NLRP7 Human Gene Knockout Kit (CRISPR)

SKU KN215065LP

NLRP7 - human gene knockout kit via CRISPR, HDR mediated

Product Data

• Format: 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
• Vector: Luciferase-Puro
• Target Symbol: NLRP7
• Locus ID: 199713
• Components:

  KN215065G1, NLRP7 gRNA vector 1 in pCas-Guide CRISPR vector

  KN215065G2, NLRP7 gRNA vector 2 in pCas-Guide CRISPR vector

  KN215065LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

  GE100003, scramble sequence in pCas-Guide vector

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001127255, NM_139176, NM_206828
• UniProt ID: Q8WX94
• Synonyms: CLR19.4; HYDM; NALP7; NOD12; PAN7; PYPAF3
• Summary: This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
• Shipping: Ambient