SOD2 (NM_000636) Human Tagged ORF Clone
SKU
RC202330
SOD2 (Myc-DDK-tagged)-Human superoxide dismutase 2, mitochondrial (SOD2), nuclear gene encoding mitochondrial protein, transcript variant 1
$450.00
In Stock*
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
|---|---|
| Target Symbol | SOD2 |
| Synonyms | GClnc1; IPO-B; IPOB; Mn-SOD; MNSOD; MVCD6 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Chromatograms |
Chromatograms
 Sequencher program is needed, download here |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_000636 |
| ORF Size | 666 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_000636.4 |
| RefSeq Size | 1593 bp |
| RefSeq ORF | 669 bp |
| Locus ID | 6648 |
| UniProt ID | P04179, A0A384NL29 |
| Cytogenetics | 6q25.3 |
| Domains | sodfe |
| Protein Families | Druggable Genome, Transcription Factors |
| Protein Pathways | Huntington's disease |
| MW | 24.8 kDa |
| Summary | This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. provided by RefSeq, Apr 2016 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_000636" in other vectors (7)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC202330L1 | Lenti ORF clone of Human superoxide dismutase 2, mitochondrial (SOD2), nuclear gene encoding mitochondrial protein, transcript variant 1, Myc-DDK-tagged | 10 ug |
$750.00
|
|
| RC202330L2 | Lenti ORF clone of Human superoxide dismutase 2, mitochondrial (SOD2), nuclear gene encoding mitochondrial protein, transcript variant 1, mGFP tagged | 10 ug |
$750.00
|
|
| RC202330L3 | Lenti ORF clone of Human superoxide dismutase 2, mitochondrial (SOD2), nuclear gene encoding mitochondrial protein, transcript variant 1, Myc-DDK-tagged | 10 ug |
$750.00
|
|
| RC202330L4 | Lenti ORF clone of Human superoxide dismutase 2, mitochondrial (SOD2), nuclear gene encoding mitochondrial protein, transcript variant 1, mGFP tagged | 10 ug |
$750.00
|
|
| RG202330 | SOD2 (tGFP-tagged) - Human superoxide dismutase 2, mitochondrial (SOD2), nuclear gene encoding mitochondrial protein, transcript variant 1 | 10 ug |
$650.00
|
|
| SC127816 | SOD2 (untagged)-Human superoxide dismutase 2, mitochondrial (SOD2), nuclear gene encoding mitochondrial protein, transcript variant 1 | 10 ug |
$450.00
|
|
| SC323760 | SOD2 (untagged)-Human superoxide dismutase 2, mitochondrial (SOD2), nuclear gene encoding mitochondrial protein, transcript variant 1 | 10 ug |
$450.00
|
|
Citations
Proteomic and functional analysis on endothelial cell heterogeneity identifies key regulators in hyperglycemia-induced dysfunction
Minjares, Jaiswal, Li et al
Am J Physiol Cell Physiol (2025) 329 (6), C1894-C1906 DOI: 10.1152/ajpcell.00273.2025
Minjares, Jaiswal, Li et al
Am J Physiol Cell Physiol (2025) 329 (6), C1894-C1906 DOI: 10.1152/ajpcell.00273.2025
Cited by 2
SOD2 is a regulator of proteasomal degradation promoting an adaptive cellular starvation response
Ibrahim, Schreek, Cinar et al
Cell Rep (2025) 44 (4), 115434 DOI: 10.1016/j.celrep.2025.115434
Ibrahim, Schreek, Cinar et al
Cell Rep (2025) 44 (4), 115434 DOI: 10.1016/j.celrep.2025.115434
Cited by 5
The Impact of Heterogeneity on Endothelial Function Under Hyperglycemia
Minjares
Thesis (2025)
Minjares
Thesis (2025)
AI Summary: OriGene products contributed to this study by providing the SOD2 overexpression plasmid (#RC202330) and the control plasmid pCMV6-Entry (#PS100001), which were used to investigate the effects of SOD2 overexpression on endothelial function under hyperglycemic conditions.
