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Human PACE4 (PCSK6) activation kit by CRISPRa

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SKU
GA103368
PCSK6 CRISPRa kit - CRISPR gene activation of human proprotein convertase subtilisin/kexin type 6
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA329886 Rabbit Polyclonal Anti-PCSK6 Antibody
100 ul
$525.00
RC213553 PCSK6 (Myc-DDK-tagged)-Human proprotein convertase subtilisin/kexin type 6 (PCSK6), transcript variant 7
10 ug
$893.00

Other products for "PCSK6"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol PCSK6
Locus ID 5046
Components

GA103368G1, PACE4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA103368G2, PACE4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA103368G3, PACE4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001291309, NM_002570, NM_138319, NM_138320, NM_138321, NM_138322, NM_138323, NM_138324, NM_138325
UniProt ID P29122
Synonyms PACE4; SPC4
Summary This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. The encoded protease is constitutively secreted into the extracellular matrix and expressed in many tissues, including neuroendocrine, liver, gut, and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression and left-right patterning. Alternatively spliced transcript variants encoding different isoforms have been identified. provided by RefSeq, Feb 2014
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Documents
Resources
Other Versions
SKU Description Size Price
KN213553 PCSK6 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN213553BN PCSK6 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN213553LP PCSK6 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN213553RB PCSK6 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN413553 PCSK6 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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