OriGene Logo

Customer Login

Checkout as a new customer

Creating an account has many benefits:

  • See order and shipping status
  • Track order history
  • Check out faster
Create an Account

Human PD-L1 (CD274) activation kit by CRISPRa

Be the first to review this product
SKU
GA109256
CD274 CRISPRa kit - CRISPR gene activation of human CD274 molecule
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA507087 PD-L1 / CD274 mouse monoclonal antibody, clone OTI2C7 (formerly 2C7) 100 ul
$447.00
RC213071 PD-L1 / CD274 (Myc-DDK-tagged)-Human PD-L1 / CD274 molecule (PD-L1 / CD274)
10 ug
$300.00

Other products for "CD274"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol CD274
Locus ID 29126
Components

GA109256G1, PD-L1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA109256G2, PD-L1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA109256G3, PD-L1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_001267706, NM_001314029, NM_014143, NR_052005
UniProt ID Q9NZQ7
Synonyms B7-H; B7H1; PD-L1; PDCD1L1; PDCD1LG1; PDL1
Summary This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. provided by RefSeq, Sep 2015
Reviews
Write Review
 
 
 
 
 

Be the first to review this product

Please note:
Only reviews with images are eligible for a $20/20€ Amazon gift card.
Reviews without images are eligible for a $10/10€ Amazon gift card.
For more details about the terms and conditions, please visit the promotion page.

Review image
Documents
Resources
Other Versions
SKU Description Size Price
KN213071 CD274 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN213071BN CD274 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN213071LP CD274 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN213071RB CD274 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN413071 CD274 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

file-alt Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Related Products