Superoxide Dismutase 1 (SOD1) Mouse Monoclonal Antibody [Clone ID: OTI8B10]
$447.00
In Stock*
Specifications
| Product Data | |
| Clone Name | OTI8B10 |
|---|---|
| Application | FC, IHC, WB |
| Recommended Dilution | WB 1:1000~2000, IHC 1:50, FLOW 1:100 |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG2b |
| Clonality | Monoclonal |
| Immunogen | Full length human recombinant protein of human SOD1 (NP_000445) produced in HEK293T cell. |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide |
| Concentration | 1 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 15.8 kDa |
| Gene Name | superoxide dismutase 1 |
| Database Link | |
| Background | The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. provided by RefSeq |
| Synonyms | ALS; ALS1; HEL-S-44; homodimer; hSod1; IPOA; SOD |
| Reference Data | |
| Protein Categories | Cytokines, Intracellular Proteins, Nervous system: Neurodegenerative diseases |
| Protein Families | Druggable Genome |
| Protein Pathways | Amyotrophic lateral sclerosis (ALS), Huntington's disease, Prion diseases |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "OTI8B10" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| CF500495 | Carrier-free (BSA/glycerol-free) SOD1 mouse monoclonal antibody, clone OTI8B10 (formerly 8B10) | 100 ug |
$620.00
|
|
| TA500495AM | SOD1 mouse monoclonal antibody, clone 8B10, Biotinylated | 100 ul |
$509.00
|
|
| TA500495BM | SOD1 mouse monoclonal antibody, clone 8B10, HRP conjugated | 100 ul |
$509.00
|
|
| TA500495S | SOD1 (Superoxide Dismutase 1) mouse monoclonal antibody, clone OTI8B10 (formerly 8B10) | 30 ul |
$200.00
|
|
Citations
Housefly (Musca domestica) larvae powder, preventing oxidative stress injury via regulation of UCP4 and CyclinD1 and modulation of JNK and P38 signaling in APP/PS1 mice
He, Yang, Jiao et al
Food Funct (2019) 10 (1), 235-243 DOI: 10.1039/c8fo02052c
He, Yang, Jiao et al
Food Funct (2019) 10 (1), 235-243 DOI: 10.1039/c8fo02052c
Cited by 7
AI Summary: In this study, OriGene products—specifically the anti-UCP4 antibody (TA326085), anti-CyclinD1 antibody (TA500249), anti-SOD1 antibody (TA500053), and anti-CAT antibody (TA352768)—were used for immunohistochemistry and western blot analyses to assess protein expression levels in APP/PS1 mice, thereby enabling evaluation of the protective effects of housefly larvae powder against oxidative stress and memory impairment.
Protein-rich extract of Musca domestica larvae alleviated metabolic disorder in STZ-induced type 2 diabetic rat model via hepatoprotective and pancreatic β-cell protective activities
Mei, Xu, He et al
J Biosci (2018) 43 (5), 969-983
Mei, Xu, He et al
J Biosci (2018) 43 (5), 969-983
AI Summary: In this study, OriGene products—including anti-GLUT4 antibody (TA327321), anti-PPARγ antibody (TA328582), and anti-SOD1 antibody (TA500053)—were used for detecting the expression of key metabolic and oxidative stress-related proteins via immunohistochemistry and western blot, helping to elucidate the mechanisms by which Musca domestica larvae extract alleviated metabolic disorders in diabetic rats.
Defective activation of the MAPK/ERK pathway, leading to PARP1 and DNMT1 dysregulation, is a common defect in IgA nephropathy and Henoch-Schönlein purpura
Milillo, Molinario, Costanzi et al
J. Nephrol. (2018)
Milillo, Molinario, Costanzi et al
J. Nephrol. (2018)
AI Summary: OriGene contributed to this study by providing the anti-BCL2 antibody, which was used to assess BCL2 protein expression levels as part of the molecular analysis of the MAPK/ERK pathway in IgA nephropathy and Henoch-Schönlein purpura patients.
Snippet: and quanti- fied with Image J. In this study, the following primary antibodies were used: anti-human IgA (Novus Biological, 1:5000), anti- human ERK1/2 (Cell Signalling 1:1000), anti-human phospho ERK1/2 (Pierce 1:1000, Cell Signalling 1:2000), anti-BCL2 (Origene
Pterostilbene Decreases the Antioxidant Defenses of Aggressive Cancer Cells in Vivo: a Physiological Glucocorticoids- and Nrf2-Dependent Mechanism
Benlloch, Obrador, Valles et al
Antioxid. Redox Signal. (2015)
Benlloch, Obrador, Valles et al
Antioxid. Redox Signal. (2015)
Cited by 68
AI Summary: OriGene’s anti-human SOD1 and CAT monoclonal antibodies were used for western blot analysis to measure antioxidant enzyme levels in cancer cells, helping to assess the effects of pterostilbene on cellular antioxidant defenses in this study.
Snippet: Proteins were transferred to a nitrocellulose membrane and subjected to western blotting with anti-human SOD1 or CAT monoclonal antibodies (OriGene, Rockville, MD). Blots were developed using horseradish peroxidase-conjugated secondary antibody and enhanced chemiluminescence (ECL system, Amersham). …
Showing 1-4 of 4 papers.
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