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NOTCH1 Human Gene Knockout Kit (CRISPR)

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SKU
KN211365LP
NOTCH1 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "NOTCH1 or NM_017617"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Vector Luciferase-Puro
Target Symbol NOTCH1
Locus ID 4851
Components

KN211365G1, NOTCH1 gRNA vector 1 in pCas-Guide CRISPR vector

KN211365G2, NOTCH1 gRNA vector 2 in pCas-Guide CRISPR vector

KN211365LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_017617
UniProt ID P46531
Synonyms AOS5; AOVD1; hN1; TAN1
Summary This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma. provided by RefSeq, Jan 2016
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Documents
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Other Versions
SKU Description Size Price
GA103238 NOTCH1 CRISPRa kit - CRISPR gene activation of human notch receptor 1 1 kit
$1,657.00
KN211365 NOTCH1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN211365BN NOTCH1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN211365RB NOTCH1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN411365 NOTCH1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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