoma cell proliferation by short hairpin RNA of frizzled 2 with Sonazoid-enhanced irradiation Int. J. Oncol. Jan 2016 shRNA TR312884
FZD2 Suppression of hepatocellular carcinoma cell proliferation by short hairpin RNA of frizzled 2 with Sonazoid-enhanced irradiation International Journal of Oncology Nov 2015 shRNA TR312884
FZD2 Gastric cancer cell proliferation is suppressed by frizzled-2 short hairpin RNA Int. J. Oncol. Mar 2015 shRNA TR312884
FZD2 Short hairpin RNA of frizzled-2 suppresses the proliferation of hepatocellular carcinoma cells ONCOLOGY LETTERS Aug 2014 shRNA TR312884
FZD2 Frizzled-2: A potential novel target for molecular pancreatic cancer therapy Oncology Letters 74 Nov 2013 shRNA TR312884
FZD2 Identification of Predictive Markers of Response to the MEK1/2 Inhibitor Selumetinib (AZD6244) in K-ras–Mutated Colorectal Cancer Mol. Cancer Ther., Dec 2010; 9: 3351 - 3362 shRNA TR312884
FZD5 Frizzled-5: a high affinity receptor for secreted frizzled-related protein-2 activation of nuclear factor of activated T-cells c3 signaling to promote angiogenesis Angiogenesis 2017 shRNA TG312882
Galm Topological analysis of metabolic networks integrating co-segregating transcriptomes and metabolomes in type 2 diabetic rat congenic series Genome Med 2016 shRNA TG700891
GAS2 The Interferon Consensus Sequence Binding Protein (ICSBP) Decreases Bcatenin-Activity in Myeloid Cells By Repressing GAS2 Transcription Mol. Cell. Biol., Oct 2010; 30: 4575 - 4594 shRNA TR511218
GATA4 Meox1 accelerates myocardial hypertrophic decompensation through Gata4. Cardiovasc. Res.2017 shRNA TL500773
GATA4 GATA-4 upregulates glucose-dependent insulinotropic polypeptide expression in cells of pancreatic and intestinal lineage Mol Cell Endocrinol. 2008 June 11; 287(1-2): 20–29 shRNA TR500773
GB200002 DAB2IP regulates cancer stem cell phenotypes through modulating stem cell factor receptor and ZEB1 Oncogene July 2014 shRNA HC121827
GCLC EPITHELIAL AND MESENCHYMAL CELL BIOLOGY: Endogenous Hydrogen Peroxide Regulates Glutathione Redox via Nuclear Factor Erythroid 2-Related Factor 2 Downstream of Phosphatidylinositol 3-Kinase during Muscle Differentiation Am. J. Pathol., Jun 2008; 172: 1529 - 1541. shRNA TR312813
GFP PKR Regulates B56{alpha}-mediated BCL2 Phosphatase Activity in Acute Lymphoblastic Leukemia-derived REH Cells J. Biol. Chem., Dec 2008; 283: 35474 - 35485. shRNA
GFP-tagged siRNA Motoneurons Secrete Angiogenin to Induce RNA Cleavage in Astroglia J. Neurosci., Apr 2012; 32: 5024 - 5038. shRNA
GFPT1 Hyperglycemia exacerbates colon cancer malignancy through hexosamine biosynthetic pathway Oncogenesis 2017 shRNA TL511601
GHSR The suppression of ghrelin signaling mitigates age-associated thermogenic impairment Aging (Albany NY) Dec 2014 shRNA TG506242
GJA1 Connexin hemichannel and pannexin channel electrophysiology: How do they differ? FEBS Lett., Jan 2014. shRNA TR312771
GJA1 Context dependent reversion of tumor phenotype by connexin-43 expression in MDA-MB231 cells and MCF-7 cells: Role of Beta-catenin/connexin43 association Exp Cell Res. 2013 Dec 10;319(20):3065-80 shRNA TR312771
GJA1 Gap Junctions/Hemichannels Modulate Interkinetic Nuclear Migration in the Forebrain Precursors J. Neurosci., Mar 2010; 30: 4197 - 4209 shRNA TR500808
GLI1 Modulation of the IL-6 Receptor a Underlies GLI2-Mediated Regulation of Ig Secretion in Waldenström Macroglobulinemia Cells J. Immunol. Aug 2015 shRNA TG312756
GLI1 Hedgehog Signaling Drives Cellular Survival in Human Colon Carcinoma Cells Cancer Res., Feb 2011; 71: 1092 - 1102 shRNA TR312756
GLI2 Novel Molecular Mechanism of Regulation of CD40 Ligand by the Transcription Factor GLI2 J. Immunol. 2017 shRNA TR312755
GLI2 Hedgehog and TGFß signaling converge on Gli2 to control bony invasion and bone destruction in oral squamous cell carcinoma Oncotarget 2016 shRNA TR312755
GLI2 Modulation of the IL-6 Receptor a Underlies GLI2-Mediated Regulation of Ig Secretion in Waldenström Macroglobulinemia Cells J. Immunol. Aug 2015 shRNA TG312755
GLI2 Hedgehog Signaling Drives Cellular Survival in Human Colon Carcinoma Cells Cancer Res., Feb 2011; 71: 1092 - 1102 shRNA TR312755
GLUL Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma Nat. Cell Biol. Dec 2015 shRNA TL312740
GMNN Geminin deletion increases the number of fetal hematopoietic stem cells by affecting the expression of key transcription factors Development Jan 2015 shRNA TL304304
GNB2L1 NPY1-36 and PYY1-36 activate cardiac fibroblasts: an effect enhanced by genetic hypertension and inhibition of dipeptidyl peptidase 4. Am. J. Physiol. Heart Circ. Physiol. Sep 2015 shRNA TR312717
GOLGA2 GOLGA2/GM130, cis-Golgi Matrix Protein, is a Novel Target of Anticancer Gene Therapy Molecular Therapy doi:10.1038/mt.2012.125 shRNA TR312706
GOLPH3 Lentivirus Mediated GOLPH3 shRNA Inhibits Growth and Metastasis of Esophageal Squamous Cancer Asian Pac. J. Cancer Prev. 5391-6 Nov 2013 shRNA TL317415
GOT1 Endogenous sulfur dioxide alleviates collagen remodeling via inhibiting TGF-ß/Smad pathway in vascular smooth muscle cells Sci Rep Jan 2016 shRNA TF709215
Got1 Sulfur dioxide inhibits vascular smooth muscle cell proliferation via suppressing the Erk/MAP kinase pathway mediated by cAMP/PKA signaling Cell Death Dis May 2014 shRNA TF709215
GOT2 Endogenous sulfur dioxide alleviates collagen remodeling via inhibiting TGF-ß/Smad pathway in vascular smooth muscle cells Sci Rep Jan 2016 shRNA TF709767
Got2 Sulfur dioxide inhibits vascular smooth muscle cell proliferation via suppressing the Erk/MAP kinase pathway mediated by cAMP/PKA signaling Cell Death Dis May 2014 shRNA TF709767
GPAT3 GPAT3 and GPAT4 are regulated by insulin-stimulated phosphorylation and play distinct roles in adipogenesis J. Lipid Res., Jul 2010; 51: 1971 - 1981 shRNA TR307398
GPAT4 GPAT3 and GPAT4 are regulated by insulin-stimulated phosphorylation and play distinct roles in adipogenesis J. Lipid Res., Jul 2010; 51: 1971 - 1981 shRNA TR306795
GPNMB The Potential Role of the Glycoprotein Osteoactivin/Glycoprotein Nonmetastatic Melanoma Protein B in Pancreatic Cancer Pancreas Nov 2014 shRNA TG312675
GPR120 Different roles of GPR120 and GPR40 in the acquisition of malignant properties in pancreatic cancer cells Biochem. Biophys. Res. Commun. Aug 2015 shRNA TF307824
GPR120 Opposite effects of GPR120 and GPR40 on cell motile activity induced by ethionine in liver epithelial cells Biochem. Biophys. Res. Commun. Nov 2014 shRNA TG703763
GPR120 Role of GPR120 in cell motile activity induced by 12-O-tetradecanoylphorbol-13-acetate in liver epithelial WB-F344 cells Mol. Cell. Biochem. Nov 2014 shRNA TG703763
GPR68 Reciprocal regulation of two G protein-coupled receptors sensing extracellular concentrations of Ca2+ and H Proc. Natl. Acad. Sci. U.S.A. Aug 2015 shRNA TF507234
GPSM1 G Protein-Coupled Receptor Kinase-6 Interacts with Activator of G Protein Signaling-3 To Regulate CXCR2-Mediated Cellular Functions J. Immunol., Feb 2014. shRNA TG713072
GRM1 GRM1 is An Androgen-Regulated Gene and its Expression Correlates with Prostate Cancer Progression in Pre-Clinical Models Clin. Cancer Res. 2016 shRNA RG214400
GRN The perlecan-interacting growth factor progranulin regulates ubiquitination, sorting, and lysosomal degradation of sortilin Matrix Biol. 2017 shRNA TR312595
GRN Sortilin regulates progranulin action in castration-resistant prostate cancer cells Endocrinology Nov 2014 shRNA TR312595
GRN(PEPI) Proepithelin is an autocrine growth factor for bladder cancer Carcinogenesis, May 2009; 30: 861 - 868. shRNA TR312595
GSK3A Selectively Silencing GSK-3 Isoforms Reduces Plaques and Tangles in Mouse Models of Alzheimer's Disease J. Neurosci., May 2012; 32: 7392 - 7402. shRNA TR320375
GSTM4 Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages Proc. Natl. Acad. Sci. U.S.A. 2016 shRNA TR304180
GSTT2 GSTT2, a phase II gene induced by apple polyphenols, protects colon epithelial cells against genotoxic damage Molecular Nutrition & Food Research Volume 53 Issue 10, Pages 1245 - 1253 shRNA TR312581
GTF2I DNA damage response defect in Williams-Beuren syndrome Int. J. Mol. Med. 2017 shRNA TG304176
GTF2I PLA2G16 represents a switch between entry and clearance of Picornaviridae Nature 2017 shRNA TG304176
H19 Long noncoding RNA H19 regulates EZH2 expression by interacting with miR-630 and promotes cell invasion in nasopharyngeal carcinoma Biochem. Biophys. Res. Commun. May 2016 shRNA TL318197
HABP2 Hyaluronic Acid Binding Protein 2 Is a Novel Regulator of Vascular Integrity Arterioscler Thromb Vasc Biol, Mar 2010; 30: 483 - 490 shRNA TR312532
HABP2 Hyaluronic Acid Binding Protein 2 Is a Novel Regulator of Vascular Integrity Arterioscler Thromb Vasc Biol, Dec 2009; 10.1161/ATVBAHA.109.200451 shRNA TR312532
HAND1 Directed Differentiation of Patient-Specific Induced Pluripotent Stem Cells Identifies the Transcriptional Repression and Epigenetic Modification of NKX2-5, HAND1, and NOTCH1 in Hypoplastic Left Heart Syndrome PLoS ONE July 2014 shRNA TR316857
HBP1 Transcription factor ICBP90 regulates the MIF promoter and immune susceptibility locus J. Clin. Invest. Feb 2016 shRNA TL312507
HDAC1 Chronic sun exposure is associated with distinct histone acetylation changes in human skin Br. J. Dermatol.2017 shRNA TR312496
HDAC1 Transcriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacteylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B Cell Acute Lymphoblastic Leukemia J. Biol. Chem. Dec 2015 shRNA TG312496
HDAC1 Nuclear Localization of the Transcriptional Regulator MIER1a Requires Interaction with HDAC1/2 in Breast Cancer Cells PLoS ONE Dec 2013. shRNA TG312496
HDAC1 Histone Deacetylase 2 Cell Autonomously Suppresses Excitatory and Enhances Inhibitory Synaptic Function in CA1 Pyramidal Neurons J. Neurosci., Apr 2013; 33: 5924 - 5929. shRNA TG312496
HDAC1 Histone Deacetylase Inhibitors Stimulate Histone H3 Lysine 4 Methylation in Part Via Transcriptional Repression of Histone H3 Lysine 4 Demethylases Mol. Pharmacol., Jan 2011; 79: 197 - 206 shRNA TR312496
HDAC2 Ethanol exposure regulates Gabra1 expression via histone deacetylation at the promoter in cultured cortical neurons J. Pharmacol. Exp. Ther. 2017 shRNA TL711866
HDAC2 LPS impairs oxygen utilization in epithelia by triggering degradation of the mitochondrial enzyme Alcat1 J. Cell. Sci. Nov 2015 shRNA TG312495
HDAC2 HDAC2-dependent Deacetylation of MORF4L1 Enhances Its Homodimerization J. Biol. Chem., Jan 2014. shRNA TG312495
HDAC2 Histone Deacetylase 2 (HDAC2) Protein-dependent Deacetylation of Mortality Factor 4-like 1 (MORF4L1) Protein Enhances Its Homodimerization Journal of Biological Chemistry Jan 2014 shRNA TG312495
HDAC2 Nuclear Localization of the Transcriptional Regulator MIER1a Requires Interaction with HDAC1/2 in Breast Cancer Cells PLoS ONE Dec 2013. shRNA TG312495
HDAC2 Histone Deacetylase Inhibitors Stimulate Histone H3 Lysine 4 Methylation in Part Via Transcriptional Repression of Histone H3 Lysine 4 Demethylases Mol. Pharmacol., Jan 2011; 79: 197 - 206 shRNA TR312495
HDAC3 Histone Deacetylase Inhibitors Stimulate Histone H3 Lysine 4 Methylation in Part Via Transcriptional Repression of Histone H3 Lysine 4 Demethylases Mol. Pharmacol., Jan 2011; 79: 197 - 206 shRNA TR312494
HDAC4 HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder Hum. Mol. Genet. 2016 shRNA TL510852
HDAC4 Inhibition of androgen receptor activity by histone deacetylase 4 through receptor SUMOylation Oncogene (17 January 2011) doi:10.1038/onc.2010.600 Original Article shRNA TR312493
HDAC5 HDAC5, a potential therapeutic target and prognostic biomarker, promotes proliferation, invasion and migration in human breast cancer Oncotarget 2016 shRNA TG312492
HDAC6 HDAC6 Deacetylates and Ubiquitinates MSH2 to Maintain Proper Levels of MutSa Mol. Cell May 2014 shRNA TR312491
HDAC6 Histone Deacetylase Inhibitors Stimulate Histone H3 Lysine 4 Methylation in Part Via Transcriptional Repression of Histone H3 Lysine 4 Demethylases Mol. Pharmacol., Jan 2011; 79: 197 - 206 shRNA TR312491
HDAC6 Histone deacetylase 6 interacts with the microtubule-associated protein tau Journal of Neurochemistry. 106(5):2119-2130, September 2008 shRNA TR312491
HDAC8 Histone Deacetylase Inhibitors Stimulate Histone H3 Lysine 4 Methylation in Part Via Transcriptional Repression of Histone H3 Lysine 4 Demethylases Mol. Pharmacol., Jan 2011; 79: 197 - 206 shRNA TR304143
HES1 Notch-HES1 signaling axis controls hemato-endothelial fate decisions of human embryonic and induced pluripotent stem cells Blood, Aug 2013; 122: 1162 - 1173. shRNA TG312478
HES1 (RFP) Notch/HES1-mediated PARP1 activation: a cell type–specific mechanism for tumor suppression Blood, Mar 2011; 117: 2891 - 2900 shRNA TR312478
HES5 Growth differentiation factor 5 is a key physiological regulator of dendrite growth during development Development. 2013 Dec;140(23):4751-62 shRNA TG312477
HEXIM1 Identification of HEXIM1 as a Positive Regulator of p53 J. Biol. Chem., Oct 2012; 287: 36443 - 36454. shRNA TG312473
HHEX PRH/HHex inhibits the migration of breast and prostate epithelial cells through direct transcriptional regulation of Endoglin Oncogene Nov 2013 shRNA TG312464
HHEX DNA compaction by the higher-order assembly of PRH/Hex homeodomain protein oligomers Nucleic Acids Res., Jul 2010; 10.1093/nar/gkq659. shRNA TR312464
HHEX PRH/HHex controls cell survival through coordinate transcriptional regulation of VEGF signalling Mol. Cell. Biol., May 2010; 30: 2120 - 2134 shRNA TR312464
HHIP Stromal cells expressing hedgehog-interacting protein regulate the proliferation of myeloid neoplasms Blood Cancer Journal 2, e87 doi:10.1038/bcj.2012.36 shRNA TR304118
Hif1a Secretion-mediated STAT3 activation promotes self-renewal of glioma stem-like cells during hypoxia Oncogene 2017 shRNA TR517255
HIF1A Placental growth factor silencing ameliorates liver fibrosis and angiogenesis and inhibits activation of hepatic stellate cells in a murine model of chronic liver disease J. Cell. Mol. Med. 2017 shRNA TR320380
HIF1A Activation of EGFR/p38/HIF-1a is pivotal for angiogenesis and tumorigenesis of malignantly transformed cells induced by hexavalent chromium J. Biol. Chem. May 2016 shRNA TL320380
HIF1A Cell type-dependent modulation of the gene encoding heat shock protein HSPA2 by hypoxia-inducible factor HIF-1: Down-regulation in keratinocytes and up-regulation in HeLa cells Biochim. Biophys. Acta Jul 2015 shRNA TL320380
HIF1A Hypoxic niche-mediated regeneration of hematopoiesis in the engraftment window is dominantly affected by oxygen tension in the milieu Stem Cells Dev. Jun 2015 shRNA TF517255
HIF1A Hypoxia-Sensitive Epigenetic Regulation of an Antisense-Oriented lncRNA Controls WT1 Expression in Myeloid Leukemia Cells PLoS ONE Mar 2015 shRNA TR320380
HIF1A Regulation of Noxa-mediated apoptosis in Helicobacter pylori-infected gastric epithelial cells FASEB J. Nov 2014 shRNA TG320380
HIF1A A Splice Variant of the Human Ion Channel TRPM2 Modulates Neuroblastoma Tumor Growth Through HIF-1/2a J. Biol. Chem. Nov 2014 shRNA TG320380
HIF1A The dual PI3K/mTOR inhibitor NVP-BEZ235 prevents epithelial-mesenchymal transition induced by hypoxia and TGF-β1 Eur. J. Pharmacol., Feb 2014. shRNA TG320380
HIF1A Tirapazamine Sensitizes Hepatocellular Carcinoma Cells to Topoisomerase I Inhibitors via Cooperative Modulation of Hypoxia-Inducible Factor-1a Mol. Cancer Ther. Dec 2013. shRNA TG320380
HIF1A Role of HIF-1 and NF-B Transcription Factors in the Modulation of Transferrin Receptor by Inflammatory and Anti-inflammatory Signals J. Biol. Chem., Jul 2008; 283: 20674 - 20686 shRNA TR517255
HIF1A[GFP vector] Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion British Journal of Cancer (15 December 2009) doi:10.1038/sj.bjc.6605486 Full Paper shRNA TR320380
HLA CIITA Enhances HIV-1 Attachment to CD4+ T Cells Leading to Enhanced Infection and Cell Depletion J. Immunol., Dec 2010; 185: 6480 - 6488 shRNA TG304088
HMGA2 Chaperoning HMGA2 Protein Protects Stalled Replication Forks in Stem and Cancer Cells Cell Rep, Feb 2014. shRNA TR319507
HMGB1 Inhibiting the cytoplasmic location of HMGB1 reverses cisplatin resistance in human cervical cancer cells Mol Med Rep 2017 shRNA TG316576
HMGB1 HMGB1 knockdown effectively inhibits the progression of rectal cancer by suppressing HMGB1 expression and promoting apoptosis of rectal cancer cells Mol Med Rep May 2016 shRNA TG316576
HMGB1 Interference with HMGB1 increases the sensitivity to chemotherapy drugs by inhibiting HMGB1-mediated cell autophagy and inducing cell apoptosis Tumour Biol. Jun 2015 shRNA TG316576
HMGB1 Soluble HMGB1 is a novel adipokine stimulating IL-6 secretion through RAGE receptor in SW872 preadipocyte cell line: contribution to chronic inflammation in fat tissue PLoS One. 2013 Sep 20;8(9):e76039 shRNA TR316576
HMGCS2 Fsp27/CIDEC is a CREB target gene induced during early fasting in liver and regulated by FA oxidation rate J. Lipid Res., Mar 2013; 54: 592 - 601. shRNA TR312391
HMGCS2 Human HMGCS2 Regulates Mitochondrial Fatty Acid Oxidation and FGF21 Expression in HepG2 Cell Line J. Biol. Chem., Jun 2011; 286: 20423 - 20430 shRNA TR312391
HMGN2 Histone H1 and Chromosomal Protein HMGN2 Regulate Prolactin-Induced STAT5 Transcription Factor Recruitment and Function in Breast Cancer Cells J. Biol. Chem 2016 shRNA TF319505
HMOX1 4-Hydroxyestradiol induces mammary epithelial cell transformation through Nrf2-mediated heme oxygenase-1 overexpression Oncotarget 2017 shRNA TR312388
HMOX1 The Flavonoid, Eriodictyol, Induces Long-term Protection in ARPE-19 Cells through Its Effects on Nrf2 Activation and Phase 2 Gene Expression Invest. Ophthalmol. Vis. Sci., May 2009; 50: 2398 - 2406. shRNA TR312388
Hmox2 Heme oxygenase-2 deletion impairs macrophage function: implication in wound healing FASEB J. Oct 2014 shRNA TR514171
HNF1B Inhibition of Cell Death and Induction of G2 Arrest Accumulation in Human Ovarian Clear Cells by HNF-1ß Transcription Factor: Chemosensitivity Is Regulated by Checkpoint Kinase CHK1 Int. J. Gynecol. Cancer Jun 2014 shRNA TG308907
HNF4 Modification in Oxidative Stress, Inflammation, and Lipoprotein Assembly in Response to Hepatocyte Nuclear Factor 4{alpha} Knockdown in Intestinal Epithelial Cells J. Biol. Chem., Dec 2010; 285: 40448 - 40460 shRNA TR320382
Hnf4a Hepatocyte Nuclear Factor-4 alpha in Noise-Induced Cochlear Neuropathy Dev Neurobiol Apr 2016 shRNA TL500970
HNRNP The RNA binding protein hnRNP Q modulates the utilization of exon 7 in the survival motor neuron 2 (SMN2) gene Mol. Cell. Biol., Nov 2008; 28: 6929 - 6938 shRNA TR304074
HNRNPK Anxiety-associated alternative polyadenylation of the serotonin transporter mRNA confers translational regulation by hnRNPK PNAS, Jul 2013; 110: 11624 - 11629. shRNA TG712371
HNRNPL HnRNP L is important for the expression of oncogene SRSF3 and oncogenic potential of oral squamous cell carcinoma cells Sci Rep 2016 shRNA TG312371
HNRNPL Separate cis-trans Pathways Post-transcriptionally Regulate Murine CD154 (CD40 Ligand) Expression: A NOVEL FUNCTION FOR CA REPEATS IN THE 3'-UNTRANSLATED REGION J. Biol. Chem., Sep 2008; 283: 25606 - 25616 shRNA TR312371
HNRNPM The Role of the Carcinoembryonic Antigen Receptor in Colorectal Cancer Progression Journal of Integrative Oncology 2017 shRNA TR304071
HOXA10 HOXA10 controls proliferation, migration and invasion in oral squamous cell carcinoma Int J Clin Exp Pathol Jun 2015 shRNA TG316581
HOXA11 Knockdown of Hoxa11 In Vivo in the Uterosacral Ligament and Uterus of Mice Results in Altered Collagen and Matrix Metalloproteinase Activity Biol Reprod, Jul 2012; 86: 100. shRNA TR312366
HOXA11 Knockdown of Hoxa11 In Vivo in the Uterosacral Ligament and Uterus of Mice Results in Altered Collagen and Matrix Metalloproteinase Activity Biol Reprod, Apr 2012; 86: 100. shRNA TR312366
HOXA11 HoxA-11 and FOXO1A Cooperate to Regulate Decidual Prolactin Expression: Towards Inferring the Core Transcriptional Regulators of Decidual Genes PLoS ONE 4(9): e6845. doi:10.1371/journal.pone.0006845 shRNA TR312366
HOXA13 Reprogramming Antagonizes the Oncogenicity of HOXA13-Long Noncoding RNA HOTTIP Axis in Gastric Cancer Cells Stem Cells 2017 shRNA TR312365
HOXA13 Reprogramming Antagonizes the Oncogenicity of HOXA13-Long Noncoding RNA HOTTIP Axis in Gastric Cancer Cells Stem Cells 2017 shRNA TR312365
HOXA9 TWIST1-WDR5-Hottip regulates Hoxa9 chromatin to facilitate prostate cancer metastasis Cancer Res. 2017 shRNA TG307647
HOXA9 TWIST1-WDR5-Hottip regulates Hoxa9 chromatin to facilitate prostate cancer metastasis Cancer Res. 2017 shRNA TG500979
HOXA9 Transcriptional profiling of HOXA9-regulated genes in human glioblastoma cell models Genomics Data Sep 2015 shRNA TG307647
HOXA9 Transcriptional profiling of HOXA9-regulated genes in humanglioblastoma cell models Genomics Data May 2015 shRNA TG307647
HOXA9 A transcriptomic signature mediated by HOXA9 promotes human glioblastoma initiation, aggressiveness and resistance to temozolomide Oncotarget Feb 2015 shRNA TG307647
HOXA9 HOXA9 promotes homotypic and heterotypic cell interactions that facilitate ovarian cancer dissemination via its induction of P-cadherin Mol. Cancer July 2014 shRNA TG307647
HOXC13 Transcriptional regulation of the proto-oncogene Zfp521 by SPI1 (PU.1) and HOXC13 Genesis 2016 shRNA TL304059
HPSE Heparanase regulates the M1 polarization of renal macrophages and their crosstalk with renal epithelial tubular cells after ischemia/reperfusion injury FASEB J. 2017 shRNA TF307138
HPSE Sphingosine-1-phosphate induced epithelial-mesenchymal transition of hepatocellular carcinoma via an MMP-7/ syndecan-1/TGF-ß autocrine loop Oncotarget 2016 shRNA TL307138
HPSE Heparanase: A Potential New Factor Involved in the Renal Epithelial Mesenchymal Transition (EMT) Induced by Ischemia/Reperfusion (I/R) Injury PLoS ONE 2016 shRNA TR307138
HPSE Everolimus-induced epithelial to mesenchymal transition in immortalized human renal proximal tubular epithelial cells: key role of heparanase J Transl Med 292 Nov 2013 shRNA TR307138
