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siRNA Related Product

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SKU
SR30003
Trilencer-27 HPRT Positive control siRNA duplex - 1 nmol
  $142.00
In Stock*

Frequently Bought Together (1)

TT300007S A non-viral, non-electroporation, non-liposomal transfection kit using engineered mammalian proteins, tailored for high-efficiency delivery into a wide range of primary cells and difficult to transfect cell lines such as immune cells, stem cells, and neuronal cells.
20 ul
$265.00
Specifications
Specifications
Product Data
Quality Control This duplex was sequence verified and functionally validated.
Storage Store at -20°C.
Components
1 vial of HPRT Positive control siRNA duplex (1 nmol)
Stability The control is stable for one year from date of shipping when stored at -20oC.
Shipping Ambient
Note Single siRNA duplex (10nmol) can be ordered.
Reference Data
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Documents
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file-alt Citations

The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension
Sporbeck, Haas, Pastor-Maldonado et al
Commun Biol (2023) 6 (1), 872 DOI: 10.1038/s42003-023-05236-9
Cited by 13
AI Summary: In this study, OriGene products pCMV6-MAPK1 (MR222304-OR) and pCMV6-Entry (PS100001) were used as expression plasmids to investigate the molecular pathways regulating WIPI1-mediated autophagy and its impact on lifespan extension.
Snippet: ds were used to express tagged WIPI1 and WIPI2 fusion proteins: GFP-WIPI17,9, GFP-WIPI2B7,9, 9E10-WIPI114 and mCherry-WIPI186. pCMV6-MAPK1 (MR222304-OR) and pCMV6-Entry (PS100001) were purchased from Origene. pCMV-myc-ERK2-MEK1_fusion was provided by Melanie Cobb (Addgene, #39197). pCMV3-untagged negative control plasmid (CV011) and pCMV3-untagged c-MYC cDNA ORF (HG11346-UT) were purchased from Si
FigureFigureFigure
Id4 promotes the elimination of the pro-activation factor Ascl1 to maintain quiescence of adult hippocampal stem cells
Blomfield, Rocamonde, Masdeu et al
Elife (2019) 8 DOI: 10.7554/eLife.48561
AI Summary: In this study, OriGene's HPRT-targeting siRNA was used as a positive control to validate the efficiency of siRNA-mediated gene silencing in neural stem cell experiments investigating the role of Id4 in maintaining stem cell quiescence.
Snippet: … NSCs were transfected with a cocktail of three siRNAs at 20 nM each, or 60 nM control scrambled siRNA, or 60 nM HPRT-targeting siRNA as a positive control (Origene). To silence Id4 in combination with Id1, Id2 or Id3, 30 nM of Id4 ‘A’ siRNA was co-transfected with 30 nM of siRNA ‘A’ targeting Id1, 2 or 3. …
FigureFigureFigure
The N-recognin UBR4 of the N-end rule pathway is targeted to and required for the biogenesis of the early endosome
Kim, Lee, Tasaki et al
J. Cell. Sci. (2018)
AI Summary: OriGene's EEA1 siRNA (Cat# SR30003) was used in this study to selectively knock down EEA1 expression, enabling the investigation of EEA1's role alongside UBR4 in early endosome biogenesis.
Snippet: Technologies. Transfection was performed according to the manufacture's protocol. Briefly, Cells were transfected with either siControl (cat. #4390843), EEA1 siRNA (Origene, Cat#SR30003), or UBR4 siRNA (cat. #4392420, ID #23628) at a final concentration of 10
DNA Methylation Profiling in Human Huntington's Disease Brain
De Souza, Islam, McEwen et al
Hum. Mol. Genet. (2016)
Cited by 74
AI Summary: OriGene contributed three CTCF siRNA constructs (SR307273), an HPRT siRNA (SR30003), and a scramble siRNA (SR30004) to this study, which were used to knock down target genes in HEK293 cells to assess the effects on gene expression relevant to DNA methylation and Huntington's Disease.
Snippet: Three siRNA constructs for CTCF, a siRNA against HPRT, and a scramble siRNA were obtained from Origene (Catalogue numbers: SR307273, SR30003, SR30004). … In the case of CTCF, a cocktail of equal amounts all three siRNA variants was used. 48 hours after transfection, cells were collected and processed for RT-qPCR as detailed above. …
Showing 1-4 of 4 papers.
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