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MRP5 (ABCC5) Human Gene Knockout Kit (CRISPR)

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SKU
KN217669BN
ABCC5 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Vector mBFP-Neo
Target Symbol MRP5
Locus ID 10057
Components

KN217669G1, MRP5 gRNA vector 1 in pCas-Guide CRISPR vector

KN217669G2, MRP5 gRNA vector 2 in pCas-Guide CRISPR vector

KN217669BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001023587, NM_001320032, NM_005688, NR_135125
UniProt ID O15440
Synonyms ABC33; EST277145; MOAT-C; MOATC; MRP5; pABC11; SMRP
Summary The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants. provided by RefSeq, Feb 2016
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Documents
Resources
Other Versions
SKU Description Size Price
GA106814 ABCC5 CRISPRa kit - CRISPR gene activation of human ATP binding cassette subfamily C member 5 1 kit
$1,657.00
KN217669 ABCC5 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN217669LP ABCC5 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN217669RB ABCC5 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN417669 ABCC5 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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