HPSE Heparanase and Syndecan-1 Interplay Orchestrates Fibroblast Growth Factor-2-induced Epithelial-Mesenchymal Transition in Renal Tubular Cells J. Biol. Chem., Jan 2012; 287: 1478 - 1488. shRNA TR307138
HPSE Heparanase Alters Arterial Structure, Mechanics, and Repair Following Endovascular Stenting in Mice Circulation Research:Volume 104(3)13 February 2009pp 380-387 shRNA TR307138
HS6ST1 Ovarian Cancer Cell Heparan Sulfate 6-O-Sulfotransferases Regulate an Angiogenic Program Induced by HB-EGF/EGF Receptor Signaling J. Biol. Chem., Feb 2014. shRNA TG312328
Hsc70 The Molecular Chaperone Hsc70 Interacts with Tyrosine Hydroxylase to Regulate Enzyme Activity and Synaptic Vesicle Localization J. Biol. Chem. 2016 shRNA TR501001
Hsc70 The Molecular Chaperone Hsc70 Interacts with Tyrosine Hydroxylase to Regulate Enzyme Activity and Synaptic Vesicle Localization J Biol Chem 2016 shRNA TR501001
HSP27 HSP27 phosphorylation modulates TRAIL-induced activation of Src-Akt/ERK signaling through interaction with Beta-arrestin2 Cell. Signal. Dec 2013. shRNA TR320383
Hspa1a Tumor-derived inducible heat-shock protein 70 (HSP70) is an essential component of anti-tumor immunity Oncogene Mar 2014 shRNA TF312308
Hspa1b Tumor-derived inducible heat-shock protein 70 (HSP70) is an essential component of anti-tumor immunity Oncogene Mar 2014 shRNA TF312307
HSPA5 The loss of glucose-regulated protein 78 (GRP78) during normal aging or from siRNA knockdown augments human alpha-synuclein (a-syn) toxicity to rat nigral neurons Neurobiol. Aging Mar 2015 shRNA TG312303
HSPA5 The Loss of Glucose Regulated Protein 78 (GRP78) during Normal Aging or from siRNA Knockdown Augments Human Alpha-Synuclein (a-syn) Toxicity to Rat Nigral Neurons Neurobiology of Aging Mar 2015 shRNA TG312303
Hspb1 Noxa/HSP27 complex delays degradation of ubiquitylated IkBα in airway epithelial cells to reduce pulmonary inflammation Mucosal Immunol 2018 shRNA TG501011
HxKII Regulation of VDAC trafficking modulates cell death Cell Death Discov 2016 shRNA TR312415
ICAM-5 ICAM-5/Telencephalin Is a Functional Entry Receptor for Enterovirus D68 Cell Host & Microbe 2016 shRNA TL312266
ID4 Inhibitor of DNA binding-4 promotes angiogenesis and growth of glioblastoma multiforme by elevating matrix GLA levels Oncogene (10 May 2010) doi:10.1038/onc.2010.147 Original Article shRNA TR319484
IDH2 Reductive carboxylation and 2-hydroxyglutarate formation by wild-type IDH2 in breast carcinoma cells Int. J. Biochem. Cell Biol. May 2015 shRNA TG312260
IDO1 Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells Nat Commun 2017 shRNA TL312147
IDO1 INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) IS UPREGULATED IN THYROID CARCINOMA AND DRIVES THE DEVELOPMENT OF AN IMMUNOSUPPRESSANT TUMOR MICROENVIRONMENT J. Clin. Endocrinol. Metab., Feb 2014. shRNA TG312147
IFITM1 Respiratory Syncytial Virus Infection is Inhibited by Interferon-Induced Transmembrane Proteins J. Gen. Virol. Sep 2014 shRNA TG312242
IFITM2 Respiratory Syncytial Virus Infection is Inhibited by Interferon-Induced Transmembrane Proteins J. Gen. Virol. Sep 2014 shRNA TG312241
IFITM3 Respiratory Syncytial Virus Infection is Inhibited by Interferon-Induced Transmembrane Proteins J. Gen. Virol. Sep 2014 shRNA TG303991
IFNAR1 Type-1 interferons contribute to oxygen glucose deprivation induced neuro-inflammation in BE(2)M17 human neuroblastoma cells J Neuroinflammation Mar 2014 shRNA TG312233
IFNAR1 Type-1 interferon signaling mediates neuro-inflammatory events in models of Alzheimer's disease Neurobiol. Aging Dec 2013. shRNA TR312233
IFNAR1 Type-1 interferon signalling mediates neuro-inflammatory events in models of Alzheimer's disease Neurobiology of Aging shRNA TG312233
IGF1 Acute Inflammation Induces Insulin-like Growth Factor-1 to Mediate Bcl-2 and Muc5ac Expression in Airway Epithelial Cells Am. J. Respir. Cell Mol. Biol., Dec 2012; 47: 784 - 791. shRNA TG319480
IGF1 Intracellular Insulin-like Growth Factor-1 Induces Bcl-2 Expression in Airway Epithelial Cells J. Immunol., May 2012; 188: 4581 - 4589. shRNA TR319480
IGF1R Procyanidins from Cinnamomi Cortex promote proteasome-independent degradation of nuclear Nrf2 through phosphorylation of insulin-like growth factor-1 receptor in A549 cells Arch. Biochem. Biophys. 2017 shRNA TG320384
IGF1R TGFß signaling confers sorafenib resistance via induction of multiple RTKs in hepatocellular carcinoma cells Mol. Carcinog. 2016 shRNA TG320384
IGF1R TGFß signaling confers sorafenib resistance via induction of multiple RTKs in hepatocellular carcinoma cells Mol. Carcinog. 2016 shRNA TG320384
IGF1R Regulación de la captación de glucosa en astrocitos por el eje insulina/IGF-I Thesis Oct 2014 shRNA TG320384
IGF1R(RFP) TDP-43 neurotoxicity and protein aggregation modulated by heat shock factor and insulin/IGF-1 signaling Hum. Mol. Genet., Mar 2011; 10.1093/hmg/ddr076 shRNA TR320384
IGF2BP3 IGF2BP3-mediated translation in cell protrusions promotes cell invasiveness and metastasis of pancreatic cancer Oncotarget Aug 2014 shRNA TG312221
IGFBP3 STAT-1 expression is regulated by IGFBP-3 in malignant glioma cells and is a strong predictor of poor survival in patients with glioblastoma J. Neurosurg. May 2014 shRNA TF312217
IGFBP5 Genetic Screen Identifies Insulin-like Growth Factor Binding Protein 5 as a Modulator of Tamoxifen Resistance in Breast Cancer Cancer Res., Apr 2010; 70: 3013 - 3019 shRNA TR316591
IGFBP7 Insulin-like growth factor-binding protein 7 alters the sensitivity to interferon-based anticancer therapy in hepatocellular carcinoma cells British Journal of Cancer (20 April 2010) doi:10.1038/sj.bjc.6605669 Full Paper shRNA TR312216
IGFIR The insulin-like growth factor I receptor regulates glucose transport by astrocytes Glia 2016 shRNA TL501056
IHH Endogenously-produced Indian Hedgehog Regulates TGFß-driven Chondrogenesis of Human Bone Marrow Stromal/Stem Cells Stem Cells Dev. Dec 2014 shRNA TG312208
IKBKB A constitutively-active IKK-complex at the axon initial segment Brain Res. 2017 shRNA TG509787
IKBKE Glucose Metabolism Reprogrammed by Overexpression of IKKe Promotes Pancreatic Tumor Growth. Cancer Res 2016 shRNA TG517180
IKBKE Glucose metabolism reprogrammed by overexpression of IKK-epsilon promotes pancreatic tumor growth Cancer Research 2016 shRNA TG517180
IKZF1 Ikaros regulation of the BCL6/BACH2 axis and its clinical relevance in acute lymphoblastic leukemia Oncotarget 2017 shRNA TG308127
IKZF1 Targeting High Dynamin-2 (DNM2) Expression by Restoring Ikaros Function in Acute Lymphoblastic Leukemia Sci Rep 2016 shRNA TG308127
IKZF1 Transcriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacteylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B Cell Acute Lymphoblastic Leukemia J. Biol. Chem. Dec 2015 shRNA TG308127
IL-37 Interleukin-37 suppresses the osteogenic responses of human aortic valve interstitial cells in vitro and alleviates valve lesions in mice Proc. Natl. Acad. Sci. U.S.A 2017 shRNA TL303957
IL18 TLR2 controls the development of hepatocellular carcinoma by reducing interleukin-18-mediated immunosuppression Cancer Res. Jan 2015 shRNA TG510212
IL1A Mitogen-Activated Protein Kinase-Dependent Interleukin-1a Intracrine Signaling Is Modulated by YopP during Yersinia enterocolitica Infection Infect. Immun., Jan 2012; 80: 289 - 297. shRNA TR312183
IL1R1 Sensitizing leukemia stem cells to NF-κB inhibitor treatment in vivo by inactivation of both TNF and IL-1 signaling Oncotarget 2017 shRNA TG501076
IL33 Notch Inhibition Enhances Cardiac Reprogramming by Increasing MEF2C Transcriptional Activity Stem Cell Reports 2017 shRNA MR203528
IL3RA Transcriptional regulation of SPROUTY2 by MYB influences myeloid cell proliferation and stem cell properties by enhancing responsiveness to IL-3 Leukemia 2017 shRNA TG516353
IL6 Autocrine IL-6 mediates pituitary tumor senescence Oncotarget 2017 shRNA TG709233
IL6 Harpagoside suppresses IL-6 expression in primary human osteoarthritis chondrocytes J. Orthop. Res. Apr 2016 shRNA TG312162
IL6 Metastatic Cells Can Escape the Proapoptotic Effects of TNF-a through Increased Autocrine IL-6/STAT3 Signaling Cancer Res., Feb 2012; 72: 865 - 875. shRNA TR312162
IL6RA Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages Nature Immunology 12, 551-559 (24 April 2011) doi:10.1038/ni.2030 Article shRNA TR501088
IL6ST Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages Nature Immunology 12, 551-559 (24 April 2011) doi:10.1038/ni.2030 Article shRNA TR501089
ILK CCN1 induces a reversible epithelial–mesenchymal transition in gastric epithelial cells Laboratory Investigation (10 May 2010) doi:10.1038/labinvest.2010.101 Research Article shRNA TR712638
IMMT Mic60/mitofilin overexpression alters mitochondrial dynamics and attenuates vulnerability of dopaminergic cells to dopamine and rotenone Neurobiol. Dis. Mar 2016 shRNA TR312153
IMPDH2 IMPDH2 mediate radioresistance and chemoresistance in osteosarcoma cells Eur Rev Med Pharmacol Sci Oct 2014 shRNA TR312150
ING1b Tumour suppressor ING1b maintains genomic stability upon replication stress Nucleic Acids Res., Jan 2011; 10.1093/nar/gkq1337 shRNA TR312146
Inpp5d IVIG activates FcγRIIB-SHIP1-PIP3 Pathway to stabilize mast cells and suppress inflammation after ICH in mice Sci Rep 2017 shRNA TG516227
INSIG2 Insulin-induced gene 2 expression correlates with colorectal cancer metastasis and disease outcome IUBMB Life Dec 2015 shRNA TG303915
INSR Regulación de la captación de glucosa en astrocitos por el eje insulina/IGF-I Thesis Oct 2014 shRNA TG320387
IPMK Inositol Polyphosphate Multikinase Is a Coactivator of p53-Mediated Transcription and Cell Death Sci. Signal., Apr 2013; 6: ra22. shRNA TG303904
IPO7 Knockdown of Importin 7 Inhibits Lung Tumorigenesis in K-ras(LA1) Lung Cancer Mice Anticancer Res. 2017 shRNA TF312126
IR The insulin-like growth factor I receptor regulates glucose transport by astrocytes Glia 2016 shRNA TL501102
IRF6 TGFß3 Regulates Periderm Removal through ?Np63 in the Developing Palate J. Cell. Physiol. Oct 2014 shRNA TR312109
IRF7 Soluble amyloid triggers a myeloid differentiation factor 88 and interferon regulatory factor 7 dependent neuronal type-1 interferon response in vitro J Neuroinflammation Apr 2015 shRNA TR315487
IRF7 Translational control of the innate immune response through IRF-7 Nature 452, 323 - 328 (13 Feb 2008) shRNA TR315487
IRF8 Interferon Regulatory Factor 8 Protects Against Cerebral Ischaemic-Reperfusion Injury J. Neurochem., Feb 2014. shRNA TG701093
IRS1 Expression levels of insulin receptor substrate-1 modulate the osteoblastic differentiation of mesenchymal stem cells and osteosarcoma cells Growth Factors, Jan 2014. shRNA TF516309
ITG?3 Inhibition of tumor-associated avß3 integrin regulates the angiogenic switch by enhancing expression of IGFBP-4 leading to reduced melanoma growth and angiogenesis in vivo Angiogenesis Sep 2014 shRNA TR312082
ITGA2 CD49b inhibits osteogenic differentiation and plays an important role in osteosarcoma progression Oncotarget 2017 shRNA TG312097
ITGAM Microglial complement receptor 3 regulates brain Aß levels through secreted proteolytic activity J. Exp. Med 2017 shRNA TL501116
ITGB1 Physical and Functional Interactions between a Glioma Cation Channel and Integrin ß1 Require a-Actinin Am. J. Physiol., Cell Physiol. Jun 2015 shRNA TG320392
ITGB1 Effect of Brain- and Tumor-Derived Connective Tissue Growth Factor on Glioma Invasion J Natl Cancer Inst, Aug 2011; 103: 1162 - 1178. shRNA TR320392
ITGB1 Extracellular matrix-induced transforming growth factor-ß receptor signaling dynamics Oncogene (25 January 2010) doi:10.1038/onc.2009.514 Original Article shRNA TR320392
ITGB1BP3 SNARE-dependent interaction of Src, EGF receptor and β1 integrin regulates invadopodium formation and tumour cell invasion J. Cell. Sci., Feb 2014. shRNA TF315677
ITGB3 Estudio de los mecanismos celulares y moleculares implicados en la adhesión y migración de células de carcinoma pulmonar no microcítico inducidas por TGFß Thesis May 2015 shRNA TR312082
ITGB3 Combined targeting of TGF-beta1 and integrin beta3 impairs lymph node metastasis in a mouse model of non-small-cell lung cancer Mol. Cancer May 2014 shRNA TR312082
JAG2 Distinct Biological Roles for the Notch Ligands Jagged-1 and Jagged-2 J. Biol. Chem., Jun 2009; 284: 17766 - 17774 shRNA TR303860
JAM-A Inhibition of junctional adhesion molecule-A/LFA interaction attenuates leukocyte trafficking and inflammation in brain ischemia/reperfusion injury Neurobiol. Dis. Mar 2014 shRNA TG501134
JMJD6 Elevated expression of JMJD6 is associated with oral carcinogenesis and maintains cancer stemness properties Carcinogenesis Dec 2015 shRNA TL310083
Jnk1 Sustained Gq-Protein Signaling Disrupts Striatal Circuits via JNK J. Neurosci. 2016 shRNA TR511480
Jnk2 Sustained Gq-Protein Signaling Disrupts Striatal Circuits via JNK J. Neurosci. 2016 shRNA TR502601
Jnk3 Sustained Gq-Protein Signaling Disrupts Striatal Circuits via JNK J. Neurosci. 2016 shRNA TR502599
JUN Sensitizing leukemia stem cells to NF-κB inhibitor treatment in vivo by inactivation of both TNF and IL-1 signaling Oncotarget 2017 shRNA TG501139
JUN MicroRNA 10b promotes abnormal expression of the proto-oncogene c-Jun in metastatic breast cancer cells Oncotarget 2016 shRNA TR320397
Jun Co-inhibition of NF-?B and JNK is synergistic in TNF-expressing human AML J. Exp. Med. May 2014 shRNA TG501139
JUN PNAS Plus: Aberrant expression of c-Jun in glioblastoma by internal ribosome entry site (IRES)-mediated translational activation PNAS, Oct 2012; 109: E2875 - E2884. shRNA TG320397
JUNB Sensitizing leukemia stem cells to NF-κB inhibitor treatment in vivo by inactivation of both TNF and IL-1 signaling Oncotarget 2017 shRNA TG516091
JUND Human T-Cell Leukemia Virus Type 1 (HTLV-1) bZIP Factor Requires Cellular Transcription Factor JunD To Upregulate HTLV-1 Antisense Transcription from the 3' Long Terminal Repeat J. Virol., Sep 2012; 86: 9070 - 9078. shRNA TG312046
JUND1 Sensitizing leukemia stem cells to NF-κB inhibitor treatment in vivo by inactivation of both TNF and IL-1 signaling Oncotarget 2017 shRNA TG501140
JUP Plakoglobin interacts with the transcription factor p53 and regulates the expression of 14-3-3{sigma} J. Cell Sci., Jul 2013; 126: 3031 - 3042. shRNA TG312045
JUP Molecular characterization of the tumor/metastasis suppressor activity of plakoglobin Thesis Jan 2013 shRNA TG312045
KAP1 Exonuclease-1 interacts with the transcriptional co-repressor KAP1 Matters 2016 shRNA TR320633
Kbtbd5 Kbtbd5 is regulated by MyoD and restricted to the myogenic lineage Differentiation Dec 2013. shRNA TG303840
Kcna1 Control and Plasticity of the Presynaptic Action Potential Waveform at Small CNS Nerve Terminals Neuron Nov 2014 shRNA TR713329
Kcnc1 Control and Plasticity of the Presynaptic Action Potential Waveform at Small CNS Nerve Terminals Neuron Nov 2014 shRNA TR709473
KCNQ1 Synergistic Restoring Effects of Isoproterenol and Magnesium on KCNQ1-Inhibited Bradycardia Cell Models Cultured in Microelectrode Array Cardiology, Feb 2014. shRNA TR711664
KCTD5 KCTD5 and Ubiquitin Proteasome Signaling Are Required for Helicobacter pylori Adherence Front Cell Infect Microbiol 2017 shRNA TG303786
KDM1A Regulation of Protein Quality Control by UBE4B and LSD1 through p53-Mediated Transcription PLoS Biol. Apr 2015 shRNA TF316984
KDM3A The Hypoxia-Inducible Epigenetic Regulators Jmjd1a and G9a Provide a Mechanistic Link between Angiogenesis and Tumor Growth Mol. Cell. Biol. July 2014 shRNA TG303857
KDM5A Vitamin C promotes pluripotency of human induced pluripotent stem cells via the histone demethylase JARID1A Biol. Chem. 2016 shRNA TL312057
KDM6B Folic Acid Remodels Chromatin on Hes1 and Neurog2 Promoters during Caudal Neural Tube Development J. Biol. Chem., Nov 2010; 285: 36922 - 36932 shRNA TR320873
KDR CD133(+) cancer stem cells promoted by VEGF accelerate the recurrence of hepatocellular carcinoma Sci Rep 2017 shRNA TR320400
KDR CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development Cell Res. Feb 2015 shRNA TG320400
KDR Autocrine VEGF signaling promotes cell proliferation and modulates the sorafenib treatment efficacy in hepatocellular carcinoma Hepatology May 2014 shRNA TG320400
KHK Ketohexokinase-Dependent Metabolism of Fructose Induces Proinflammatory Mediators in Proximal Tubular Cells . Am. Soc. Nephrol., Mar 2009; 20: 545 - 553. shRNA TR311985
KHSRP KSRP specifies monocytic and granulocytic differentiation through regulating miR-129 biogenesis and RUNX1 expression Nat Commun 2017 shRNA TL311984
KHSRP KSRP Modulation of GAP-43 mRNA Stability Restricts Axonal Outgrowth in Embryonic Hippocampal Neurons PLoS ONE e79255 Nov 2013 shRNA TG311984
Kif19a Production of transgenic mice by random recombination of targeted genes in female germline stem cells J Mol Cell Biol, Dec 2010; 10.1093/jmcb/mjq043 shRNA TR517467
KIF20A KIF20A-Mediated RNA Granule Transport System Promotes the Invasiveness of Pancreatic Cancer Cells Neoplasia Dec 2014 shRNA TG311916
KIF3A Live-Cell Imaging Evidence for the Ciliary Transport of Rod Photoreceptor Opsin by Heterotrimeric Kinesin-2 J. Neurosci., Aug 2012; 32: 10587 - 10593. shRNA TR311911
KISS1R KISS1R signaling promotes invadopodia formation in human breast cancer cell via ß-arrestin2/ERK Cell. Signal. Dec 2015 shRNA TR303680
KISS1R Regulation of GPR54 Signaling by GRK2 and {beta}-Arrestin Mol. Endocrinol., Oct 2009; 10.1210/me.2009-0013 shRNA TR303680
KL Klotho upregulation contributes to the neuroprotection of ligustilide against cerebral ischemic injury in mice Eur. J. Pharmacol. 2017 shRNA TG303679
KLF3 Epigenetic silencing of Kruppel like factor-3 increases expression of pro-metastatic miR-182 Cancer Lett. Aug 2015 shRNA TL303669
KLF4 Imbalance of a KLF4-miR-7 auto-regulatory feedback loop promotes prostate cancer cell growth by impairing microRNA processing Am J Cancer Res 2018 shRNA TG316853
KLF4 Kruppel-like factor4 regulates PRDM1 expression through binding to an autoimmune risk allele JCI Insight 2017 shRNA TL316853
KLF4 Putative Tumor-Suppressive Function of Krüppel-Like Factor 4 in Primary Lung Carcinoma Clin. Cancer Res., Sep 2009; 15: 5688 - 5695 shRNA TR316853
KLF6 Energy Restriction-mimetic Agents Induce Apoptosis in Prostate Cancer Cells in Part through Epigenetic Activation of KLF6 Tumor Suppressor Gene Expression J. Biol. Chem., Mar 2011; 286: 9968 - 9976 shRNA TR311885
KLHDC8B The Kelch Protein KLHDC8B Guards against Mitotic Errors, Centrosomal Amplification, and Chromosomal Instability J. Biol. Chem., Nov 2012; 287: 39083 - 39093. shRNA TR318087
KLHDC8B Mutations in a gene encoding a midbody kelch protein in familial and sporadic classical Hodgkin lymphoma lead to binucleated cells PNAS, Sep 2009; 106: 14920 - 14925 shRNA TR318087
KLHL34 Epigenetic Regulation of KLHL34 Predictive of Pathologic Response to Preoperative Chemoradiation Therapy in Rectal Cancer Patients Int. J. Radiat. Oncol. Biol. Phys. Mar 2015 shRNA TG307679
KLK5 (GFP) Kallikrein-5 Promotes Cleavage of Desmoglein-1 and Loss of Cell-Cell Cohesion in Oral Squamous Cell Carcinoma J. Biol. Chem., Mar 2011; 286: 9127 - 9135 shRNA TR311870
KMT2A Targeting the MLL complex in castration-resistant prostate cancer Nat. Med. Apr 2015 shRNA TL311462
KMT2B Targeting the MLL complex in castration-resistant prostate cancer Nat. Med. Apr 2015 shRNA TL315696
KNSTRN Characterization of SKAP/Kinastrin isoforms - The N-terminus defines tissue specificity and Pontin binding Hum. Mol. Genet. May 2016 shRNA TL306156
LAMP1 Large Putative PEST-like Sequence Motif at the Carboxyl Tail of Human Calcium Receptor Directs Lysosomal Degradation and Regulates Cell Surface Receptor Level J. Biol. Chem., Feb 2012; 287: 4165 - 4176. shRNA TR311795
LAMP1 Visualizing Microtubule-Dependent Vasopressin Type 2 Receptor Trafficking Using a New High-Affinity Fluorescent Vasopressin Ligand Endocrinology, Oct 2011; 152: 3893 - 3904. shRNA TR311795
LAMP2 Chronic acidosis in the tumour microenvironment selects for overexpression of LAMP2 in the plasma membrane Nat Commun Dec 2015 shRNA TR311794
LARP1 The RNA-binding protein LARP1 is a post-transcriptional regulator of survival and tumorigenesis in ovarian cancer Nucleic Acids Res. Dec 2015 shRNA TF303581
Lcn2 Mutant p53 Together with TGFß Signaling Influence Organ-Specific Hematogenous Colonization Patterns of Pancreatic Cancer Clin. Cancer Res. 2016 shRNA TR511895
Lcn2 Mutant p53 Together with TGFß Signaling Influence Organ-Specific Hematogenous Colonization Patterns of Pancreatic Cancer Clin. Cancer Res. 2016 shRNA MR226233
LCN2 Lipocalin 2 Enhances Migration and Resistance against Cisplatin in Endometrial Carcinoma Cells PLoS ONE May 2016 shRNA TG311777
LCN2 Lipocalin 2 attenuates iron-related oxidative stress and prolongs the survival of ovarian clear cell carcinoma cells by up-regulating the CD44 variant Free radical Research Feb 2016 shRNA TG311777
LDHA Sirtuin 6 suppresses hypoxia-induced inflammatory response in human osteoblasts via inhibition of reactive oxygen species production and glycolysis-A therapeutic implication in inflammatory bone resorption Biofactors 2016 shRNA TL311769
LEF1 MicroRNAs Regulate Pituitary Development, and MicroRNA 26b Specifically Targets Lymphoid Enhancer Factor 1 (Lef-1), Which Modulates Pituitary Transcription Factor 1 (Pit-1) Expression J. Biol. Chem., Nov 2010; 285: 34718 - 34728 shRNA TR712526
LEO1 A role for the RNA pol II–associated PAF complex in AID-induced immune diversification J. Exp. Med., Oct 2012; 209: 2099 - 2111. shRNA TG303551
LEO1 A role for the RNA pol II–associated PAF complex in AID-induced immune diversification J. Exp. Med., Sep 2012; 10.1084/jem.20112145. shRNA TR303551
LETM1 LETM1-mediated K+ and Na+ homeostasis regulates mitochondrial Ca2+ efflux Frontiers in Physiology 2017 shRNA TR311758
LGALS1 Galectin-1 suppression delineates a new strategy to inhibit myeloma-induced angiogenesis and tumoral growth in vivo. Leukemia 2016 shRNA TL311756
