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TDP43 (TARDBP) Human shRNA Plasmid Kit (Locus ID 23435)

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SKU
TL308946
TARDBP - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
4 Weeks*

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Specifications
Specifications
Product Data
Locus ID 23435
Synonyms ALS10; TDP-43
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components TARDBP - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 23435). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_007375, NM_007375.1, NM_007375.2, NM_007375.3, BC095435, BC095435.1, BC001487, BC059955, BC071657, BM716882, NM_007375.4
UniProt ID Q13148
Summary HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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file-alt Citations

The Abl1 tyrosine kinase is a key player in doxorubicin-induced cardiomyopathy and its p53/p73 cell death mediated signaling differs in atrial and ventricular cardiomyocytes
Borlak, Ciribilli, Bisio et al
Research Square (2024)
Snippet: e reader (Berthold technologies, Milan, Italy). WESTERN BLOTTING AND IMMUNOFLUORESCENCE MICROSCOPY We examined CDK1 (BM2206P, Acris Antibodies GmbH, Hiddenhausen, Germany which has been acquired by OriGene Technologies) and Abl1 protein expression (A5844, Sigma-Aldrich Chemie, Munich, Germany) in nuclear extracts of heart and liver tissue and cell culture assays by Western immunoblotting. In add...
Neuronal STING activation in amyotrophic lateral sclerosis and frontotemporal dementia
Marques, Held, Dorfman et al
Acta Neuropathol (2024) 147 (1), 56 DOI: 10.1007/s00401-024-02688-z
Cited by 63
AI Summary: OriGene contributed lentiviral shRNAs targeting TDP-43 and a scrambled shRNA control (product: TL308946V), which were used to manipulate TDP-43 expression in neuronal cells to study STING pathway activation in ALS/FTD models.
Snippet: … Lentiviral shRNA neuronal transduction Two separate lentiviral shRNAs directed against TDP-43 and a scrambled shRNA control were obtained from Origene (TL308946V). For shRNA lentiviral particle transduction, isoTDP-43+/+ NGN2 neurons were incubated for 4 h with media containing lentivirus particles for GFP-shScramble or GFP-shTDP-43 and cul;- Two separate lentiviral shRNAs directed against TDP-43 and a scrambled shRNA control were obtained from Origene (TL308946V). …
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Showing 1-2 of 2 papers.
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