Human C9ORF46 (PLGRKT) activation kit by CRISPRa

SKU GA111017

PLGRKT CRISPRa kit - CRISPR gene activation of human plasminogen receptor with a C-terminal lysine

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: PLGRKT
• Locus ID: 55848
• Components:

  GA111017G1, C9ORF46 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA111017G2, C9ORF46 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA111017G3, C9ORF46 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_018465
• UniProt ID: Q9HBL7
• Synonyms: AD025; C9orf46; MDS030; Plg-R(KT); PLG-RKT
• Summary: Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator-dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metalloproteinase activation, such as of MMP2 and MMP9.[UniProtKB/Swiss-Prot Function]