LIMK1 Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects Nature Medicine 18, 1087-1094 doi:10.1038/nm.2834 shRNA TR320403
LMNA Promoter hypermethylation as a mechanism for Lamin A/C silencing in a subset of neuroblastoma cells PLoS ONE 2017 shRNA TG303510
LNP1 Lunapark Is a Component of a Ubiquitin Ligase Complex Localized to the Endoplasmic Reticulum Three-way Junctions J. Biol. Chem. 2016 shRNA TR320968
LOXL2 Lysyl oxidase-like protein-2 regulates sprouting angiogenesis and type IV collagen assembly in the endothelial basement membrane Blood, Oct 2011; 118: 3979 - 3989. shRNA TR311699
LPA Effects of LPA1 and LPA6 on the regulation of colony formation activity in colon cancer cells treated with anticancer drugs J. Recept. Signal Transduct. Res. 2018 shRNA TL311698
LPA Involvement of LPA receptor-5 in the enhancement of cell motile activity by phorbol ester and anticancer drug treatments in melanoma A375 cells Biochem. Biophys. Res. Commun. 2018 shRNA TL311698
LPAR1 Lysophosphatidic acid signaling via LPA1 and LPA3 regulates cellular functions during tumor progression in pancreatic cancer cells Experimental Cell Research 2017 shRNA TR313300
LPAR1 Different induction of LPA receptors by chemical liver carcinogens regulates cellular functions of liver epithelial WB-F344 cells Mol. Carcinog. Sep 2015 shRNA TF712271
Lpar1 LPA signaling through LPA receptors regulates cellular functions of endothelial cells treated with anticancer drugs Mol. Cell. Biochem. Jun 2015 shRNA TG509224
LPAR2 Enhanced cellular functions through induction of LPA2 by cisplatin in fibrosarcoma HT1080 cells Mol. Cell. Biochem 2017 shRNA TR313298
Lpar2 LPA signaling through LPA receptors regulates cellular functions of endothelial cells treated with anticancer drugs Mol. Cell. Biochem. Jun 2015 shRNA TG502984
LPAR3 Lysophosphatidic acid signaling via LPA1 and LPA3 regulates cellular functions during tumor progression in pancreatic cancer cells Experimental Cell Research 2017 shRNA TR313295
LPAR3 Different induction of LPA receptors by chemical liver carcinogens regulates cellular functions of liver epithelial WB-F344 cells Mol. Carcinog. Sep 2015 shRNA TG710942
Lpar3 LPA signaling through LPA receptors regulates cellular functions of endothelial cells treated with anticancer drugs Mol. Cell. Biochem. Jun 2015 shRNA TG517410
LPAR4 Lysophosphatidic acid (LPA) signaling via LPA4 and LPA6 negatively regulates cell motile activities of colon cancer cells. Biochem. Biophys. Res. Commun 2016 shRNA TR312652
LPAR4 Diverse effects of LPA4, LPA5 and LPA6 on the activation of tumor progression in pancreatic cancer cells Biochem. Biophys. Res. Commun. Apr 2015 shRNA TF312652
LPAR5 Diverse effects of LPA4, LPA5 and LPA6 on the activation of tumor progression in pancreatic cancer cells Biochem. Biophys. Res. Commun. Apr 2015 shRNA TG304222
LPAR5 Inhibitory effects of lysophosphatidic acid receptor-5 on cellular functions of sarcoma cells Growth Factors May 2014 shRNA TG304222
LPAR5 Lysophosphatidic acid receptor-5 negatively regulates cell motile and invasive activities of human sarcoma cell lines Mol. Cell. Biochem. March 2014 shRNA TG304222
Lpar5 Lysophosphatidic acid receptor-5 negatively regulates cellular responses in mouse fibroblast 3T3 cells Biochem. Biophys. Res. Commun. Mar 2014 shRNA TG304222
LPAR6 Lysophosphatidic acid (LPA) signaling via LPA4 and LPA6 negatively regulates cell motile activities of colon cancer cells. Biochem. Biophys. Res. Commun 2016 shRNA TR310642
LPAR6 Diverse effects of LPA4, LPA5 and LPA6 on the activation of tumor progression in pancreatic cancer cells Biochem. Biophys. Res. Commun. Apr 2015 shRNA TF310642
Lrp6 Oncogenic KRAS signalling promotes the Wnt/ß-catenin pathway through LRP6 in colorectal cancer Oncogene Dec 2014 shRNA TL706439
LRRFIP1(GFP vector) The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a ß-catenin-dependent pathway Nature Immunology 11, 487-494 (9 May 2010) doi:10.1038/ni.1876 Article shRNA TR311663
LTA4H Resveratrol, a Red Wine Polyphenol, Suppresses Pancreatic Cancer by Inhibiting Leukotriene A4 Hydrolase Cancer Res., Dec 2010; 70: 9755 - 9764 shRNA TR311651
LTA4H [6]-Gingerol Suppresses Colon Cancer Growth by Targeting Leukotriene A4 Hydrolase Cancer Res., Jul 2009; 69: 5584 - 5591 shRNA TR311651
LTB4DH Leukotriene B4 BLT Receptor Signaling Regulates the Level and Stability of Cyclooxygenase-2 (COX-2) mRNA through Restricted Activation of Ras/Raf/ERK/p42 AUF1 Pathway J. Biol. Chem., Jul 2010; 285: 23568 - 23580. shRNA TR311650
LTC4S Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages Proc. Natl. Acad. Sci. U.S.A. 2016 shRNA TR319192
MAD2L1 Phosphoinositide 3-kinase ß regulates chromosome segregation in mitosis Mol. Biol. Cell, Dec 2012; 23: 4526 - 4542. shRNA TG311623
MAFA Calcineurin/Nuclear Factor of Activated T Cells and MAPK Signaling Induce TNF-{alpha} Gene Expression in Pancreatic Islet Endocrine Cells J. Biol. Chem., Jan 2011; 286: 1025 - 1036 shRNA TR303385
Mageb16 Depletion of Mageb16 induces differentiation of pluripotent stem cells predominantly into mesodermal derivatives Sci Rep 2017 shRNA TG321071
MAGMAS Magmas, a Gene Newly Identified as Overexpressed in Human and Mouse ACTH-Secreting Pituitary Adenomas, Protects Pituitary Cells from Apoptotic Stimuli Endocrinology, Oct 2010; 151: 4635 - 4642 shRNA TR513987
MAP1LC3B Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways PLoS ONE Aug 2015 shRNA TG503902
MAP2K1 Cyclin-dependent kinase 5 contributes to endoplasmic reticulum stress induced podocyte apoptosis via promoting MEKK1 phosphorylation at Ser280 in diabetic nephropathy Cell. Signal 2016 shRNA TR502589
MAP2K3 The survival kinase Mirk/dyrk1B is activated through Rac1-MKK3 signaling J Biol Chem. 2005 Dec 23;280(51):42097-105. shRNA TR320491
MAP3K8 Tpl2 Is a Key Mediator of Arsenite-Induced Signal Transduction Cancer Res., Oct 2009; 69: 8043 - 8049 shRNA TR512220
Mapk8 Plumbagin induces apoptosis in lymphoma cells via oxidative stress mediated glutathionylation and inhibition of mitogen-activated protein kinase phosphatases (MKP1/2) Cancer Lett. Nov 2014 shRNA TR511480
MAPKAPK2 Phosphorylation of the RNA-binding protein Dazl by MAPKAP kinase 2 regulates spermatogenesis Mol. Biol. Cell 2016 shRNA TR320609
MAPKAPK2 Phosphorylation of the RNA-binding protein Dazl by MAPKAP kinase 2 regulates spermatogenesis Mol. Biol. Cell 2016 shRNA TR320609
MAPT Glucocorticoids activate a synapse weakening pathway culminating in tau phosphorylation in the hippocampus Pharmacol. Res. 2017 shRNA TG710015
MAPT Tau Phosphorylation at Serine 396 Residue Is Required for Hippocampal LTD J. Neurosci. Mar 2015 shRNA TG710015
MARE DEPDC5 and NPRL3 modulate cell size, filopodial outgrowth, and localization of mTOR in neural progenitor cells and neurons Neurobiol. Dis. 2018 shRNA TG501301
MARK4 MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism Nat Commun 2017 shRNA TL303343
MBD4 Epigenetic silencing of RNF144A expression in breast cancer cells through promoter hypermethylation and MBD4 Cancer Med 2018 shRNA TG311558
MCAM CD146 is a novel marker for highly tumorigenic cells and a potential therapeutic target in malignant rhabdoid tumor Oncogene Apr 2016 shRNA TG311550
MCL1 ER Stress-Mediated Upregulation of miR-29a Enhances Sensitivity to Neuronal Apoptosis Eur. J. Neurosci. Jan 2016 shRNA TG303313
MCL1 Dinaciclib, a CDK inhibitor promotes proteasomal degradation of Mcl-1 and enhances ABT-737 mediated cell death in malignant human glioma cell lines J. Pharmacol. Exp. Ther. Nov 2015 shRNA TR303313
MCL1 Modulation of Mcl-1 sensitizes glioblastoma to TRAIL-induced apoptosis Apoptosis Nov 2013 shRNA TG303313
MCL1 Survivin Inhibitor YM-155 Sensitizes Tumor Necrosis Factor– Related Apoptosis-Inducing Ligand-Resistant Glioma Cells to Apoptosis through Mcl-1 Downregulation and by Engaging the Mitochondrial Death Pathway J. Pharmacol. Exp. Ther., Aug 2013; 346: 201 - 210. shRNA TG303313
MCL1 YM-155 Potentiates the Effect of ABT-737 in Malignant Human Glioma Cells via Survivin and Mcl-1 Downregulation in an EGFR-Dependent Context Mol. Cancer Ther., Mar 2013; 12: 326 - 338. shRNA TG303313
MCL1 Inhibition of NF-{kappa}B Signaling by Quinacrine Is Cytotoxic to Human Colon Carcinoma Cell Lines and Is Synergistic in Combination with Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) or Oxaliplatin J. Biol. Chem., Jun 2010; 285: 19162 - 19172 shRNA TR303313
Mcm4 Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells Nature July 2014 shRNA TL514127
Mcm6 Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells Nature July 2014 shRNA TL510769
MCOLN2 Zinc Dyshomeostasis Is Linked with the Loss of Mucolipidosis IV-associated TRPML1 Ion Channel J. Biol. Chem., Nov 2010; 285: 34304 - 34308 shRNA TR303306
MDC1 BRCT-domain protein BRIT1 influences class switch recombination Proc. Natl. Acad. Sci. U.S.A. 2017 shRNA TL517490
MDIG Paradoxical roles of mineral dust induced gene on cell proliferation and migration/invasion PLoS ONE, Feb 2014. shRNA TF317654
MDK Quantitative Analysis of Human Pluripotency and Neural Specification by In-Depth (Phospho)Proteomic Profiling Stem Cell Reports 2016 shRNA TG319183
MDM2 p53 participates in the protective effects of ischemic post-conditioning against OGD-reperfusion injury in primary cultured spinal cord neurons Neurosci. Lett 2016 shRNA TL311529
MDM2 Exonuclease-1 interacts with the transcriptional co-repressor KAP1 Matters 2016 shRNA TR311529
MDM2 FATS is an E2-independent ubiquitin ligase that stabilizes p53 and promotes its activation in response to DNA damage Oncogene Nov 2013 shRNA TG311529
MDM2 EMILIN1–a4/a9 integrin interaction inhibits dermal fibroblast and keratinocyte proliferation J. Cell Biol., Oct 2011; 195: 131 - 145. shRNA TR311529
MECOM Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition Oncogene 2016 shRNA TG313148
MECOM Identifying a Potential Molecular Therapeutic Target for MLL-AF9 Leukemia Thesis Jan 2014 shRNA TG313148
MEG3 Crosstalk between Meg3 and miR-1297 regulates growth of testicular germ cell tumor through PTEN/PI3K/AKT pathway Am J Transl Res May 2016 shRNA TG320132
MEG3 Skp2 regulates non-small cell lung cancer cell growth by Meg3 and miR-3163 Tumour Biol. Oct 2015 shRNA TL320132
MEN1 miR-29b Modulates Intestinal Epithelium Homeostasis by Repressing Menin Translation Biochem. J. Oct 2014 shRNA TG501333
MEOX1 Mesoderm/mesenchyme homeobox gene l promotes vascular smooth muscle cell phenotypic modulation and vascular remodeling Int. J. Cardiol.2017 shRNA TG311507
MET FOXO1 Suppression is a Determinant of Acquired Lapatinib-Resistance in HER2-Positive Gastric Cancer Cells Through MET Upregulation. Cancer Res Treat 2017 shRNA TG320418
MET Induction of tumor initiation is dependent on CD44s in c-Met(+) hepatocellular carcinoma BMC Cancer Apr 2015 shRNA TG320418
MET Induction of tumor initiation is dependent on CD44s in c-Met+ hepatocellular carcinoma BMC Cancer Mar 2015 shRNA TG320418
METTL3 Kaposi's Sarcoma-Associated Herpesvirus Utilizes and Manipulates RNA N6-Adenosine Methylation To Promote Lytic Replication J. Virol. 2017 shRNA TL303281
MFGE8 Endometrial MFG-E8 regulates TGF-ß induced EMT promoting trophoblast invasion and implantation Reproduction Jun 2016 shRNA TR311492
MGEA5 Epithelial mesenchymal transition induces aberrant glycosylation through hexosamine biosynthetic pathway activation J. Biol. Chem. Apr 2016 shRNA TG315637
MGMT O(6)-Methylguanine-DNA Methyltransferase Is a Novel Negative Effector of Invasion in Glioblastoma Multiforme Mol. Cancer Ther., Nov 2012; 11: 2440 - 2450. shRNA TG316615
MGP Inhibitor of DNA binding-4 promotes angiogenesis and growth of glioblastoma multiforme by elevating matrix GLA levels Oncogene (10 May 2010) doi:10.1038/onc.2010.147 Original Article shRNA TR311480
MGRN1 E3 ligase mahogunin (MGRN1) influences amyloid precursor protein maturation and secretion Oncotarget 2017 shRNA TL303267
MGRN1 Aging Triggers Cytoplasmic Depletion and Nuclear Translocation of the E3 Ligase Mahogunin: A Function for Ubiquitin in Neuronal Survival Mol. Cell 2017 shRNA TL702100
MICAL1 Podocyte Shape Regulation by Semaphorin 3A and MICAL-1 Methods Mol. Biol. 2016 shRNA TF506165
MIF Macrophage Migration Inhibitory Factor Regulates Akt Signaling in Hypoxic Culture to Modulate Senescence of Human Mesenchymal Stem Cells Stem Cells Dev. Nov 2013 shRNA TR319111
Miro1 Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal stem cell rescue efficacy EMBO J., Feb 2014. shRNA TG309816
MKRN2 Ubiquitous Expression of MAKORIN-2 in Normal and Malignant Hematopoietic Cells and Its Growth Promoting Activity PLoS ONE Mar 2014 shRNA TG311466
MLH1 MicroRNA-148b regulates radioresistance in non-small lung cancer cells via regulation of MutL homolog 1 Biosci. Rep. Jan 2016 shRNA TL320419
MLL1 Protein kinase Msk1 physically and functionally interacts with the KMT2A/MLL1 methyltransferase complex and contributes to the regulation of multiple target genes Epigenetics Chromatin 2016 shRNA TR517798
MLL1 Protein kinase Msk1 physically and functionally interacts with the KMT2A/MLL1 methyltransferase complex and contributes to the regulation of multiple target genes Epigenetics Chromatin 2016 shRNA TR517798
MLLT11 Involvement of AF1q/MLLT11 in the progression of ovarian cancer Oncotarget 2017 shRNA TF319110
MLLT4 Concomitant binding of Afadin to LGN and F-actin directs planar spindle orientation Nat. Struct. Mol. Biol. Feb 2016 shRNA TL311457
MLX The glucose-sensing transcription factor MLX promotes myogenesis via myokine signaling Genes Dev. Dec 2015 shRNA TL513600
MMP-7 Sphingosine-1-phosphate induced epithelial-mesenchymal transition of hepatocellular carcinoma via an MMP-7/ syndecan-1/TGF-ß autocrine loop Oncotarget 2016 shRNA TL311438
MMP1 Activation of EGFR/p38/HIF-1a is pivotal for angiogenesis and tumorigenesis of malignantly transformed cells induced by hexavalent chromium J. Biol. Chem. May 2016 shRNA TG311450
MMP13 Pituitary tumor-transforming gene 1 regulates invasion of prostate cancer cells through MMP13 Tumour Biol. Jul 2015 shRNA TG311446
MMP9 MicroRNA-3713 regulates bladder cell invasion via MMP9 Sci Rep 2016 shRNA TL311436
MMS19 IOP1 Protein Is an External Component of the Human Cytosolic Iron-Sulfur Cluster Assembly (CIA) Machinery and Functions in the MMS19 Protein-dependent CIA Pathway J. Biol. Chem., Jun 2013; 288: 16680 - 16689. shRNA TG303224
MNX1 MNX1 is oncogenically upregulated in African-American prostate cancer Cancer Res. 2016 shRNA TL319509
MPG Germ-line variants of human N-methylpurine DNA glycosylase show impaired DNA repair activity and facilitate 1,N6 ethenoadenine induced mutations J. Biol. Chem. Dec 2014 shRNA TR311419
MPS1 Mps1 kinase activity restrains anaphase during an unperturbed mitosis and targets Mad2 to kinetochores J. Cell Biol., Jun 2008; 10.1083/jcb.200712028. shRNA TR312256
MSH2 Der Einfluss des Mismatch Reparaturfaktors hMSH2 auf distinkte Reparaturwege der DNA Doppelstrangbruch Reparatur thesis Feb 2015 shRNA TR311383
MSH3 Der Einfluss des Mismatch Reparaturfaktors hMSH2 auf distinkte Reparaturwege der DNA Doppelstrangbruch Reparatur thesis Feb 2015 shRNA TR311382
MSH6 Der Einfluss des Mismatch Reparaturfaktors hMSH2 auf distinkte Reparaturwege der DNA Doppelstrangbruch Reparatur thesis Feb 2015 shRNA TR311380
MSI1 The RNA-binding protein Musashi 1 stabilizes the onco tachykinin 1 mRNA in breast cancer cells to promote cell growth FASEB J. Sep 2015 shRNA TF311379
Msk1 Protein kinase Msk1 physically and functionally interacts with the KMT2A/MLL1 methyltransferase complex and contributes to the regulation of multiple target genes Epigenetics Chromatin 2016 shRNA TR504795
Msk1 Protein kinase Msk1 physically and functionally interacts with the KMT2A/MLL1 methyltransferase complex and contributes to the regulation of multiple target genes Epigenetics Chromatin 2016 shRNA TR504795
MSLN Mesothelin promotes epithelial-to-mesenchymal transition and tumorigenicity of human lung cancer and mesothelioma cells Mol. Cancer 2017 shRNA TL311377
MSLN Role of mesothelin in carbon nanotube-induced carcinogenic transformation of human bronchial epithelial cells Am. J. Physiol. Lung Cell Mol. Physiol. 2016 shRNA TL311377
MSLN Mesothelin overexpression promotes autocrine IL-6/sIL-6R trans-signaling to stimulate pancreatic cancer cell proliferation Carcinogenesis, Jul 2011; 32: 1013 - 1024. shRNA TR311377
msr1 Expression of scavenger receptor-AI promotes alternative activation of murine macrophages to limit hepatic inflammation and fibrosis Hepatology 2016 shRNA TR515183
MSRA Methionine sulfoxide reductase A down-regulation in human breast cancer cells results in a more aggressive phenotype PNAS, Oct 2010; 107: 18628 - 18633 shRNA TR316620
MSRB3 A stemness-related ZEB1-MSRB3 axis governs cellular pliancy and breast cancer genome stability Nat. Med. 2017 shRNA TL315359
Mstn Myostatin induces DNA damage in skeletal muscle of streptozotocin-induced type 1 diabetic mice J. Biol. Chem., Jan 2014. shRNA TG512805
MT2A Development of an Integrated Genomic Classifier for a Novel Agent in Colorectal Cancer: Approach to Individualized Therapy in Early Development Clin. Cancer Res., Jun 2010; 16: 3193 - 3204 shRNA TR319082
mTOR Inactivation of the mTORC1-Eukaryotic Translation Initiation Factor 4E Pathway Alters Stress Granule Formation Mol. Cell. Biol., Jun 2013; 33: 2285 - 2301. shRNA TG320364
MUC1 MUC1 protein induces urokinase-type plasminogen activator (uPA) by forming a complex with NF-?B p65 transcription factor and binding to the uPA promoter, leading to enhanced invasiveness of cancer cells J. Biol. Chem. Nov 2014 shRNA TG316625
MURC MURC/cavin-4 Is Co-Expressed with Caveolin-3 in Rhabdomyosarcoma Tumors and Its Silencing Prevents Myogenic Differentiation in the Human Embryonal RD Cell Line PLoS ONE Jun 2015 shRNA TG315318
MUS81 Phosphorylation By CK2 Regulates MUS81/EME1 In Mitosis And After Replication Stress bioRxiv 2018 shRNA TR303095
MX2 MX2 is an interferon-induced inhibitor of HIV-1 infection Nature. 2013 Oct 24;502(7472):563-6. shRNA TL311334
MYB MYB is a novel regulator of pancreatic tumour growth and metastasis Br. J. Cancer Dec 2015 shRNA TG311329
MYB Regulation of the Flt3 Gene in Haematopoietic Stem and Early Progenitor Cells PLoS ONE Sep 2015 shRNA TL311329
MYB Mitochondrial Hep27 is a c-Myb target gene that inhibits Mdm2 and stabilizes p53 Mol. Cell. Biol., Aug 2010; 30: 3981 - 3993 shRNA TR311329
MYC c-Myc Dependent Cell Competition in Human Cancer Cells J. Cell. Biochem 2016 shRNA TF311323
Myc GM-CSF Induces Inflammatory Macrophages by Regulating Glycolysis and Lipid Metabolism J. Immunol. 2016 shRNA TR509322
MYC Novel IL-21 signaling pathway up-regulates c-Myc and induces apoptosis of diffuse large B-cell lymphomas Blood, Jan 2010; 115: 570 - 580 shRNA TR311323
MYC Regulation of reactive oxygen species homeostasis by peroxiredoxins and c-Myc J. Biol. Chem., Dec 2008; 10.1074/jbc.M807564200. shRNA TR311323
MYD88 Plasmodium falciparum Histidine-Rich Protein II Compromises Brain Endothelial Barriers and May Promote Cerebral Malaria Pathogenesis MBio Jun 2016 shRNA TG311320
MYD88 Deubiquitinase CYLD acts as a negative regulator for bacterium NTHi-induced inflammation by suppressing K63-linked ubiquitination of MyD88 Proc. Natl. Acad. Sci. U.S.A. Jan 2016 shRNA TG311320
MYH10 Cytoplasmic mislocalization of RNA splicing factors and aberrant neuronal gene splicing in TDP-43 transgenic pig brain Mol Neurodegener Sep 2015 shRNA TL711338
MYH9 Proteomics Analysis of the Non-Muscle Myosin Heavy Chain IIa-Enriched Actin-Myosin Complex Reveals Multiple Functions within the Podocyte PLoS ONE Jun 2014 shRNA TF311309
MYO5A Actin and Myosin-dependent localization of mRNA to dendrites PLoS ONE Mar 2014 shRNA TL311295
MYO5A Myosin Va is Required for the Transport of Fragile X Mental Retardation Protein (FMRP) Granules shRNA TR311295
MYO5A Myosin Va Is Required for P Body but Not Stress Granule Formation J. Biol. Chem., Apr 2011; 286: 11519 - 11528 shRNA TR311295
MYOD1 Repression of ESR1 transcription by MYOD potentiates letrozole-resistance in ERα-positive breast cancer cells Biochem. Biophys. Res. Commun. 2017 shRNA TR311289
Myt1 Enhancer Analysis Unveils Genetic Interactions between TLX and SOX2 in Neural Stem Cells and In Vivo Reprogramming Stem Cell Reports Oct 2015 shRNA TG501427
MZF1 Phosphorylation-dependent stabilization of MZF1 upregulates N-cadherin expression during protein kinase CK2-mediated epithelial-mesenchymal transition Oncogenesis 2018 shRNA TG303059
MZF1 Myeloid Zinc Finger 1 (MZF-1) Regulates Expression of the CCN2/CTGF and CCN3/NOV Genes in the Hematopoietic Compartment J. Cell. Physiol. Apr 2015 shRNA TG303059
MZF1 The glyceraldehyde 3-phosphate dehydrogenase gene (GAPDH) is regulated by myeloid zinc finger 1 (MZF-1) and is induced by calcitriol Biochem. Biophys. Res. Commun. July 2014 shRNA TR303059
NALP1 NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing apoptosis in metastatic melanoma Oncogene 2017 shRNA TG303052
NANOG The allosteric glycogen synthase kinase-3 inhibitor NP12 limits myocardial remodeling and promotes angiogenesis in an acute myocardial infarction model J. Biol. Chem. 2017 shRNA TF303039
NANOG CD133(+) cancer stem cells promoted by VEGF accelerate the recurrence of hepatocellular carcinoma Sci Rep 2017 shRNA TR303039
NANOG Overexpression of NANOG in Gestational Trophoblastic Diseases: Effect on Apoptosis, Cell Invasion, and Clinical Outcome Am. J. Pathol., Oct 2008; 173: 1165 - 1172 shRNA TR303039
NAV3 MiR-21 promoted proliferation and migration in hepatocellular carcinoma through negative regulation of Navigator-3 Biochem. Biophys. Res. Commun. Jul 2015 shRNA TL311261
NBPF1 NBPF1, a tumor suppressor candidate in neuroblastoma, exerts growth inhibitory effects by inducing a G1 cell cycle arrest BMC Cancer May 2015 shRNA TR307077
NBPF14 NBPF1, a tumor suppressor candidate in neuroblastoma, exerts growth inhibitory effects by inducing a G1 cell cycle arrest BMC Cancer May 2015 shRNA TR303019
