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S100a4 Mouse Gene Knockout Kit (CRISPR)

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SKU
KN315238
S100a4 - mouse gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

Frequently Bought Together (3)

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Other products for "S100a4 or BC051214"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 GFP-puro donor, 1 scramble control
Vector GFP-puro
Target Symbol S100a4
Locus ID 20198
Components

KN315238G1, S100a4 gRNA vector 1 in pCas-Guide CRISPR vector

KN315238G2, S100a4 gRNA vector 2 in pCas-Guide CRISPR vector

KN315238D, donor DNA containing left and right homologous arms and GFP-puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_011311
UniProt ID P07091
Synonyms 18A2; 42a; Capl; FSp1; metastasin; Mts1; PeL98; pk9a
Summary Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy (PubMed:20519440). Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9 (PubMed:8051043). Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis (PubMed:8051043). Modulates also the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels (By similarity). Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes (PubMed:20103644). In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors (By similarity).UniProtKB/Swiss-Prot Function
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Other Versions
SKU Description Size Price
GA203747 S100a4 CRISPRa kit - CRISPR gene activation of mouse S100 calcium binding protein A4 1 kit
$1,657.00
KN315238BN S100a4 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN315238LP S100a4 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN315238RB S100a4 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN515238 S100a4 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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