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Mouse S100a4 activation kit by CRISPRa

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SKU
GA203747
S100a4 CRISPRa kit - CRISPR gene activation of mouse S100 calcium binding protein A4
  $1,657.00
4 Weeks*

Other products for "S100a4"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol S100a4
Locus ID 20198
Components

GA203747G1, S100a4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA203747G2, S100a4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA203747G3, S100a4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_011311
UniProt ID P07091
Synonyms 18A2; 42a; Capl; FSp1; metastasin; Mts1; PeL98; pk9a
Summary Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy (PubMed:20519440). Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9 (PubMed:8051043). Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis (PubMed:8051043). Modulates also the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels (By similarity). Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes (PubMed:20103644). In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors (By similarity).UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN315238 S100a4 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN315238BN S100a4 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN315238LP S100a4 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN315238RB S100a4 - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN515238 S100a4 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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