NBPF9 NBPF1, a tumor suppressor candidate in neuroblastoma, exerts growth inhibitory effects by inducing a G1 cell cycle arrest BMC Cancer May 2015 shRNA TR311258
NCOA1 MicroRNA-223-3p inhibits human bladder cancer cell migration and invasion Tumour Biol 2017 shRNA TG320589
NCOA2 Fc?-receptor IIa-mediated Src Signaling Pathway is Essential for the Antibody-Dependent Enhancement of Ebola Virus Infection PLoS Pathog 2016 shRNA TR311243
NCOA3 Fc?-receptor IIa-mediated Src Signaling Pathway is Essential for the Antibody-Dependent Enhancement of Ebola Virus Infection PLoS Pathog 2016 shRNA TR320577
NdufA10 Cardiolipin promotes electron transport between ubiquinone and complex I to rescue PINK1 deficiency J. Cell Biol 2017 shRNA TR311229
Nedd4l Mutations in the HECT domain of NEDD4L lead to AKT-mTOR pathway deregulation and cause periventricular nodular heterotopia Nat. Genet. 2016 shRNA TG505433
Negative Control CNTNAP2 stabilizes interneuron dendritic arbors through CASK Mol. Psychiatry 2018 shRNA TR30013
Negative Control SORLA-driven endosomal trafficking regulates the oncogenic fitness of HER2 bioRxiv 2018 shRNA TR30021
Negative Control Role of miR-31 and SATB2 in arsenic-induced malignant BEAS-2B cell transformation Mol. Carcinog. 2018 shRNA TR30013
Negative Control Fluorescence Fluctuation Spectroscopy Reveals Differential SUN Protein Oligomerization In Living Cells Mol. Biol. Cell 2018 shRNA TR30015
Negative Control Epigenetic modifiers promote mitochondrial biogenesis and oxidative metabolism leading to enhanced differentiation of neuroprogenitor cells Cell Death Dis 2018 shRNA TR30015
Negative Control Knockdown of ZEB1 suppressed the formation of vasculogenic mimicry and epithelial-mesenchymal transition in the human breast cancer cell line MDA-MB-231 Mol Med Rep 2018 shRNA TR30021
Negative Control Reduced N-Type Ca2+Channels in Atrioventricular Ganglion Neurons Are Involved in Ventricular Arrhythmogenesis J Am Heart Assoc 2018 shRNA TR30021
Negative Control Sphingosine 1-phosphate regulates proliferation, cell cycle and apoptosis of hepatocellular carcinoma cells via syndecan-1 Prog. Biophys. Mol. Biol.2017 shRNA TR30021
Negative Control Astrocytes promote progression of breast cancer metastases to the brain via a KISS1-mediated autophagy Autophagy 2017 shRNA TR30013
Negative Control Innate sensing of influenza A virus hemagglutinin glycoproteins by the host endoplasmic reticulum (ER) stress pathway triggers a potent antiviral response via ER-associated protein degradation J. Virol. 2017 shRNA TR30021
Negative Control Serpine 1 induces alveolar type II cell senescence through activating p53-p21-Rb pathway in fibrotic lung disease Aging Cell 2017 shRNA TR30013
Negative Control An E2F1/MiR-17-92 Negative Feedback Loop mediates proliferation of Mouse Palatal Mesenchymal Cells Sci Rep 2017 shRNA TR30013
Negative Control RBM10 promotes transformation-associated processes in small cell lung cancer and is directly regulated by RBM5 PLoS ONE 2017 shRNA TR30003
Negative Control Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas J. Clin. Invest 2017 shRNA TR30013
Negative Control Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination Nat Commun 2017 shRNA TR30021
Negative Control Hyperglycemia-induced Changes in ZIP7 and ZnT7 Expression Cause Zn(2+) Release from the Sarco(endo)plasmic Reticulum and Mediate ER-stress in the Heart Diabetes 2017 shRNA TR30033
Negative Control PLA2G16 represents a switch between entry and clearance of Picornaviridae Nature 2017 shRNA TR30013
Negative Control Delaying histone deacetylase response to injury accelerates conversion into repair Schwann cells and nerve regeneration Nat Commun 2017 shRNA TR30021
Negative Control Inhibiting the cytoplasmic location of HMGB1 reverses cisplatin resistance in human cervical cancer cells Mol Med Rep 2017 shRNA TR30013
Negative Control DNA damage response defect in Williams‑Beuren syndrome INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 2017 shRNA TR30013
Negative control Gata6 promotes hair follicle progenitor cell renewal by genome maintenance during proliferation EMBO J. 2016 shRNA TR30015
Negative Control Silencing peroxiredoxin-2 sensitizes human colorectal cancer cells to ionizing radiation and oxaliplatin. Cancer Lett 2016 shRNA TR30015
negative control Identification of CTCF as a master regulator of the clustered protocadherin genes Nucleic Acids Res., Dec 2011; 10.1093/nar/gkr1260. shRNA
NEIL1 Cockayne syndrome group B protein stimulates repair of formamidopyrimidines by NEIL1 DNA glycosylase J. Biol. Chem., Jan 2009; 10.1074/jbc.M807006200. shRNA TR307276
NEK3 Identification of NEK3 Threonine 165 as a Novel Regulatory Phosphorylation Site that Modulates Focal Adhesion Remodeling Necessary for Breast Cancer Cell Migration J. Biol. Chem. 2016 shRNA TF320430
NELF RNAP II processivity is a limiting step for HIV-1 transcription independent of orientation to and activity of endogenous neighboring promoters Virology Sep 2015 shRNA TL317072
NES Identification and Cytoprotective Function of a Novel Nestin Isoform, Nes-S, in Dorsal Root Ganglia Neurons J. Biol. Chem., Mar 2013; 288: 8391 - 8404. shRNA TR311207
NEUROD1 Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice Nat. Neurosci 2017 shRNA TL311201
NEUROD1 Rapid neurogenesis through transcriptional activation in human stem cells Mol. Syst. Biol. Nov 2014 shRNA TL311201
NF2 Expression of P2X7 Receptor Increases In Vivo Tumor Growth Cancer Res., Jun 2012; 72: 2957 - 2969. shRNA TR316639
NFAT1 CD3-T Cell Receptor Co-stimulation through SLAMF3 and SLAMF6 Receptors Enhances RORt Recruitment to the IL17A Promoter in Human T Lymphocytes J. Biol. Chem., Nov 2012; 287: 38168 - 38177. shRNA TG311198
NFATC1 TRPC6 channel activation promotes neonatal glomerular mesangial cell apoptosis via calcineurin/NFAT and FasL/Fas signaling pathways Sci Rep 2016 shRNA TG302973
NFATC2 NFATc2 is an intrinsic regulator of melanoma dedifferentiation Oncogene Sep 2015 shRNA TF311198
NFATC2 NFAT Targets Signaling Molecules to Gene Promoters in Pancreatic ß Cells Mol. Endocrinol. Dec 2014 shRNA TG516359
NFE2L2 Nrf2 deficiency exacerbates ochratoxin A-induced toxicity in vitro and in vivo Toxicology 2017 shRNA TL311194
NFE2L2 Nuclear factor erythroid 2-related factor 2 enhances carcinogenesis by suppressing apoptosis and promoting autophagy in nickel-transformed cells J. Biol. Chem 2017 shRNA TG311194
NFE2L2 Different roles of ROS and Nrf2 in Cr(VI)-induced inflammatory responses in normal and Cr(VI)-transformed cells. Toxicol. Appl. Pharmacol. 2016 shRNA TG311194
Nfe2l2 1,4-Naphthoquinone, a pro-oxidant, ameliorated radiation induced gastro-intestinal injury through perturbation of cellular redox and activation of Nrf2 pathway Drug Discov Ther Apr 2016 shRNA TF515053
NFE2L2 Anti-oncogenic and oncogenic properties of Nrf2 in arsenic-induced carcinogenesis J. Biol. Chem. Sep 2015 shRNA TG311194
NFE2L2 ROS/Autophagy/Nrf2 Pathway Mediated Low-Dose Radiation Induced Radio-Resistance in Human Lung Adenocarcinoma A549 Cell Int. J. Biol. Sci. Jun 2015 shRNA TG311194
NFKB1 Plasmodium falciparum Histidine-Rich Protein II Compromises Brain Endothelial Barriers and May Promote Cerebral Malaria Pathogenesis MBio Jun 2016 shRNA TR318700
NFKB1 Leptin pro-angiogenic signature in breast cancer is linked to IL-1 signalling British Journal of Cancer 104, 128-137 (7 December 2010) doi:10.1038/sj.bjc.6606013 Full Pape shRNA TR516641
NGFR Effects of p75 neurotrophin receptor on regulating hypoxia-induced angiogenic factors in retinal pigment epithelial cells Mol. Cell. Biochem. Sep 2014 shRNA TL311178
NHERF1 Convergent Signaling Pathways Regulate Parathyroid Hormone and Fibroblast Growth Factor-23 Action on NPT2A-mediated Phosphate Transport J. Biol. Chem. 2016 shRNA TR309271
NHERF1 NHERF1 Regulates Parathyroid Hormone Receptor Desensitization: Interference with ß-Arrestin Binding Mol. Pharmacol., May 2009; 75: 1189 - 1197. shRNA TR316855
NIT1 A novel role for the tumour suppressor Nitrilase1 modulating the Wnt/ß-catenin signalling pathway Cell Discovery Jan 2016 shRNA TG311168
NKD2 Naked2 Acts as a Cargo Recognition and Targeting Protein to Ensure Proper Delivery and Fusion of TGF-{alpha}-containing Exocytic Vesicles at the Lower Lateral Membrane of Polarized MDCK Cells. Mol Biol Cell. 2007 Aug;18(8):3081-93. shRNA TR302950
NKX2 Directed Differentiation of Patient-Specific Induced Pluripotent Stem Cells Identifies the Transcriptional Repression and Epigenetic Modification of NKX2-5, HAND1, and NOTCH1 in Hypoplastic Left Heart Syndrome PLoS ONE July 2014 shRNA TR311165
NLRP3 Enhancement of endothelial permeability by free fatty acid through lysosomal cathepsin B-mediated Nlrp3 inflammasome activation Oncotarget 2016 shRNA TG510752
NLRP3 Involvement of the P2X7-NLRP3 axis in leukemic cell proliferation and death Sci Rep May 2016 shRNA TG305382
NLRP3 Instigation of endothelial Nlrp3 inflammasome by adipokine visfatin promotes inter-endothelial junction disruption: role of HMGB1 J. Cell. Mol. Med. Aug 2015 shRNA TG510752
NLRP3 Gene silencing of NLRP3 protects against the sepsis-induced hyper -bileacidemia in a rat model Clin. Exp. Immunol. Sep 2014 shRNA TG305382
NLRP3 Measles Virus V Protein Inhibits NLRP3 Inflammasome-Mediated Interleukin-1ß Secretion J. Virol., Dec 2011; 85: 13019 - 13026. shRNA TR305382
NLRP3 Francisella tularensis Reveals a Disparity between Human and Mouse NLRP3 Inflammasome Activation J. Biol. Chem., Nov 2011; 286: 39033 - 39042. shRNA TR305382
NLRX1 Nlrx1 regulates neuronal cell death Mol Brain Dec 2014 shRNA TG515304
NME2 Promoter-proximal transcription factor binding is transcriptionally active when coupled with nucleosome repositioning in immediate vicinity Nucleic Acids Res. July 2014 shRNA TR311160
NOD1 Cdx2 expression and intestinal metaplasia induced by H. pylori infection of gastric cells is regulated by NOD1-mediated innate immune responses Cancer Res. Jan 2016 shRNA TG511305
NODAL Endogenous Nodal promotes melanoma undergoing epithelial-mesenchymal transition via Snail and Slug in vitro and in vivo Am J Cancer Res Aug 2015 shRNA TG501492
NODAL Nodal promotes the generation of M2-like macrophages and downregulates the expression of IL-12 Eur J Immunol. 2013 Oct 1. shRNA TG302929
Non-effective 29-mer Scrambled shRNA The role of the ATPase inhibitor factor 1 (IF1) in cancer cells adaptation to hypoxia and anoxia Biochimica et Biophysica Acta (BBA) - Bioenergetics 2017 shRNA TR30013
Non-effective Control Evaluation of tryptophan-aspartic acid repeat-containing protein 34 as a novel tumor-suppressor molecule in human oral cancer Biochem. Biophys. Res. Commun. 2017 shRNA TR30012
Non-Effective GFP RhoC regulates actin remodeling to form phagosomes during FcγR-mediated phagocytosis J. Cell. Sci.2017 shRNA TR30008
NONO p54nrb/NONO Regulates cAMP-dependent Glucocorticoid Production by Modulating Phosphodiesterase mRNA Splicing and Degradation Mol. Cell. Biol. Jan 2015 shRNA TG311143
NOP2 A novel AHI-1-BCR-ABL-DNM2 complex regulates leukemic properties of primitive CML cells through enhanced cellular endocytosis and ROS-mediated autophagy Leukemia 2017 shRNA TL311150
NOS2 Inducible nitric oxide synthase (NOS2) knockout mice as a model of trichotillomania PeerJ 2018 shRNA TR709254
Nos2 Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype Nat. Immunol. 2016 shRNA TR512302
NOS2 Apoptotic Programs Are Determined during Lineage Commitment of CD4+ T Effectors: Selective Regulation of T Effector-Memory Apoptosis by Inducible Nitric Oxide Synthase J. Immunol., Jan 2013; 190: 97 - 105. shRNA TG512302
Notch1 Notch1 regulated autophagy controls survival and suppressor activity of activated murine T-regulatory cells Elife Jun 2016 shRNA TG513589
NOTCH1 Directed Differentiation of Patient-Specific Induced Pluripotent Stem Cells Identifies the Transcriptional Repression and Epigenetic Modification of NKX2-5, HAND1, and NOTCH1 in Hypoplastic Left Heart Syndrome PLoS ONE July 2014 shRNA TR302916
NOTCH2 NOTCH2 signaling confers immature morphology and aggressiveness in human hepatocellular carcinoma cells Oncol. Rep. Oct 2015 shRNA TR302915
NOTCH2 Short hairpin RNA targeting Notch2 inhibits U87 human glioma cell proliferation by inducing cell cycle arrest and apoptosis in vitro and in vivo Mol Med Rep Dec 2014 shRNA TG302915
Notch3 Notch3 is necessary for neuronal differentiation and maturation in the adult spinal cord J. Cell. Mol. Med. Aug 2014 shRNA TR515445
NOX1 Nox1 promotes colon cancer cell metastasis via activation of the ADAM17 pathway Eur Rev Med Pharmacol Sci 2016 shRNA TF311135
NOX1 Nox1 promotes colon cancer cell metastasis via activation of the ADAM17 pathway Eur Rev Med Pharmacol Sci 2016 shRNA TF311135
NOX3 Targeting tyrosine kinase inhibitor resistant non-small-cell lung cancer by inducing EGFR degradation via methionine 790 oxidation Antioxid. Redox Signal. Nov 2015 shRNA TG302912
NOXA1 Obatoclax Interacts Synergistically with the Irreversible Proteasome Inhibitor Carfilzomib in GC- and ABC-DLBCL Cells In Vitro and In Vivo Mol. Cancer Ther., May 2012; 11: 1122 - 1132. shRNA TR311134
NP100005 NRP-1 expression is strongly associated with the progression of pituitary adenomas Oncol. Rep. Aug 2014 shRNA TR30019
NP100041 Retinoic acid synergizes ATO-mediated cytotoxicity by precluding Nrf2 activity in AML cells Br. J. Cancer July 2014 shRNA TR20003
Npr3 NPR3 protects cardiomyocytes from apoptosis through inhibition of cytosolic BRCA1 and TNF-a Cell Cycle 2016 shRNA TR709485
NQO2 Control of stability of cyclin D1 by quinone reductase 2 in CWR22Rv1 prostate cancer cells Carcinogenesis, Mar 2012; 33: 670 - 677. shRNA TR311108
Nr1h3 Regulation of Insulin Resistance and Adiponectin Signaling in Adipose Tissue by Liver X Receptor Activation Highlights a Cross-Talk with PPAR? PLoS ONE Jun 2014 shRNA TG502381
NR1H4 Impaired Itching Perception in Murine Models of Cholestasis Is Supported by Dysregulation of GPBAR1 Signaling PLoS ONE Jul 2015 shRNA TG320627
NR1I2 Effects of silenced PAR-2 on cell proliferation, invasion and metastasis of esophageal cancer Oncology Letters 2017 shRNA TG320596
nr3c1 Glucocorticoid receptor beta increases migration of human bladder cancer cells Oncotarget 2016 shRNA TL320374
NR4A1 Dendrogenin A drives LXR to trigger lethal autophagy in cancers Nat Commun 2017 shRNA TG514239
Nr4a1 ß-cell deletion of Nr4a1 and Nr4a3 nuclear receptors impedes mitochondrial respiration and insulin secretion Am. J. Physiol. Endocrinol. Metab. May 2016 shRNA TL711049
NR4A1 Chymase Mediates Injury and Mitochondrial Damage in Cardiomyocytes during Acute Ischemia/Reperfusion in the Dog PLoS ONE e94732 9 4. April 2014 shRNA TG320381
Nr4a3 Dendrogenin A drives LXR to trigger lethal autophagy in cancers Nat Commun 2017 shRNA TF501493
Nrf Different roles of ROS and Nrf2 in Cr(VI)-induced inflammatory responses in normal and Cr(VI)-transformed cells Toxicol. Appl. Pharmacol. 2016 shRNA TR311098
Nrf2 Role of KEAP1/NRF2 and TP53 Mutations in Lung Squamous Cell Carcinoma Development and Radiation Resistance Cancer Discov 2016 shRNA TL515053
NRIP1 New Target Genes in Endometrial Tumors Show a Role for the Estrogen-Receptor Pathway in Microsatellite Unstable Cancers Hum. Mutat. Sep 2014 shRNA TG311094
NRP1 Neuropilin1 is an important niche component and exerts context-dependent effects on hematopoietic stem cells Stem Cells Dev. 2016 shRNA TR513573
NRP1 NRP-1 expression is strongly associated with the progression of pituitary adenomas Oncol. Rep. Aug 2014 shRNA TR311093
NRP1(NP-1) The Plexin-A1 Receptor Activates Vascular Endothelial Growth Factor-Receptor 2 and Nuclear Factor-B to Mediate Survival and Anchorage-Independent Growth of Malignant Mesothelioma Cells Cancer Res., Feb 2009; 69: 1485 - 1493 shRNA TR311093
Ntrk2 BDNF repairs podocyte damage by microRNA-mediated increase of actin polymerization J. Pathol. Nov 2014 shRNA TR510739
NTRK2 TrkB induces EMT and has a key role in invasion of head and neck squamous cell carcinoma Oncogene (18 January 2010) doi:10.1038/onc.2009.486 Original Article shRNA TR320436
NUCB2 Nucleobindin-2 is a positive regulator for insulin-stimulated glucose transporter 4 translocation in fenofibrate treated E11 podocytes [Rapid Communication] Endocr. J. Sep 2014 shRNA TR502933
Nucb2 Nucleobindin-2 Is a Positive Modulator of EGF-Dependent Signals Leading to Enhancement of Cell Growth and Suppression of Adipocyte Differentiation Endocrinology, Jul 2012; 153: 3308 - 3319. shRNA TR502933
NUMA1 Concomitant binding of Afadin to LGN and F-actin directs planar spindle orientation Nat. Struct. Mol. Biol. Feb 2016 shRNA TL311065
NUMB NUMB and NUMBL differences in gene regulation Oncotarget 2018 shRNA TR311064
NUMB The cargo protein MAP17 (PDZK1IP1) regulates the cancer stem cell pool activating the Notch pathway by abducting NUMB Clin. Cancer Res 2017 shRNA TR311064
Numb Numb-like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy Oncotarget 2016 shRNA TR311064
NUMB Uric acid crystal could inhibit Numb-induced URAT1 lysosome degradation in uric acid nephropathy J. Physiol. Biochem. Mar 2015 shRNA TR311064
NUMBL NUMB and NUMBL differences in gene regulation Oncotarget 2018 shRNA TR311063
NumbL Numb-like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy Oncotarget 2016 shRNA TR311063
Nur77 Bile Acids Regulate Nuclear Receptor (Nur77) Expression and Intracellular Location to Control Proliferation and Apoptosis Mol. Cancer Res. Sep 2014 shRNA TL711049
OCIAD2 OCIAD2 suppressed tumor growth and invasion via AKT pathway in Hepatocelluar carcinoma Carcinogenesis 2017 shRNA TL311040
OCLN Occludin deficiency promotes ethanol-induced disruption of colonic epithelial junctions, gut barrier dysfunction and liver damage in mice Biochim. Biophys. Acta Dec 2015 shRNA TL311039
OCT4 OCT4 as a target of miR-34a stimulates p63 but inhibits p53 to promote human cell transformation Cell Death Dis, Jan 2014. shRNA TG310267
ODAM ODAM inhibits RhoA-dependent invasion in breast cancer Cell Biochem. Funct. Sep 2015 shRNA TG307066
OGT The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis Nat Commun 2017 shRNA TG302811
OGT Epithelial mesenchymal transition induces aberrant glycosylation through hexosamine biosynthetic pathway activation J. Biol. Chem. Apr 2016 shRNA TG302811
OMA1 OMA1 mediates OPA1 proteolysis and mitochondrial fragmentation in experimental models of ischemic kidney injury Am. J. Physiol. Renal Physiol. . March 2014 shRNA TR302802
OPRS1 Loss of function of the ALS protein SigR1 leads to ER pathology associated with defective autophagy and lipid raft disturbances Cell Death Dis Jun 2014 shRNA TF311012
ORAI1 Arachidonic acid-induced Ca2+entry and migration in a neuroendocrine cancer cell line Cancer Cell Int. 2018 shRNA TF301009
ORAI1 Molecular mechanisms of spontaneous and directed mast cell motility J. Leukoc. Biol., Nov 2012; 92: 1029 - 1041. shRNA TG301009
ORAI1 Evidence for STIM1- and Orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells: role in proliferation and migration FASEB J, Apr 2009; 10.1096/fj.09-131128. shRNA TR301009
Orai1 Canonical Transient Receptor Potential 5 Channel in Conjunction with Orai1 and STIM1 Allows Sr2+ Entry, Optimal Influx of Ca2+, and Degranulation in a Rat Mast Cell Line J. Immunol., Feb 2008; 180: 2233 - 2239. shRNA TR301009
ORAI3 Arachidonic acid-induced Ca2+entry and migration in a neuroendocrine cancer cell line Cancer Cell Int. 2018 shRNA TF307587
OSBPL2 Oxysterol-related-binding-protein related Protein-2 (ORP2) regulates cortisol biosynthesis and cholesterol homeostasis Mol. Cell. Endocrinol. Mar 2016 shRNA TG310662
OSR1 Odd-skipped related 1 is a novel tumor suppressor gene and a potential prognostic biomarker in gastric cancer J. Pathol. Jun 2014 shRNA TG302745
P130 Tissue-specific Gene Targeting by the Multiprotein Mammalian DREAM Complex J. Biol. Chem., Aug 2011; 286: 27867 - 27871. shRNA TR311147
p38 p38 MAPK mediates epithelial-mesenchymal transition by regulating p38IP and Snail in head and neck squamous cell carcinoma Oral Oncology 2016 shRNA TG320309
P4HB Inhibition of prolyl 4-hydroxylase, beta polypeptide (P4HB) attenuates temozolomide resistance in malignant glioma via the endoplasmic reticulum stress response (ERSR) pathways Neuro Oncology, May 2013; 15: 562 - 577. shRNA TR310639
P4HB Inhibition of prolyl 4-hydroxylase, beta polypeptide (P4HB) attenuates temozolomide resistance in malignant glioma via the endoplasmic reticulum stress response (ERSR) pathways Neuro Oncology, Feb 2013; 10.1093/neuonc/not005. shRNA TR310639
P4HB Extracellular protein disulfide isomerase regulates coagulation on endothelial cells through modulation of phosphatidylserine exposure Blood, Aug 2010; 116: 993 - 1001 shRNA TR310639
p53 Deacetylation of p53 induces autophagy by suppressing Bmf expression J. Cell Biol., Apr 2013; 201: 427 - 437. shRNA TG320558
p63 OCT4 as a target of miR-34a stimulates p63 but inhibits p53 to promote human cell transformation Cell Death Dis, Jan 2014. shRNA TG308688
p65 COMMD7 is correlated with a novel NF-?B positive feedback loop in hepatocellular carcinoma Oncotarget 2016 shRNA TR302038
p66 Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney Am J Physiol Renal Physiol, Dec 2012; 303: F1629 - F1640. shRNA TG310310
PABPC4 The Cytoplasmic poly(A) Binding Protein, PABPC4, Serves a Critical Role in Erythroid Differentiation Mol. Cell. Biol., Jan 2014. shRNA TG510913
Padi4 Citrullination regulates pluripotency and histone H1 binding to chromatin Nature, Feb 2014. shRNA TF501611
PAF1 A role for the RNA pol II–associated PAF complex in AID-induced immune diversification J. Exp. Med., Oct 2012; 209: 2099 - 2111. shRNA TG302706
PAF1 A role for the RNA pol II–associated PAF complex in AID-induced immune diversification J. Exp. Med., Sep 2012; 10.1084/jem.20112145. shRNA TR302706
PAK1 Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis Cell Rep Nov 2014 shRNA TG501572
