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SOD2 Human siRNA Oligo Duplex (Locus ID 6648)

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SKU
SR321855
SOD2 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each
  • SR321855 is the updated version of SR304519.
  $518.00
In Stock*

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Other products for "SOD2 or NM_000636"

Specifications
Specifications
Product Data
Purity HPLC purified
Quality Control Tested by ESI-MS
Sequences Available with shipment
Components
SOD2 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 6648)
Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmol
Included - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml
Stability One year from date of shipment when stored at -20°C.
Shipping Ambient
# of Transfections Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM).
Note Single siRNA duplex (10nmol) can be ordered.
Reference Data
RefSeq NM_000636, NM_001024465, NM_001024466, NM_001322814, NM_001322815, NM_001322816, NM_001322817, NM_001322819, NM_001322820
UniProt ID P04179
Synonyms GClnc1; IPO-B; IPOB; Mn-SOD; MNSOD; MVCD6
Summary This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. provided by RefSeq, Apr 2016
Performance Guaranteed OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency.

For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required).
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Documents
Resources

file-alt Citations

Nimbolide Inhibits SOD2 to Control Pancreatic Ductal Adenocarcinoma Growth and Metastasis
Mehmetoglu-Gurbuz, Lakshmanaswamy, Perez et al
Antioxidants (2023) 12 (10), 1791 DOI: 10.3390/antiox12101791
Cited by 14
AI Summary: OriGene contributed to this study by providing three different SOD2 siRNA subtypes (Cat# SR321855), which were used to silence SOD2 expression and investigate its role in pancreatic cancer cell growth and metastasis.
Snippet: …Silencing SOD2 in Pancreatic Cell Line Three different SOD2 siRNA subtypes were obtained from OriGene (Cat# SR321855, Rockville, MD, USA) with different sequences (see Supplementary Materials) were used. Mirus bio TransIT siQUEST (Cat#MIR2110, Marietta, GA, USA) transfection reagent was used f;Three different SOD2 siRNA subtypes were obtained from OriGene (Cat# SR321855, Rockville, MD, USA) with different sequences (see Supplementary Materials) were used
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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