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Human MRP5 (ABCC5) activation kit by CRISPRa

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SKU
GA106814
ABCC5 CRISPRa kit - CRISPR gene activation of human ATP binding cassette subfamily C member 5
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA808487 ABCC5 mouse monoclonal antibody, clone OTI2C8 (formerly 2C8) 100 ul
$447.00
RC217669 ABCC5 (Myc-DDK-tagged)-Human ATP-binding cassette, sub-family C (CFTR/MRP), member 5 (ABCC5), transcript variant 2
10 ug
$450.00

Other products for "ABCC5"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol ABCC5
Locus ID 10057
Components

GA106814G1, MRP5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA106814G2, MRP5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA106814G3, MRP5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001023587, NM_001320032, NM_005688, NR_135125
UniProt ID O15440
Synonyms ABC33; EST277145; MOAT-C; MOATC; MRP5; pABC11; SMRP
Summary The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants. provided by RefSeq, Feb 2016
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Documents
Resources
Other Versions
SKU Description Size Price
KN217669 ABCC5 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN217669BN ABCC5 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN217669LP ABCC5 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN217669RB ABCC5 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN417669 ABCC5 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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