PAK1 P21 Activated Kinase-1 (Pak1) Promotes Prostate Tumor Growth and Microinvasion via Inhibition of Transforming Growth Factor ß Expression and Enhanced Matrix Metalloproteinase 9 Secretion J. Biol. Chem., Feb 2013; 288: 3025 - 3035. shRNA TG320442
PAK4 p21-Activated kinase 4 promotes prostate cancer progression through CREB Oncogene doi:10.1038/onc.2012.255 shRNA TR320637
PAK4 p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients PNAS, Oct 2010; 107: 18622 - 18627 shRNA TR320637
PAK6 P21 Activated Kinase-1 (Pak1) Promotes Prostate Tumor Growth and Microinvasion via Inhibition of Transforming Growth Factor ß Expression and Enhanced Matrix Metalloproteinase 9 Secretion J. Biol. Chem., Feb 2013; 288: 3025 - 3035. shRNA TF320717
PALB2 PALB2 Functionally Connects the Breast Cancer Susceptibility Proteins BRCA1 and BRCA2 Mol. Cancer Res., Jul 2009; 7: 1110 - 1118. shRNA TR307284
PANX1 Loss of Pannexin 1 Attenuates Melanoma Progression by Reversion to a Melanocytic Phenotype J. Biol. Chem., Aug 2012; 287: 29184 - 29193. shRNA TR302694
PANX1 The Pannexin 1 Channel Activates the Inflammasome in Neurons and Astrocytes J. Biol. Chem., Jul 2009; 284: 18143 - 18151 shRNA TR302694
PANX3 Characterization and Function of the~ 70 kDa Immunoreactive Species of Pannexin3 in Rhabdomyosarcomas Thesis Jan 2015 shRNA TF302692
Panx3 Pannexin 1 and Pannexin 3 Channels Regulate Skeletal Muscle Myoblast Proliferation and Differentiation J. Biol. Chem. Sep 2014 shRNA TF302692
PARK2 Parkin Protects Against Misfolded SOD1 Toxicity by Promoting Its Aggresome Formation and Autophagic Clearance Mol. Neurobiol. Nov 2015 shRNA TG310609
PARP1 The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1 PLoS Genet. 2016 shRNA TG315488
PARP1 Epstein-Barr Virus Oncoprotein LMP1 Mediates Epigenetic Changes in Host Gene Expression through PARP1 J. Virol. 2016 shRNA TL709663
PARP1 Poly(ADP-ribose) Contributes to an Association between Poly(ADP-ribose) Polymerase-1 and Xeroderma Pigmentosum Complementation Group A in Nucleotide Excision Repair J. Biol. Chem., Nov 2012; 287: 39824 - 39833. shRNA TG315488
PARP1 Thrombomodulin Is Silenced in Malignant Mesothelioma by a Poly(ADP-ribose) Polymerase-1-mediated Epigenetic Mechanism J. Biol. Chem., Jun 2011; 286: 19478 - 19488 shRNA TR315488
PARP1 (GFP) Notch/HES1-mediated PARP1 activation: a cell type–specific mechanism for tumor suppression Blood, Mar 2011; 117: 2891 - 2900 shRNA TR315488
ParvB Expression of parvin-ß is a prognostic factor for patients with urothelial cell carcinoma of the upper urinary tract British Journal of Cancer 103, 852-860 (24 August 2010) doi:10.1038/sj.bjc.6605835 Full Paper shRNA TR310602
PATE4 shRNA mediated ablation of prostate and testis expressed (Pate) messenger RNA results in impaired sperm function and fertility Andrology 2017 shRNA TG707288
PAX5 PAX5 is the transcriptional activator of mucolipin-2 (MCOLN2) gene Gene Nov 2014 shRNA TG302663
PAX6 Pax6 Regulates the Expression of Dkk3 in Murine and Human Cell Lines, and Altered Responses to Wnt Signaling Are Shown in FlpIn-3T3 Cells Stably Expressing Either the Pax6 or the Pax6(5a) Isoform PLoS ONE July 2014 shRNA TG310597
Pbx3 PBX3 is an important cofactor of HOXA9 in leukemogenesis Blood, Feb 2013; 121: 1422 - 1431. shRNA TG310590
PCAF PCAF interacts with XBP-1S and mediates XBP-1S-dependent transcription Nucleic Acids Res., Jan 2011; 39: 429 - 439 shRNA TR310589
PCAF Acetylation of Rb by PCAF is required for nuclear localization and keratinocyte differentiation J. Cell Sci., Nov 2010; 123: 3718 - 3726 shRNA TR310589
PCBP1 PolyC-binding proteins enhance expression of the CDK2 cell cycle regulatory protein via alternative splicing. Nucleic Acids Res. 2017 shRNA TG310588
PCDH17 Loss of protocadherin-17 (PCDH-17) promotes metastasis and invasion through hyperactivation of EGFR/MEK/ERK signaling pathway in hepatocellular carcinoma Tumour Biol. Sep 2015 shRNA TL310584V
pCMVENTRY Kinesin KIF4A transports integrin ß1 in developing axons of cortical neurons Mol. Cell. Neurosci. Sep 2014 shRNA TR30013
PCMVMIR Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells Nature July 2014 shRNA TR30021
PCSK5 Furin Is the Major Proprotein Convertase Required for KISS1-to-Kisspeptin Processing PLoS ONE, Jan 2014. shRNA TF310565
PCSK7 Furin Is the Major Proprotein Convertase Required for KISS1-to-Kisspeptin Processing PLoS ONE, Jan 2014. shRNA TF310564
PCSK9 ß-Estradiol Results in a PCSK9-Dependent Increase in LDLR Levels in Human Hepatic HuH7 Cells FEBS J. Apr 2015 shRNA TG302581
PCTM1 The MicroRNA 15a/16–1 Cluster Down-regulates Protein Repair Isoaspartyl Methyltransferase in Hepatoma Cells: IMPLICATIONS FOR APOPTOSIS REGULATION J. Biol. Chem., Dec 2011; 286: 43690 - 43700. shRNA
PDCD4 MicroRNA-429 sensitizes pancreatic cancer cells to gemcitabine through regulation of PDCD4 Am J Transl Res 2017 shRNA TG302573
PDCD6 Apoptosis-linked gene 2 promotes breast cancer growth and metastasis by regulating the cytoskeleton Oncotarget 2017 shRNA TG310558
PDE5A Expression and Function of Phosphodiesterase Type 5 in Human Breast Cancer Cell Lines and Tissues: Implications for Targeted Therapy Clin. Cancer Res. Dec 2015 shRNA TL316826
PDGFR Primary breast cancer cell culture yields intra-tumor heterogeneous subpopulations expressing exclusive patterns of receptor tyrosine kinases BMC Cancer 2016 shRNA TG310534
PDGFRA PDGFRa Regulates Follicular Cell Differentiation Driving Treatment Resistance and Disease Recurrence in Papillary Thyroid Cancer EBioMedicine 2016 shRNA TR310535
PDGFRA Culture dimensionality influences the resistance of glioblastoma stem-like cells to multikinase inhibitors Mol. Cancer Ther. April 2014 shRNA TR310535
PDI Recycling of peroxiredoxin IV provides a novel pathway for disulphide formation in the endoplasmic reticulum The EMBO Journal 29, 4185-4197 (5 November 2010) doi:10.1038/emboj.2010.273 Article shRNA TR310528
PDK1 HMGB1 Is Phosphorylated by Classical Protein Kinase C and Is Secreted by a Calcium-Dependent Mechanism J. Immunol., May 2009; 182: 5800 - 5809. shRNA TR320448
PDK2 Retinoic acid-related orphan receptor alpha reprograms glucose metabolism in glutamine-deficient hepatoma cells Hepatology Oct 2014 shRNA TR320449
PDPK1 Targeting Endoplasmic Reticulum Stress and Akt with OSU-03012 and Gefitinib or Erlotinib to Overcome Resistance to Epidermal Growth Factor Receptor Inhibitors Cancer Res., Apr 2008; 68: 2820 - 2830 shRNA TR320448
Per1 Period1 gates the circadian modulation of memory-relevant signaling in mouse hippocampus by regulating the nuclear shuttling of the CREB kinase pP90RSK J. Neurochem. Jun 2016 shRNA TG501619
PERP PERP, a p53 pro-apoptotic target, mediates apoptotic cell death in renal ischemia Am J Physiol Renal Physiol, Jan 2009; 10.1152/ajprenal.90438.2008. shRNA TR302542
PEX5 A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS Nature Cell Biology doi:10.1038/ncb2822 shRNA TG310491
PFKFB3 A ROLE FOR PFKFB3/IPFK2 IN OVERNUTRITION-ASSOCIATED ADIPOSE TISSUE AND INTESTINE INFLAMMATORY RESPONSES AND INSULIN RESISTANCE Thesis Nov 2013 shRNA TR517196
PFKFB3 Disruption of Inducible 6-Phosphofructo-2-kinase Ameliorates Diet-induced Adiposity but Exacerbates Systemic Insulin Resistance and Adipose Tissue Inflammatory Response J. Biol. Chem., Feb 2010; 285: 3713 - 3721 shRNA TR517196
PGAM2 Oxidative stress activates SIRT2 to deacetylate and stimulate phosphoglycerate mutase Cancer Res. May 2014 shRNA TG310477
pGFP-C-shLenti Whole-transcriptome microarray analysis reveals regulation of Rab4 by RBM5 in neurons Neuroscience 2017 shRNA TR30021
PHF1 Polycomb Group Protein PHF1 Regulates p53-dependent Cell Growth Arrest and Apoptosis J. Biol. Chem., Jan 2013; 288: 529 - 539. shRNA TG302514
PI3K Phosphoinositide 3-kinase beta controls replication factor C assembly and function Nucleic Acids Res., Jan 2013; 41: 855 - 868. shRNA TG501641
PI3K Nuclear but not cytosolic phosphoinositide 3-kinase beta has an essential function in cell survival Mol. Cell. Biol., Mar 2011; 10.1128/MCB.01313-10 shRNA
PIEZO2 A critical role for Piezo2 channels in the mechanotransduction of mouse proprioceptive neurons Sci Rep May 2016 shRNA TR509519
Pik3c3 Notch1 regulated autophagy controls survival and suppressor activity of activated murine T-regulatory cells Elife Jun 2016 shRNA TG506698
PIK3C3 pp60c-Src Phosphorylates and Activates Vacuolar Protein Sorting 34 to Mediate Cellular Transformation Cancer Res., Jul 2010; 70: 5974 - 5983 shRNA TR310429
PIK3CB Nuclear phosphoinositide 3-kinase ß controls double-strand break DNA repair PNAS, Apr 2010; 107: 7491 - 7496 shRNA TR310427
PIK3CB Specific function of phosphoinositide 3-kinase beta in the control of DNA replication PNAS, May 2009; 106: 7525 - 7530. shRNA TR310427
Pik3r1 Phosphoinositide 3-kinase beta controls replication factor C assembly and function Nucleic Acids Res., Nov 2012; 10.1093/nar/gks1095. shRNA TG509680
PIK3R1 p85ß phosphoinositide 3-kinase subunit regulates tumor progression PNAS, Jun 2012; 10.1073/pnas.1118138109. shRNA TR307821
PIM1 HistoneH3 demethylase JMJD2A promotes growth of liver cancer cells through up-regulating miR372 Oncotarget 2017 shRNA TG315503
PINK1 Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin-mediated mitophagy J. Neurochem. Oct 2015 shRNA TR320728
PINK1 Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission J. Biol. Chem., May 2009; 284: 13843 - 13855. shRNA TR320728
Pip5k1b DNA damage causes rapid accumulation of phosphoinositides for ATR signaling Nat Commun 2017 shRNA TF517012
PIWIL2 Piwil2 is reactivated by HPV oncoproteins and initiates cell reprogramming via epigenetic regulation during cervical cancer tumorigenesis Oncotarget 2016 shRNA TG302470
Pkm Functional polarization of tumour-associated macrophages by tumour-derived lactic acid Nature July 2014 shRNA TG511241
PKR Identification of the PKR Nuclear Interactome Reveals Roles in Ribosome Biogenesis, mRNA Processing and Cell Division J. Cell. Physiol. Dec 2013. shRNA TG320493
Pla2g6 H2O2-activated mitochondrial phospholipase iPLA2? prevents lipotoxic oxidative stress in synergy with UCP2, amplifies signaling via G-protein-coupled receptor GPR40, and regulates insulin secretion in pancreatic ß-cells Antioxid. Redox Signal. Apr 2015 shRNA TG700671
Pla2g6 Group VIA phospholipase A2 in both host and tumor cells is involved in ovarian cancer development FASEB J, Jun 2010; 10.1096/fj.10-161356 shRNA TR515018
plasmid Oxygen-coupled redox regulation of the skeletal muscle ryanodine receptor-Ca2+ release channel by NADPH oxidase 4 PNAS, Sep 2011; 108: 16098 - 16103. shRNA
PLCB4 Functional screening implicates miR-371-3p and peroxiredoxin 6 in reversible tolerance to cancer drugs Nat Commun 2016 shRNA TL310374
PLCG1 CCR7/CCL21 Migration on Fibronectin Is Mediated by Phospholipase C{gamma}1 and ERK1/2 in Primary T Lymphocytes J. Biol. Chem., Dec 2010; 285: 38781 - 38787 shRNA TF302445
PLD3 Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease Nature Dec 2013. shRNA TG310364
PLD3 Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease Nature Dec 2013. shRNA TG501676
PLK1 PLK1 inhibition downregulates polycomb group protein BMI1 via modulation of the miR-200c/141 cluster J. Biol. Chem. Dec 2014 shRNA TG320457
PLK1 PLK1 Inhibitors Synergistically Potentiate HDAC Inhibitor Lethality in Imatinib Mesylate–Sensitive or –Resistant BCR/ABL+ Leukemia Cells In Vitro and In Vivo Clin. Cancer Res., Jan 2013; 19: 404 - 414. shRNA TG320457
PLK1 Centrosomal Protein 55 (Cep55) Stability Is Negatively Regulated by p53 Protein through Polo-like Kinase 1 (Plk1) J. Biol. Chem., Feb 2012; 287: 4376 - 4385. shRNA TR320457
PLXNA1 The Plexin-A1 Receptor Activates Vascular Endothelial Growth Factor-Receptor 2 and Nuclear Factor-B to Mediate Survival and Anchorage-Independent Growth of Malignant Mesothelioma Cells Cancer Res., Feb 2009; 69: 1485 - 1493 shRNA TR302406
Pmaip1 Noxa/HSP27 complex delays degradation of ubiquitylated IkBα in airway epithelial cells to reduce pulmonary inflammation Mucosal Immunol 2018 shRNA TR512752
PMAIP1 NVP-BKM120 potentiates apoptosis in tumor necrosis factor-related apoptosis-inducing ligand-resistant glioma cell lines via upregulation of Noxa and death receptor 5 Int. J. Oncol. Jun 2015 shRNA TR318983
PMCA2 Sphingomyelin-induced inhibition of the plasma membrane calcium ATPase causes neurodegeneration in type A Niemann-Pick disease Mol. Psychiatry 2016 shRNA TL509635
Pnpla8 H2O2-activated mitochondrial phospholipase iPLA2? prevents lipotoxic oxidative stress in synergy with UCP2, amplifies signaling via G-protein-coupled receptor GPR40, and regulates insulin secretion in pancreatic ß-cells Antioxid. Redox Signal. Apr 2015 shRNA TG706565
PODXL High Podocalyxin levels promote cell viability partially through up-regulation of Annexin A2 Biochem. Biophys. Res. Commun. 2016 shRNA TG310316
PODXL Methylation of an intronic region regulates miR-199a in testicular tumor malignancy Oncogene (7 March 2011) doi:10.1038/onc.2011.60 Original Article shRNA TR310316
PON1 Paraoxonase-1 (PON1) induces metastatic potential and apoptosis escape via its antioxidative function in lung cancer cells Oncotarget 2017 shRNA TR310286
PON2 Antioxidative properties of paraoxonase 2 in intestinal epithelial cells Am J Physiol Gastrointest Liver Physiol, Sep 2012; 303: G623 - G634. shRNA TR515293
Positive Control An integrated transcriptomics-guided genome-wide promoter analysis and next-generation proteomics approach to mine factor(s) regulating cellular differentiation DNA Res 2017 shRNA TR30002
POU1F1 Transcription factor ICBP90 regulates the MIF promoter and immune susceptibility locus J. Clin. Invest. Feb 2016 shRNA TG310279
POU3F1 Delaying histone deacetylase response to injury accelerates conversion into repair Schwann cells and nerve regeneration Nat Commun 2017 shRNA TL712899
POU5F1 OCT-4: a novel estrogen receptor-a collaborator that promotes tamoxifen resistance in breast cancer cells Oncogene Apr 2016 shRNA TL310267
POU5F1 MiR-145 regulates cancer stem-like properties and epithelial-to-mesenchymal transition in lung adenocarcinoma-initiating cells Tumour Biol. Jun 2014 shRNA TF310267
PPAP2B Endothelial lipid phosphate phosphatase-3 deficiency that disrupts the endothelial barrier function is a modifier of cardiovascular development Cardiovasc. Res. Apr 2016 shRNA TG302357
PPAPDC2 Role of Phosphatidic Acid Phosphatase Domain Containing 2 (PPAPDC2) In Squalestatin 1-Mediated Activation of the Constitutive Androstane Receptor in Primary Cultured Rat Hepatocytes Drug Metab. Dispos. Dec 2015 shRNA TR703334
PPARD PPARβ Is Essential for Maintaining Normal Levels of PGC-1α and Mitochondria and for the Increase in Muscle Mitochondria Induced by Exercise Cell Metab. 2017 shRNA TF709733
PPARD   Changes in PPARδ expression in a rat model of stress-induced depression Clin. Exp. Pharmacol. Physiol 2017 shRNA TR709733
PPARG Lack of epithelial PPARγ causes cystic adenomatoid malformations in mouse fetal lung Biochem. Biophys. Res. Commun. 2017 shRNA TG510219
PPARG Activation of peroxisome proliferator-activated receptor a stimulates ADAM10-mediated proteolysis of APP Proc. Natl. Acad. Sci. U.S.A. Jul 2015 shRNA TG320459
PPARG TGFß can stimulate the p(38)/ß-catenin/PPAR? signaling pathway to promote the EMT, invasion and migration of non-small cell lung cancer (H460 cells) Clin. Exp. Metastasis Aug 2014 shRNA TR320459
PPARGC1A Skeletal muscle increases FGF21 expression in mitochondrial disorders to compensate for energy metabolic insufficiency by activating the mTOR-YY1-PGC1a pathway Free Radic. Biol. Med. Apr 2015 shRNA TL509292
PPARGC1A PGC-1a mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis Nat. Cell Biol. Sep 2014 shRNA TG310260
PPP2CA Restoration of PPP2CA expression reverses epithelial-to-mesenchymal transition and suppresses prostate tumour growth and metastasis in an orthotopic mouse model Br. J. Cancer Mar 2014 shRNA TG310229
PPP2R1A Clinicopathological effects of protein phosphatase 2, regulatory subunit A, alpha mutations in gastrointestinal stromal tumors Mod. Pathol. 2016 shRNA TR310227
PRB Transcriptional Activation by pRB and Its Coordination with SWI/SNF Recruitment Cancer Res., Nov 2010; 70: 8282 - 8287 shRNA TR310199
PRDX1 Dithiol-based Compounds Maintain Expression of Antioxidant Protein Peroxiredoxin 1 That Counteracts Toxicity of Mutant Huntingtin J. Biol. Chem., Jun 2012; 287: 22717 - 22729. shRNA TR302287
PRDX2 Silencing peroxiredoxin-2 sensitizes human colorectal cancer cells to ionizing radiation and oxaliplatin. Cancer Lett 2016 shRNA TR310194
PRDX5 Regulation of Reactive Oxygen Species Homeostasis by Peroxiredoxins and c-Myc J. Biol. Chem., Mar 2009; 284: 6520 - 6529. shRNA TR503057
PRDX5 Regulation of Reactive Oxygen Species Homeostasis by Peroxiredoxins and c-Myc J. Biol. Chem., Mar 2009; 284: 6520 - 6529. shRNA TR513832
PRDX5 Regulation of reactive oxygen species homeostasis by peroxiredoxins and c-Myc J. Biol. Chem., Dec 2008; 10.1074/jbc.M807564200. shRNA TR503057
PRDX6 Peroxiredoxin 6 (Prdx6) supports NADPH oxidase1 (Nox1)-based superoxide generation and cell migration Free Radic. Biol. Med. Apr 2016 shRNA TR310191
PRKAA1 Folate Metabolism Regulates Oligodendrocyte Survival and Differentiation by Modulating AMPKα Activity Sci Rep 2017 shRNA TR505729
PRKAA1 Underactivation of the adiponectin-adiponectin receptor 1 axis in clear cell renal cell carcinoma: implications for progression Clin Exp Metastasis. 2013 Oct 5 shRNA TG505729
PRKAA2 Identification of a novel AMPK-PEA15 axis in the anoikis-resistant growth of mammary cells Breast Cancer Res. Aug 2014 shRNA TF320462
PRKAA2 AMPK protects proximal tubular cells from stress-induced apoptosis by an ATP-independent mechanism: potential role of Akt activation Am J Physiol Renal Physiol, Dec 2011; 301: F1177 - F1192. shRNA TR320462
Prkca Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology Nat Commun 2018 shRNA TG501653
PRKCA Caveolin-1 promotes resistance to chemotherapy-induced apoptosis in Ewing's sarcoma cells by modulating PKC{ALPHA} phosphorylation shRNA TR320466
PRKCA PCPH/ENTPD5 Expression Confers to Prostate Cancer Cells Resistance against Cisplatin-Induced Apoptosis through Protein Kinase C–Mediated Bcl-2 Stabilization Cancer Res., Jan 2009; 69: 102 - 110. shRNA TR320466
PRKCD Protein Kinase C Delta restrains growth in ACTH-secreting pituitary adenoma cells Mol. Cell. Endocrinol. Oct 2015 shRNA TG513052
PRKCD Distinct ICD substrate modifications selectively regulate ectodomain cleavage of NRG1 or CD44 Mol. Cell. Biol. Jul 2015 shRNA TG320468
PRKCD Adenosine A1 receptor activation modulates human equilibrative nucleoside transporter 1 (hENT1) activity via PKC-mediated phosphorylation of serine-281 Cell. Signal. May 2015 shRNA TR320468
PRKCD PKCd maintains phenotypes of tumor initiating cells through cytokine-mediated autocrine loop with positive feedback Oncogene Mar 2015 shRNA TG320468
PRKCD Resveratrol inhibits NLRP3 inflammasome activation by preserving mitochondrial integrity and augmenting autophagy J. Cell. Physiol. Dec 2014 shRNA TG513052
PRKCD miR-26a Plays an Important Role in Cell Cycle Regulation in ACTH-Secreting Pituitary Adenomas by Modulating Protein Kinase C Endocrinology, May 2013; 154: 1690 - 1700. shRNA TG320468
PRKCD Sprouty2 Interacts with Protein Kinase C and Disrupts Phosphorylation of Protein Kinase D1 J. Biol. Chem., Jul 2009; 284: 19623 - 19636 shRNA TR320468
PRKCD Connexin43 Potentiates Osteoblast Responsiveness to Fibroblast Growth Factor 2 via a Protein Kinase C-Delta/Runx2–dependent Mechanism Mol. Biol. Cell, Jun 2009; 20: 2697 - 2708 shRNA TR320468
PRKCD PCPH/ENTPD5 Expression Enhances the Invasiveness of Human Prostate Cancer Cells by a Protein Kinase C{delta} Dependent Mechanism. Cancer Res. 2007 Nov 15;67(22):10859-68 shRNA TR320468
PRKCE Adenosine A1 receptor activation modulates human equilibrative nucleoside transporter 1 (hENT1) activity via PKC-mediated phosphorylation of serine-281 Cell. Signal. May 2015 shRNA TR320469
PRKCI PRKCI negatively regulates autophagy via PIK3CA/AKT-MTOR signaling Biochem. Biophys. Res. Commun. Feb 2016 shRNA TR320472
PRKCI Identification of a Small Molecule with Synthetic Lethality for K-Ras and Protein Kinase C Iota Cancer Res. 2008; 68(18): p. 7403-7408 shRNA TR320472
PRKCQ Suppression of protein kinase C theta contributes to enhanced myogenesis In vitro via IRS1 and ERK1/2 phosphorylation BMC Cell Biol. 2013 Sep 21;14:39. shRNA TG501657
PRKCZ Identification of a Small Molecule with Synthetic Lethality for K-Ras and Protein Kinase C Iota Cancer Res. 2008; 68(18): p. 7403-7408 shRNA TR320477
PRKDC DNA-PKcs controls calcineurin mediated IL-2 production in T lymphocytes PLoS ONE 2017 shRNA TR320478
PRKDC PRKDC regulates chemosensitivity and is a potential prognostic and predictive marker of response to adjuvant chemotherapy in breast cancer patients Oncol. Rep. 2017 shRNA TL320478
PRMT5 Protein Arginine Methyltransferase 5 (PRMT5) Signaling Suppresses Protein Kinase C- and p38-dependent Signaling and Keratinocyte Differentiation J. Biol. Chem., Mar 2012; 287: 7313 - 7323. shRNA TR310167
PRNP Hypoxia-induced expression of cellular prion protein improves the therapeutic potential of mesenchymal stem cells Cell Death Dis 2016 shRNA TL302273
PROM1 Ultrasound-targeted microbubble destruction-mediated downregulation of CD133 inhibits epithelial-mesenchymal transition, stemness and migratory ability of liver cancer stem cells Oncol. Rep. Sep 2015 shRNA TG310163
pRS Exonuclease-1 interacts with the transcriptional co-repressor KAP1 Matters 2016 shRNA TR20003
PRS Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infection J. Exp. Med., Aug 2011; 208: 1823 - 1834. shRNA
pRS The Elk-1 and Serum Response Factor Binding Sites in the Major Immediate-Early Promoter of the Human Cytomegalovirus are Required for Efficient Viral Replication in Quiescent Cells and Compensate for Inactivation of the NF-{kappa}B Sites in Proliferating Cells J. Virol., May 2010; 84: 4481 - 4493 shRNA
