LC3B (MAP1LC3B) Human Gene Knockout Kit (CRISPR)

SKU KN207356BN

MAP1LC3B - human gene knockout kit via CRISPR, HDR mediated

Product Data

• Format: 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
• Vector: mBFP-Neo
• Target Symbol: LC3B
• Locus ID: 81631
• Components:

  KN207356G1, LC3B gRNA vector 1 in pCas-Guide CRISPR vector

  KN207356G2, LC3B gRNA vector 2 in pCas-Guide CRISPR vector

  KN207356BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_022818
• UniProt ID: Q9GZQ8
• Synonyms: ATG8F; LC3B; MAP1A/1BLC3; MAP1LC3B-a
• Summary: The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component. [provided by RefSeq, Jul 2008]
• Shipping: Ambient