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p53 (TP53) (NM_000546) Human Mass Spec Standard

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SKU
PH300003
TP53 MS Standard C13 and N15-labeled recombinant protein (NP_000537)
Size:
10 ug
  $3,360.00
In Stock*
Bulk/Customize

Frequently Bought Together (2)

TA502870 TP53 mouse monoclonal antibody, clone OTI5E2 (formerly 5E2) 100 ul
$447.00
LY400186 Transient overexpression lysate of tumor protein p53 (TP53), transcript variant 1 (as WB positive control) 100 ug
$436.00

Other products for "p53 or NM_000546"

Specifications
Specifications
Product Data
Tag C-Myc/DDK
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC200003
Predicted MW 43.7 kDa
Protein Sequence
Protein Sequence
>Peptide sequence encoded by RC200003
Blue=ORF Red=Cloning site Green=Tag(s)

MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEA
APPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLA
KTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLD
DRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCA
CPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELN
EALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
TRTRPLEQKLISEEDLAANDILDYKDDDDKV

Recombinant protein using RC200003 also available, TP300003
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with U- 13C6, 15N4-L-Arginine and U- 13C6, 15N2-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Storage Store at -80°C. Avoid repeated freeze-thaw cycles.
Stability Stable for 3 months from receipt of products under proper storage and handling conditions.
Shipping Dry Ice
Reference Data
RefSeq NP_000537
RefSeq Size 2591
RefSeq ORF 1179
Synonyms BCC7; BMFS5; LFS1; P53; TRP53
Locus ID 7157
UniProt ID P04637
Cytogenetics 17p13.1
Summary This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). provided by RefSeq, Dec 2016
Protein Families Druggable Genome, Stem cell - Pluripotency, Transcription Factors
Protein Pathways Amyotrophic lateral sclerosis (ALS), Apoptosis, Basal cell carcinoma, Bladder cancer, Cell cycle, Chronic myeloid leukemia, Colorectal cancer, Endometrial cancer, Glioma, Huntington's disease, MAPK signaling pathway, Melanoma, Neurotrophin signaling pathway, Non-small cell lung cancer, p53 signaling pathway, Pancreatic cancer, Pathways in cancer, Prostate cancer, Small cell lung cancer, Thyroid cancer, Wnt signaling pathway
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Other "p53" proteins (16)
SKU Description Size Price
PH325502 TP53 MS Standard C13 and N15-labeled recombinant protein (NP_001119586) 10 ug
$3,360.00
PH325604 TP53 MS Standard C13 and N15-labeled recombinant protein (NP_001119584) 10 ug
$3,360.00
LC400186 Lyophilized TP53 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LC426652 Lyophilized TP53 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LC426653 Lyophilized TP53 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LC426654 Lyophilized TP53 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY400186 Transient overexpression lysate of tumor protein p53 (TP53), transcript variant 1 (as WB positive control) 100 ug
$436.00
LY426652 Transient overexpression lysate of tumor protein p53 (TP53), transcript variant 2 (as WB positive control) 100 ug
$436.00
LY426653 Transient overexpression lysate of tumor protein p53 (TP53), transcript variant 4 (as WB positive control) 100 ug
$436.00
LY426654 Transient overexpression lysate of tumor protein p53 (TP53), transcript variant 3 (as WB positive control) 100 ug
$436.00
TP300003 Recombinant protein of human tumor protein p53 (TP53), transcript variant 1, 20 µg 20 ug
$867.00
TP325502 Purified recombinant protein of Homo sapiens tumor protein p53 (TP53), transcript variant 3, 20 µg 20 ug
$867.00
TP325604 Recombinant protein of human tumor protein p53 (TP53), transcript variant 2, 20 µg 20 ug
$867.00
TP701001 Purified recombinant protein of human tumor protein P53 (TP53), transcript variant 1, mutant (Y220C), expressed in HEK293 cells, 20ug 20 ug
$900.00
TP710022 Recombinant protein of human tumor protein p53 (TP53), transcript variant 1, full length, with C-terminal DDK tag, expressed in sf9 cells. 20 ug
$540.00
TP750119 Purified recombinant protein of Human tumor protein p53 (TP53), transcript variant 1, full length, N-terminal His and GST tag, expressed in E. coli, 50ug 50 ug
$270.00

file-alt Citations

Improvement and induction property of radiation-responsive promoter through DNA shuffling of 5'-flanking regions of the human p21 gene
Kagiya, Ogawa, Cook et al
J Biosci Bioeng (2010) 110 (1), 118-23 DOI: 10.1016/j.jbiosc.2009.12.013
Cited by 4
AI Summary: In this study, OriGene’s pGL4.20[luc2/Puro] vector and p21 promoter constructs were used as key tools for cloning and functional analysis, enabling the evaluation and improvement of radiation-responsive promoter activity through DNA shuffling.
FigureFigure
Showing 1-1 of 1 papers.
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