Superoxide Dismutase 3 (SOD3) (NM_003102) Human Tagged ORF Clone
$450.00
In Stock*
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
|---|---|
| Target Symbol | Superoxide Dismutase 3 |
| Synonyms | EC-SOD |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Chromatograms |
Chromatograms
 Sequencher program is needed, download here |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_003102 |
| ORF Size | 720 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_003102.1, NP_003093.1 |
| RefSeq Size | 1546 bp |
| RefSeq ORF | 723 bp |
| Locus ID | 6649 |
| UniProt ID | P08294 |
| Cytogenetics | 4p15.2 |
| Domains | sodcu |
| Protein Families | Druggable Genome, Secreted Protein |
| MW | 25.9 kDa |
| Summary | This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the brain, lungs, and other tissues from oxidative stress. Proteolytic processing of the encoded protein results in the formation of two distinct homotetramers that differ in their ability to interact with the extracellular matrix (ECM). Homotetramers consisting of the intact protein, or type C subunit, exhibit high affinity for heparin and are anchored to the ECM. Homotetramers consisting of a proteolytically cleaved form of the protein, or type A subunit, exhibit low affinity for heparin and do not interact with the ECM. A mutation in this gene may be associated with increased heart disease risk. provided by RefSeq, Oct 2015 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_003102" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC204156L1 | Lenti ORF clone of Human superoxide dismutase 3, extracellular (SOD3), Myc-DDK-tagged | 10 ug |
$750.00
|
|
| RC204156L2 | Lenti ORF clone of Human superoxide dismutase 3, extracellular (SOD3), mGFP tagged | 10 ug |
$750.00
|
|
| RC204156L3 | Lenti ORF clone of Human superoxide dismutase 3, extracellular (SOD3), Myc-DDK-tagged | 10 ug |
$750.00
|
|
| RC204156L4 | Lenti ORF clone of Human superoxide dismutase 3, extracellular (SOD3), mGFP tagged | 10 ug |
$750.00
|
|
| RG204156 | SOD3 (tGFP-tagged) - Human superoxide dismutase 3, extracellular (SOD3) | 10 ug |
$650.00
|
|
| SC118157 | SOD3 (untagged)-Human superoxide dismutase 3, extracellular (SOD3) | 10 ug |
$300.00
|
|
Citations
HDAC6 inhibition upregulates endothelial SOD3 expression via Sp1 acetylation and attenuates angiotensin II-induced hypertension
Chi, Do, Kausar et al
FEBS J (2025)
Chi, Do, Kausar et al
FEBS J (2025)
Cited by 5
AI Summary: OriGene products Sp1-Myc-FLAG (#RC209154) and SOD3-Myc-FLAG (#RC204156), subcloned into the pCMV6-Entry vector (#PS100001), were used for overexpression studies to investigate the roles of Sp1 and SOD3 in HDAC6 inhibition-mediated regulation of oxidative stress and hypertension.
Snippet: … Sp1-Myc-FLAG (#RC209154) and SOD3-Myc-FLAG (#RC204156), subcloned into the pCMV6-Entry vector (#PS100001), were purchased from OriGene Technologies (Rockville, MD, USA). The K703R mutation was introduced into the Sp1-Myc-FLAG template using the Muta-Direct Site Directed Mutagenesis Kit (#15071, iNtRON Biotechnology, Se
Inhibition of HDAC6 elicits anticancer effects on head and neck cancer cells through Sp1/SOD3/MKP1 signaling axis to downregulate ERK phosphorylation
Kausar, Nguyen, Le et al
Cell Signal (2025) 127, 111587 DOI: 10.1016/j.cellsig.2024.111587
Kausar, Nguyen, Le et al
Cell Signal (2025) 127, 111587 DOI: 10.1016/j.cellsig.2024.111587
Cited by 4
AI Summary: OriGene products SOD3-FLAG (#RC204156) and pCMV6-Entry vector (#PS100001) were used in this study to overexpress SOD3 and as a control vector, respectively, enabling the researchers to investigate the molecular mechanisms by which HDAC6 inhibition affects antioxidant enzyme levels and cancer cell signaling.
Snippet: 54), SOD3-FLAG (#RC204156), and pCMV6-Entry vector (#PS100001) were purchased from OriGene Technologies (Rockville, MD, USA). The lysine 703 residue in the Sp1-FLAG plasmid was mutated to arginine using primers (forward: 5′-GGAGTGACCACCTGTCAAGACATATCAAGACCCACC-3′;reverse: 5′-GGTGGGTCTTGATATGTCTTGACAGGTGGTCACTCC-3′) and the M
Maternal Exercise-Induced SOD3 Reverses the Deleterious Effects of Maternal High Fat Diet on Offspring Metabolism Through Stabilization of H3K4me3 and Protection Against WDR82 Carbonylation
Kusuyama, Makarewicz, Albertson et al
Diabetes (2022) 71 (6), 1170-1181 DOI: 10.2337/db21-0706
Kusuyama, Makarewicz, Albertson et al
Diabetes (2022) 71 (6), 1170-1181 DOI: 10.2337/db21-0706
Cited by 40
SOD3 Acts as a Tumor Suppressor in PC-3 Prostate Cancer Cells via Hydrogen Peroxide Accumulation
KIM, MIZOKAMI, SHIN et al
Anticancer Research (2014) 34, 2821-2831
KIM, MIZOKAMI, SHIN et al
Anticancer Research (2014) 34, 2821-2831
AI Summary: OriGene's pCMV6-SOD3 plasmid and pCMV6-Entry vector were used to transiently and stably transfect PC-3 prostate cancer cells, enabling the study of SOD3's tumor suppressor function in the research.
Snippet: PC-3 cells were transiently and stably transfected with 0.25, 0.5, and 1 μg of pCMV6-SOD3 plasmid or pCMV6-Entry plasmid as a vector control (OriGene Technologies, Rockville, MD, USA) by Lipofectamine Reagent (Invitrogen) according to the manufacturer's ... Cite SaveSaving
Showing 1-4 of 4 papers.
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