pRS vector HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer Nature (13 December 2009) doi:10.1038/nature08697 Letter shRNA
pRS vector Heparanase Alters Arterial Structure, Mechanics, and Repair Following Endovascular Stenting in Mice Circ. Res., Dec 2008; 10.1161/CIRCRESAHA.108.180695. shRNA
pRS vector Tumor Suppressor Activity of CCAAT/Enhancer Binding Protein {alpha} Is Epigenetically Down-regulated in Head and Neck Squamous Cell Carcinoma Cancer Res. 2007 May 15;67(10):4657-64. shRNA
PRSS21 Proteolytic activation of the protease-activated receptor (PAR)-2 by the GPI-anchored serine protease testisin J. Biol. Chem. Dec 2014 shRNA TL310139
PS100001 Funktionelle Charakterisierung des putativen Tumorsuppressors Epithelial Membrane Protein 3 Thesis Jan 2014 shRNA TR30007
PS100001 CD109 plays a role in osteoclastogenesis PLoS ONE Apr2013 shRNA TR30013
PS100027 Direct Transcriptional Repression of Zfp423 by Zfp521 Mediates a Bone Morphogenic Protein-Dependent Osteoblast versus Adipocyte Lineage Commitment Switch Mol. Cell. Biol. Aug 2014 shRNA TR30013
PSMB5 Inhibition of store-operated calcium entry by sub-lethal levels of proteasome inhibition is associated with STIM1/STIM2 degradation Cell Calcium Mar 2016 shRNA TL310110
PSME3 REGγ controls Hippo signaling and reciprocal NF-κB-YAP regulation to promote colon cancer Clin. Cancer Res. 2018 shRNA TR501768
PSME3 REG? is critical for skin carcinogenesis by modulating the Wnt/ß-catenin pathway Nat Commun Apr 2015 shRNA TG302223
PSME3 PA28 is a novel corepressor of HTLV-1 replication and controls viral latency Blood, Jan 2013; 121: 791 - 800. shRNA TG302223
PSTPIP1 PSTPIP1 inhibition of TCR signalling depends on its SH3 domain FEBS J. July 2014 shRNA TF310088
PTAFR Feed forward reciprocal activation of PAFR and STAT3 regulates epithelial-mesenchymal transition in non-small cell lung cancer Cancer Res. Sep 2015 shRNA TR310087
PTAFR Platelet-activating factor receptor-mediated PI3K/AKT activation contributes to the malignant development of esophageal squamous cell carcinoma Oncogene Feb 2015 shRNA TR310087
PTEN Long noncoding RNA MEG3 suppresses liver cancer cells growth through inhibiting β-catenin by activating PKM2 and inactivating PTEN Cell Death Dis 2018 shRNA TG320498
PTEN Sensitivity of PTEN deficient non-small cell lung cancer to ionising radiation through inhibition of ataxia terangiectasia related 3 kinase (ATR) Cancer Research 2017 shRNA TG320498
PTEN Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways PLoS ONE Aug 2015 shRNA TG320498
PTEN Signaling mechanisms coupled to CXCL12/CXCR4-mediated cellular proliferation are PTEN-dependent Am J Clin Exp Urol Aug 2015 shRNA TR320498
PTEN RIP1 Kinase Is an Oncogenic Driver in Melanoma Cancer Res. Feb 2015 shRNA TG320498
PTEN Atorvastatin overcomes gefitinib resistance in KRAS mutant human non-small cell lung carcinoma cells Cell Death Dis. 2013 Sep 26;4:e814. doi: 10.1038/cddis.2013.312. shRNA TR320498
PTEN Short hairpin RNA against PTEN enhances regenerative growth of corticospinal tract axons after spinal cord injury J Neurosci. 2013 Sep 25;33(39):15350-61 shRNA TR320498
PTEN Cooperation of protease-activated receptor 1 and integrin a?ß5 in thrombin-mediated lung cancer cell invasion Oncol. Rep. Aug 2012 shRNA TG320498
PTEN MicroRNA-21 Is a Downstream Effector of AKT That Mediates Its Antiapoptotic Effects via Suppression of Fas Ligand J. Biol. Chem., Jun 2010; 285: 20281 - 20290 shRNA TR320498
PTEN Immunosuppressive Cyclosporin A Activates AKT in Keratinocytes through PTEN Suppression: IMPLICATIONS IN SKIN CARCINOGENESIS J. Biol. Chem., Apr 2010; 285: 11369 - 11377 shRNA TR320498
PTGER2 Cell entry of bovine ephemeral fever virus requires activation of Src-JNK-AP1 and PI3K-Akt-NF?B pathways as well as Cox-2-mediated PGE2 /EP receptor signaling to enhance clathrin-mediated virus endocytosis Cell. Microbiol. Jan 2015 shRNA TG310080
PTGER4 Cell entry of bovine ephemeral fever virus requires activation of Src-JNK-AP1 and PI3K-Akt-NF?B pathways as well as Cox-2-mediated PGE2 /EP receptor signaling to enhance clathrin-mediated virus endocytosis Cell. Microbiol. Jan 2015 shRNA TG310079
PTGER4 Prostaglandin E receptor EP4 is a therapeutic target in breast cancer cells with stem-like properties Breast Cancer Res. Treat. Nov 2013 shRNA TR310079
PTGS2 Analysis of the in vitro and in vivo effects of Photodynamic Therapy on Prostate Cancer by using new photosensitizers, protoporphyrin IX-polyamine derivatives Biochim. Biophys. Acta 2017 shRNA TR310074
PTGS2 Identification and validation of COX-2 as a co-target for overcoming cetuximab resistance in colorectal cancer cells Oncotarget 2016 shRNA TG310074
PTGS2 IMP1 suppresses breast tumor growth and metastasis through the regulation of its target mRNAs Oncotarget Feb 2016 shRNA TG310074
PTGS2 Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections Nat. Med. Aug 2015 shRNA TG310074
PTGS2 Cell entry of bovine ephemeral fever virus requires activation of Src-JNK-AP1 and PI3K-Akt-NF?B pathways as well as Cox-2-mediated PGE2 /EP receptor signaling to enhance clathrin-mediated virus endocytosis Cell. Microbiol. Jan 2015 shRNA TG501784
PTK2 Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis Cell Rep Nov 2014 shRNA TG514293
PTK7 Protein-tyrosine pseudokinase 7 (PTK7) directs cancer cell motility and metastasis J. Biol. Chem. July 2014 shRNA TF200451
PTP4A3 PRL-3 activates mTORC1 in Cancer Progression Sci Rep Nov 2015 shRNA TR320652
Ptpn12 Macrophage Fusion Is Controlled by the Cytoplasmic Protein Tyrosine Phosphatase PTP-PEST/PTPN12 Mol. Cell. Biol., Jun 2013; 33: 2458 - 2469. shRNA TG310066
PTPN21 BMX negatively regulates BAK function thereby increasing apoptotic resistance to chemotherapeutic drugs Cancer Res. Feb 2015 shRNA TR310062
PTPN5 Tyrosine dephosphorylation is required for Bak activation in apoptosis The EMBO Journal (19 October 2010) doi:10.1038/emboj.2010.244 Article shRNA TR310058
PTPN6 SC-2001 Overcomes STAT3-mediated Sorafenib Resistance through RFX-1/SHP-1 Activation in Hepatocellular Carcinoma Neoplasia July 2014 shRNA TG310057
PTPRJ/DEP-1 Tumor Suppressor Density-enhanced Phosphatase-1 (DEP-1) Inhibits the RAS Pathway by Direct Dephosphorylation of ERK1/2 Kinases J. Biol. Chem., Aug 2009; 284: 22048 - 22058 shRNA TR310052
PTRF Cavin-1 and Caveolin-1 are both required to support cell proliferation, migration and anchorage-independent cell growth in rhabdomyosarcoma Lab. Invest. Mar 2015 shRNA TR310045
PTRF SDPR induces membrane curvature and functions in the formation of caveolae Nat Cell Biol. 2009 Jul;11(7):807-14. shRNA TR310045
PTRH2 Downregulation of Bit1 expression promotes growth, anoikis resistance, and transformation of immortalized human bronchial epithelial cells via Erk activation-dependent suppression of E-cadherin Biochem. Biophys. Res. Commun.2017 shRNA TR302190
PTTG1 Pituitary tumor-transforming gene 1 regulates invasion of prostate cancer cells through MMP13 Tumour Biol. Jul 2015 shRNA TG310042
PTTG1 PTTG1 Oncogene Promotes Tumor Malignancy via Epithelial to Mesenchymal Transition and Expansion of Cancer Stem Cell Population J. Biol. Chem., Jun 2012; 287: 19516 - 19527. shRNA TR310042
PUM2 Translational Regulation of Acetylcholinesterase by the RNA-binding Protein Pumilio-2 at the Neuromuscular Synapse J. Biol. Chem., Oct 2011; 286: 36492 - 36499. shRNA TR302189
PURA Pur-alpha regulates cytoplasmic stress granule dynamics and ameliorates FUS toxicity Acta Neuropathol. Jan 2016 shRNA TL310036V
PXR Pregnane X Receptor As a Therapeutic Target to Inhibit Androgen Activity Endocrinology, Oct 2010; 10.1210/en.2010-0708 shRNA TR320596
Pygo2 Overexpression of Pygopus-2 is required for canonical Wnt activation in human lung cancer Oncol Lett, Dec 2013. shRNA TF317702
PYGO2 Overexpression of Pygopus-2 is required for canonical Wnt activation in human lung cancer Oncology Letters 233 Nov 2013 shRNA TF317702
Pyk2 Sustained Gq-Protein Signaling Disrupts Striatal Circuits via JNK J. Neurosci. 2016 shRNA TR501788
QPRT The Endogenous Tryptophan Metabolite and NAD+ Precursor Quinolinic Acid Confers Resistance of Gliomas to Oxidative Stress Cancer Res., Jun 2013; 73: 3225 - 3234. shRNA TG310018
RAB10 Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience Genome Med 2017 shRNA TG302162
RAB11A Angiotensin II stimulates internalization and degradation of arterial myocyte plasma membrane BK channels to induce vasoconstriction Am. J. Physiol., Cell Physiol. Jul 2015 shRNA TG310015
Rab31 INVESTIGATIONS ON RAB31'S ROLE IN EGFR TRAFFICKING AND NEURAL PROGENITOR CELL DIFFERENTIATION TOWARDS ASTROGLIA Thesis Apr 2014 shRNA TF509046
Rab31 Engagement of the Small GTPase Rab31 and its Effector, Early Endosome Antigen 1, is Important for Trafficking of Ligand-bound Epidermal Growth Factor Receptor from Early to Late Endosome J. Biol. Chem. Mar 2014 shRNA TF509046
RAB4A Angiotensin II stimulates internalization and degradation of arterial myocyte plasma membrane BK channels to induce vasoconstriction Am. J. Physiol., Cell Physiol. Jul 2015 shRNA TG309988
RAB7A Rab7 Regulates CDH1 Endocytosis, Circular Dorsal Ruffles Genesis and Thyroglobulin Internalization in a Thyroid Cell Line J. Cell. Physiol. Nov 2015 shRNA TR710925
RAB7A Bovine Ephemeral Fever Virus Uses a Clathrin-Mediated and Dynamin 2-Dependent Endocytosis Pathway That Requires Rab5 and Rab7 as Well as Microtubules J. Virol., Dec 2012; 86: 13653 - 13661. shRNA TG309983
RAB7A Large Putative PEST-like Sequence Motif at the Carboxyl Tail of Human Calcium Receptor Directs Lysosomal Degradation and Regulates Cell Surface Receptor Level J. Biol. Chem., Feb 2012; 287: 4165 - 4176. shRNA TR309983
RAC2 Rac2-MRC-cIII–generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors Blood, May 2012; 119: 4253 - 4263. shRNA TR318935
RAD17 ATR Mediates a Checkpoint at the Nuclear Envelope in Response to Mechanical Stress Cell July 2014 shRNA TR302133
RAD21 ASXL1 interacts with the cohesin complex to maintain chromatid separation and gene expression for normal hematopoiesis Sci Adv 2017 shRNA TL501846
RAD54 BLM helicase stimulates the ATPase and chromatin-remodeling activities of RAD54 J. Cell Sci., Aug 2009; 10.1242/jcs.051813 shRNA TR309964
RAD9 Rapid and transient recruitment of DNMT1 to DNA double-strand breaks is mediated by its interaction with multiple components of the DNA damage response machinery Hum. Mol. Genet., Oct 2010; 10.1093/hmg/ddq451 shRNA TR309962
RALA Nodal signals via ß-arrestins and RalGTPases to regulate trophoblast invasion Cell. Signal. May 2014 shRNA TR309957
RALa Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK Cellular Signalling, Volume 21, Issue 7, July 2009, Pages 1207-1217 shRNA TR309957
RALa ß-Arrestin/Ral Signaling Regulates Lysophosphatidic Acid–Mediated Migration and Invasion of Human Breast Tumor Cells Mol. Cancer Res., Jul 2009; 7: 1064 - 1077 shRNA TR309957
RALb Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK Cellular Signalling, Volume 21, Issue 7, July 2009, Pages 1207-1217 shRNA TR309956
RALb ß-Arrestin/Ral Signaling Regulates Lysophosphatidic Acid–Mediated Migration and Invasion of Human Breast Tumor Cells Mol. Cancer Res., Jul 2009; 7: 1064 - 1077 shRNA TR309956
RAMP1 Calcitonin Gene-Related Peptide Rescues Proximity Associations of Its Receptor Components Calcitonin Receptor-Like-Receptor and Receptor Activity Modifying Protein1 in Rat Uterine Artery Smooth Muscle Cells Exposed to Tumor Necrosis Factor-Alpha Biol. Reprod. 2016 shRNA TR711449
RANBP2 Cdk1 Activates Pre-mitotic Nuclear Envelope Dynein Recruitment and Apical Nuclear Migration in Neural Stem Cells Dev. Cell Jun 2015 shRNA TG309949
Rap1gds1 Microgravity simulation activates Cdc42 via Rap1GDS1 to promote vascular branch morphogenesis during vasculogenesis Stem Cell Res2017 shRNA TG506858
RAPGEF3 Pancreatic ß-Cell Response to Increased Metabolic Demand and to Pharmacologic Secretagogues Requires EPAC2A Diabetes, Aug 2013; 62: 2796 - 2807. shRNA TR512817
RARRES3 RARRES3 suppressed metastasis through suppression of MTDH to regulate epithelial-mesenchymal transition in colorectal cancer Am J Cancer Res Aug 2015 shRNA TL320510
RASSF1 The RASSF1A Tumor Suppressor Regulates XPA-Mediated DNA repair Mol. Cell. Biol. Nov 2014 shRNA TR307696
RASSF10 RASSF10 is Epigenetically Inactivated and Suppresses Cell Proliferation and Induces Cell Apoptosis by Activating the p53 Signalling Pathway in Papillary Thyroid Carcinoma Cancer Cell. Physiol. Biochem 2017 shRNA TR320923
RASSF10 Ras association domain family member 10 suppresses gastric cancer growth by cooperating with GSTP1 to regulate JNK/c-Jun/AP-1 pathway Oncogene Aug 2015 shRNA TG320923
RASSF5 NORE1A Tumor Suppressor Candidate Modulates p21CIP1 via p53 Cancer Res., Jun 2009; 69: 4629 - 4637. shRNA TR302093
RAT STIM1 in GFP Mitochondria depletion abolishes agonist-induced Ca2+ plateau in airway smooth muscle cells - potential role of H2O2 Am J Physiol Lung Cell Mol Physiol, Nov 2009; 10.1152/ajplung.00134.2009 shRNA TR707032
Rbfox3 Rbfox3-regulated alternative splicing of Numb promotes neuronal differentiation during development J. Cell Biol., Feb 2013; 200: 443 - 458. shRNA TR502927
RBL1 p107-Dependent recruitment of SWI/SNF to the alkaline phosphatase promoter during osteoblast differentiation Bone Aug 2014 shRNA TF509105
RBM25 A novel splicing factor RBM25 modulates Bcl-x pre-mRNA 5' splice site selection Mol. Cell. Biol. published 28 July 2008, 10.1128/MCB.00560-08 shRNA TR302072
RBM5 Whole-transcriptome microarray analysis reveals regulation of Rab4 by RBM5 in neurons Neuroscience 2017 shRNA TL704115
RBM5 Decreased RNA-binding motif 5 expression is associated with tumor progression in gastric cancer Tumour Biol 2017 shRNA TR309910
RBPJ Notch Inhibition Enhances Cardiac Reprogramming by Increasing MEF2C Transcriptional Activity Stem Cell Reports 2017 shRNA MR226108
Rbpj Notch1 regulated autophagy controls survival and suppressor activity of activated murine T-regulatory cells Elife Jun 2016 shRNA TG512813
RC214100 ANALYSIS OF THE UPSTREAM SIGNALLING PATHWAY CONTROLLING DELTANP63ALPHA PROTEIN STABILITY AND FUNCTION Thesis Aug 2014 shRNA TR313197
RC218884 Nodal signals via ß-arrestins and RalGTPases to regulate trophoblast invasion Cell. Signal. Jan 2014 shRNA TR306567
RCAN1 RCAN1-4 is a thyroid cancer growth and metastasis suppressor JCI Insight 2017 shRNA TR304903
RCAN1 Pituitary adenylate cyclase-activating polypeptide (PACAP) targets Down syndrome candidate region 1 (DSCR1/RCAN1) to control neuronal differentiation J. Biol. Chem. Jul 2015 shRNA TG713231
RCAN1 APP facilitates the RCAN1-mediated apoptosis by downregulating PSMA5 and PSMB7 Neurobiology of Aging Aug 2014 shRNA TF304903
RCAN1 The Regulator of Calcineurin 1 (RCAN1/DSCR1) Activates the cAMP Response Element-binding Protein (CREB) Pathway J. Biol. Chem., Oct 2011; 286: 37841 - 37848. shRNA TR511392
REC8 REC8 inhibits EMT by downregulating EGR1 in gastric cancer cells Oncol. Rep. 2018 shRNA TG309883
REC8 REC8 functions as a tumor suppressor and is epigenetically downregulated in gastric cancer, especially in EBV-positive subtype Oncogene May 2016 shRNA TG309883
RECQL4 Human RecQL4 Helicase Plays Critical Roles in Prostate Carcinogenesis Cancer Res., Nov 2010; 70: 9207 - 9217 shRNA TR309882
REG REG{gamma} deficiency promotes premature aging via the casein kinase 1 pathway PNAS, Jul 2013; 110: 11005 - 11010. shRNA TG309878
REG REG{gamma} modulates p53 activity by regulating its cellular localization J. Cell Sci., Dec 2010; 123: 4076 - 4084 shRNA TR302039
RELA Time-lapse imaging of p65 and IκBα translocation kinetics following Ca2+-induced neuronal injury reveals biphasic translocation kinetics in surviving neurons Molecular and Cellular Neuroscience 2017 shRNA TG713753
RELA NF-?B regulates neuronal ankyrin-G via a negative feedback loop Sci Rep 2017 shRNA TR516660
RELA Bortezomib Sensitizes Malignant Human Glioma Cells to TRAIL, Mediated by Inhibition of the NF-{kappa}B Signaling Pathway Mol. Cancer Ther., Jan 2011; 10: 198 - 208 shRNA TR302038
RELA Angiotensin II-regulated transcription regulatory genes in adrenal steroidogenesis Physiol Genomics, Nov 2010; 42A: 259 - 266 shRNA TR302038
RETNLA Hypoxia-Induced Mitogenic Factor Acts as a Nonclassical Ligand of Calcium-Sensing Receptor, Therapeutically Exploitable for Intermittent Hypoxia-Induced Pulmonary Hypertension Hypertension 2017 shRNA TL711770
RFC1 Phosphoinositide 3-kinase beta controls replication factor C assembly and function Nucleic Acids Res., Jan 2013; 41: 855 - 868. shRNA TG501877
RFC2 DNA damage response defect in Williams-Beuren syndrome Int. J. Mol. Med. 2017 shRNA TG309864
RFC2 PLA2G16 represents a switch between entry and clearance of Picornaviridae Nature 2017 shRNA TG309864
RFC2 DNA damage response defect in Williams‑Beuren syndrome INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 2017 shRNA TG309864
RFC4 Phosphoinositide 3-kinase beta controls replication factor C assembly and function Nucleic Acids Res., Jan 2013; 41: 855 - 868. shRNA TG505746
RFX1 RFX-1-dependent activation of SHP-1 inhibits STAT3 signaling in hepatocellular carcinoma cells Carcinogenesis Oct 2014 shRNA TG309857
RFX1 SC-2001 Overcomes STAT3-mediated Sorafenib Resistance through RFX-1/SHP-1 Activation in Hepatocellular Carcinoma Neoplasia July 2014 shRNA TR309857
RGS4 Decreased levels of RGS4 in the paraventricular nucleus facilitate GABAergic inhibition during the acute stress response Biochem. Biophys. Res. Commun. Mar 2016 shRNA TG510988
RGS4 Breast Cancer Migration and Invasion Depend on Proteasome Degradation of Regulator of G-Protein Signaling 4 Cancer Res., Jul 2009; 69: 5743 - 5751. shRNA TR309833
RHBDF1 Human Rhomboid Family-1 (RHBDF1) Suppresses Oxygen-Independent Degradation of Hypoxia-Inducible Factor-1a in Breast Cancer Cancer Res. Mar 2014 shRNA TF302009
RHOU (Wrch-1) The Transforming Rho Family GTPase Wrch-1 Disrupts Epithelial Cell Tight Junctions and Epithelial Morphogenesis Mol. Cell. Biol., Feb 2009; 29: 1035 - 1049. shRNA TR307205
RICTOR Potential Role of mTORC2 as a Therapeutic Target in Clear Cell Carcinoma of the Ovary Mol. Cancer Ther., Jul 2013; 12: 1367 - 1377. shRNA TG307650
RIG-I Measles Virus V Protein Inhibits NLRP3 Inflammasome-Mediated Interleukin-1ß Secretion J. Virol., Dec 2011; 85: 13019 - 13026. shRNA TR313514
RIOK1 Targeting posttranslational modifications of RioK1 inhibits the progression of colorectal and gastric cancers bioRxiv 2017 shRNA TL320739
RIPK1 RIPK1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy Autophagy May 2015 shRNA TG320591
RIPK1 RIP1 Kinase Is an Oncogenic Driver in Melanoma Cancer Res. Feb 2015 shRNA TG320591
RNASEK A Subtle Alternative Splicing Event Gives Rise to a Widely Expressed Human RNase k Isoform PLoS ONE May 2014 shRNA TR318608
RNF144A RBR-type E3 ubiquitin ligase RNF144A targets PARP1 for ubiquitin-dependent degradation and regulates PARP inhibitor sensitivity in breast cancer cells Oncotarget 2017 shRNA TL309788
RNF8 Identification of RNF8 as a Ubiquitin Ligase Involved in Targeting the p12 Subunit of DNA Polymerase for Degradation in Response to DNA Damage J. Biol. Chem., Feb 2013; 288: 2941 - 2950. shRNA TG309783
RNH1 Genomic Analysis of Chemo-Resistance to HDAC inhibitor in Gastric Cancer cells Thesis Jul 2014 shRNA TG309781
RNH1 RNH1 regulation of reactive oxygen species contributes to histone deacetylase inhibitor resistance in gastric cancer cells Oncogene doi:10.1038/onc.2013.104 shRNA TG309781
ROCK1 Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways PLoS ONE Aug 2015 shRNA TG309775
ROR2 Ror2, a developmentally regulated kinase, promotes tumor growth potential in renal cell carcinoma Oncogene (18 May 2009) doi:10.1038/onc.2009.116 Original Article shRNA TR320439
RORA Epigenetic identification of receptor tyrosine kinase-like orphan receptor 2 as a functional tumor suppressor inhibiting Beta-catenin and AKT signaling but frequently methylated in common carcinomas Cell Mol Life Sci. 2013 Oct 25 shRNA TR320515
RPA1 ATR Mediates a Checkpoint at the Nuclear Envelope in Response to Mechanical Stress Cell July 2014 shRNA TR309767
RPA3 Elevated Expression of RPA3 Is Involved in Gastric Cancer Tumorigenesis and Associated with Poor Patient Survival Dig. Dis. Sci. 2017 shRNA TL316699
RPN13 Regulation of NF-{kappa}B activity and inducible nitric oxide synthase by regulatory particle non-ATPase subunit 13 (Rpn13) PNAS, Aug 2010; 107: 13854 - 13859 shRNA TR306807
RPS27A RPS27a enhances EBV-encoded LMP1-mediated proliferation and invasion by stabilizing of LMP1 Biochem. Biophys. Res. Commun. 2017 shRNA TL309716
RPS6KA1 Caveolin-1 promotes Ewing sarcoma metastasis regulating MMP-9 expression through MAPK/ERK pathway Oncotarget 2016 shRNA TR320517
RPS6KA3 Phosphorylation of RSK2 at Tyr529 by FGFR2-p38 enhances human mammary epithelial cells migration Biochim. Biophys. Acta July 2014 shRNA TG320519
Rps6ka4 miR-93 regulates Msk2-mediated chromatin remodelling in diabetic nephropathy Nat Commun 2016 shRNA TR503222
Rps6kb1 S6K directly phosphorylates IRS-1 on Ser270 to promote insulin resistance in response to TNF-alpha signaling through IKK2 J. Biol. Chem. published 24 October 2008, 10.1074/jbc.M806480200 shRNA TR504743
RSU1 Role of PINCH and Its Partner Tumor Suppressor Rsu-1 in Regulating Liver Size and Tumorigenesis PLoS One. 2013 Sep 18;8(9):e74625 shRNA RG203334
RUNX1 MiR-18a increased the permeability of BTB via RUNX1 mediated down-regulation of ZO-1, occludin and claudin-5 Cell. Signal. Oct 2014 shRNA TG309685
RUNX2 RUNX2 in subtype specific breast cancer and mammary gland differentiation Dis Model Mech Mar 2014 shRNA TG309683
Rxra Retinoid-X-Receptors (a/ß) in Melanocytes Modulate Innate Immune Responses and Differentially Regulate Cell Survival following UV Irradiation PLoS Genet. May 2014 shRNA TG501955
Rxrb Retinoid-X-Receptors (a/ß) in Melanocytes Modulate Innate Immune Responses and Differentially Regulate Cell Survival following UV Irradiation PLoS Genet. May 2014 shRNA TF501956
