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GRAMD1B Human Gene Knockout Kit (CRISPR)

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SKU
KN219269BN
GRAMD1B - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "GRAMD1B or NM_001286563"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Vector mBFP-Neo
Target Symbol GRAMD1B
Locus ID 57476
Components

KN219269G1, GRAMD1B gRNA vector 1 in pCas-Guide CRISPR vector

KN219269G2, GRAMD1B gRNA vector 2 in pCas-Guide CRISPR vector

KN219269BND, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001286563, NM_001286564, NM_001330396, NM_020716, NM_001354837, NM_001367420, NM_001367421, NM_001367418, NM_001367419
UniProt ID Q3KR37
Summary Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity).UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
GA111521 GRAMD1B CRISPRa kit - CRISPR gene activation of human GRAM domain containing 1B 1 kit
$1,657.00
KN219269 GRAMD1B - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN219269LP GRAMD1B - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN219269RB GRAMD1B - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN419269 GRAMD1B - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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