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Vhl Mouse Gene Knockout Kit (CRISPR)

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SKU
KN318888BN
Vhl - mouse gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

Frequently Bought Together (3)

MR201630 Vhl (Myc-DDK-tagged) - Mouse von Hippel-Lindau tumor suppressor (Vhl)
10 ug
$289.00 $300.00
GE100003 pCAS-Scramble, pCas-Guide vector with a scrambled sequence as a negative control (10 µg)
10 ug
$470.00
TT300007S A non-viral, non-electroporation, non-liposomal transfection kit using engineered mammalian proteins, tailored for high-efficiency delivery into a wide range of primary cells and difficult to transfect cell lines such as immune cells, stem cells, and neuronal cells.
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$265.00

Other products for "Vhl or BC052417"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Vector mBFP-Neo
Target Symbol Vhl
Locus ID 22346
Components

KN318888G1, Vhl gRNA vector 1 in pCas-Guide CRISPR vector

KN318888G2, Vhl gRNA vector 2 in pCas-Guide CRISPR vector

KN318888BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_009507
UniProt ID P40338
Synonyms Vhlh
Summary Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2 (By similarity).UniProtKB/Swiss-Prot Function
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Other Versions
SKU Description Size Price
GA204595 Vhl CRISPRa kit - CRISPR gene activation of mouse von Hippel-Lindau tumor suppressor 1 kit
$1,657.00
KN318888 Vhl - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN318888LP Vhl - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN318888RB Vhl - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN518888 Vhl - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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