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E Cadherin (CDH1) Human Gene Knockout Kit (CRISPR)

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SKU
KN220731LP
CDH1 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "E Cadherin or NM_001317184"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Vector Luciferase-Puro
Target Symbol E Cadherin
Locus ID 999
Components

KN220731G1, E Cadherin gRNA vector 1 in pCas-Guide CRISPR vector

KN220731G2, E Cadherin gRNA vector 2 in pCas-Guide CRISPR vector

KN220731LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001317184, NM_001317185, NM_001317186, NM_004360
UniProt ID P12830
Synonyms Arc-1; CD324; CDHE; ECAD; LCAM; UVO
Summary This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. provided by RefSeq, Nov 2015
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Documents
Resources
Other Versions
SKU Description Size Price
GA100713 CDH1 CRISPRa kit - CRISPR gene activation of human cadherin 1 1 kit
$1,657.00
KN220731 CDH1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN220731BN CDH1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN220731RB CDH1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN420731 CDH1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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