Superoxide Dismutase 3 (SOD3) (NM_003102) Human Tagged ORF Clone Lentiviral Particle
- LentiORF®
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Specifications
| Product Data | |
| Type | Human Tagged ORF Clone Lentiviral Particle |
|---|---|
| Tag | mGFP |
| Target Symbol | Superoxide Dismutase 3 |
| Synonyms | EC-SOD |
| Vector | pLenti-C-mGFP |
| Mammalian Cell Selection | None |
| Sequence Data | |
| ACCN | NM_003102 |
| ORF Size | 720 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NM_003102.2, NP_003093.1 |
| RefSeq Size | 1546 bp |
| RefSeq ORF | 723 bp |
| Locus ID | 6649 |
| UniProt ID | P08294 |
| Cytogenetics | 4p15.2 |
| Domains | sodcu |
| Protein Families | Druggable Genome, Secreted Protein |
| MW | 25.9 kDa |
| Summary | This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the brain, lungs, and other tissues from oxidative stress. Proteolytic processing of the encoded protein results in the formation of two distinct homotetramers that differ in their ability to interact with the extracellular matrix (ECM). Homotetramers consisting of the intact protein, or type C subunit, exhibit high affinity for heparin and are anchored to the ECM. Homotetramers consisting of a proteolytically cleaved form of the protein, or type A subunit, exhibit low affinity for heparin and do not interact with the ECM. A mutation in this gene may be associated with increased heart disease risk. provided by RefSeq, Oct 2015 |
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