CD3E (NM_000733) Human Recombinant Protein

CAT#: TP308276

Recombinant protein of human CD3e molecule, epsilon (CD3-TCR complex) (CD3E)


 Product Datasheet for 'TP308276'

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USD 748.00


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Size
    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human CD3e molecule, epsilon (CD3-TCR complex) (CD3E)
Species Human
Expression Host HEK293T
Expression cDNA Clone or AA Sequence Recombinant protein was produced with TrueORF clone, RC208276. Click on the TrueORF clone link to view cDNA and protein sequences.
Tag C-MYC/DDK
Predicted MW 20.7 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. Store at –80C. Avoid repeated freeze-thaw cycles. Stable for 3 months from receipt of products under proper storage and handling conditions.
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_000724
Locus ID 916
Refseq Size 1534
Cytogenetics 11q23.3
Refseq ORF 624
Synonyms IMD18; T3E; TCRE
Summary The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]
Protein Families Transmembrane, Druggable Genome
Protein Pathways Hematopoietic cell lineage, T cell receptor signaling pathway, Primary immunodeficiency

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