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Mcam Mouse Gene Knockout Kit (CRISPR)

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SKU
KN309859RB
Mcam - mouse gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
Vector RFP-BSD
Target Symbol Mcam
Locus ID 84004
Components

KN309859G1, Mcam gRNA vector 1 in pCas-Guide CRISPR vector, Target Sequence: CGCCCGACCTGGTGGAGGCA

KN309859G2, Mcam gRNA vector 2 in pCas-Guide CRISPR vector, Target Sequence: TGTGGCCCCTCACGGGCCTC

KN309859RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette.

Homologous arm and RFP-BSD sequences:

pUC vector backbone in gray; Left arm sequence in blue; RFP-BSD in green; Right arm in violet

CTGACGTCAC TCCTGCCCAC TCTCTGGTTT TTGACCTAAC CCTTGGCGGA GACTGACCCC TCTAGACTTG GATGGGGTCT TCAGATTGTA TTGCAGCGTT TCTTGACATG CTACTGTGGG AACATAAATC ATAGCCTCTG GCTAGAGTTG GCTCACTGTG TCTTCCAGAG GATTTGGGGG ACAGAGGGTA GAATAGTGAC GTCTTCGTGG AGGGGGGGCA CACAAAGGGG CCTGTGTGCC CCAGCCTGGC ACATGCCTTA CATTCCCCTA GTCTGAGCTC ACCAGGACTA GGAAGGGGCC CAGGAGCAAA GGGGCCTTCA TCTTGGCCCA GAGCCCATGT TGCTCTTATC TGTCTCTCCA CCAGCTTCTT CTAAGATATA CCCAGTCACT CTGTCTGTGT TTCACTCCGT ATTACACTGG GAGAGGTCTG ACCCAGGTTG GGGGTGTGGG CTTGGTGAAG TTGAGGGTAA GGAGAGGGTA AGGCCCTCCC CAGACCCTTC AAGTGGGACA GCTGCAGTGA ACCAGGAGAG GGGAGGGGAC CGGACAGAAC ACCTGGAGCT GACAAAGCTG CCTGGGCATG CCCCTCTCTT TCCCCAGGTG CAACTTCAGC CAAGTGGACT GGTTTTTGGT GAGCGCCTGG ACTTTGGAGG GCAGTAGTTG TGTGGGAAGC AACTGTCTCT CTGGCAGGTA GCTCATCTCT CAGCTCCTTT CCCTCAGATT CACAAGGAGA GGCAGATACT GATTTTCCGT GTGCACCAAG GCAAGGGCCA GCGGGAACCT GGTGAATATG AGCACCGCCT TAGCCTCCAA GACTCGGTGG CTACTCTGGC CCTGAGTCAC GTCACTCCCC ATGATGAGCG AATGTTCCTG TGTAAGAGCA AGCGACCACG GCTCCAGGAT CACTACGTTG AGCTTCAGGT CTTCAGTGAG TGCCCCCCTC GTTTCTGCCT TCAGGGTCGT GTGGACCATG TAGCAAAGAT GGGTCTCCAT GTCCCTGTTC ATTCCCCTTC CACTGTAGAA GCCCCAGAGG AACCAACTAT TCAAGCCAAT GTCGTGGGCA TCCATGTGGA CAGGCAAGAG CTCAGGGAGG TGAGAGGCAC TCGGTCAAAT GATGGTGGAT AGAGGCTAAG CAGGGACGGG GGTGGGGGGG GGTGGTATGT GGCAGACGCA AGGAGACTCT CGTCCTGTCC TCCTTAGGTT

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_023061, NM_001359530
UniProt ID Q8R2Y2
Synonyms 1-gicerin; AV025631; CD146; CD149; Muc18; s-endo; s-gicerin
Summary Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration (By similarity).UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
GA211277 Mcam CRISPRa kit - CRISPR gene activation of mouse melanoma cell adhesion molecule 1 kit
$1,657.00
KN309859 Mcam - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN309859BN Mcam - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN309859LP Mcam - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN509859 Mcam - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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