S100A14 Increased S100A15 expression and decreased DNA methylation of its gene promoter are involved in high metastasis potential and poor outcome of lung adenocarcinoma Oncotarget 2017 shRNA TL318900
S100B S100B Promotes Glioma Growth through Chemoattraction of Myeloid-Derived Macrophages Clin. Cancer Res., Jul 2013; 19: 3764 - 3775. shRNA TG309665
SAA3 Serum Amyloid A3 Secreted by Preosteoclasts Inhibits Parathyroid Hormone-Stimulated cAMP Signaling in Murine Osteoblasts J. Biol. Chem. Dec 2015 shRNA TL501964
SAR1A Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience Genome Med 2017 shRNA TG301838
SATB1 Silencing SATB1 influences cell invasion, migration, proliferation, and drug resistance in nasopharyngeal carcinoma Int J Clin Exp Pathol Apr 2014 shRNA TG309643
SATB2 Role of miR-31 and SATB2 in arsenic-induced malignant BEAS-2B cell transformation Mol. Carcinog. 2018 shRNA TG301833
SATB2 Molecular Mechanisms of Malignant Transformation by Low Dose Cadmium in Normal Human Bronchial Epithelial Cells PLoS ONE May 2016 shRNA TG301833
SATB2 SATB2 expression increased anchorage-independent growth and cell migration in human bronchial epithelial cells Toxicol. Appl. Pharmacol. Jan 2016 shRNA TG301833
SAV1 Salvador Protein Is a Tumor Suppressor Effector of RASSF1A with Hippo Pathway-independent Functions J. Biol. Chem., May 2011; 286: 18483 - 18491 shRNA TR301832
SC115948 Hax-1 is required for Rac1-Cortactin interaction and ovarian carcinoma cell migration Genes Cancer March 2014 shRNA TF312515
SC118589 Oncomorphic TP53 Mutations in Gynecologic Cancers Lose the Normal Protein: Protein Interactions with the microRNA Microprocessing Complex Journal of Cancer Therapy April 2014 shRNA TR320558
SC400669 Oncomorphic Tp53 mutations in advanced serous ovarian carcinomas Thesis Aug 2014 shRNA TF320558
SCARB1 Chlamydia trachomatis utilizes the mammalian CLA1 lipid transporter to acquire host phosphatidylcholine essential for growth Cell. Microbiol. Sep 2015 shRNA TG309633
SCG3 Carboxypeptidase E and Secretogranin III Coordinately Facilitate Efficient Sorting of Proopiomelanocortin to the Regulated Secretory Pathway in AtT20 Cells Mol. Endocrinol 2016 shRNA TL516044
SCG3 Carboxypeptidase E and Secretogranin III coordinately facilitate efficient sorting of pro-opiomelanocortin to the regulated secretory pathway in AtT20 cells Molecular Endocrinology Dec2015 shRNA TR516044
SCIMP SCIMP, a Transmembrane Adaptor Protein Involved in Major Histocompatibility Complex Class II Signaling Mol. Cell. Biol., Nov 2011; 31: 4550 - 4562. shRNA
SCPEP1 Serine carboxypeptidase SCPEP1 and Cathepsin A play complementary roles in regulation of vasoconstriction via inactivation of endothelin-1 PLoS Genet. Feb 2014 shRNA TF505007
Scrambled Control Imbalance of a KLF4-miR-7 auto-regulatory feedback loop promotes prostate cancer cell growth by impairing microRNA processing Am J Cancer Res 2018 shRNA TR30013
Scrambled Control Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience Genome Med 2017 shRNA TR30013
Scrambled shRNA Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology Nat Commun 2018 shRNA TR30012
Scrambled shRNA Calcium release mediated by redox-sensitive RyR2 channels has a central role in hippocampal structural plasticity and spatial memory Antioxid. Redox Signal. 2018 shRNA TR30013
scrambled shRNA Calcium release mediated by redox-sensitive RyR2 channels has a central role in hippocampal structural plasticity and spatial memory Antioxid. Redox Signal. 2018 shRNA TR30015
SCRT2 Scratch2 Modulates Neurogenesis and Cell Migration Through Antagonism of bHLH Proteins in the Developing Neocortex Cereb Cortex, Nov 2012; 10.1093/cercor/bhs356. shRNA TG307416
SDC1 Sphingosine 1-phosphate regulates proliferation, cell cycle and apoptosis of hepatocellular carcinoma cells via syndecan-1 Prog. Biophys. Mol. Biol.2017 shRNA TL309598
SDC1 Sphingosine-1-phosphate induced epithelial-mesenchymal transition of hepatocellular carcinoma via an MMP-7/ syndecan-1/TGF-ß autocrine loop Oncotarget 2016 shRNA TL309598
SDC2 Binding of Y-P30 to Syndecan 2/3 Regulates the Nuclear Localization of CASK PLoS ONE, Feb 2014. shRNA TR309597
SDC3 Binding of Y-P30 to Syndecan 2/3 Regulates the Nuclear Localization of CASK PLoS ONE, Feb 2014. shRNA TR309596
SDCBP Syntenin promotes VEGF-induced VEGFR2 endocytosis and angiogenesis by increasing ephrin-B2 function in endothelial cells Oncotarget 2017 shRNA TL309594
SDCBP Syntenin regulates TGF-ß1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-ß type I receptor internalization Oncogene Apr 2015 shRNA TL309594
Sec8 CREG1 Interacts with Sec8 to Promote Cardiomyogenic Differentiation and Cell-Cell Adhesion Stem Cells 2016 shRNA TR502000
SELENOP Selenoprotein P neutralizes lipopolysaccharide and participates in hepatic cell endoplasmic reticulum stress response FEBS Lett 2016 shRNA TR309547
SEMA6A Nrf2 in ischemic neurons promotes retinal vascular regeneration through regulation of semaphorin 6A Proc. Natl. Acad. Sci. U.S.A. Dec 2015 shRNA TL510568
SEMA6D The Plexin-A1 Receptor Activates Vascular Endothelial Growth Factor-Receptor 2 and Nuclear Factor-B to Mediate Survival and Anchorage-Independent Growth of Malignant Mesothelioma Cells Cancer Res., Feb 2009; 69: 1485 - 1493 shRNA TR301776
SENP2 SUMOylation determines the voltage required to activate cardiac IKs channels Proc. Natl. Acad. Sci. U.S.A. 2017 shRNA TL517117
SENP2 Accumulation of histone variant H3. 3 with age is associated with profound changes in the histone methylation landscape Nucleic Acids Research 2017 shRNA TL517117
SENP3 Increased SUMO-2/3-ylation mediated by SENP3 degradation is protective against cadmium-induced caspase 3-dependent cytotoxicity J Toxicol Sci 2017 shRNA TG505363
SENP3 Protective effect of SENP3-mediated SUMOylation against cadmium toxicity J Toxicol Sci 2017 shRNA TG701864
SENP7 Novel SUMO-Protease SENP7S Regulates ß-catenin Signaling and Mammary Epithelial Cell Transformation Sci Rep 2017 shRNA TR301771
SEPT2 Septins promote macropinosome maturation and traffic to the lysosome by facilitating membrane fusion J. Cell Biol. 2016 shRNA TG515794
Serpina1 Endothelial-mesenchymal transition in atherosclerotic lesion calcification Atherosclerosis 2016 shRNA TR710718
SERPINB2 PNAS Plus: TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2 PNAS, Jan 2012; 109: E177 - E186. shRNA TR309533
SERPINB9 Anti-Apoptotic Gene Delivery with cyclo-(d-Trp-Tyr) Peptide Nanotube via Eye Drop Following Corneal Epithelial Debridement Pharmaceutics Jul 2015 shRNA TF309527
SERPINE1 Serpine 1 induces alveolar type II cell senescence through activating p53-p21-Rb pathway in fibrotic lung disease Aging Cell 2017 shRNA TF709263
SETD7 SET9-Mediated Regulation of TGF-ß Signaling Links Protein Methylation to Pulmonary Fibrosis Cell Rep Jun 2016 shRNA TG301748
SETMAR(Metnase) Metnase mediates chromosome decatenation in acute leukemia cells Blood, May 2009; 10.1182/blood-2008-08-175760 shRNA TR309513
Sf1 DNA damage causes rapid accumulation of phosphoinositides for ATR signaling Nat Commun 2017 shRNA TF516038
SF1 cAMP-stimulated transcription of DGK{theta} requires steroidogenic factor 1 and sterol regulatory element binding protein 1 J. Lipid Res., Aug 2013; 54: 2121 - 2132. shRNA TG311103
Sfpi1 A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease Nat. Neurosci. 2017 shRNA TG502008
SFRP5 Secreted frizzled-related protein 5 protects against oxidative stress-induced apoptosis in human aortic endothelial cells via downregulation of Bax J. Biochem. Mol. Toxicol. 2017 shRNA TR309497
sh-Luc(in vivo application) RNA interference-mediated in vivo silencing of FasL as a strategy for the enhancement of DNA vaccine potency Human Gene Therapy. August 2008, 19(8): 763-773 shRNA
SH3BGRL SH3BGRL as a novel prognostic biomarker is down-regulated in acute myeloid leukemia Leuk. Lymphoma 2017 shRNA TG309466
shank3 SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism Molecular Psychiatry (24 May 2011) doi:10.1038/mp.2011.57 Original Article shRNA TR320871
SHIP2 The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamics J. Cell Biol., Aug 2010; 10.1083/jcb.201005018 shRNA TR312134
shRNA Human ß-defensin-2 enhances IFN-{gamma} and IL-10 production and suppresses IL-17 production in T cells J. Leukoc. Biol., Jun 2011; 89: 935 - 944 shRNA
shRNA GPR103b Functions in the Peripheral Regulation of Adipogenesis Mol. Endocrinol., Aug 2010; 24: 1615 - 1625 shRNA
shRNA A New Type of Membrane Raft-Like Microdomains and Their Possible Involvement in TCR Signaling J. Immunol., Apr 2010; 184: 3689 - 3696 shRNA
shRNA TRAF6 distinctively mediates MyD88- and IRAK-1-induced activation of NF-B J. Leukoc. Biol., Mar 2008; 83: 702 - 707 shRNA
SIGLECE Siglec-E Is Up-Regulated and Phosphorylated Following Lipopolysaccharide Stimulation in Order to Limit TLR-Driven Cytokine Production J. Immunol., Dec 2009; 183: 7703 - 7709 shRNA TR512042
SIGMAR1 Altered localization, abnormal modification and loss of function of Sigma receptor-1 in amyotrophic lateral sclerosis Hum. Mol. Genet., Apr 2013; 22: 1581 - 1600. shRNA TG311012
SIGMAR1 Altered localization, abnormal modification and loss of function of Sigma receptor-1 in amyotrophic lateral sclerosis Hum. Mol. Genet., Jan 2013; 10.1093/hmg/ddt008. shRNA TG311012
SIRT1 Chronic sun exposure is associated with distinct histone acetylation changes in human skin Br. J. Dermatol.2017 shRNA TG309433
SIRT1 SIRT1 promotes metastasis of human osteosarcoma cells Oncotarget 2016 shRNA TG309433
SIRT7 SIRT7 promotes genome integrity and modulates non-homologous end joining DNA repair EMBO J. May 2016 shRNA TR301690
SKP2 OCT-4: a novel estrogen receptor-a collaborator that promotes tamoxifen resistance in breast cancer cells Oncogene Apr 2016 shRNA TL301684
SLAMF1 SLAMF1 regulation of chemotaxis and autophagy determines CLL patient response J. Clin. Invest. Jan 2016 shRNA TG309422
SLC15A2 Dipeptide species regulate p38MAPK-Smad3 signalling to maintain chronic myelogenous leukaemia stem cells Nat Commun Aug 2015 shRNA TL503323
SLC17A5 From the Cover: Sialin (SLC17A5) functions as a nitrate transporter in the plasma membrane PNAS, Aug 2012; 109: 13434 - 13439. shRNA TR309394
SLC17A5 Sialin (SLC17A5) functions as a nitrate transporter in the plasma membrane PNAS, Jul 2012; 10.1073/pnas.1116633109. shRNA TR309394
SLC1A3 Insulin Regulates Astrocytic Glucose Handling Through Cooperation With IGF-I Diabetes 2017 shRNA TR515328
SLC29A1 SLC29A1 (ENT1) polymorphisms and outcome of complete remission in acute myeloid leukemia Cancer Chemother. Pharmacol. 2016 shRNA TG309346
Slc2a1 The insulin-like growth factor I receptor regulates glucose transport by astrocytes Glia 2016 shRNA TL511086
Slc2a1 The insulin-like growth factor I receptor regulates glucose transport by astrocytes Glia 2016 shRNA TL501102
SLC2A1 A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect Nat Commun 3608 5 . April 2014 shRNA TL309344
SLC2A4 GLUT4 Mobilization Supports Energetic Demands of Active Synapses Neuron 2017 shRNA TR709372
Slc30a8(rat) Down-Regulation of ZnT8 Expression in INS-1 Rat Pancreatic Beta Cells Reduces Insulin Content and Glucose-Inducible Insulin Secretion PLoS ONE 4(5):e5679, 2009 shRNA TR708553
SLC36A4 Tumor-Repopulating Cells Induce PD-1 Expression in CD8+T Cells by Transferring Kynurenine and AhR Activation Cancer Cell 2018 shRNA TG507107
SLC39A12 Neurulation and neurite extension require the zinc transporter ZIP12 (slc39a12) PNAS, Jun 2013; 110: 9903 - 9908. shRNA TG301572
SLC39A4/ZIP4 Down-regulation of ZIP4 by RNA Interference Inhibits Pancreatic Cancer Growth and Increases the Survival of Nude Mice with Pancreatic Cancer Xenografts Clin. Cancer Res., Oct 2009; 15: 5993 - 6001 shRNA TR317306
SLC7A8 Tumor-Repopulating Cells Induce PD-1 Expression in CD8+T Cells by Transferring Kynurenine and AhR Activation Cancer Cell 2018 shRNA TG502853
SLC9A3R1 Extracellular anti-angiogenic proteins augment an endosomal protein trafficking pathway to reach mitochondria and execute apoptosis in HUVECs Cell Death Differ. 2018 shRNA TF316855
SLC9A3R1 NHERF1 regulates parathyroid hormone receptor membrane retention without affecting recycling. J Biol Chem. 2007 Dec 14;282(50):36214-22. shRNA TR316855
SLC9A3R1(NHERF1 ) NHERF1 Regulates Parathyroid Hormone Receptor Desensitization; Interference with -arrestin Binding Mol. Pharmacol., Feb 2009; 10.1124/mol.108.054486. shRNA TR316855
SLC9A3R2 Na/H Exchanger Regulatory Factors Control Parathyroid Hormone Receptor Signaling by Facilitating Differential Activation of G{alpha} Protein Subunits J. Biol. Chem., Aug 2010; 285: 26976 - 26986 shRNA TR309271
SLK SLK-dependent activation of ERMs controls LGN-NuMA localization and spindle orientation J. Cell Biol. Jun 2014 shRNA TG320620
Slug MicroRNA-124 suppresses Slug-mediated lung cancer metastasis Eur Rev Med Pharmacol Sci 2016 shRNA TR309225
SMAD2 The transcription factor GLI1 interacts with SMAD proteins to modulate TGFß-induced gene expression in a PCAF-dependent manner J. Biol. Chem. April 2014 shRNA TG309255
Smad2 Response gene to complement 32 interacts with Smad3 to promote epithelial-mesenchymal transition of human renal tubular cells Am J Physiol Cell Physiol, Jun 2011; 300: C1415 - C1421 shRNA TR309255
Smad3 Response gene to complement 32 interacts with Smad3 to promote epithelial-mesenchymal transition of human renal tubular cells Am J Physiol Cell Physiol, Jun 2011; 300: C1415 - C1421 shRNA TR309254
SMAD4 Loss of Trefoil Factor 2 From Pancreatic Duct Glands Promotes Formation of Intraductal Papillary Mucinous Neoplasms in Mice Gastroenterology 2016 shRNA TG309253
SMAD4 The transcription factor GLI1 interacts with SMAD proteins to modulate TGFß-induced gene expression in a PCAF-dependent manner J. Biol. Chem. April 2014 shRNA TG309253
Smad7 microRNA-181a has a critical role in ovarian cancer progression through the regulation of the epithelial-mesenchymal transition Nat Commun, Jan 2014. shRNA TG320409
SMARCE1(BAF57) SWI/SNF Regulates the Cellular Response to Hypoxia J. Biol. Chem., Feb 2009; 284: 4123 - 4131 shRNA TR309242
SMARCF1 A signaling cascade including ARID1A, GADD45B and DUSP1 induces apoptosis and affects the cell cycle of germ cell cancers after romidepsin treatment Oncotarget 2016 shRNA TG306603
SMC1A ASXL1 interacts with the cohesin complex to maintain chromatid separation and gene expression for normal hematopoiesis Sci Adv 2017 shRNA TL513033
SMG1 Downregulation of SMG-1 in HPV-Positive Head and Neck Squamous Cell Carcinoma Due to Promoter Hypermethylation Correlates with Improved Survival Clin. Cancer Res., Mar 2012; 18: 1257 - 1267. shRNA TR318864
SMO Targeting Smoothened Sensitizes Gastric Cancer to Chemotherapy in Experimental Models Med. Sci. Monit 2017 shRNA TL510788
SMO Targeting Smoothened Sensitizes Gastric Cancer to Chemotherapy in Experimental Models Med. Sci. Monit 2017 shRNA MR210692L2
SMO Sonic hedgehog induces response of commissural axons to Semaphorin repulsion during midline crossing Nature Neuroscience (29 November 2009) shRNA TR309234
SMPD3 The cationic small molecule GW4869 is cytotoxic to high phosphatidylserine-expressing myeloma cells Br. J. Haematol 2017 shRNA TL301492
SMPDL3B Rituximab Targets Podocytes in Recurrent Focal Segmental Glomerulosclerosis Science Translational Medicine, Jun 2011; 3: 85ra46 shRNA TR309229
SNAI1 Endothelial Snail Regulates Capillary Branching Morphogenesis via Vascular Endothelial Growth Factor Receptor 3 Expression PLoS Genet. Jul 2015 shRNA TL502087
SNAI1 Inflammatory mediators drive metastasis and drug resistance in head and neck squamous cell carcinoma Laryngoscope Mar 2015 shRNA TG309226
SNAI1 BMK1 Kinase Suppresses Epithelial–Mesenchymal Transition through the Akt/GSK3ß Signaling Pathway Cancer Res., Mar 2012; 72: 1579 - 1587. shRNA TR309226
SNAI1 Role of {Delta}Np63{gamma} in Epithelial to Mesenchymal Transition J. Biol. Chem., Feb 2011; 286: 3915 - 3924 shRNA TG309226
SNAI1 Proinflammatory Mediators Upregulate Snail in Head and Neck Squamous Cell Carcinoma Clin. Cancer Res., Oct 2009; 15: 6018 - 6027 shRNA TR309226
SNAP25 The SNARE Proteins SNAP25 and Synaptobrevin Are Involved in Endocytosis at Hippocampal Synapses J. Neurosci., May 2013; 33: 9169 - 9175. shRNA TF711123
SNCA a-Synuclein, a chemoattractant, directs microglial migration via H2O2-dependent Lyn phosphorylation Proc. Natl. Acad. Sci. U.S.A. Apr 2015 shRNA TL710189
SNX27 Actin-Sorting Nexin 27-Retromer Complex Mediates Rapid Parathyroid Hormone Receptor Recycling J. Biol. Chem. Mar 2016 shRNA TF301468
SOCS3 Human ß-defensin-2 enhances IFN-{gamma} and IL-10 production and suppresses IL-17 production in T cells J. Leukoc. Biol., Jun 2011; 89: 935 - 944 shRNA TR316847
SOD2 Different roles of ROS and Nrf2 in Cr(VI)-induced inflammatory responses in normal and Cr(VI)-transformed cells. Toxicol. Appl. Pharmacol. 2016 shRNA TG309190
SOD2 Different roles of ROS and Nrf2 in Cr(VI)-induced inflammatory responses in normal and Cr(VI)-transformed cells Toxicol. Appl. Pharmacol. 2016 shRNA TR309190
SOD2 Anti-oncogenic and oncogenic properties of Nrf2 in arsenic-induced carcinogenesis J. Biol. Chem. Sep 2015 shRNA TG309190
SOD2 Mitochondrial superoxide dismutase has a pro-tumorigenic role in ovarian clear cell carcinoma Cancer Res. Sep 2015 shRNA TG309190
SOD2 Constitutive activation of epidermal growth factor receptor promotes tumorigenesis of Cr(VI)-transformed cells through decreased reactive oxygen species and apoptosis resistance development J. Biol. Chem. Dec 2014 shRNA TG309190
Sort1 Sortilin regulates sorting and secretion of Sonic hedgehog J. Cell. Sci. 2016 shRNA TR502101
SORT1 Sortilin regulates progranulin action in castration-resistant prostate cancer cells Endocrinology Nov 2014 shRNA TG309180
Sox2 YAP1 and COX2 coordinately regulate urothelial cancer stem-like cells Cancer Res.2017 shRNA TL515613
SOX2 Efficient extravasation of tumor-repopulating cells depends on cell deformability Sci Rep Jan 2016 shRNA TG515613
SOX2 Enhancer Analysis Unveils Genetic Interactions between TLX and SOX2 in Neural Stem Cells and In Vivo Reprogramming Stem Cell Reports Oct 2015 shRNA TG515613
SOX2 SOX2 expression in the developing, adult, as well as, diseased prostate Prostate Cancer Prostatic Dis. Aug 2014 shRNA TR309173
Sox2 Matrix softness regulates plasticity of tumour-repopulating cells via H3K9 demethylation and Sox2 expression Nat Commun Aug 2014 shRNA TG515613
SOX4 SOX4 interacts with EZH2 and HDAC3 to suppress microRNA-31 in invasive esophageal cancer cells Mol. Cancer Feb 2015 shRNA TF315513
SOX4 Down-regulated SOX4 expression suppresses cell proliferation, metastasis and induces apoptosis in Xuanwei female lung cancer patients J. Cell. Biochem. Jan 2015 shRNA TG315513
SOX4 The early retinal progenitor-expressed gene Sox11 regulates the timing of the differentiation of retinal cells Development, Feb 2013; 140: 740 - 750. shRNA TF315513
SOX9 Oncogenicity of the Developmental Transcription Factor Sox9 Cancer Res., Mar 2012; 72: 1301 - 1315. shRNA TR309170
SP1 Resveratrol Represses Pokemon Expression in Human Glioma Cells Molecular Neurobiology Jan 2015 shRNA TL301453
SP1 The Specificity Protein Factor Sp1 Mediates Transcriptional Regulation of P2X7 Receptors in the Nervous System J. Biol. Chem., Dec 2012; 287: 44628 - 44644. shRNA TF502115
SPC24 SPC24 promotes osteosarcoma progression by increasing EGFR/MAPK signaling Oncotarget 2017 shRNA TG301421
SPC24 SPC24 is critical for anaplastic thyroid cancer progression Oncotarget 2017 shRNA TR301421
SPHK1 Comprehensive gene and microRNA expression profiling reveals a role for miRNAs in the oncogenic roles of SphK1 in papillary thyroid cancer J. Cancer Res. Clin. Oncol 2016 shRNA TR301413
Sphk1 Inducible IL-33 Expression by Mast Cells Is Regulated by a Calcium-Dependent Pathway J. Immunol., Oct 2012; 189: 3421 - 3429. shRNA TG301413
Sphk2 Inducible IL-33 Expression by Mast Cells Is Regulated by a Calcium-Dependent Pathway J. Immunol., Oct 2012; 189: 3421 - 3429. shRNA TG301412
SPI1 A common haplotype lowers SPI1 (PU. 1) expression in myeloid cells and delays age at onset for Alzheimer's disease bioRxiv 2017 shRNA TG502008
SPI1 Transcriptional regulation of the proto-oncogene Zfp521 by SPI1 (PU.1) and HOXC13 Genesis 2016 shRNA TL316738
SPI1 Repression of primitive erythroid program is critical for the initiation of multi-lineage hematopoiesis in mouse development J. Cell. Physiol. May 2016 shRNA TG502008
SPP1(OPN1) Identification of a Biphasic Role for Genistein in the Regulation of Prostate Cancer Growth and Metastasis Cancer Res., Apr 2009; 69: 3695 - 3703. shRNA TR309135
SPRY2 Regulation of vascular signalling by nuclear Sprouty2 in fetal lung epithelial cells: Implications for co-ordinated airway and vascular branching in lung development Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 2018 shRNA TR309130
SPRY2 Transcriptional regulation of SPROUTY2 by MYB influences myeloid cell proliferation and stem cell properties by enhancing responsiveness to IL-3 Leukemia 2017 shRNA TG515588
Spry4 Novel Function of Sprouty4 as a Regulator of Stemness and Differentiation of Embryonic Stem Cells Development & Reproduciton 2016 shRNA TL509780
Spry4(in vivo application) Suppression of Sproutys Has a Therapeutic Effect for a Mouse Model of Ischemia by Enhancing Angiogenesis PLoS ONE. 2009; 4(5): e5467 shRNA TR509780
SPTBN1 Transcriptional Regulation of STAT3 by SPTBN1 and SMAD3 in HCC Through cAMP-Response Element-Binding Proteins ATF3 and CREB2* Carcinogenesis Aug 2014 shRNA TR301396
SQSTM1 Anti-oncogenic and oncogenic properties of Nrf2 in arsenic-induced carcinogenesis J. Biol. Chem. Sep 2015 shRNA TG309121
SR30004 Liver Molecular Mechanisms Involved in Type 2 Diabetes: An Investigation Using Roux-en Y Gastric Bypass as a Human Model of Diabetes Remission Thesis July 2014 shRNA TR30015
SRC Fc?-receptor IIa-mediated Src Signaling Pathway is Essential for the Antibody-Dependent Enhancement of Ebola Virus Infection PLoS Pathog 2016 shRNA TR320529
