C9ORF46 (PLGRKT) Human Gene Knockout Kit (CRISPR)

SKU KN202315

PLGRKT - human gene knockout kit via CRISPR, HDR mediated

Product Data

• Format: 2 gRNA vectors, 1 GFP-puro donor, 1 scramble control
• Vector: GFP-puro
• Target Symbol: C9ORF46
• Locus ID: 55848
• Components:

  KN202315G1, C9ORF46 gRNA vector 1 in pCas-Guide CRISPR vector

  KN202315G2, C9ORF46 gRNA vector 2 in pCas-Guide CRISPR vector

  KN202315D, donor DNA containing left and right homologous arms and GFP-puro functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_018465
• UniProt ID: Q9HBL7
• Synonyms: AD025; C9orf46; MDS030; Plg-R(KT); PLG-RKT
• Summary: Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator-dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metalloproteinase activation, such as of MMP2 and MMP9.[UniProtKB/Swiss-Prot Function]
• Shipping: Ambient