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Human NOTCH1 activation kit by CRISPRa

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SKU
GA103238
NOTCH1 CRISPRa kit - CRISPR gene activation of human notch receptor 1
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA500078 Anti-Notch1 mouse monoclonal antibody, clone OTI3E12 (formerly 3E12) 100 ul
$447.00
RC211365 NOTCH1 (Myc-DDK-tagged)-Human notch 1 (NOTCH1)
10 ug
$3,164.00

Other products for "NOTCH1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol NOTCH1
Locus ID 4851
Components

GA103238G1, NOTCH1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA103238G2, NOTCH1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA103238G3, NOTCH1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_017617
UniProt ID P46531
Synonyms AOS5; AOVD1; hN1; TAN1
Summary This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma. provided by RefSeq, Jan 2016
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Documents
Resources
Other Versions
SKU Description Size Price
KN211365 NOTCH1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN211365BN NOTCH1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN211365LP NOTCH1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN211365RB NOTCH1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN411365 NOTCH1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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