Snippet: sfection success. 5.2.6 Plasmid Overexpression The SOD2 overexpression plasmid (#RC202330) and the control plasmid pCMV6- Entry (#PS100001) were purchased from ORIGENE. TurboFectin reagent was used as per the manufacturer’s protocol. HDMVECs were treated in 6-well plates for 72 hours in combination with the high glucose or manni
Mitochondrial DNA transcription and mitochondrial genome-encoded long noncoding RNA in diabetic retinopathy
Kumar, Kowluru
Mitochondrion (2024) 78, 101925 DOI: 10.1016/j.mito.2024.101925
Kumar, Kowluru
Mitochondrion (2024) 78, 101925 DOI: 10.1016/j.mito.2024.101925
Cited by 6
AI Summary: OriGene products contributed to this study by providing plasmids for mitochondrial superoxide dismutase (Sod2, Cat no. RC202330) and Sirtuin 1 (Sirt1, Cat No. RC218134), which were used to investigate their protective roles in mitochondrial DNA transcription and homeostasis in diabetic retinopathy.
Snippet: Biotech, Piscataway, NJ, USA), or the gene encoding for mitochondrial superoxide dismutase (Sod2, Cat no. RC202330, OriGene Technologies, Rockville, MD, USA), or Sirtuin 1 (Sirt1, Cat No. RC218134, OriGene Technologies), or with LncCytB-siRNA (Seq: 5′ GTCTGCGGCTAGGAGTCAA-3;Cat No. ID:339511, Qiagen, Valencia, CA, USA), using the transfection protocols
M6A demethylase ALKBH5 regulates FOXO1 mRNA stability and chemoresistance in triple-negative breast cancer
Liu, Li, Huang et al
Redox Biol (2023) 69, 102993 DOI: 10.1016/j.redox.2023.102993
Liu, Li, Huang et al
Redox Biol (2023) 69, 102993 DOI: 10.1016/j.redox.2023.102993
Cited by 61
AI Summary: OriGene products, specifically the pCMV6-SOD2 expression plasmid (Cat. No RC202330) and the pCMV6-XL5 empty plasmid, were used in this study to manipulate SOD2 expression in TNBC cells, enabling the investigation of SOD2’s role in ROS regulation and chemoresistance.
Snippet: … Expression plasmid for pCMV6-SOD2 (Cat. No RC202330), and pCMV6-XL5 empty plasmid was purchased from Origene (Rockville, MD). … After 72 h transfection, stably expressing;Expression plasmid for pCMV6-SOD2 (Cat. No RC202330), and pCMV6-XL5 empty plasmid was purchased from Origene (Rockville, MD). …
Targeting prooxidant MnSOD effect inhibits triple-negative breast cancer (TNBC) progression and M2 macrophage functions under the oncogenic stress
Al Haq, Tseng, Chen et al
Cell Death Dis (2022) 13 (1), 49 DOI: 10.1038/s41419-021-04486-x
Al Haq, Tseng, Chen et al
Cell Death Dis (2022) 13 (1), 49 DOI: 10.1038/s41419-021-04486-x
Cited by 51
AI Summary: OriGene’s breast cancer cDNA arrays were used to analyze and demonstrate elevated SOD2 mRNA expression in advanced-stage breast tumor tissues, supporting the study’s findings on MnSOD’s role in TNBC progression.
Snippet: at MCTS1 and SOD2 expression was positively correlated in breast cancer patients (p ;- Further characterization of SOD2 mRNA levels was conducted with breast cancer cDNA arrays (OriGene). SOD2 expression was enriched among stage II (3.57-fold) and advanced-stage (III/IV) (7.36-fold) tumor tissues (Fig. 1D) relative to normal breast tissues.
Showing 1-6 of 18 papers.
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