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PACE4 (PCSK6) Human Gene Knockout Kit (CRISPR)

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SKU
KN213553LP
PCSK6 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "PACE4 or NM_001291309"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Vector Luciferase-Puro
Target Symbol PACE4
Locus ID 5046
Components

KN213553G1, PACE4 gRNA vector 1 in pCas-Guide CRISPR vector

KN213553G2, PACE4 gRNA vector 2 in pCas-Guide CRISPR vector

KN213553LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001291309, NM_002570, NM_138319, NM_138320, NM_138321, NM_138322, NM_138323, NM_138324, NM_138325
UniProt ID P29122
Synonyms PACE4; SPC4
Summary This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. The encoded protease is constitutively secreted into the extracellular matrix and expressed in many tissues, including neuroendocrine, liver, gut, and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression and left-right patterning. Alternatively spliced transcript variants encoding different isoforms have been identified. provided by RefSeq, Feb 2014
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Documents
Resources
Other Versions
SKU Description Size Price
GA103368 PCSK6 CRISPRa kit - CRISPR gene activation of human proprotein convertase subtilisin/kexin type 6 1 kit
$1,657.00
KN213553 PCSK6 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN213553BN PCSK6 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN213553RB PCSK6 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN413553 PCSK6 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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