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DCAMKL1 (DCLK1) Human Gene Knockout Kit (CRISPR)

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SKU
KN217050LP
DCLK1 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "DCAMKL1 or NM_001195415"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Vector Luciferase-Puro
Target Symbol DCAMKL1
Locus ID 9201
Components

KN217050G1, DCAMKL1 gRNA vector 1 in pCas-Guide CRISPR vector

KN217050G2, DCAMKL1 gRNA vector 2 in pCas-Guide CRISPR vector

KN217050LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001195415, NM_001195416, NM_001195430, NM_004734, NM_001330071, NM_001330072
UniProt ID O15075
Synonyms CL1; CLICK1; DCAMKL1; DCDC3A; DCLK
Summary This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.provided by RefSeq, Sep 2010
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Documents
Resources
Other Versions
SKU Description Size Price
GA106133 DCLK1 CRISPRa kit - CRISPR gene activation of human doublecortin like kinase 1 1 kit
$1,657.00
KN217050 DCLK1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN217050BN DCLK1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN217050RB DCLK1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN417050 DCLK1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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