Human NLRP7 activation kit by CRISPRa

SKU GA116312

NLRP7 CRISPRa kit - CRISPR gene activation of human NLR family pyrin domain containing 7

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: NLRP7
• Locus ID: 199713
• Components:

  GA116312G1, NLRP7 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA116312G2, NLRP7 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA116312G3, NLRP7 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001127255, NM_139176, NM_206828
• UniProt ID: Q8WX94
• Synonyms: CLR19.4; HYDM; NALP7; NOD12; PAN7; PYPAF3
• Summary: This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]