Human mtTFA (TFAM) activation kit by CRISPRa

SKU GA104828

TFAM CRISPRa kit - CRISPR gene activation of human transcription factor A, mitochondrial

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: TFAM
• Locus ID: 7019
• Components:

  GA104828G1, mtTFA gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104828G2, mtTFA gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104828G3, mtTFA gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001270782, NM_003201, NM_012251, NR_073073
• UniProt ID: Q00059
• Synonyms: MTTF1; MTTFA; TCF6; TCF6L1; TCF6L2; TCF6L3
• Summary: This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]