SRC Fc?-receptor IIa-mediated Src Signaling Pathway is Essential for the Antibody-Dependent Enhancement of Ebola Virus Infection PLoS Pathog 2016 shRNA TR320529
SRC Fc?-receptor IIa-mediated Src Signaling Pathway is Essential for the Antibody-Dependent Enhancement of Ebola Virus Infection PLoS Pathog 2016 shRNA TR320529
SRC alpha3/4 Fucosyltransferase 3-Dependent Synthesis of Sialyl Lewis A on CD44 Variant Containing Exon 6 Mediates Polymorphonuclear Leukocyte Detachment from Intestinal Epithelium during Transepithelial Migration J Immunol. 2013 Nov 1;191(9):4804-17 shRNA TG320529
SRC TR3 Modulates Platinum Resistance in Ovarian Cancer Cancer Res., Aug 2013; 73: 4758 - 4769. shRNA TG320529
SREBF1 Myostatin induces insulin resistance via Cblb-mediated degradation of IRS1 in response to high calorie diet intake J. Biol. Chem., Jan 2014. shRNA TG514167
SREBF1 Activation of Androgen Receptor, Lipogenesis, and Oxidative Stress Converged by SREBP-1 Is Responsible for Regulating Growth and Progression of Prostate Cancer Cells Mol. Cancer Res., Jan 2012; 10: 133 - 142. shRNA TR309117
SREBF1 Androgen Receptor Survival Signaling Is Blocked by Anti-ß2-microglobulin Monoclonal Antibody via a MAPK/Lipogenic Pathway in Human Prostate Cancer Cells J. Biol. Chem., Mar 2010; 285: 7947 - 7956 shRNA TR309117
SRRT Mutagenesis of ARS2 Domains to Assess Possible Roles in Cell Cycle Progression, MicroRNA and Replication-dependent Histone mRNA Biogenesis Mol. Cell. Biol. Aug 2015 shRNA TG514443
SRSF1 Regulation of the Alternative Splicing and Function of Cyclin T1 by the Serine-arginine-rich Protein ASF/SF2 J. Cell. Biochem. 2017 shRNA TR309496
St6galnac4 Aberrant glycosylation promotes lung cancer metastasis through adhesion to galectins in the metastatic niche Cancer Discov Nov 2014 shRNA TG502032
STARD4 STARD4 abundance regulates sterol transport and sensing Mol. Biol. Cell, Nov 2011; 22: 4004 - 4015. shRNA TR506047
STAT1 Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells Nat Commun 2017 shRNA TL301349
STAT1 Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas J. Clin. Invest 2017 shRNA TG502153
STAT1 STAT1 drives tumor progression in serous papillary endometrial cancer Cancer Res. Sep 2014 shRNA TG301349
STAT1 A switch from hBrm to Brg1 at IFN?-activated sequences mediates the activation of human genes Cell Research 20, 1345-1360 (16 November 2010) doi:10.1038/cr.2010.155 Original Article shRNA
STAT3 Regulation of endometrial cell proliferation by estrogen-induced BDNF signaling pathway Gynecol. Endocrinol 2017 shRNA TR301348
STAT3 Oncogenic transformation of human lung bronchial epithelial cells induced by arsenic involves ROS-dependent activation of STAT3-miR-21-PDCD4 mechanism Sci Rep 2016 shRNA TR301348
STAT3 Oncogenic transformation of human lung bronchial epithelial cells induced by arsenic involves ROS-dependent activation of STAT3-miR-21-PDCD4 mechanism Sci Rep 2016 shRNA TR301348
STAT3 Rig-G is a growth inhibitory factor of lung cancer cells that suppresses STAT3 and NF-κB Oncotarget 2016 shRNA TR301348
STAT3 Hexavalent chromium induces malignant transformation of human lung bronchial epithelial cells via ROS-dependent activation of miR-21-PDCD4 signaling Oncotarget 2016 shRNA TR301348
STAT3 Feed forward reciprocal activation of PAFR and STAT3 regulates epithelial-mesenchymal transition in non-small cell lung cancer Cancer Res. Sep 2015 shRNA TR301348
STAT3 Microenvironmental interleukin-6 suppresses toll-like receptor signaling in human leukemia cells through miR-17/19A Blood Jun 2015 shRNA TL301348
STAT3 Autophagy inhibition by sustained over-production of IL-6 contributes to arsenic-induced carcinogenesis Cancer Res. May 2014 shRNA TF301348
STIM Canonical Transient Receptor Potential 5 Channel in Conjunction with Orai1 and STIM1 Allows Sr2+ Entry, Optimal Influx of Ca2+, and Degranulation in a Rat Mast Cell Line J. Immunol., Feb 2008; 180: 2233 - 2239. shRNA TR309049
STIM1 Axonal Endoplasmic Reticulum Ca(2+) Content Controls Release Probability in CNS Nerve Terminals Neuron 2017 shRNA TR707032
STIM1 Cooperative and alternate functions for STIM1 and STIM2 in macrophage activation and in the context of inflammation Immunity, Inflammation and Disease May 2015 shRNA TF502160
STIM1 STIM1 and STIM2 Proteins Differently Regulate Endogenous Store-operated Channels in HEK293 Cells J. Biol. Chem. Dec 2014 shRNA TR309049
STIM1 JBC Papers in Press. Published on December 22, 2014 as Manuscript M114. 601856 The Journal of Biological Chemistry Dec 2014 shRNA TR309049
STIM1 Amplified lipid rafts of malignant cells constitute a target for inhibition of aberrantly active NFAT and melanoma tumor growth by the aminobisphosphonate zoledronic acid Carcinogenesis Aug 2014 shRNA TG309049
STIM1 Molecular mechanisms of spontaneous and directed mast cell motility J. Leukoc. Biol., Nov 2012; 92: 1029 - 1041. shRNA TG309049
STIM1 Lipid rafts couple store-operated Ca2+ entry to constitutive activation of PKB/Akt in a Ca2+/calmodulin-, Src- and PP2A-mediated pathway and promote melanoma tumor growth Carcinogenesis, Feb 2012; 10.1093/carcin/bgs021. shRNA TR309049
STIM1 Evidence for STIM1- and Orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells: role in proliferation and migration FASEB J, Apr 2009; 10.1096/fj.09-131128. shRNA TR309049
STIM1 Store-operated cyclic AMP signalling mediated by STIM1 Nature Cell Biology 11, 433-442 (15 March 2009) shRNA TR309049
STK11 Latrepirdine is a potent activator of AMP-activated protein kinase and reduces neuronal excitability Transl Psychiatry. 2013 Oct 22;3:e317 shRNA TG706613
STRIP2 STRIP2 is indispensable for the onset of embryonic stem cell differentiation olecular Therapy: Methods & Clinical Developmen 2017 shRNA TR508344
Strip2 Fam40b is required for lineage commitment of murine embryonic stem cells Cell Death Dis July 2014 shRNA TR508344
STUB1 Hsp90 inhibition renders iNOS aggregation and the clearance of iNOS aggregates by proteasomes requires SPSB2 Free Radic. Biol. Med. 2018 shRNA TG316909
STX12 Functional screening implicates miR-371-3p and peroxiredoxin 6 in reversible tolerance to cancer drugs Nat Commun 2016 shRNA TL301328
SUMO1 Adenosine Signaling Mediates SUMO-1 Modification of IB during Hypoxia and Reoxygenation J. Biol. Chem., May 2009; 284: 13686 - 13695. shRNA TR316774
SUN1 Fluorescence Fluctuation Spectroscopy Reveals Differential SUN Protein Oligomerization In Living Cells Mol. Biol. Cell 2018 shRNA TF300647
SUN2 Fluorescence Fluctuation Spectroscopy Reveals Differential SUN Protein Oligomerization In Living Cells Mol. Biol. Cell 2018 shRNA TF300646
SUPT5H A role for the RNA pol II–associated PAF complex in AID-induced immune diversification J. Exp. Med., Oct 2012; 209: 2099 - 2111. shRNA TG309005
SUPT5H A role for the RNA pol II–associated PAF complex in AID-induced immune diversification J. Exp. Med., Sep 2012; 10.1084/jem.20112145. shRNA TR309005
Sv2c Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinsons disease bioRxiv 2016 shRNA TR711401
SYK Fc?-receptor IIa-mediated Src Signaling Pathway is Essential for the Antibody-Dependent Enhancement of Ebola Virus Infection PLoS Pathog 2016 shRNA TR320543
SYK The Spleen Tyrosine Kinase (syk) Regulates Alzheimer's Aß Production and Tau Hyperphosphorylation J. Biol. Chem. Oct 2014 shRNA TG320543
SYNGR3 Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau Neuron 2018 shRNA TF705557
Syvn1 The ubiquitin-proteasome system functionally links neuronal Tomosyn-1 to dendritic morphology J. Biol. Chem. 2017 shRNA TL704173
TACSTD2 Trop2 enhances invasion of thyroid cancer by inducing MMP2 through ERK and JNK pathways BMC Cancer 2017 shRNA TR308966
TAP1 Cellular and Molecular Requirements for the Selection of In Vitro–Generated CD8 T Cells Reveal a Role for Notch J. Immunol., Aug 2013; 191: 1704 - 1715. shRNA TG308949
TBC1D23 Homozygous Truncating Variants in TBC1D23 Cause Pontocerebellar Hypoplasia and Alter Cortical Development Am. J. Hum. Genet. 2017 shRNA TR503947
TBC1D9 Delivery of Functional Anti-miR-9 by Mesenchymal Stem Cell-derived Exosomes to Glioblastoma Multiforme Cells Conferred Chemosensitivity Mol Ther Nucleic Acids. 2013 Oct 1;2:e126 shRNA TF308932
TBX20 Tbx20 controls the expression of the KCNH2 gene and of hERG channels Proc. Natl. Acad. Sci. U.S.A 2017 shRNA TL503288
TC10 GTP Hydrolysis of TC10 Promotes Neurite Outgrowth through Exocytic Fusion of Rab11- and L1-Containing Vesicles by Releasing Exocyst Component Exo70 PLoS ONE e79689 Nov 2013 shRNA TF309817
TDP1 Expression Of TDP-43 C-terminal fragments in vitro recapitulates pathological features of TDP-43 proteinopathies J. Biol. Chem., Jan 2009; 10.1074/jbc.M809462200. shRNA TR308891
TESK Tesk1 Interacts with Spry2 to Abrogate Its Inhibition of ERK Phosphorylation Downstream of Receptor Tyrosine Kinase Signaling J. Biol. Chem., Jan 2008; 283: 1679 - 1691. shRNA TR308879
TET2 TET2 Protects against oxLDL-Induced HUVEC Dysfunction by Upregulating the CSE/H2S System Front Pharmacol 2017 shRNA TG303734
Tet2 Ten-Eleven Translocation-2 (Tet2) Is Involved in Myogenic Differentiation of Skeletal Myoblast Cells in Vitro Sci Rep 2017 shRNA TR513547
TET2 Tet methylcytosine dioxygenase 2 inhibits atherosclerosis via upregulation of autophagy in ApoE-/- mice. Oncotarget 2016 shRNA TL303734
TF312515 Hax-1 is required for Rac1-Cortactin interaction and ovarian carcinoma cell migration Genes Cancer March 2014 shRNA TF312515
TFAM Mitochondrial transcription factor A regulated ionizing radiation-induced mitochondrial biogenesis in human lung adenocarcinoma A549 cells J Radiat Res, May 2013; 10.1093/jrr/rrt046. shRNA TR316756
TFEB Oncogenic H-Ras Up-Regulates Acid β-Hexosaminidase by a Mechanism Dependent on the Autophagy Regulator TFEB PLOS ONE, Feb 2014. shRNA TR308867
TGFB1 TGF Beta1 Expression Correlates with Survival and Tumor Aggressiveness of Prostate Cancer Ann. Surg. Oncol. Aug 2015 shRNA TG308855
TGFB1 TGF-ß1 mediates the radiation response of prostate cancer J. Mol. Med. Sep 2014 shRNA TG308855
TGFB1 Altered mineralization of human osteoarthritic osteoblasts is attributable to abnormal type I collagen production Arthritis & Rheumatism Volume 60 Issue 5, Pages 1438 - 1450 shRNA TR308855
TGFBR1 The role of Alk-1 and Alk-5 in the mechanosensing of chondrocytes Cell. Mol. Biol. Lett. Dec 2014 shRNA TG709395
Tgfbr2 TGF-ß Signaling Regulates Cementum Formation through Osterix Expression Sci Rep May 2016 shRNA TR516186
Tgfbr2 Metastatic tumor evolution and organoid modeling implicate TGFBR2 as a cancer driver in diffuse gastric cancer Genome Biology Aug 2014 shRNA TG516186
tGFP The RNA-binding protein LARP1 is a post-transcriptional regulator of survival and tumorigenesis in ovarian cancer Nucleic Acids Res. Dec 2015 shRNA TR30016
TIAM1 Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis Cell Rep Nov 2014 shRNA TG511327
TIMP-1 Targeting tissue inhibitor of metalloproteinase 1/2 using a shRNA lentiviral system offers a novel treatment strategy against hepatic fibrosis Int J Clin Exp Med 2016 shRNA TL712176
TIMP-2 Targeting tissue inhibitor of metalloproteinase 1/2 using a shRNA lentiviral system offers a novel treatment strategy against hepatic fibrosis Int J Clin Exp Med 2016 shRNA TL710553
TIMP1 Regulation of soluble vascular endothelial growth factor receptor 1 secretion from human endothelial cells by tissue inhibitor of metalloproteinase 1 Molecular Human Reproduction, doi:10.1093/molehr/gap053 shRNA TR308814
TIMP3 Mesenchymal Stem Cells Regulate Blood-Brain Barrier Integrity Through TIMP3 Release After Traumatic Brain Injury Science Translational Medicine, Nov 2012; 4: 161ra150. shRNA TR308813
Tissue Imaging of motor-dependent transport in neuronal and nonneuronal cells at high spatial and temporal resolution Methods in Cell Biology Jun 2015 shRNA TR30007
Tle1 Transducin-like Enhancer of Split-1 (TLE1) Combines with Forkhead Box Protein G1 (FoxG1) to Promote Neuronal Survival J. Biol. Chem., Apr 2012; 287: 14749 - 14759. shRNA TG511107
TLK1 DNA damage response and repair data with pharmacological modulators of Tousled Data in Brief Mar 2016 shRNA TG320623
TLR2 Plasmodium falciparum Histidine-Rich Protein II Compromises Brain Endothelial Barriers and May Promote Cerebral Malaria Pathogenesis MBio Jun 2016 shRNA TR320553
TLR4 Resveratrol alleviates lysophosphatidylcholine-induced damage and inflammation in vascular endothelial cells Mol Med Rep 2017 shRNA TG320555
TLR4 HSV-2 Increases TLR4-Dependent Phosphorylated IRFs and IFN-ß Induction in Cervical Epithelial Cells PLoS ONE e94806 9 4. April 2014 shRNA TG320555
TLR4 TLR4-MyD88/Mal-NF-kB Axis Is Involved in Infection of HSV-2 in Human Cervical Epithelial Cells PLoS ONE e80327 Nov 2013 shRNA TG320555
TLR5 Plasmodium falciparum Histidine-Rich Protein II Compromises Brain Endothelial Barriers and May Promote Cerebral Malaria Pathogenesis MBio Jun 2016 shRNA TR308792
TLR9 Plasmodium falciparum Histidine-Rich Protein II Compromises Brain Endothelial Barriers and May Promote Cerebral Malaria Pathogenesis MBio Jun 2016 shRNA TR301076
TM4SF5 Interaction of tetraspan(in) TM4SF5 with CD44 promotes self-renewal and circulating capacities of hepatocarcinoma cells Hepatology Jan 2015 shRNA TG308787
TMEM106A Transmembrane protein 106A is silenced by promoter region hypermethylation and suppresses gastric cancer growth by inducing apoptosis J. Cell. Mol. Med. Jun 2014 shRNA TF301042
TMEM127 Germline mutations in TMEM127 confer susceptibility to pheochromocytoma Nature Genetics 42, 229-233 (14 February 2010) doi:10.1038/ng.533 Letter shRNA TR301024
TMEM142B(Orai2) Evidence for STIM1- and Orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells: role in proliferation and migration FASEB J, Apr 2009; 10.1096/fj.09-131128. shRNA TR301008
TMEM142C(Orai3) Evidence for STIM1- and Orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells: role in proliferation and migration FASEB J, Apr 2009; 10.1096/fj.09-131128. shRNA TR307587
TMEM16F Fusion Stage of HIV-1 Entry Depends on Virus-Induced Cell Surface Exposure of Phosphatidylserine Cell Host Microbe 2017 shRNA TF511035
Tmem16f Calcium-dependent phospholipid scrambling by TMEM16F Nature 468, 834-838 (24 November 2010) doi:10.1038/nature09583 Letter shRNA TR511035
TMEM184A Heparin decreases in TNFa;-induced endothelial stress responses require transmembrane protein 184A and induction of dual specificity phosphatase-1 J. Biol. Chem. Jan 2016 shRNA TG702927
TMEM88 Transmembrane protein 88 (TMEM88) promoter hypomethylation is associated with platinum resistance in ovarian cancer Gynecol. Oncol. 2016 shRNA TR318781
TNF Transmembrane TNF-alpha promotes chemoresistance in breast cancer cells Oncogene 2018 shRNA TG318768
TNFA Targeting Transmembrane TNF-a Suppresses Breast Cancer Growth Cancer Res., Jul 2013; 73: 4061 - 4074. shRNA TG318768
TNFAIP6 Acute and Temporal Expression of TNF-a-stimulated Gene 6 Product,TSG-6,in Mesenchymal Stem Cells Creates Microenvironments Required for Their Successul Transplantation into the Muscle Tissue J. Biol. Chem. Jul 2015 shRNA TF517014
TNFRSF1A TNF-α receptor 1 knockdown in subfornical organ ameliorates sympathetic excitation and cardiac hemodynamics in heart failure rats. Am. J. Physiol. Heart Circ. Physiol. 2017 shRNA TL709687
TNFRSF1B WISP1, a Pro-mitogenic, Pro-survival Factor, Mediates Tumor Necrosis Factor- (TNF-)-stimulated Cardiac Fibroblast Proliferation but Inhibits TNF--induced Cardiomyocyte Death J. Biol. Chem., May 2009; 284: 14414 - 14427 shRNA TR308733
Tnfrsf21 Induction of microRNA-17-5p by p53 protects against renal ischemia-reperfusion injury by targeting death receptor 6 Kidney Int. 2017 shRNA TL706747
TNIK Identification of Phosphorylation Consensus Sequences and Endogenous Neuronal Substrates of the Psychiatric Risk Kinase TNIK J. Pharmacol. Exp. Ther. Dec 2015 shRNA TF320665
TNK2 ACK1 promotes hepatocellular carcinoma progression via downregulating WWOX and activating AKT signaling Int. J. Oncol. May 2015 shRNA TR320634
TNPO3 Knockdown of the host cellular protein transportin 3 attenuates prototype foamy virus infection Biosci. Biotechnol. Biochem. Feb 2015 shRNA TG315644
Tomo1 Dynamic Partitioning of Synaptic Vesicle Pools by the SNARE-Binding Protein Tomosyn J. Neurosci. 2016 shRNA TL518079
TOP2B(GFP vector) Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements Nature Genetics (4 July 2010) doi:10.1038/ng.613 Article shRNA
TOPBP1 ATR Mediates a Checkpoint at the Nuclear Envelope in Response to Mechanical Stress Cell July 2014 shRNA TR308695
TOX3 TOX3 is a neuronal survival factor that induces transcription depending on the presence of CITED1 or phosphorylated CREB in the transcriptionally active complex J. Cell Sci., Jan 2011; 124: 252 - 260 shRNA TR300899
TP300755 Tumours with elevated levels of the Notch and Wnt pathways exhibit efficacy to PF-03084014, a ?-secretase inhibitor, in a preclinical colorectal explant model British Journal of Cancer doi:10.1038/bjc.2013.361 shRNA TF302060
TP53 p53 is essential for embelin-induced apoptosis in p53-wildtype prostate cancer cells Int J Clin Exp Med 2016 shRNA TR320558
TP53 p53 is essential for embelin-induced apoptosis in p53-wildtype prostate cancer cells Int J Clin Exp Med 2016 shRNA TR320558
TP53 Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways PLoS ONE Aug 2015 shRNA TG320558
TP53 Endothelial p53 Deletion Improves Angiogenesis and Prevents Cardiac Fibrosis and Heart Failure Induced by Pressure Overload in Mice J Am Heart Assoc Feb 2015 shRNA TL320558
TP53 Harnessing the p53-PUMA Axis to Overcome DNA Damage Resistance in Renal Cell Carcinoma Neoplasia Dec 2014 shRNA TR320558
TP53 Gene Expression Profiles Resulting from Stable Loss of p53 Mirrors Its Role in Tissue Differentiation PLOS ONE e82494 Nov 2013 shRNA TG320558
TP53 Downregulation of SMG-1 in HPV-Positive Head and Neck Squamous Cell Carcinoma Due to Promoter Hypermethylation Correlates with Improved Survival Clin. Cancer Res., Mar 2012; 18: 1257 - 1267. shRNA TR320558
TP53BP1 Heterozygous PALB2 c.1592delT mutation channels DNA double-strand break repair into error-prone pathways in breast cancer patients Oncogene Dec 2015 shRNA TR308691
TP53BP1 MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5' end resection Nature Mar 2015 shRNA TF308691
TP53BP1 MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5' end resection Nature Mar 2015 shRNA TR308691
TP63 TGFß3 Regulates Periderm Removal through ?Np63 in the Developing Palate J. Cell. Physiol. Oct 2014 shRNA TR308688
TP73 The p53 family member p73 modulates the pro-proliferative role of IGFBP3 in short children born SGA Mol. Biol. Cell Jun 2015 shRNA TR308689
Tpcn2 VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling Proc. Natl. Acad. Sci. U.S.A. Oct 2014 shRNA TR300883
TPR Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways PLoS ONE Aug 2015 shRNA TG308677
TR20003 Circadian Modulation of 8-Oxoguanine DNA Damage Repair Sci Rep Sep 2015 shRNA TR20003
TR20003 Feed forward reciprocal activation of PAFR and STAT3 regulates epithelial-mesenchymal transition in non-small cell lung cancer Cancer Res. Sep 2015 shRNA TR20003
TR20003 Actin-Modulating Protein Cofilin Is Involved in the Formation of Measles Virus Ribonucleoprotein Complex at the Perinuclear Region J. Virol. Aug 2015 shRNA TR20003
TR20003 SLC9A3R1 stimulates autophagy via BECN1 stabilization in breast cancer cells Autophagy Jul 2015 shRNA TR20003
TR20003 STX13 regulates cargo delivery from recycling endosomes during melanosome biogenesis J. Cell. Sci. Jul 2015 shRNA TR20003
TR20003 TNF Apoptosis Protection Fraction (TAPF) prevents apoptosis induced by TNF, but not by Fas or TRAIL, via NF-?B-induced increase in cFLIP Cytokine Jul 2015 shRNA TR20003
TR20003 Different states of integrin LFA-1 aggregation are controlled through its association with tetraspanin CD9 Biochim. Biophys. Acta May 2015 shRNA TR20003
TR20003 Redox signalling to nuclear regulatory proteins by reactive oxygen species contributes to oestrogen-induced growth of breast cancer cells Br. J. Cancer May 2015 shRNA TR20003
TR20003 Characterisation of mesothelioma-initiating cells and their susceptibility to anti-cancer agents PLoS ONE May 2015 shRNA TR20003
TR20003 Involvement of aldehyde dehydrogenase 1A2 in the regulation of cancer stem cell properties in neuroblastoma Int. J. Oncol. Dec 2014 shRNA TR20003
TR20003 STING agonists induce an innate antiviral immune response against hepatitis B virus Antimicrob. Agents Chemother. Dec 2014 shRNA TR20003
TR30002 Aberrant glycosylation promotes lung cancer metastasis through adhesion to galectins in the metastatic niche Cancer Discov Nov 2014 shRNA TR30002
TR30003 A novel miR-371a-5p-mediated pathway, leading to BAG3 upregulation in cardiomyocytes in response to epinephrine, is lost in Takotsubo cardiomyopathy Cell Death Dis Oct 2015 shRNA TR30003
TR30003 TNF Apoptosis Protection Fraction (TAPF) prevents apoptosis induced by TNF, but not by Fas or TRAIL, via NF-?B-induced increase in cFLIP Cytokine Jul 2015 shRNA TR30003
TR30007 Transcription factor ICBP90 regulates the MIF promoter and immune susceptibility locus J. Clin. Invest. Feb 2016 shRNA TR30007
TR30007 Effect of Co-transfection of Anti-myostatin shRNA Constructs in Caprine Fetal Fibroblast Cells Anim. Biotechnol. Jan 2016 shRNA TR30007
TR30007 SLAMF1 regulation of chemotaxis and autophagy determines CLL patient response J. Clin. Invest. Jan 2016 shRNA TR30007
TR30007 Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways PLoS ONE Aug 2015 shRNA TR30007
TR30007 Effects of Ezrin and Heat Shock Protein 70 on Apoptosis and Proliferation of Human Osteosarcoma Cells Orthop Surg Aug 2015 shRNA TR30007
TR30007 Fe65 Suppresses Breast Cancer Cell Migration and Invasion through Tip60 Mediated Cortactin Acetylation Sci Rep Jul 2015 shRNA TR30007
TR30007 Cellular and subcellular imaging of motor protein-based behavior in embryonic rat brain Methods in Cell Biology Jun 2015 shRNA TR30007
TR30007 Construction of DKK1-siRN