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p53 (TP53) Human Gene Knockout Kit (CRISPR)

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SKU
KN200003BN
TP53 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "p53 or NM_000546"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Vector mBFP-Neo
Target Symbol p53
Locus ID 7157
Components

KN200003G1, p53 gRNA vector 1 in pCas-Guide CRISPR vector

KN200003G2, p53 gRNA vector 2 in pCas-Guide CRISPR vector

KN200003BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_000546, NM_001126112, NM_001126113, NM_001126114, NM_001126115, NM_001126116, NM_001126117, NM_001126118, NM_001276695, NM_001276696, NM_001276697, NM_001276698, NM_001276699, NM_001276760, NM_001276761
UniProt ID P04637
Synonyms BCC7; LFS1; P53; TRP53
Summary This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). provided by RefSeq, Dec 2016
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Documents
Resources
Other Versions
SKU Description Size Price
GA104942 TP53 CRISPRa kit - CRISPR gene activation of human tumor protein p53 1 kit
$1,657.00
KN200003 TP53 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN200003LP TP53 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN200003RB TP53 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN400003 TP53 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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